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  1. Article ; Online: Perhejuhlasta potilaaksi - osa 1

    Laitinen, Mika

    2020  

    Abstract: Nuoren miehen oireet alkoivat pian keväisen perhejuhlan jälkeen. Paikalla oli ollut henkilö, joka myöhemmin todettiin COVID-19-positiiviseksi. ... Peer ... ...

    Abstract Nuoren miehen oireet alkoivat pian keväisen perhejuhlan jälkeen. Paikalla oli ollut henkilö, joka myöhemmin todettiin COVID-19-positiiviseksi.

    Peer reviewed
    Keywords Coronavirus Infections ; +diagnosis ; Critical Illness ; Dyspnea ; Clinical Deterioration ; Symptom Flare Up ; Fever ; Cough ; Nausea ; Myalgia ; Male ; Adult ; 3121 Sisätaudit ; covid19
    Language Finnish
    Publishing country fi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Book ; Thesis: Expression and regulation of growth factors controlling ovarian folliculogenesis

    Laitinen, Mika

    1999  

    Author's details Mika Laitinen
    Keywords Wachstumsfaktor ; Genexpression ; Eifollikel ; Reifung
    Subject Reifegrad ; Reifungsstadium ; Folliculi ovarici ; Eibläschen
    Language English
    Size Getr. Zählung : Ill., graph. Darst.
    Publishing country Finland
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Helsinki, Univ., Diss., 1999
    HBZ-ID HT011242180
    ISBN 952-91-1066-9 ; 978-952-91-1066-7
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2000 E 1182 order for loan Magazin

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  3. Book: Viking age brew

    Laitinen, Mika

    the craft of brewing sahti farmhouse ale

    2019  

    Abstract: Viking Age Brew takes readers on a lavishly illustrated tour of rustic brewhouses fueled by wood and passion. Sahti is a Nordic farmhouse ale that is still crafted in accordance with ancient traditions dating back to the Viking Age. It is often thought ... ...

    Author's details Mika Laitinen
    Abstract "Viking Age Brew takes readers on a lavishly illustrated tour of rustic brewhouses fueled by wood and passion. Sahti is a Nordic farmhouse ale that is still crafted in accordance with ancient traditions dating back to the Viking Age. It is often thought of as an oddity among beer styles, but this book demonstrates that a thousand years ago such ales were the norm in northern Europe, before the modern-style hopped beer we drink today reached the masses. Viking Age Brew is the first English-language book to describe the tradition, history, and hands-on brewing of this ale." -- Back cover.
    Keywords Sahti ; Brewing ; Brewing. ; Sahti.
    Language English
    Size viii, 232 pages :, illustrations (chiefly color), color map ;, 23 cm
    Document type Book
    ISBN 9781641600477 ; 1641600470
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Perhejuhlasta potilaaksi- tapauksen ratkaisu

    Lönnqvist, Lasse / Laitinen, Mika

    2020  

    Abstract: Positiivisen COVID-19-testituloksen saanut nuori mies otettiin oireiden vaikeuduttua sairaalaan osastoseurantaan. Vointi koheni ja hänet kotiutettiin, -mutta kotona oireet palasivat ja yleistila heikkeni. ... Peer ... ...

    Abstract Positiivisen COVID-19-testituloksen saanut nuori mies otettiin oireiden vaikeuduttua sairaalaan osastoseurantaan. Vointi koheni ja hänet kotiutettiin, -mutta kotona oireet palasivat ja yleistila heikkeni.

    Peer reviewed
    Keywords Coronavirus Infections ; +therapy ; Critical Illness ; Dyspnea ; Clinical Deterioration ; Symptom Flare Up ; Fever ; Cough ; Nausea ; Myalgia ; Thrombosis ; Male ; Adult ; 3121 Sisätaudit ; covid19
    Language Finnish
    Publishing country fi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Differentiation of Murine C2C12 Myoblasts Strongly Reduces the Effects of Myostatin on Intracellular Signaling.

    Lautaoja, Juulia H / Pekkala, Satu / Pasternack, Arja / Laitinen, Mika / Ritvos, Olli / Hulmi, Juha J

    Biomolecules

    2020  Volume 10, Issue 5

    Abstract: Alongside in vivo models, a simpler and more mechanistic approach is required to study the effects of myostatin on skeletal muscle because myostatin is an important negative regulator of muscle size. In this study, myostatin was administered to murine ( ... ...

    Abstract Alongside in vivo models, a simpler and more mechanistic approach is required to study the effects of myostatin on skeletal muscle because myostatin is an important negative regulator of muscle size. In this study, myostatin was administered to murine (C2C12) and human (CHQ) myoblasts and myotubes. Canonical and noncanonical signaling downstream to myostatin, related ligands, and their receptor were analyzed. The effects of tumorkines were analyzed after coculture of C2C12 and colon cancer-C26 cells. The effects of myostatin on canonical and noncanonical signaling were strongly reduced in C2C12 cells after differentiation. This may be explained by increased follistatin, an endogenous blocker of myostatin and altered expression of activin receptor ligands. In contrast, CHQ cells were equally responsive to myostatin, and follistatin remained unaltered. Both myostatin administration and the coculture stimulated pathways associated with inflammation, especially in C2C12 cells. In conclusion, the effects of myostatin on intracellular signaling may be cell line- or organism-specific, and C2C12 myotubes seem to be a nonoptimal in vitro model for investigating the effects of myostatin on canonical and noncanonical signaling in skeletal muscle. This may be due to altered expression of activin receptor ligands and their regulators during muscle cell differentiation.
    MeSH term(s) Activins/metabolism ; Activins/pharmacology ; Animals ; Cell Differentiation ; Cell Line ; Cell Line, Tumor ; Culture Media, Conditioned/pharmacology ; Follistatin/metabolism ; Follistatin/pharmacology ; Humans ; Mice ; Muscle Fibers, Skeletal/cytology ; Muscle Fibers, Skeletal/drug effects ; Muscle Fibers, Skeletal/metabolism ; Myoblasts/cytology ; Myoblasts/drug effects ; Myoblasts/metabolism ; Myostatin/pharmacology ; Signal Transduction
    Chemical Substances Culture Media, Conditioned ; Follistatin ; Myostatin ; Activins (104625-48-1)
    Language English
    Publishing date 2020-04-30
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom10050695
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Hydro-mechanical modelling of MX-80 bentonite

    Abed Ayman A. / Laitinen Mika / Lämsä Joni / Harjupatana Tero / Sołowski Wojciech T. / Kataja Markku

    E3S Web of Conferences, Vol 9, p

    one dimensional study

    2016  Volume 18005

    Abstract: As a first step towards modelling the coupled Thermo-Hydro-Mechanical-Chemical (THMC) behaviour of bentonite, the Barcelona Basic Model (BBM) has been implemented into Numerrinfinite element code. This model has beenfully coupled with the single phase ... ...

    Abstract As a first step towards modelling the coupled Thermo-Hydro-Mechanical-Chemical (THMC) behaviour of bentonite, the Barcelona Basic Model (BBM) has been implemented into Numerrinfinite element code. This model has beenfully coupled with the single phase flow equation for unsaturated soils which models liquid water transport. Suction obtained from solving the flow equation is used as an input for the BBM model and the volumetric deformations from the mechanical analysis are used to update the pore water pressure field. As an alternative, BBM is used alongside the Kröhn’s model which assumes that bentonite re-saturation is mainly driven by water vapour diffusion. The paper simulates one dimensional infiltration test on MX-80bentonite with both implemented modelsfor water transport and compares the results withthose from a laboratory experiments based on X-ray tomography.The numerical results of the simulations are similar despite taking into account different physical phenomena.
    Keywords Environmental sciences ; GE1-350
    Subject code 621
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Systemic blockade of ACVR2B ligands attenuates muscle wasting in ischemic heart failure without compromising cardiac function.

    Szabó, Zoltán / Vainio, Laura / Lin, Ruizhu / Swan, Julia / Hulmi, Juha J / Rahtu-Korpela, Lea / Serpi, Raisa / Laitinen, Mika / Pasternack, Arja / Ritvos, Olli / Kerkelä, Risto / Magga, Johanna

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology

    2020  Volume 34, Issue 8, Page(s) 9911–9924

    Abstract: Signaling through activin receptors regulates skeletal muscle mass and activin receptor 2B (ACVR2B) ligands are also suggested to participate in myocardial infarction (MI) pathology in the heart. In this study, we determined the effect of systemic ... ...

    Abstract Signaling through activin receptors regulates skeletal muscle mass and activin receptor 2B (ACVR2B) ligands are also suggested to participate in myocardial infarction (MI) pathology in the heart. In this study, we determined the effect of systemic blockade of ACVR2B ligands on cardiac function in experimental MI, and defined its efficacy to revert muscle wasting in ischemic heart failure (HF). Mice were treated with soluble ACVR2B decoy receptor (ACVR2B-Fc) to study its effect on post-MI cardiac remodeling and on later HF. Cardiac function was determined with echocardiography, and myocardium analyzed with histological and biochemical methods for hypertrophy and fibrosis. Pharmacological blockade of ACVR2B ligands did not rescue the heart from ischemic injury or alleviate post-MI remodeling and ischemic HF. Collectively, ACVR2B-Fc did not affect cardiomyocyte hypertrophy, fibrosis, angiogenesis, nor factors associated with cardiac regeneration except modification of certain genes involved in metabolism or cell growth/survival. ACVR2B-Fc, however, was able to reduce skeletal muscle wasting in chronic ischemic HF, accompanied by reduced LC3II as a marker of autophagy and increased mTOR signaling and Cited4 expression as markers of physiological hypertrophy in quadriceps muscle. Our results ascertain pharmacological blockade of ACVR2B ligands as a possible therapy for skeletal muscle wasting in ischemic HF. Pharmacological blockade of ACVR2B ligands preserved myofiber size in ischemic HF, but did not compromise cardiac function nor exacerbate cardiac remodeling after ischemic injury.
    MeSH term(s) Activin Receptors, Type II/antagonists & inhibitors ; Activin Receptors, Type II/metabolism ; Animals ; Disease Models, Animal ; Heart/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Muscular Atrophy/etiology ; Muscular Atrophy/metabolism ; Muscular Atrophy/pathology ; Muscular Atrophy/prevention & control ; Myocardial Ischemia/complications ; Signal Transduction ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Ventricular Remodeling/physiology
    Chemical Substances Cited4 protein, mouse ; Transcription Factors ; Activin Receptors, Type II (EC 2.7.11.30) ; activin receptor type II-B (EC 2.7.11.30)
    Language English
    Publishing date 2020-05-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639186-2
    ISSN 1530-6860 ; 0892-6638
    ISSN (online) 1530-6860
    ISSN 0892-6638
    DOI 10.1096/fj.201903074RR
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2266: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 296: Show issues

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  8. Book ; Thesis: Expression and regulation of growth factors controlling ovarian folliculogenesis

    Laitinen, Mika

    1999  

    Author's details Mika Laitinen
    Language English
    Size 59 S, getr. Zählung, Ill., graph. Darst
    Publisher Cosmoprint Oy
    Publishing place Helsinki
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ.,Diss.--Helsinki, 1999
    Note Enth. 4 Zeitschriftensonderdrucke
    ISBN 9529110669 ; 9789529110667
    Database Former special subject collection: coastal and deep sea fishing

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  9. Article: Model-based optimization of ultrasonic transducers.

    Heikkola, Erkki / Laitinen, Mika

    Ultrasonics sonochemistry

    2005  Volume 12, Issue 1-2, Page(s) 53–57

    Abstract: Numerical simulation and automated optimization of Langevin-type ultrasonic transducers are investigated. These kind of transducers are standard components in various applications of high-power ultrasonics such as ultrasonic cleaning and chemical ... ...

    Abstract Numerical simulation and automated optimization of Langevin-type ultrasonic transducers are investigated. These kind of transducers are standard components in various applications of high-power ultrasonics such as ultrasonic cleaning and chemical processing. Vibration of the transducer is simulated numerically by standard finite element method and the dimensions and shape parameters of a transducer are optimized with respect to different criteria. The novelty value of this work is the combination of the simulation model and the optimization problem by efficient automatic differentiation techniques. The capabilities of this approach are demonstrated with practical test cases in which various aspects of the operation of a transducer are improved.
    MeSH term(s) Computer Simulation ; Computer-Aided Design ; Equipment Design/methods ; Equipment Failure Analysis/methods ; Models, Theoretical ; Sonication/instrumentation ; Transducers
    Language English
    Publishing date 2005-01
    Publishing country Netherlands
    Document type Comparative Study ; Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1208333-1
    ISSN 1873-2828 ; 1350-4177
    ISSN (online) 1873-2828
    ISSN 1350-4177
    DOI 10.1016/j.ultsonch.2004.05.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4441: Show issues Location:
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  10. Article ; Online: Systemic Blockade of ACVR2B Ligands Protects Myocardium from Acute Ischemia-Reperfusion Injury.

    Magga, Johanna / Vainio, Laura / Kilpiö, Teemu / Hulmi, Juha J / Taponen, Saija / Lin, Ruizhu / Räsänen, Markus / Szabó, Zoltán / Gao, Erhe / Rahtu-Korpela, Lea / Alakoski, Tarja / Ulvila, Johanna / Laitinen, Mika / Pasternack, Arja / Koch, Walter J / Alitalo, Kari / Kivelä, Riikka / Ritvos, Olli / Kerkelä, Risto

    Molecular therapy : the journal of the American Society of Gene Therapy

    2019  Volume 27, Issue 3, Page(s) 600–610

    Abstract: Activin A and myostatin, members of the transforming growth factor (TGF)-β superfamily of secreted factors, are potent negative regulators of muscle growth, but their contribution to myocardial ischemia-reperfusion (IR) injury is not known. The aim of ... ...

    Abstract Activin A and myostatin, members of the transforming growth factor (TGF)-β superfamily of secreted factors, are potent negative regulators of muscle growth, but their contribution to myocardial ischemia-reperfusion (IR) injury is not known. The aim of this study was to investigate if activin 2B (ACVR2B) receptor ligands contribute to myocardial IR injury. Mice were treated with soluble ACVR2B decoy receptor (ACVR2B-Fc) and subjected to myocardial ischemia followed by reperfusion for 6 or 24 h. Systemic blockade of ACVR2B ligands by ACVR2B-Fc was protective against cardiac IR injury, as evidenced by reduced infarcted area, apoptosis, and autophagy and better preserved LV systolic function following IR. ACVR2B-Fc modified cardiac metabolism, LV mitochondrial respiration, as well as cardiac phenotype toward physiological hypertrophy. Similar to its protective role in IR injury in vivo, ACVR2B-Fc antagonized SMAD2 signaling and cell death in cardiomyocytes that were subjected to hypoxic stress. ACVR2B ligand myostatin was found to exacerbate hypoxic stress. In addition to acute cardioprotection in ischemia, ACVR2B-Fc provided beneficial effects on cardiac function in prolonged cardiac stress in cardiotoxicity model. By blocking myostatin, ACVR2B-Fc potentially reduces cardiomyocyte death and modifies cardiomyocyte metabolism for hypoxic conditions to protect the heart from IR injury.
    MeSH term(s) Activin Receptors, Type II/genetics ; Activin Receptors, Type II/metabolism ; Animals ; Male ; Mice ; Mice, Inbred C57BL ; Myocardial Reperfusion Injury/metabolism ; Myocardium/metabolism ; Myocytes, Cardiac/metabolism ; Myostatin/metabolism ; Signal Transduction/genetics ; Signal Transduction/physiology ; Smad2 Protein/genetics ; Smad2 Protein/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism
    Chemical Substances Cited4 protein, mouse ; Myostatin ; Smad2 Protein ; Transcription Factors ; Activin Receptors, Type II (EC 2.7.11.30) ; activin receptor type II-B (EC 2.7.11.30)
    Language English
    Publishing date 2019-01-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2010592-7
    ISSN 1525-0024 ; 1525-0016
    ISSN (online) 1525-0024
    ISSN 1525-0016
    DOI 10.1016/j.ymthe.2019.01.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5640: Show issues Location:
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