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Book ; Thesis: Distorsionsprodukte otoakustischer Emissionen bei Normalhörenden und bei schwerhörigen Probanden in drei verschiedenen Altersgruppen

Lakatos, Andrea

1997

Author's details	vorgelegt von Andrea Lakatos
Language	German
Size	95 Bl. : Ill., graph. Darst.
Edition	[Mikrofiche-Ausg.]
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Mainz, Univ., Diss., 1997
Note	Mikrofiche-Ausg.: 1 Mikrofiche : 24x
HBZ-ID	HT009058096
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Probing the allosteric NBD-TMD crosstalk in the ABC transporter MsbA by solid-state NMR.

Novischi, S Y Phoebe / Karoly-Lakatos, Andrea / Chok, Kerby / Bonifer, Christian / Becker-Baldus, Johanna / Glaubitz, Clemens

Communications biology

2024 Volume 7, Issue 1, Page(s) 43

Abstract: The ABC transporter MsbA plays a critical role in Gram-negative bacteria in the regulation of the outer membrane by translocating core-LPS across the inner membrane. Additionally, a broad substrate specificity for lipophilic drugs has been shown. The ... ...

Abstract	The ABC transporter MsbA plays a critical role in Gram-negative bacteria in the regulation of the outer membrane by translocating core-LPS across the inner membrane. Additionally, a broad substrate specificity for lipophilic drugs has been shown. The allosteric interplay between substrate binding in the transmembrane domains and ATP binding and turnover in the nucleotide-binding domains must be mediated via the NBD/TMD interface. Previous studies suggested the involvement of two intracellular loops called coupling helix 1 and 2 (CH1, CH2). Here, we demonstrate by solid-state NMR spectroscopy that substantial chemical shift changes within both CH1 and CH2 occur upon substrate binding, in the ATP hydrolysis transition state, and upon inhibitor binding. CH2 is domain-swapped within the MsbA structure, and it is noteworthy that substrate binding induces a larger response in CH2 compared to CH1. Our data demonstrate that CH1 and CH2 undergo structural changes as part of the TMD-NBD cross-talk.
MeSH term(s)	Magnetic Resonance Imaging ; ATP-Binding Cassette Transporters ; Cross Reactions ; Magnetic Resonance Spectroscopy ; Adenosine Triphosphate
Chemical Substances	ATP-Binding Cassette Transporters ; Adenosine Triphosphate (8L70Q75FXE)
Language	English
Publishing date	2024-01-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-023-05617-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Comparative evaluation of approach to cardiovascular care in neonatal encephalopathy undergoing therapeutic hypothermia.

Kovacs, Kata / Giesinger, Regan E / Lakatos, Andrea / Szabo, Attila J / Szabo, Miklos / Jermendy, Agnes / McNamara, Patrick J

Journal of perinatology : official journal of the California Perinatal Association

2022 Volume 42, Issue 12, Page(s) 1637–1643

Abstract: Objective: To analyze the association between cardiovascular care and adverse outcome in infants undergoing therapeutic hypothermia for neonatal encephalopathy (NE).: Study design: This was a retrospective cohort study of 176 infants with NE and ... ...

Abstract	Objective: To analyze the association between cardiovascular care and adverse outcome in infants undergoing therapeutic hypothermia for neonatal encephalopathy (NE). Study design: This was a retrospective cohort study of 176 infants with NE and hypotension, admitted to the SickKids Hospital (Center A, n = 86) or Semmelweis University (Center B, n = 90). Result: The lowest systolic/diastolic blood pressures were comparable amongst centers; however, proportion of cardiovascular support was lower in Center A (51% vs 97% in Center B). Overall rate of death or abnormal MRI (adverse outcome) were comparable between centers, although pattern differed with more basal ganglia injury in Center B. A 24-hour longer duration of cardiovascular support increased the odds for adverse outcome by 14%. Conclusion: We demonstrated that management of hemodynamic instability in infants with NE was markedly different in two high-volume NICUs and showed that longer duration of cardiovascular medication is an independent risk factor for adverse outcome.
MeSH term(s)	Infant ; Infant, Newborn ; Humans ; Hypoxia-Ischemia, Brain/diagnostic imaging ; Hypoxia-Ischemia, Brain/therapy ; Hypoxia-Ischemia, Brain/etiology ; Retrospective Studies ; Hypothermia, Induced/adverse effects ; Infant, Newborn, Diseases/therapy ; Intensive Care Units, Neonatal
Language	English
Publishing date	2022-07-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	645021-0
ISSN	1476-5543 ; 0743-8346
ISSN (online)	1476-5543
ISSN	0743-8346
DOI	10.1038/s41372-022-01459-6
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Book ; Conference proceedings: Program és előadás-összefoglalók / XXII Kémiai Előadói Napok : Szegedi Akadémiai Bizottság Székháza, 1999. november 1 - 3. ; a Magyar Kémikusok Egyesülete Csongrád Megyei Csoportja és a Magyar Kémikusok egyesülete közös rendezvénye

Lakatos, Andrea

1999

Institution	Kémiai Előadói Napok Magyar Kémikusok Egyesülete
Event/congress	Kémiai Előadói Napok (22, 1999.11.01-03, Szeged)
Author's details	[szerk.: Lakatos Andrea ...]
Language	Hungarian
Size	186 S, graph. Darst
Publishing place	S.l.
Document type	Book ; Conference proceedings
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Neurodevelopmental effect of intracranial hemorrhage observed in hypoxic ischemic brain injury in hypothermia-treated asphyxiated neonates - an MRI study.

Lakatos, Andrea / Kolossváry, Márton / Szabó, Miklós / Jermendy, Ágnes / Barta, Hajnalka / Gyebnár, Gyula / Rudas, Gábor / Kozák, Lajos R

BMC pediatrics

2019 Volume 19, Issue 1, Page(s) 430

Abstract: Background: Identification of early signs of hypoxic ischemic encephalopathy (HIE) with magnetic resonance imaging (MRI) has proven of prognostic significance. Yet, the importance of intracranial hemorrhage (ICH), being present concomitantly had not ... ...

Abstract	Background: Identification of early signs of hypoxic ischemic encephalopathy (HIE) with magnetic resonance imaging (MRI) has proven of prognostic significance. Yet, the importance of intracranial hemorrhage (ICH), being present concomitantly had not been investigated yet, despite the known influence of hypothermia on hemostasis. We aimed to determine whether presence of ICH on MRI alongside the signs of HIE have an impact on prognosis in neonates with the clinical diagnosis of HIE. Methods: A retrospective study of consecutively sampled 108 asphyxiated term infants admitted to a tertiary neonatal intensive care unit (between 2007 and 2016), treated with whole body hypothermia and having brain MRI within 1 week of life was conducted. Presence or absence of HIE signs on MRI (basal ganglia-thalamus, watershed pattern and total brain injury) and on MR spectroscopy (lactate peak with decreased normal metabolites measured by Lac/NAA ratio) and/or of the five major types of ICH were recorded. Neurodevelopmental outcome was measured with Bayley Scales of Infant Development-II (BSID-II) test. Death or abnormal neurodevelopment (BSID-II score < 85) was defined as poor outcome in Chi-square test. Multivariate logistic regression analysis was performed on survivors. Results: MRI and MR-spectroscopy (MRS) signs of HIE were present in 72% (n = 78). 36% (n = 39) of neonates had ICH, being mainly small in size. Chi-square test showed a relationship between neurodevelopmental outcome and initial MRI. Unadjusted logistic regression showed that neonates presenting MRI and MRS signs of HIE have 6.23 times higher odds for delayed mental development (OR = 6.2292; CI95% = [1.2642; 30.6934], p = 0.0246), than infants without imaging alterations; with no ICH effect on outcome. Adjustment for clinical and imaging parameters did not change the pattern of results, i.e. HIE remained an independent risk factor for delayed neurodevelopment (OR = 6.2496; CI95% = [1.2018; 32.4983], p = 0.0294), while ICH remained to have no significant effect. Conclusion: HIE related MRI abnormalities proved to be important prognostic factors of poor outcome in cooled asphyxiated infants when present, suggesting that early MRI with MRS is beneficial for prognostication. Interestingly, ICHs present in about one third of all cases had no significant effect on neurodevelopmental outcome, despite the known hemostasis altering effects of hypothermia.
MeSH term(s)	Asphyxia Neonatorum/complications ; Asphyxia Neonatorum/therapy ; Brain/diagnostic imaging ; Child Development ; Humans ; Hypothermia, Induced ; Hypoxia-Ischemia, Brain/complications ; Hypoxia-Ischemia, Brain/diagnostic imaging ; Hypoxia-Ischemia, Brain/physiopathology ; Infant, Newborn ; Infant, Newborn, Diseases ; Intracranial Hemorrhages/complications ; Intracranial Hemorrhages/diagnostic imaging ; Logistic Models ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Neurodevelopmental Disorders/diagnosis ; Neurodevelopmental Disorders/etiology ; Prognosis ; Retrospective Studies
Language	English
Publishing date	2019-11-12
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2041342-7
ISSN	1471-2431 ; 1471-2431
ISSN (online)	1471-2431
ISSN	1471-2431
DOI	10.1186/s12887-019-1777-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Fluorescence and excited state dynamics of the deprotonated Schiff base retinal in proteorhodopsin.

Bühl, Elena / Braun, Markus / Lakatos, Andrea / Glaubitz, Clemens / Wachtveitl, Josef

Biological chemistry

2015 Volume 396, Issue 9-10, Page(s) 1109–1115

Abstract: The UV light absorbing species of proteorhodopsin with deprotonated Schiff base retinal was investigated using steady-state fluorescence and femtosecond pump-probe spectroscopy. Compared to the all-trans retinal with protonated Schiff base, the ... ...

Abstract	The UV light absorbing species of proteorhodopsin with deprotonated Schiff base retinal was investigated using steady-state fluorescence and femtosecond pump-probe spectroscopy. Compared to the all-trans retinal with protonated Schiff base, the deprotonated chromophore absorbs at 365 nm and exhibits a blue-shifted fluorescence spectrum. The unusually long-lived excited state decays bi-exponentially with time constants of 8 ps and 130 ps to form a deprotonated 13-cis retinal as the primary photo-product.
MeSH term(s)	Fluorescence ; Hydrogen-Ion Concentration ; Molecular Dynamics Simulation ; Protons ; Retinaldehyde/chemistry ; Rhodopsins, Microbial/chemistry ; Schiff Bases/chemistry ; Spectrometry, Fluorescence
Chemical Substances	Protons ; Rhodopsins, Microbial ; Schiff Bases ; proteorhodopsin ; Retinaldehyde (RR725D715M)
Language	English
Publishing date	2015-09
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1334659-3
ISSN	1437-4315 ; 1431-6730 ; 1432-0355
ISSN (online)	1437-4315
ISSN	1431-6730 ; 1432-0355
DOI	10.1515/hsz-2015-0108
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Article ; Online: How to investigate interactions between membrane proteins and ligands by solid-state NMR.

Lakatos, Andrea / Mörs, Karsten / Glaubitz, Clemens

Methods in molecular biology (Clifton, N.J.)

2012 Volume 914, Page(s) 65–86

Abstract: Solid-state NMR is an established method for biophysical studies of membrane proteins within the lipid bilayers and an emerging technique for structural biology in general. In particular magic angle sample spinning has been found to be very useful for ... ...

Abstract	Solid-state NMR is an established method for biophysical studies of membrane proteins within the lipid bilayers and an emerging technique for structural biology in general. In particular magic angle sample spinning has been found to be very useful for the investigation of large membrane proteins and their interaction with small molecules within the lipid bilayer. Using a number of examples, we illustrate and discuss in this chapter, which information can be gained and which experimental parameters need to be considered when planning such experiments. We focus especially on the interaction of diffusive ligands with membrane proteins.
MeSH term(s)	Humans ; Ligands ; Magnetic Resonance Spectroscopy/methods ; Membrane Proteins/metabolism ; Models, Molecular ; Protein Binding ; Receptor, Bradykinin B2/chemistry ; Receptor, Bradykinin B2/metabolism
Chemical Substances	Ligands ; Membrane Proteins ; Receptor, Bradykinin B2
Language	English
Publishing date	2012
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-62703-023-6_5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Novel structured MRI reporting system in neonatal hypoxic-ischemic encephalopathy - issues of development and first use experiences.

Lakatos, Andrea / Kolossváry, Márton / Szabó, Miklós / Jermendy, Ágnes / Bagyura, Zsolt / Barsi, Péter / Rudas, Gábor / Kozák, Lajos R

Ideggyogyaszati szemle

2018 Volume 71, Issue 7-08, Page(s) 265–276

Abstract: Background and purpose: To develop an evidence-based, standardized structured reporting (SR) method for brain MRI examinations in neonatal hypoxic-ischemic encephalopathy (HIE) suitable both for clinical and research use.: Methods: SR template ... ...

Title translation	Strukturált koponya-MR-leletezés neonatalis hypoxiásischaemiás encephalopathiában - a fejlesztés speciális kérdései és első tapasztalatok.
Abstract	Background and purpose: To develop an evidence-based, standardized structured reporting (SR) method for brain MRI examinations in neonatal hypoxic-ischemic encephalopathy (HIE) suitable both for clinical and research use. Methods: SR template development was based on comprehensive review of the pertinent literature with the basic sections and subdivisions of the template defined according to MRI sequences (both conventional and diffusion-weighted, MR-spectroscopy (MRS), and T2-weighted imaging), and the items targeted on age-related imaging patterns of HIE. In order to evaluate the usability of the proposed SR template we compared data obtained from the brain MR image analysis of 87 term and 19 preterm neonates with the literature. The enrolled 106 infants were born between 2013 and 2015, went through therapeutic hypothermia according to the TOBY criteria due to moderate to severe asphyxia and had at least one brain MRI examination within the first two weeks of life. Ethical approval was obtained for this retrospective study. Descriptive statistical analysis was also performed on data exported from the structured reporting system as feasibility test. Results:* The mean gestational age of the study population was 38.3±2.2 weeks; brain MRI was performed on 5.8±2.9 day of life, hence in 78% of our patients after the conclusion of therapeutic hypothermia. Our main imaging findings were concordant to the pertinent literature. Moreover, we identified a characteristic temporal evolution of diffusion changes. Interestingly 18% (n=19/106) of the clinically asphyxiated infants had isolated axial-extraaxial haemorrhage without any imaging sign of HIE. Conclusion: In this article our approach of reporting HIE cases with our novel SR template is described. The SR template was found suitable for reporting HIE cases, moreover it uncovered time and location dependent evolution of diffusion abnormalities (and pseudonormalization, as well), suggesting its usefulness in clinical research applications. The high number of isolated intracranial haemorrhages, and the changing diffusion pattern emphasizes the importance of early imaging in HIE.
MeSH term(s)	Brain/pathology ; Humans ; Hypothermia, Induced ; Hypoxia-Ischemia, Brain/diagnostic imaging ; Infant ; Infant, Newborn ; Magnetic Resonance Imaging/methods ; Neonatal Screening/methods ; Retrospective Studies
Language	English
Publishing date	2018-04-11
Publishing country	Hungary
Document type	Journal Article
ZDB-ID	2240317-6
ISSN	0019-1442
ISSN	0019-1442
DOI	10.18071/isz.71.0265
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Zs.A 6335: Show issues

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Article ; Online: Prognostic value of early, conventional proton magnetic resonance spectroscopy in cooled asphyxiated infants.

Barta, Hajnalka / Jermendy, Agnes / Kolossvary, Marton / Kozak, Lajos R / Lakatos, Andrea / Meder, Unoke / Szabo, Miklos / Rudas, Gabor

BMC pediatrics

2018 Volume 18, Issue 1, Page(s) 302

Abstract: Background: Neonatal hypoxic-ischemic encephalopathy (HIE) commonly leads to neurodevelopmental impairment, raising the need for prognostic tools which may guide future therapies in time. Prognostic value of proton MR spectroscopy (H-MRS) between 1 and ... ...

Abstract	Background: Neonatal hypoxic-ischemic encephalopathy (HIE) commonly leads to neurodevelopmental impairment, raising the need for prognostic tools which may guide future therapies in time. Prognostic value of proton MR spectroscopy (H-MRS) between 1 and 46 days of age has been extensively studied; however, the reproducibility and generalizability of these methods are controversial in a general clinical setting. Therefore, we investigated the prognostic performance of conventional H-MRS during first 96 postnatal hours in hypothermia-treated asphyxiated neonates. Methods: Fifty-one consecutive hypothermia-treated HIE neonates were examined by H-MRS at three echo-times (TE = 35, 144, 288 ms) between 6 and 96 h of age, depending on clinical stability. Patients were divided into favorable (n = 35) and unfavorable (n = 16) outcome groups based on psychomotor and mental developmental index (PDI and MDI, Bayley Scales of Infant Development II) scores (≥ 70 versus < 70 or death, respectively), assessed at 18-26 months of age. Associations between 36 routinely measured metabolite ratios and outcome were studied. Age-dependency of metabolite ratios in whole patient population was assessed. Prognostic performance of metabolite ratios was evaluated by Receiver Operating Characteristics (ROC) analysis. Results: Three metabolite ratios showed significant difference between outcome groups after correction for multiple testing (p < 0.0014): myo-inositol (mIns)/N-acetyl-aspartate (NAA) height, mIns/creatine (Cr) height, both at TE = 35 ms, and NAA/Cr height at TE = 144 ms. Assessment of age-dependency showed that all 3 metabolite ratios (mIns/NAA, NAA/Cr and mIns/Cr) stayed constant during first 96 postnatal hours, rendering them optimal for prediction. ROC analysis revealed that mIns/NAA gives better prediction for outcome than NAA/Cr and mIns/Cr with cut-off values 0.6798 0.6274 and 0.7798, respectively, (AUC 0.9084, 0.8396 and 0.8462, respectively, p < 0.00001); mIns/NAA had the highest specificity (95.24%) and sensitivity (84.62%) for predicting outcome of neonates with HIE any time during the first 96 postnatal hours. Conclusions: Our findings suggest that during first 96 h of age even conventional H-MRS could be a useful prognostic tool in predicting the outcome of asphyxiated neonates; mIns/NAA was found to be the best and age-independent predictor.
MeSH term(s)	Aspartic Acid/analogs & derivatives ; Aspartic Acid/metabolism ; Brain/metabolism ; Creatine/metabolism ; Epilepsy/etiology ; Female ; Hearing Loss/etiology ; Hospital Mortality ; Humans ; Hypothermia, Induced ; Hypoxia-Ischemia, Brain/metabolism ; Hypoxia-Ischemia, Brain/therapy ; Infant, Newborn ; Inositol/metabolism ; Male ; Neurodevelopmental Disorders/etiology ; Neurodevelopmental Disorders/prevention & control ; Prognosis ; Proton Magnetic Resonance Spectroscopy ; Retrospective Studies ; Time Factors
Chemical Substances	Aspartic Acid (30KYC7MIAI) ; Inositol (4L6452S749) ; N-acetylaspartate (997-55-7) ; Creatine (MU72812GK0)
Language	English
Publishing date	2018-09-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041342-7
ISSN	1471-2431 ; 1471-2431
ISSN (online)	1471-2431
ISSN	1471-2431
DOI	10.1186/s12887-018-1269-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Thesis: Distorsionsprodukte otoakustischer Emissionen bei Normalhörenden und bei schwerhörigen Probanden in drei verschiedenen Altersgruppen

Lakatos, Andrea

1997

Author's details	vorgelegt von Andrea Lakatos
Language	German
Size	1 Mikrofiche, Ill., graph. Darst
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Univ., Diss.--Mainz, 1997
Database	Former special subject collection: coastal and deep sea fishing

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