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Article ; Online: Tanning Wastewater Sterilization in the Dark and Sunlight Using

Lakshmaiya, Natrayan / Surakasi, Raviteja / Nadh, V Swamy / Srinivas, Chidurala / Kaliappan, Seniappan / Ganesan, Velmurugan / Paramasivam, Prabhu / Dhanasekaran, Seshathiri

ACS omega

2023 Volume 8, Issue 42, Page(s) 39680–39689

Abstract: ... ...

Abstract	Employing
Language	English
Publishing date	2023-10-09
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c05588
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Article ; Online: Performance and exergy analysis of an inclined solar still with baffle arrangements

Seralathan, S. / Chenna Reddy, G. / Sathish, S. / Muthuram, A. / Dhanraj, Joshuva Arockia / Lakshmaiya, Natrayan / Velmurugan, Karthikeyan / Sirisamphanwong, Chatchai / Ngoenmeesri, Rattapon / Sirisamphanwong, Chattariya

Heliyon. 2023 Apr. 03, p.e14807-

2023

Abstract: This study presents the details of performance and exergy investigations on an inclined solar still with baffle arrangements. The shortage of consumable water creates the transformation of accessible brackish water into consumable water an unavoidable ... ...

Abstract	This study presents the details of performance and exergy investigations on an inclined solar still with baffle arrangements. The shortage of consumable water creates the transformation of accessible brackish water into consumable water an unavoidable one and this can be accomplished utilizing sun-oriented refining. To remove drinkable water from pungent water, sun-oriented still is broadly utilized. To build the contact season of the pungent water with sunlight-based brilliance, perplex course of action is set to expand the opposition in the stream. This prompts more vanishing of brackish water. Therefore, the objective of this study is to improve freshwater yield. The experimental study is performed for two different mass flow rates (mf₁ = 0.0833 kg/min and mf₂ = 0.166 kg/min). An increase in the mass flow of water directly deteriorates the yield of fresh water. Highest accumulated freshwater yield is achieved as 2.908 kg/m² day during the month of May for mf₁ = 0.0833 kg/min. The accumulated freshwater yield improved by 4.23% in comparison with inclined solar still designs. Moreover, the yield is better by 3.49%-61.56% in comparison with various solar still designs. Using RSM, a polynomial statistical model is specified to estimate as well as maximize the freshwater yield of ISSB. The exergy analysis for mf₁ = 0.0833 kg/min shows a maximum hourly exergy efficiency of 6.82%.
Keywords	brackish water ; drinking water ; exergy ; freshwater ; mass flow ; solar still ; statistical models ; streams ; Exergy efficiency ; Performance yield ; Inclined solar still ; Baffle arrangements
Language	English
Dates of publication	2023-0403
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Pre-press version ; Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e14807
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The paths toward non-viral CAR-T cell manufacturing: A comprehensive review of state-of-the-art methods.

Metanat, Yekta / Viktor, Patrik / Amajd, Ayesha / Kaur, Irwanjot / Hamed, Ashraf Mohammed / Abed Al-Abadi, Noor K / Alwan, Nathera Hussin / Chaitanya, M V N L / Lakshmaiya, Natrayan / Ghildiyal, Pallavi / Khalaf, Othman Mahjoob / Ciongradi, Carmen Iulia / Sârbu, Ioan

Life sciences

2024 Volume 348, Page(s) 122683

Abstract: Although CAR-T cell therapy has emerged as a game-changer in cancer immunotherapy several bottlenecks limit its widespread use as a front-line therapy. Current protocols for the production of CAR-T cells rely mainly on the use of lentiviral/retroviral ... ...

Abstract	Although CAR-T cell therapy has emerged as a game-changer in cancer immunotherapy several bottlenecks limit its widespread use as a front-line therapy. Current protocols for the production of CAR-T cells rely mainly on the use of lentiviral/retroviral vectors. Nevertheless, according to the safety concerns around the use of viral vectors, there are several regulatory hurdles to their clinical use. Large-scale production of viral vectors under "Current Good Manufacturing Practice" (cGMP) involves rigorous quality control assessments and regulatory requirements that impose exorbitant costs on suppliers and as a result, lead to a significant increase in the cost of treatment. Pursuing an efficient non-viral method for genetic modification of immune cells is a hot topic in cell-based gene therapy. This study aims to investigate the current state-of-the-art in non-viral methods of CAR-T cell manufacturing. In the first part of this study, after reviewing the advantages and disadvantages of the clinical use of viral vectors, different non-viral vectors and the path of their clinical translation are discussed. These vectors include transposons (sleeping beauty, piggyBac, Tol2, and Tc Buster), programmable nucleases (ZFNs, TALENs, and CRISPR/Cas9), mRNA, plasmids, minicircles, and nanoplasmids. Afterward, various methods for efficient delivery of non-viral vectors into the cells are reviewed.
Language	English
Publishing date	2024-05-01
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2024.122683
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Article ; Online: Dendritic cell-derived exosomes (Dex): Underlying the role of exosomes derived from diverse DC subtypes in cancer pathogenesis.

Tuluwengjiang, Gulixian / Rasulova, Irodakhon / Ahmed, Shamim / Kiasari, Bahman Abedi / Sârbu, Ioan / Ciongradi, Carmen Iulia / Omar, Thabit Moath / Hussain, Farah / Jawad, Mahmood Jasem / Castillo-Acobo, Roxana Yolanda / Hani, Thamer / Lakshmaiya, Natrayan / Samaniego, Severo Simeón Calderón

Pathology, research and practice

2024 Volume 254, Page(s) 155097

Abstract: Exosomes are nanometric membrane vesicles of late endosomal origin that are released by most, if not all, cell types as a sophisticated means of intercellular communication. They play an essential role in the movement of materials and information between ...

Abstract	Exosomes are nanometric membrane vesicles of late endosomal origin that are released by most, if not all, cell types as a sophisticated means of intercellular communication. They play an essential role in the movement of materials and information between cells, transport a variety of proteins, lipids, RNA, and other vital data, and over time, they become an essential part of the drug delivery system and a marker for the early detection of many diseases. Dendritic cells have generated interest in cancer immunotherapy due to their ability to initiate and modify effective immune responses. Apart from their cytokine release and direct interactions with other cell types, DCs also emit nanovesicles, such as exosomes, that contribute to their overall activity. Numerous studies have demonstrated exosomes to mediate and regulate immune responses against cancers. Dendritic cell-derived exosomes (DCs) have attracted a lot of attention as immunotherapeutic anti-cancer treatments since it was found that they contain functional MHC-peptide complexes along with a variety of other immune-stimulating components that together enable immune cell-dependent tumor rejection. By enhancing tumor and immunosuppressive immune cells or changing a pro-inflammatory milieu to inhibit tumor advancement, exosomes generated from dendritic cells can initiate and support tumor growth. This study reviewed the immunogenicity of dendritic cell-derived exosomes and strategies for expanding their immunogenic potential as novel and effective anti-cancer therapies.
MeSH term(s)	Humans ; Exosomes/genetics ; Dendritic Cells ; Neoplasms/pathology ; Immunity ; Immunotherapy
Language	English
Publishing date	2024-01-05
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2024.155097
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Article ; Online: Natural killer cell-mediated immune surveillance in cancer: Role of tumor microenvironment.

Saadh, Mohamed J / Rasulova, Irodakhon / Khalil, Mohamed / Farahim, Farha / Sârbu, Ioan / Ciongradi, Carmen Iulia / Omar, Thabit Moath / Alhili, Ahmed / Jawad, Mahmood Jasem / Hani, Thamer / Ali, Talat / Lakshmaiya, Natrayan

Pathology, research and practice

2024 Volume 254, Page(s) 155120

Abstract: In the immunological surveillance against cancer, natural killer (NK) cells are essential effectors that help eradicate altered cells. The complex interactions that occur between NK cells and the tumor microenvironment (TME) are thoroughly examined in ... ...

Abstract	In the immunological surveillance against cancer, natural killer (NK) cells are essential effectors that help eradicate altered cells. The complex interactions that occur between NK cells and the tumor microenvironment (TME) are thoroughly examined in this review. The review examines how cytokine stimulation affects NK cell activation, focusing on the dynamic modulation of NK cell function within the TME. It looks at NK cell-related biomarkers such as PD-1/PD-L1, methylation HOXA9 (Homeobox A9), Stroma AReactive Invasion Front Areas (SARIFA), and NKG2A/HLA-E, providing critical information about prognosis and treatment outcomes. The changing landscape of immunotherapies-including checkpoint inhibitors, CAR-NK cells, and cytokine-based interventions-is examined in the context of enhancing NK cell activity. The review highlights the potential pathways for precision medicine going forward, focusing on customized immunotherapies based on unique biomarker profiles and investigating combination medicines to produce more robust anti-tumor responses.
MeSH term(s)	Humans ; Tumor Microenvironment ; Immunologic Surveillance ; Killer Cells, Natural ; Neoplasms/pathology ; Cytokines/metabolism
Chemical Substances	Cytokines
Language	English
Publishing date	2024-01-11
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2024.155120
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Article ; Online: Quercetin modulates expression of serum exosomal long noncoding RNA NEAT1 to regulate the miR-129-5p/BDNF axis and attenuate cognitive impairment in diabetic mice.

Wang, Hui / Jayasankar, Narayanan / Thamaraikani, Tamilanban / Viktor, Patrik / Mohany, Mohamed / Al-Rejaie, Salim S / Alammar, Hasan Khalid / Anad, Enaam / Alhili, Farah / Hussein, Sinan F / Amin, Ali H / Lakshmaiya, Natrayan / Ahsan, Muhammad / Bahrami, Abolfazl / Akhavan-Sigari, Reza

publication RETRACTED

Life sciences

2024 Volume 340, Page(s) 122449

Abstract: Aims: Cognitive impairment poses a considerable health challenge in the context of type 2 diabetes mellitus (T2DM), emphasizing the need for effective interventions. This study delves into the therapeutic efficacy of quercetin, a natural flavonoid, in ... ...

Abstract	Aims: Cognitive impairment poses a considerable health challenge in the context of type 2 diabetes mellitus (T2DM), emphasizing the need for effective interventions. This study delves into the therapeutic efficacy of quercetin, a natural flavonoid, in mitigating cognitive impairment induced by T2DM in murine models. Materials and methods: Serum exosome samples were obtained from both T2DM-related and healthy mice for transcriptome sequencing, enabling the identification of differentially expressed mRNAs and long noncoding RNAs (lncRNAs). Subsequent experiments were conducted to ascertain the binding affinity between mmu-miR-129-5p, NEAT1 and BDNF. The structural characteristics and dimensions of isolated exosomes were scrutinized, and the expression levels of exosome-associated proteins were quantified. Primary mouse hippocampal neurons were cultured for in vitro validation, assessing the expression of pertinent genes as well as neuronal vitality, proliferation, and apoptosis capabilities. For in vivo validation, a T2DM mouse model was established, and quercetin treatment was administered. Changes in various parameters, cognitive ability, and the expression of insulin-related proteins, along with pivotal signaling pathways, were monitored. Key findings: Analysis of serum exosomes from T2DM mice revealed dysregulation of NEAT1, mmu-miR-129-5p, and BDNF. In vitro investigations demonstrated that NEAT1 upregulated BDNF expression by inhibiting mmu-miR-129-5p. Overexpression of mmu-miR-129-5p or silencing NEAT1 resulted in the downregulation of insulin-related protein expression, enhanced apoptosis, and suppressed neuronal proliferation. In vivo studies validated that quercetin treatment significantly ameliorated T2DM-related cognitive impairment in mice. Significance: These findings suggest that quercetin holds promise in inhibiting hippocampal neuron apoptosis and improving T2DM-related cognitive impairment by modulating the NEAT1/miR-129-5p/BDNF pathway within serum exosomes.
MeSH term(s)	Animals ; Mice ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Quercetin/pharmacology ; Brain-Derived Neurotrophic Factor/genetics ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Experimental/complications ; Cell Proliferation/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Cognitive Dysfunction/drug therapy ; Cognitive Dysfunction/genetics ; Insulins
Chemical Substances	RNA, Long Noncoding ; Quercetin (9IKM0I5T1E) ; Brain-Derived Neurotrophic Factor ; MicroRNAs ; Insulins
Language	English
Publishing date	2024-01-20
Publishing country	Netherlands
Document type	Journal Article ; Retracted Publication
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2024.122449
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Article ; Online: Retraction notice to "Quercetin modulates expression of serum exosomal long noncoding RNA NEAT1 to regulate the miR-129-5p/BDNF axis and attenuate cognitive impairment in diabetic mice" [Life Sci. 340 (2024) 122449].

Life sciences

2024 Volume 347, Page(s) 122679

Language	English
Publishing date	2024-05-01
Publishing country	Netherlands
Document type	Journal Article ; Retraction of Publication
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2024.122679
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Article: Performance and exergy analysis of an inclined solar still with baffle arrangements.

Seralathan, S / Chenna Reddy, G / Sathish, S / Muthuram, A / Dhanraj, Joshuva Arockia / Lakshmaiya, Natrayan / Velmurugan, Karthikeyan / Sirisamphanwong, Chatchai / Ngoenmeesri, Rattapon / Sirisamphanwong, Chattariya

Heliyon

2023 Volume 9, Issue 4, Page(s) e14807

Abstract	This study presents the details of performance and exergy investigations on an inclined solar still with baffle arrangements. The shortage of consumable water creates the transformation of accessible brackish water into consumable water an unavoidable one and this can be accomplished utilizing sun-oriented refining. To remove drinkable water from pungent water, sun-oriented still is broadly utilized. To build the contact season of the pungent water with sunlight-based brilliance, perplex course of action is set to expand the opposition in the stream. This prompts more vanishing of brackish water. Therefore, the objective of this study is to improve freshwater yield. The experimental study is performed for two different mass flow rates (m
Language	English
Publishing date	2023-04-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e14807
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Article ; Online: Recent progress and the emerging role of lncRNAs in cancer drug resistance; focusing on signaling pathways.

Saadh, Mohamed J / Rasulova, Irodakhon / Almoyad, Muhammad Ali Abdullah / Kiasari, Bahman Abedi / Ali, Ronak Taher / Rasheed, Tariq / Faisal, Ahmed / Hussain, Farah / Jawad, Mahmood Jasem / Hani, Thamer / Sârbu, Ioan / Lakshmaiya, Natrayan / Ciongradi, Carmen Iulia

Pathology, research and practice

2023 Volume 253, Page(s) 154999

Abstract: It is becoming more and more apparent that many of the genetic alterations associated with cancer are located in areas that do not encode proteins. lncRNAs are a class of RNAs that do not code for proteins but play a crucial role in maintaining cell ... ...

Abstract	It is becoming more and more apparent that many of the genetic alterations associated with cancer are located in areas that do not encode proteins. lncRNAs are a class of RNAs that do not code for proteins but play a crucial role in maintaining cell function and regulating various cellular processes. By doing this, they have recently introduced what may be a brand-new and essential layer of biological control. These have more than 200 nucleotides and are linked to several diseases; as a result, they have become potential tools for therapeutic intervention. Emerging technologies suggest the presence of mutations on genomic loci that give rise to lncRNAs rather than proteins in a disease as complex as cancer. These lncRNAs play essential parts in gene regulation, which impacts several cellular homeostasis processes, including proliferation, survival, migration, and genomic stability. The leading cause of death in the world today is cancer. Delays in diagnosis and a lack of standard and efficient treatments are the leading causes of the high death rate. Clinically, surgery is frequently used successfully to remove cancers that have not spread, but it is less successful in treating metastatic cancer, which has a drastically lower chance of survival. Chemotherapeutic drugs are a typical therapy to treat the cancer that has spread to other organs. Drug resistance to chemotherapy, however, presents a significant challenge to achieving positive outcomes and is frequently the cause of treatment failure. A substantial barrier to progress in medical oncology is cancer drug resistance. Resistance can develop clinically either before or after cancer treatment. According to this study, lncRNAs influence drug resistance through several different methods. LncRNAs often impact drug resistance by controlling the expression of a few intermediary regulatory variables rather than by directly affecting drug resistance. Additionally, lncRNAs have a variety of roles in cancer medication resistance. Most lncRNAs induce drug resistance when overexpressed; however, other lncRNAs have inhibitory effects. This study provides an overview of the current understanding of lncRNAs, relevance to cancer, and potential therapeutic applications.
MeSH term(s)	Humans ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplasms/pathology ; Drug Resistance, Neoplasm/genetics ; Signal Transduction/genetics
Chemical Substances	RNA, Long Noncoding
Language	English
Publishing date	2023-11-29
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2023.154999
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Article ; Online: Retraction notice to "The protective role of sulforaphane and Homer1a in retinal ischemia-reperfusion injury: Unraveling the neuroprotective interplay" [Life Sci. 329 (2023) 121968].

Saadh, Mohamed J / Castillo-Acobo, Roxana Yolanda / Baher, Hala / Narayanan, Jayasankar / Garay, Jessica Paola Palacios / Yamaguchi, Michelle Naomi Vera / Arias-Gonzáles, José Luis / Cotrina-Aliaga, Juan Carlos / Akram, Shaik Vaseem / Lakshmaiya, Natrayan / Amin, Ali H / Mohany, Mohamed / Al-Rejaie, Salim S / Ahsan, Muhammad / Bahrami, Abolfazl / Akhavan-Sigari, Reza

Life sciences

2024 Volume 345, Page(s) 122590

Language	English
Publishing date	2024-03-28
Publishing country	Netherlands
Document type	Journal Article ; Retraction of Publication
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2024.122590
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