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  1. Article ; Online: Cancer cachexia: learn from yesterday, live for today and hope for tomorrow.

    Laird, Barry J A / Jatoi, Aminah

    Current opinion in supportive and palliative care

    2023  Volume 17, Issue 3, Page(s) 161

    MeSH term(s) Humans ; Cachexia/etiology ; Cachexia/therapy ; Neoplasms/complications
    Language English
    Publishing date 2023-07-27
    Publishing country United States
    Document type Editorial
    ZDB-ID 2633726-5
    ISSN 1751-4266 ; 1751-4258
    ISSN (online) 1751-4266
    ISSN 1751-4258
    DOI 10.1097/SPC.0000000000000652
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Central neural mechanisms of cancer cachexia.

    Yule, Michael S / Brown, Leo R / Skipworth, Richard J E / Laird, Barry J A

    Current opinion in supportive and palliative care

    2024  

    Abstract: Purpose of review: Cachexia is a devasting syndrome which impacts a large number of patients with cancer. This review aims to provide a comprehensive overview of the central mechanisms of cancer cachexia. In particular, it focuses on the role of the ... ...

    Abstract Purpose of review: Cachexia is a devasting syndrome which impacts a large number of patients with cancer. This review aims to provide a comprehensive overview of the central mechanisms of cancer cachexia. In particular, it focuses on the role of the central nervous system (CNS), the melanocortin system, circulating hormones and molecules which are produced by and act on the CNS and the psychological symptoms of cancer cachexia.
    Recent findings: A growing body of evidence suggests that a central mechanism of action underpins this multi-system disorder. Recent research has focused on the role of neuroinflammation that drives the sickness behaviour seen in cancer cachexia, with emphasis on the role of the hypothalamus. Melanocortin receptor antagonists are showing promise in preclinical studies. There are also new pharmacological developments to overcome the short half-life of ghrelin. GDF-15 has been identified as a core target and trials of compounds that interfere with its signalling or its central receptor are underway.
    Summary: Understanding the central mechanisms of cancer cachexia is pivotal for enhancing treatment outcomes in patients. While emerging pharmacological interventions targeting these pathways have shown promise, further research is essential.
    Language English
    Publishing date 2024-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2633726-5
    ISSN 1751-4266 ; 1751-4258
    ISSN (online) 1751-4266
    ISSN 1751-4258
    DOI 10.1097/SPC.0000000000000707
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The Obesity Paradox in Cancer: Is Bigger Better?

    Laird, Barry J A / Skipworth, Richard J E

    Journal of cachexia, sarcopenia and muscle

    2022  Volume 13, Issue 3, Page(s) 1440–1441

    MeSH term(s) Body Mass Index ; Humans ; Neoplasms/complications ; Neoplasms/epidemiology ; Obesity/complications ; Obesity/epidemiology
    Language English
    Publishing date 2022-05-04
    Publishing country Germany
    Document type Editorial
    ZDB-ID 2586864-0
    ISSN 2190-6009 ; 2190-5991
    ISSN (online) 2190-6009
    ISSN 2190-5991
    DOI 10.1002/jcsm.13007
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  4. Article ; Online: Editorial: Cancer cachexia - bridging the gap.

    Laird, Barry J A / Jatoi, Aminah

    Current opinion in supportive and palliative care

    2020  Volume 14, Issue 4, Page(s) 301

    MeSH term(s) Cachexia/etiology ; Humans ; Neoplasms/complications
    Language English
    Publishing date 2020-11-12
    Publishing country United States
    Document type Editorial
    ZDB-ID 2633726-5
    ISSN 1751-4266 ; 1751-4258
    ISSN (online) 1751-4266
    ISSN 1751-4258
    DOI 10.1097/SPC.0000000000000528
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Editorial: Merging therapeutics and supportive care: synergy and yield.

    Jatoi, Aminah / Laird, Barry J A

    Current opinion in supportive and palliative care

    2019  Volume 13, Issue 4, Page(s) 277–278

    MeSH term(s) Antineoplastic Agents/adverse effects ; Body Mass Index ; Cachexia/etiology ; Cachexia/physiopathology ; Cachexia/therapy ; Humans ; Immunotherapy/methods ; Neoplasms/complications ; Neoplasms/drug therapy ; Palliative Care/organization & administration ; Wasting Syndrome/etiology ; Wasting Syndrome/physiopathology ; Wasting Syndrome/therapy
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2019-09-05
    Publishing country United States
    Document type Editorial ; Introductory Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2633726-5
    ISSN 1751-4266 ; 1751-4258
    ISSN (online) 1751-4266
    ISSN 1751-4258
    DOI 10.1097/SPC.0000000000000468
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: 'The shoulders, clavicles, chest and thighs melt away': a compilation of reviews on cachexia.

    Laird, Barry J A / Jatoi, Aminah

    Current opinion in supportive and palliative care

    2019  Volume 12, Issue 4, Page(s) 393

    MeSH term(s) Cachexia/physiopathology ; Cachexia/therapy ; Energy Intake ; Growth Differentiation Factor 15/metabolism ; Humans ; Nutritional Support/methods ; Sex Characteristics
    Chemical Substances Growth Differentiation Factor 15
    Language English
    Publishing date 2019-01-11
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2633726-5
    ISSN 1751-4266 ; 1751-4258
    ISSN (online) 1751-4266
    ISSN 1751-4258
    DOI 10.1097/SPC.0000000000000399
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Longitudinal characterisation of cachexia in patients undergoing surgical resection for cancer.

    Brown, Leo R / Laird, Barry J A / Wigmore, Stephen J / Skipworth, Richard J E

    Current opinion in supportive and palliative care

    2023  Volume 17, Issue 3, Page(s) 172–176

    Abstract: Purpose of review: The complexity of the cancer cachexia phenotype has undoubtedly hindered researchers' understanding of this devastating syndrome. The presence and magnitude of host-tumour interactions are rarely considered during clinical decision- ... ...

    Abstract Purpose of review: The complexity of the cancer cachexia phenotype has undoubtedly hindered researchers' understanding of this devastating syndrome. The presence and magnitude of host-tumour interactions are rarely considered during clinical decision-making within the current staging paradigm. Furthermore, treatment options for those patients who are identified as suffering from cancer cachexia remain extremely limited.
    Recent findings: Previous attempts to characterise cachexia have largely focussed on individual surrogate disease markers, often studied across a limited timeframe. While the adverse prognostic value of clinical and biochemical features is evident, the relationships between these are less clear. Investigation of patients with earlier-stage disease could allow researchers to identify markers of cachexia that precede the refractory stage of the wasting process. Appreciation of the cachectic phenotype within 'curative' populations may aid our understanding of the syndrome's genesis and provide potential routes for prevention, rather than treatment.
    Summary: Holistic, longitudinal characterisation of cancer cachexia, across all at-risk and affected populations, is of vital importance for future research in the field. This paper presents the protocol for an observational study aiming to create a robust and holistic characterisation of surgical patients with, or at risk of, cancer cachexia.
    MeSH term(s) Humans ; Cachexia/etiology ; Neoplasms/complications ; Neoplasms/surgery ; Neoplasms/pathology ; Phenotype ; Biomarkers ; Observational Studies as Topic
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-06-30
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2633726-5
    ISSN 1751-4266 ; 1751-4258
    ISSN (online) 1751-4266
    ISSN 1751-4258
    DOI 10.1097/SPC.0000000000000660
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The prevalence and prognostic value of frailty screening measures in patients undergoing surgery for colorectal cancer: observations from a systematic review.

    McGovern, Josh / Dolan, Ross D / Horgan, Paul G / Laird, Barry J / McMillan, Donald C

    BMC geriatrics

    2022  Volume 22, Issue 1, Page(s) 260

    Abstract: Introduction: Frailty is a complex multifactorial syndrome characterised by a significant increase in vulnerability and worsened health outcomes. Despite a range of proposed frailty screening measures, the prevalence and prognostic value of frailty in ... ...

    Abstract Introduction: Frailty is a complex multifactorial syndrome characterised by a significant increase in vulnerability and worsened health outcomes. Despite a range of proposed frailty screening measures, the prevalence and prognostic value of frailty in patients undergoing surgery for colorectal cancer is not clear.
    Aim: The aim of this present review was to examine the use of commonly employed frailty screening measures in patients undergoing surgery for colorectal cancer.
    Methods: A systematic search of PubMed and Medline was carried out to identify studies reporting the use of frailty screening tools or measures in patients undergoing surgery for colorectal cancer. The screening measure used and prevalence of frailty within the population were recorded. Outcomes of interest were the incidence of post-operative complications, 30-day mortality and overall survival.
    Results: Of the 15 studies included (n = 97, 898 patients), 9 studies were retrospective and included patients aged 70 years or older (n = 96, 120 patients). 5 of 12 studies reported that frailty was independently associated with the incidence of post-operative complications. There was also evidence that frailty was independently associated with 30-day mortality (1 of 4 studies, n = 9, 252 patients) and long-term survival (2 of 3 studies, n = 1, 420 patients).
    Conclusions: Frailty was common in patients with colorectal cancer and the assessment of frailty may have prognostic value in patients undergoing surgery. However, the basis of the relationship between frailty and post-operative outcomes is not clear and merits further study.
    MeSH term(s) Aged ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/surgery ; Early Detection of Cancer ; Frail Elderly ; Frailty/complications ; Frailty/diagnosis ; Frailty/epidemiology ; Humans ; Prevalence ; Prognosis ; Retrospective Studies
    Language English
    Publishing date 2022-03-29
    Publishing country England
    Document type Journal Article ; Systematic Review
    ZDB-ID 2059865-8
    ISSN 1471-2318 ; 1471-2318
    ISSN (online) 1471-2318
    ISSN 1471-2318
    DOI 10.1186/s12877-022-02928-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Understanding Cancer Cachexia and Its Implications in Upper Gastrointestinal Cancers.

    Brown, Leo R / Laird, Barry J A / Wigmore, Stephen J / Skipworth, Richard J E

    Current treatment options in oncology

    2022  Volume 23, Issue 12, Page(s) 1732–1747

    Abstract: Opinion statement: Considerable advances in the investigation and management of oesophagogastric cancer have occurred over the last few decades. While the historically dismal prognosis associated with these diseases has improved, outcomes remain very ... ...

    Abstract Opinion statement: Considerable advances in the investigation and management of oesophagogastric cancer have occurred over the last few decades. While the historically dismal prognosis associated with these diseases has improved, outcomes remain very poor. Cancer cachexia is an often neglected, yet critical, factor for this patient group. There is a persuasive argument that a lack of assessment and treatment of cachexia has limited progress in oesophagogastric cancer care. In the curative setting, the stage of the host (based on factors such as body composition, function, and inflammatory status), alongside tumour stage, has the potential to influence treatment efficacy. Phenotypical features of cachexia may decrease the survival benefit of (peri-operative) chemoradiotherapy, immunotherapy, or surgical resection in patients with potentially curative malignancy. Most patients with oesophagogastric cancer unfortunately present with disease which is not amenable, or is unlikely to respond, to these treatments. In the palliative setting, host factors can similarly impair results from systemic anti-cancer therapies, cause adverse symptoms, and reduce quality of life. To optimise treatment pathways and enhance patient outcomes, we must utilise this information during clinical decision-making. As our understanding of the genesis of cancer cachexia improves and more therapeutic options, ranging from basic (e.g. exercise and nutrition) to targeted (e.g. anti-IL1 α and anti-GDF-15), become available, there can be grounds for optimism. Cachexia can change from a hitherto neglected condition to an integral part of the oesophagogastric cancer treatment pathway.
    MeSH term(s) Humans ; Cachexia/diagnosis ; Cachexia/etiology ; Cachexia/therapy ; Quality of Life ; Neoplasms/complications ; Gastrointestinal Neoplasms/complications ; Gastrointestinal Neoplasms/diagnosis ; Gastrointestinal Neoplasms/therapy ; Prognosis ; Treatment Outcome
    Language English
    Publishing date 2022-10-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057351-0
    ISSN 1534-6277 ; 1527-2729
    ISSN (online) 1534-6277
    ISSN 1527-2729
    DOI 10.1007/s11864-022-01028-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Cancer cachexia: a nutritional or a systemic inflammatory syndrome?

    McGovern, Josh / Dolan, Ross D / Skipworth, Richard J / Laird, Barry J / McMillan, Donald C

    British journal of cancer

    2022  Volume 127, Issue 3, Page(s) 379–382

    Abstract: Cancer cachexia has long been perceived as a nutritional syndrome. However, nutritional interventions have continued to be ineffective. With the recent recognition of the importance of systemic inflammation in the definition of this syndrome and ... ...

    Abstract Cancer cachexia has long been perceived as a nutritional syndrome. However, nutritional interventions have continued to be ineffective. With the recent recognition of the importance of systemic inflammation in the definition of this syndrome and treatment, has the time come to consider whether this syndrome is primarily a manifestation of systemic inflammation with the consequent implications for future treatment?
    MeSH term(s) Cachexia/etiology ; Cachexia/therapy ; Humans ; Inflammation/complications ; Neoplasms/complications
    Language English
    Publishing date 2022-05-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-022-01826-2
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