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  1. AU="Laisi, Arttu"
  2. AU="Huang, Haibing"
  3. AU="Volk, Michelle"
  4. AU="Zijlstra, J. G."
  5. AU="Aditya Narayan"
  6. AU="Soliño, S. López"
  7. AU="Bervoets, Lieven"
  8. AU=Perween Reshma AU=Perween Reshma
  9. AU="Wang, Zhenduo"

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  1. Artikel ; Online: Exotoxin-Targeted Drug Modalities as Antibiotic Alternatives.

    Sakari, Moona / Laisi, Arttu / Pulliainen, Arto T

    ACS infectious diseases

    2022  Band 8, Heft 3, Seite(n) 433–456

    Abstract: The paradigm of antivirulence therapy dictates that bacterial pathogens are specifically disarmed but not killed by neutralizing their virulence factors. Clearance of the invading pathogen by the immune system is promoted. As compared to antibiotics, the ...

    Abstract The paradigm of antivirulence therapy dictates that bacterial pathogens are specifically disarmed but not killed by neutralizing their virulence factors. Clearance of the invading pathogen by the immune system is promoted. As compared to antibiotics, the pathogen-selective antivirulence drugs hold promise to minimize collateral damage to the beneficial microbiome. Also, selective pressure for resistance is expected to be lower because bacterial viability is not directly affected. Antivirulence drugs are being developed for stand-alone prophylactic and therapeutic treatments but also for combinatorial use with antibiotics. This Review focuses on drug modalities that target bacterial exotoxins after the secretion or release-upon-lysis. Exotoxins have a significant and sometimes the primary role as the disease-causing virulence factor, and thereby they are attractive targets for drug development. We describe the key pre-clinical and clinical trial data that have led to the approval of currently used exotoxin-targeted drugs, namely the monoclonal antibodies bezlotoxumab (toxin B/TcdB,
    Mesh-Begriff(e) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Bacillus anthracis ; Bacterial Toxins ; Clostridioides difficile ; Exotoxins
    Chemische Substanzen Anti-Bacterial Agents ; Bacterial Toxins ; Exotoxins
    Sprache Englisch
    Erscheinungsdatum 2022-01-31
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 2373-8227
    ISSN (online) 2373-8227
    DOI 10.1021/acsinfecdis.1c00296
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Combination of microbiome analysis and serodiagnostics to assess the risk of pathogen transmission by ticks to humans and animals in central Germany.

    Regier, Yvonne / Komma, Kassandra / Weigel, Markus / Kraiczy, Peter / Laisi, Arttu / Pulliainen, Arto T / Hain, Torsten / Kempf, Volkhard A J

    Parasites & vectors

    2019  Band 12, Heft 1, Seite(n) 11

    Abstract: Background: Arthropod-borne diseases remain a major health-threat for humans and animals worldwide. To estimate the distribution of pathogenic agents and especially Bartonella spp., we conducted tick microbiome analysis and determination of the ... ...

    Abstract Background: Arthropod-borne diseases remain a major health-threat for humans and animals worldwide. To estimate the distribution of pathogenic agents and especially Bartonella spp., we conducted tick microbiome analysis and determination of the infection status of wild animals, pets and pet owners in the state of Hesse, Germany.
    Results: In total, 189 engorged ticks collected from 163 animals were tested. Selected ticks were analyzed by next generation sequencing (NGS) and confirmatory PCRs, blood specimens of 48 wild animals were analyzed by PCR to confirm pathogen presence and sera of 54 dogs, one cat and 11 dog owners were analyzed by serology. Bartonella spp. were detected in 9.5% of all ticks and in the blood of 17 roe deer. Further data reveal the presence of the human and animal pathogenic species of genera in the family Spirochaetaceae (including Borrelia miyamotoi and Borrelia garinii), Bartonella spp. (mainly Bartonella schoenbuchensis), Rickettsia helvetica, Francisella tularensis and Anaplasma phagocytophilum in ticks. Co-infections with species of several genera were detected in nine ticks. One dog and five dog owners were seropositive for anti-Bartonella henselae-antibodies and one dog had antibodies against Rickettsia conorii.
    Conclusions: This study provides a snapshot of pathogens circulating in ticks in central Germany. A broad range of tick-borne pathogens are present in ticks, and especially in wild animals, with possible implications for animal and human health. However, a low incidence of Bartonella spp., especially Bartonella henselae, was detected. The high number of various detected pathogens suggests that ticks might serve as an excellent sentinel to detect and monitor zoonotic human pathogens.
    Mesh-Begriff(e) Animals ; Cat Diseases/epidemiology ; Cat Diseases/microbiology ; Cat Diseases/transmission ; Cats ; Deer/microbiology ; Deer/parasitology ; Dog Diseases/epidemiology ; Dog Diseases/microbiology ; Dog Diseases/transmission ; Dogs ; Female ; Germany/epidemiology ; Gram-Negative Bacteria/immunology ; Gram-Negative Bacteria/isolation & purification ; Gram-Negative Bacterial Infections/microbiology ; Gram-Negative Bacterial Infections/transmission ; Humans ; Male ; Microbiota ; Pets ; Risk ; Sequence Alignment/veterinary ; Seroepidemiologic Studies ; Tick-Borne Diseases/epidemiology ; Tick-Borne Diseases/microbiology ; Tick-Borne Diseases/transmission ; Ticks/microbiology
    Sprache Englisch
    Erscheinungsdatum 2019-01-07
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2409480-8
    ISSN 1756-3305 ; 1756-3305
    ISSN (online) 1756-3305
    ISSN 1756-3305
    DOI 10.1186/s13071-018-3240-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Combination of microbiome analysis and serodiagnostics to assess the risk of pathogen transmission by ticks to humans and animals in central Germany

    Regier, Yvonne / Komma, Kassandra / Weigel, Markus / Kraiczy, Peter / Laisi, Arttu / Pulliainen, Arto T / Hain, Torsten / Kempf, Volkhard A. J

    Parasites & vectors. 2019 Dec., v. 12, no. 1

    2019  

    Abstract: BACKGROUND: Arthropod-borne diseases remain a major health-threat for humans and animals worldwide. To estimate the distribution of pathogenic agents and especially Bartonella spp., we conducted tick microbiome analysis and determination of the infection ...

    Abstract BACKGROUND: Arthropod-borne diseases remain a major health-threat for humans and animals worldwide. To estimate the distribution of pathogenic agents and especially Bartonella spp., we conducted tick microbiome analysis and determination of the infection status of wild animals, pets and pet owners in the state of Hesse, Germany. RESULTS: In total, 189 engorged ticks collected from 163 animals were tested. Selected ticks were analyzed by next generation sequencing (NGS) and confirmatory PCRs, blood specimens of 48 wild animals were analyzed by PCR to confirm pathogen presence and sera of 54 dogs, one cat and 11 dog owners were analyzed by serology. Bartonella spp. were detected in 9.5% of all ticks and in the blood of 17 roe deer. Further data reveal the presence of the human and animal pathogenic species of genera in the family Spirochaetaceae (including Borrelia miyamotoi and Borrelia garinii), Bartonella spp. (mainly Bartonella schoenbuchensis), Rickettsia helvetica, Francisella tularensis and Anaplasma phagocytophilum in ticks. Co-infections with species of several genera were detected in nine ticks. One dog and five dog owners were seropositive for anti-Bartonella henselae-antibodies and one dog had antibodies against Rickettsia conorii. CONCLUSIONS: This study provides a snapshot of pathogens circulating in ticks in central Germany. A broad range of tick-borne pathogens are present in ticks, and especially in wild animals, with possible implications for animal and human health. However, a low incidence of Bartonella spp., especially Bartonella henselae, was detected. The high number of various detected pathogens suggests that ticks might serve as an excellent sentinel to detect and monitor zoonotic human pathogens.
    Schlagwörter Anaplasma phagocytophilum ; Bartonella henselae ; Borrelia garinii ; Borrelia miyamotoi ; Capreolus capreolus ; Francisella tularensis ; Rickettsia conorii ; Rickettsia helvetica ; animal pathogens ; antibodies ; arthropod-borne diseases ; blood ; disease transmission ; dogs ; high-throughput nucleotide sequencing ; humans ; microbiome ; mixed infection ; pet ownership ; pets ; polymerase chain reaction ; serology ; seroprevalence ; ticks ; wild animals ; Germany
    Sprache Englisch
    Erscheinungsverlauf 2019-12
    Umfang p. 11.
    Erscheinungsort BioMed Central
    Dokumenttyp Artikel
    ZDB-ID 2409480-8
    ISSN 1756-3305
    ISSN 1756-3305
    DOI 10.1186/s13071-018-3240-7
    Datenquelle NAL Katalog (AGRICOLA)

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