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  1. Article ; Online: Cardiac sarcoidosis with extensive and heterogeneous left ventricular FDG uptake in absence of guidelines indication for an implantable defibrillator: Ventricular tachycardia precipitated by immunosuppressive therapy, should we have done differently?

    Voisine, Emile / Lemay, Sylvain / Beaudoin, Jonathan / Jacob, Philippe / Philippon, François / Marchand, Laurie / Vallée-Marcotte, Bastien / Bernier, Florence / Laliberté, Claudine / Fortin, Sophie / Komlosy, Marie-Ève / Birnie, David H / Sénéchal, Mario

    Pacing and clinical electrophysiology : PACE

    2024  

    Abstract: A 40-year-old man, newly diagnosed with cardiac sarcoidosis (CS) presented with symptomatic ventricular tachycardia three days after starting steroid-based immunosuppressive therapy (IT). There was no clear guideline indication for implantable ... ...

    Abstract A 40-year-old man, newly diagnosed with cardiac sarcoidosis (CS) presented with symptomatic ventricular tachycardia three days after starting steroid-based immunosuppressive therapy (IT). There was no clear guideline indication for implantable cardioverter-defibrillator (ICD) before the initiation of IT. Shortly after ICD implantation and the initiation of anti-arrhythmic drugs, recurring ventricular arrhythmias required titration of the anti-arrhythmic drug therapy. One-year follow-up assessment showed no significant arrhythmias and complete PET scan FDG uptake suppression. This case, along with recent publications, suggests transient pro-arrhythmic effects of steroids in patients with CS, which are not appropriately addressed in the current guidelines. We believe ICD implantation should be considered in clinically manifest CS before initiating IT, particularly in cases with heterogeneous and/or extensive FDG uptake on PET scans.
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Case Reports
    ZDB-ID 424437-0
    ISSN 1540-8159 ; 0147-8389
    ISSN (online) 1540-8159
    ISSN 0147-8389
    DOI 10.1111/pace.14965
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1466: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 399: Show issues

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  2. Article ; Online: New Perspective in Cardiac Sarcoidosis: The Potential Role of a Dedicated Clinic and the Importance of Collaboration Among Different Specialties.

    Lemay, Sylvain / Beaudoin, Jonathan / Philippon, François / Rimac, Goran / Lalancette, Jean-Simon / De Larochellière, Hugo / Gleeton, Guylaine / Charbonneau, Éric / Dion, Geneviève / Trottier, Mikaël / Albert, Alexandra / Fortin, Sophie / Laliberté, Claudine / Komlosy, Marie-Ève / Toma, Mustafa / Nery, Pablo / Birnie, David / Sénéchal, Mario

    The Canadian journal of cardiology

    2023  Volume 39, Issue 7, Page(s) 981–984

    MeSH term(s) Humans ; Myocarditis ; Sarcoidosis/diagnosis ; Sarcoidosis/therapy ; Cardiomyopathies/diagnosis ; Cardiomyopathies/therapy
    Language English
    Publishing date 2023-04-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2023.04.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2150: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Ten Questions Cardiologists Should Be Able to Answer About Cardiac Sarcoidosis: Case-Based Approach and Contemporary Review.

    Lemay, Sylvain / Massot, Montse / Philippon, François / Belzile, David / Turgeon, Pierre Yves / Beaudoin, Jonathan / Laliberté, Claudine / Fortin, Sophie / Dion, Geneviève / Milot, Julie / Trottier, Mikaël / Gosselin, Justin / Charbonneau, Éric / Birnie, David H / Sénéchal, Mario

    CJC open

    2020  Volume 3, Issue 4, Page(s) 532–548

    Abstract: Sarcoidosis is an inflammatory multisystemic disease of unknown etiology characterized by the formation of noncaseating epithelioid cell granulomas. Cardiac sarcoidosis might be life-threatening and its diagnosis and treatment remain a challenge nowadays. ...

    Abstract Sarcoidosis is an inflammatory multisystemic disease of unknown etiology characterized by the formation of noncaseating epithelioid cell granulomas. Cardiac sarcoidosis might be life-threatening and its diagnosis and treatment remain a challenge nowadays. The aim of this review is to provide an updated overview of cardiac sarcoidosis and, through 10 practical clinical questions and real-life challenging case scenarios, summarize the main clinical presentation, diagnostic criteria, imaging findings, and contemporary treatment.
    Language English
    Publishing date 2020-12-26
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2589-790X
    ISSN (online) 2589-790X
    DOI 10.1016/j.cjco.2020.11.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effect of Acute Immunosuppression on Left Ventricular Recovery and Mortality in Fulminant Viral Myocarditis: A Case Series and Review of Literature.

    Turgeon, Pierre Yves / Massot, Montse / Beaupré, Frédéric / Belzile, David / Beaudoin, Jonathan / Bernier, Mathieu / Bourgault, Christine / Germain, Valérie / Laliberté, Claudine / Morin, Joëlle / Gervais, Philippe / Trahan, Sylvain / Charbonneau, Éric / Dagenais, François / Sénéchal, Mario

    CJC open

    2020  Volume 3, Issue 3, Page(s) 292–302

    Abstract: Background: Fulminant viral myocarditis (FVM) is a rare cause of cardiogenic shock associated with high morbidity and mortality rates. An inappropriately activated immune system results in severe myocardial inflammation. Acute immunosuppressive therapy ... ...

    Abstract Background: Fulminant viral myocarditis (FVM) is a rare cause of cardiogenic shock associated with high morbidity and mortality rates. An inappropriately activated immune system results in severe myocardial inflammation. Acute immunosuppressive therapy for FVM therefore gained in popularity and was described in numerous retrospective studies.
    Methods: We conducted an extensive review of the literature and compared it with our single-centre retrospective review of all cases of FVM from 2009-2019 to evaluate the possible effect of acute immunosuppression with intravenous immunoglobulins and/or high dose corticosteroids in patients with FVM.
    Results: We report on 17 patients with a mean age of 46 ± 15 years with a mean left ventricular ejection fraction (LVEF) of 15 ± 9% at admission. Fourteen (82%) of our patients had acute LVEF recovery to ≥ 45% after a mean time from immunosuppression of 74 ± 49 hours (3.1 days). Extracorporeal membrane oxygenation (ECMO) was required in 35% (6/17) of our patients for an average support of 126 ± 37 hours. Overall mortality was 12% (2/17). No patient needed a long-term left ventricular assist device or heart transplant. All surviving patients achieved complete long-term LVEF recovery.
    Conclusions: Our cohort of 17 severely ill patients received acute immunosuppressive therapy and showed a rapid LVEF recovery, short duration of ECMO support, and low mortality rate. Our suggested scheme of investigation and treatment is presented. These results bring more cases of successfully treated FVM with immunosuppression and ECMO to the literature, which might stimulate further prospective trials or a registry.
    Language English
    Publishing date 2020-11-11
    Publishing country United States
    Document type Journal Article
    ISSN 2589-790X
    ISSN (online) 2589-790X
    DOI 10.1016/j.cjco.2020.10.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Heavy Burden of Toxic Dilated Cardiomyopathy Among Young Adults: A Retrospective Study and Review of the Literature.

    Cinq-Mars, Alexandre / Massot, Montse / Belzile, David / Turgeon, Pierre Yves / Dubois-Sénéchal, Sacha-Michelle / Laliberté, Claudine / Komlosy, Marie-Ève / Leblanc, Marie-Hélène / Bergeron, Sébastien / O'Connor, Kim / Morin, Joëlle / Bourgault, Christine / Bernier, Mathieu / Beaudoin, Jonathan / Radermaker, Steve / Laflamme, Maxime / Charbonneau, Eric / Sénéchal, Mario

    The Canadian journal of cardiology

    2021  Volume 38, Issue 1, Page(s) 49–58

    Abstract: Background: Dilated cardiomyopathy (DCM) is a well described entity for heart failure (HF) with reduced left ventricular ejection fraction (LVEF). Recently, drugs and other substance of abuse have been recognised as potential triggers for DCM. The aim ... ...

    Abstract Background: Dilated cardiomyopathy (DCM) is a well described entity for heart failure (HF) with reduced left ventricular ejection fraction (LVEF). Recently, drugs and other substance of abuse have been recognised as potential triggers for DCM. The aim of this study was to assess the survival in patients ≤ 65 years of age with toxic cardiomyopathy (TCM). Left ventricular remodelling and the potential usefulness of left ventricular assist devices (LVADs) was also assessed.
    Methods: This was a single-centre retrospective study from January 2003 to August 2019 of 553 patients ≤ 65 years old with LVEF < 40% at a tertiary-care cardiology centre.
    Results: A total of 201 patients (36%) had a diagnosis of idiopathic DCM. Further analysis identified 38 patients (19%) for which a TCM was the most likely etiology (amphetamine [50%], cocaine [37%], anabolic steroids [8%], and energy drinks [5%]). Despite a mean LVEF of 17 ± 8% at presentation, most patients (n = 27; 71%) had event-free survival with guideline-directed medical therapy, and 61% (n = 23) recovered an LVEF ≥ 40% after a median follow-up of 21 ± 23 months. Seven patients (18%) required an LVAD and 1 patient (3%) a transplantation. All LVADs were explanted or decommissioned after partial or complete LVEF recovery after a median support time of 11 ± 4 months.
    Conclusions: TCM induced by substance abuse is a frequent cause of HF, accounting for almost 20% of patients ≤ 65 years of age with DCM of unknown etiology. Treatment must be tailored on an individual basis. Mechanical circulatory support demonstrated its usefulness in carefully selected patients.
    MeSH term(s) Cardiomyopathy, Dilated/chemically induced ; Cardiomyopathy, Dilated/therapy ; Heart-Assist Devices ; Humans ; Retrospective Studies ; Substance-Related Disorders/complications ; Ventricular Function, Left/drug effects ; Ventricular Function, Left/physiology ; Ventricular Remodeling/drug effects ; Young Adult
    Language English
    Publishing date 2021-11-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 632813-1
    ISSN 1916-7075 ; 0828-282X
    ISSN (online) 1916-7075
    ISSN 0828-282X
    DOI 10.1016/j.cjca.2021.11.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2150: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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