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Article: Adrenal Suppression With Chronic Topical Corticosteroid Use in Psoriasis Patients.

Lam, Lisa H / Sugarman, Jeffrey L

2016 Volume 15, Issue 8, Page(s) 945–948

Abstract: Background: Topical corticosteroids (TCS) are typically used for extended periods of time for chronic skin conditions, including psoriasis. Chronic TCS use may result in side effects similar to those of systemic corticosteroids. Patients may have ... ...

Abstract	Background: Topical corticosteroids (TCS) are typically used for extended periods of time for chronic skin conditions, including psoriasis. Chronic TCS use may result in side effects similar to those of systemic corticosteroids. Patients may have subclinical adrenal suppression and be unaware of their risk in the case of serious trauma. Objective: The objective of this study was to investigate the real world effects of chronic TCS use and its effects on adrenal suppression in a chronic disease such as psoriasis. Materials: This retrospective study utilized data from screening visits of a psoriasis clinical trial in which subjects had been on chronic TCS. Results: In this study, subjects with moderate to severe psoriasis affecting 16-20% of total body surface area (BSA) and using high-potency TCS at screening had a lower post-cosyntropin cortisol level (18.83 mcg/dL) compared to those with moderate psoriasis involving 10-15% of total BSA and using lower potency TCS at screening (23.22 mcg/dL; P=0.03). Both subject groups had lower post-cosyntropin cortisol levels compared to normal, healthy adults (<em>P</em><0.001 for both). Conclusion: This suggests that real world chronic use of high potency TCS over a larger BSA may result in silent adrenal suppression. <em>J Drugs Dermatol</em>. 2016;15(8):945-948.
MeSH term(s)	Administration, Cutaneous ; Adrenal Cortex Hormones/antagonists & inhibitors ; Adrenal Cortex Hormones/blood ; Adult ; Aged ; Body Surface Area ; Cosyntropin/antagonists & inhibitors ; Cosyntropin/blood ; Drug Administration Schedule ; Female ; Glucocorticoids/administration & dosage ; Glucocorticoids/adverse effects ; Humans ; Hydrocortisone/antagonists & inhibitors ; Hydrocortisone/blood ; Male ; Middle Aged ; Psoriasis/blood ; Psoriasis/diagnosis ; Psoriasis/drug therapy ; Retrospective Studies
Chemical Substances	Adrenal Cortex Hormones ; Glucocorticoids ; Cosyntropin (16960-16-0) ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2016-08-01
Publishing country	United States
Document type	Clinical Trial ; Journal Article
ZDB-ID	2145090-0
ISSN	1545-9616
ISSN	1545-9616
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Insights into the Mechanism for Vertical Graphene Growth by Plasma-Enhanced Chemical Vapor Deposition

Sun, Jie / Rattanasawatesun, Tanupong / Tang, Penghao / Bi, Zhaoxia / Pandit, Santosh / Lam, Lisa / Wasén, Caroline / Erlandsson, Malin / Bokarewa, Maria / Dong, Jichen / Ding, Feng / Xiong, Fangzhu / Mijakovic, Ivan

ACS applied materials & interfaces. 2022 Jan. 10, v. 14, no. 5

2022

Abstract: Vertically oriented graphene (VG) has attracted attention for years, but the growth mechanism is still not fully revealed. The electric field may play a role, but the direct evidence and exactly what role it plays remains unclear. Here, we conduct a ... ...

Abstract	Vertically oriented graphene (VG) has attracted attention for years, but the growth mechanism is still not fully revealed. The electric field may play a role, but the direct evidence and exactly what role it plays remains unclear. Here, we conduct a systematic study and find that in plasma-enhanced chemical vapor deposition, the VG growth preferably occurs at spots where the local field is stronger, for example, at GaN nanowire tips. On almost round-shaped nanoparticles, instead of being perpendicular to the substrate, the VG grows along the field direction, that is, perpendicular to the particles’ local surfaces. Even more convincingly, the sheath field is screened to different degrees, and a direct correlation between the field strength and the VG growth is observed. Numerical calculation suggests that during the growth, the field helps accumulate charges on graphene, which eventually changes the cohesive graphene layers into separate three-dimensional VG flakes. Furthermore, the field helps attract charged precursors to places sticking out from the substrate and makes them even sharper and turn into VG. Finally, we demonstrate that the VG-covered nanoparticles are benign to human blood leukocytes and could be considered for drug delivery. Our research may serve as a starting point for further vertical two-dimensional material growth mechanism studies.
Keywords	drugs ; electric field ; graphene ; humans ; nanowires ; vapors
Language	English
Dates of publication	2022-0110
Size	p. 7152-7160.
Publishing place	American Chemical Society
Document type	Article
ISSN	1944-8252
DOI	10.1021/acsami.1c21640
Database	NAL-Catalogue (AGRICOLA)

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Book: Encyclopaedia of textile science, technology and engineering

Lam, Lisa

2009

Author's details	Lisa Lam
Language	English
Size	304 S, Ill., graph. Darst., 23 cm
Edition	1. ed
Publisher	Anmol Publ
Publishing place	New Delhi
Document type	Book
Note	Includes index
ISBN	8126141123 ; 9788126141128
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Blastocyst Vitrification and Trophectoderm Biopsy Cumulatively Alter Embryonic Gene Expression in a Mouse Model.

Van Heertum, Kristin / Lam, Lisa / Richardson, Brian / Cartwright, Michael J / Mesiano, Sam A / Cameron, Mark J / Weinerman, Rachel

Reproductive sciences (Thousand Oaks, Calif.)

2021 Volume 28, Issue 10, Page(s) 2961–2971

Abstract: Although embryo vitrification has been used extensively in human assisted reproductive technology (ART) and animal models, epidemiologic evidence and randomized controlled trials suggest differences in pregnancy/perinatal outcomes (birthweight, risk for ... ...

Abstract	Although embryo vitrification has been used extensively in human assisted reproductive technology (ART) and animal models, epidemiologic evidence and randomized controlled trials suggest differences in pregnancy/perinatal outcomes (birthweight, risk for preterm birth, and pre-eclampsia) between babies born from fresh versus frozen embryo transfers. To address the uncertainty surrounding the effects of laboratory manipulations of embryos on clinical outcomes, we subjected mouse blastocysts to increasing levels of manipulation for transcriptome analysis. Blastocysts were randomly divided into four groups: no manipulation (control), single vitrification/thaw (1 vit), double vitrification/thaw (2 vit), and single vitrification/thaw plus trophectoderm biopsy and again vitrified/thawed (2 vit + bx). Three sets of 15 blastocysts in each group were pooled for RNA sequencing, and differentially expressed genes (DEGs) and pathways were determined by statistical analysis. Blastocysts were also stained for ZO-1 and F-actin to assess cytoskeletal integrity. Freeze/thaw and biopsy manipulation affected multiple biological pathways. The most significant differences were detected in genes related to innate immunity, apoptosis, and mitochondrial function, with the magnitude of change proportional to the extent to manipulation. Significant disruptions were also seen in cytoskeletal staining, with greater disruptions seen with greater of manipulation. Our data suggests that embryo vitrification and biopsy affect embryo gene transcription, with several identified DEGs that may have plausible mechanisms for the clinical outcomes seen in human offspring following ART. Further study is required to determine whether these alterations in gene expression are associated with clinical differences seen in children born from fresh or frozen embryo transfer.
MeSH term(s)	Animals ; Blastocyst/metabolism ; Blastocyst/pathology ; Cytoskeleton/genetics ; Cytoskeleton/metabolism ; Cytoskeleton/pathology ; Embryo Culture Techniques/methods ; Embryo Transfer/methods ; Female ; Gene Expression Profiling/methods ; Mice ; Pregnancy ; Transcription, Genetic/physiology ; Vitrification
Language	English
Publishing date	2021-04-07
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2276411-2
ISSN	1933-7205 ; 1933-7191
ISSN (online)	1933-7205
ISSN	1933-7191
DOI	10.1007/s43032-021-00560-z
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Zs.A 4113: Show issues

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Article ; Online: A Case-Based Approach to Integrating Opioid Pharmacokinetic and Pharmacodynamic Concepts in Cancer Pain Management.

Lam, Lisa H / Pirrello, Rosene D / Ma, Joseph D

Journal of clinical pharmacology

2016 Volume 56, Issue 7, Page(s) 785–793

Abstract: Opioids are prescribed for cancer pain. Over the past decade, the annual increase in opioid prescriptions has been accompanied by an increase in opioid-associated deaths. Health care professionals must be proficient in proper dosing, titrating, and ... ...

Abstract	Opioids are prescribed for cancer pain. Over the past decade, the annual increase in opioid prescriptions has been accompanied by an increase in opioid-associated deaths. Health care professionals must be proficient in proper dosing, titrating, and monitoring of opioid medications. With the numerous opioid medications and formulations available, an understanding of pharmacokinetic (PK) and pharmacodynamic (PD) concepts is necessary to appropriately individualize opioid-based cancer pain regimens. The purpose of this review is to highlight PK/PD concepts that are clinically relevant to the use of opioids. By way of a cancer pain patient case scenario, PK/PD concepts that are relevant in the initiation, titration, and rotation of an opioid regimen are discussed.
MeSH term(s)	Analgesics, Opioid/administration & dosage ; Analgesics, Opioid/pharmacokinetics ; Cancer Pain/drug therapy ; Cancer Pain/metabolism ; Drug Administration Routes ; Drug Substitution/methods ; Female ; Humans ; Middle Aged ; Pain Management/methods
Chemical Substances	Analgesics, Opioid
Language	English
Publishing date	2016
Publishing country	England
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	188980-1
ISSN	1552-4604 ; 0091-2700 ; 0021-9754
ISSN (online)	1552-4604
ISSN	0091-2700 ; 0021-9754
DOI	10.1002/jcph.676
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Article ; Online: Association of concurrent acid-suppression therapy with survival outcomes and adverse event incidence in oncology patients receiving erlotinib.

Lam, Lisa H / Capparelli, Edmund V / Kurzrock, Razelle

Cancer chemotherapy and pharmacology

2016 Volume 78, Issue 2, Page(s) 427–432

Abstract: Purpose: Acid-suppression therapy is known to decrease the systemic exposure of erlotinib. The erlotinib prescribing information recommends staggering dosing with a histamine-2 receptor antagonist (H2RA) and avoiding concurrent use of a proton pump ... ...

Abstract	Purpose: Acid-suppression therapy is known to decrease the systemic exposure of erlotinib. The erlotinib prescribing information recommends staggering dosing with a histamine-2 receptor antagonist (H2RA) and avoiding concurrent use of a proton pump inhibitor (PPI). This retrospective analysis evaluated the frequency of concurrent acid-suppression therapy in oncology patients receiving erlotinib and its association with outcomes. Methods: All patients prescribed erlotinib within UC San Diego Health System between February 26, 2011, and February 28, 2014, were assessed for eligibility, survival outcomes and adverse events. Results: Of the 76 patients in the analysis, 24 were prescribed both a PPI and an H2RA with erlotinib therapy (31.6 %). The two patient groups, with (n = 24) and without PPI/H2RA (n = 52), were similar in clinical characteristics and erlotinib dose. One patient received an H2RA therapy alone and was excluded from the analysis; no one received PPI therapy alone. Patients receiving erlotinib alone had a longer median progression-free survival (PFS) compared to patients with concurrent PPI/H2RA therapy (11.0 months vs. 5.3 months; P = 0.029). Overall survival (OS) and incidence of rash and/or diarrhea did not correlate with use of acid-suppression therapy. Conclusion: Nearly one-third of patients received acid-suppression therapy. Patients treated with erlotinib and PPI/H2RA therapy had shorter PFS, but similar OS and adverse event profile compared to those who did not receive acid-suppression.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Disease-Free Survival ; Drug Interactions ; Erlotinib Hydrochloride/administration & dosage ; Erlotinib Hydrochloride/adverse effects ; Female ; Histamine H2 Antagonists/administration & dosage ; Humans ; Incidence ; Male ; Middle Aged ; Neoplasms/drug therapy ; Proton Pump Inhibitors/administration & dosage ; Retrospective Studies ; Survival Rate
Chemical Substances	Antineoplastic Agents ; Histamine H2 Antagonists ; Proton Pump Inhibitors ; Erlotinib Hydrochloride (DA87705X9K)
Language	English
Publishing date	2016-08
Publishing country	Germany
Document type	Comparative Study ; Journal Article
ZDB-ID	6820-2
ISSN	1432-0843 ; 0344-5704 ; 0943-9404
ISSN (online)	1432-0843
ISSN	0344-5704 ; 0943-9404
DOI	10.1007/s00280-016-3087-6
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Article ; Online: Reagent-Free Identification of Clinical Yeasts by Use of Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy.

Lam, Lisa M T / Dufresne, Philippe J / Longtin, Jean / Sedman, Jacqueline / Ismail, Ashraf A

Journal of clinical microbiology

2019 Volume 57, Issue 5

Abstract: Invasive fungal infections by opportunistic yeasts have increased concomitantly with the growth of an immunocompromised patient population. Misidentification of yeasts can lead to inappropriate antifungal treatment and complications. Attenuated total ... ...

Abstract	Invasive fungal infections by opportunistic yeasts have increased concomitantly with the growth of an immunocompromised patient population. Misidentification of yeasts can lead to inappropriate antifungal treatment and complications. Attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy is a promising method for rapid and accurate identification of microorganisms. ATR-FTIR spectroscopy is a standalone, inexpensive, reagent-free technique that provides results within minutes after initial culture. In this study, a comprehensive spectral reference database of 65 clinically relevant yeast species was constructed and tested prospectively on spectra recorded (from colonies taken from culture plates) for 318 routine yeasts isolated from various body fluids and specimens received from 38 microbiology laboratories over a 4-month period in our clinical laboratory. ATR-FTIR spectroscopy attained comparable identification performance with matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). In a preliminary validation of the ATR-FTIR method, correct identification rates of 100% and 95.6% at the genus and species levels, respectively, were achieved, with 3.5% unidentified and 0.9% misidentified. By expanding the number of spectra in the spectral reference database for species for which isolates could not be identified or had been misidentified, we were able to improve identification at the species level to 99.7%. Thus, ATR-FTIR spectroscopy provides a new standalone method that can rival MALDI-TOF MS for the accurate identification of a broad range of medically important yeasts. The simplicity of the ATR-FTIR spectroscopy workflow favors its use in clinical laboratories for timely and low-cost identification of life-threatening yeast strains for appropriate treatment.
MeSH term(s)	Body Fluids/microbiology ; Databases, Factual ; Humans ; Indicators and Reagents ; Mycoses/diagnosis ; Mycoses/microbiology ; Prospective Studies ; Spectroscopy, Fourier Transform Infrared ; Yeasts/classification ; Yeasts/isolation & purification
Chemical Substances	Indicators and Reagents
Language	English
Publishing date	2019-04-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	390499-4
ISSN	1098-660X ; 0095-1137
ISSN (online)	1098-660X
ISSN	0095-1137
DOI	10.1128/JCM.01739-18
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Article ; Online: Insights into the Mechanism for Vertical Graphene Growth by Plasma-Enhanced Chemical Vapor Deposition.

ACS applied materials & interfaces

2022 Volume 14, Issue 5, Page(s) 7152–7160

Abstract	Vertically oriented graphene (VG) has attracted attention for years, but the growth mechanism is still not fully revealed. The electric field may play a role, but the direct evidence and exactly what role it plays remains unclear. Here, we conduct a systematic study and find that in plasma-enhanced chemical vapor deposition, the VG growth preferably occurs at spots where the local field is stronger, for example, at GaN nanowire tips. On almost round-shaped nanoparticles, instead of being perpendicular to the substrate, the VG grows along the field direction, that is, perpendicular to the particles' local surfaces. Even more convincingly, the sheath field is screened to different degrees, and a direct correlation between the field strength and the VG growth is observed. Numerical calculation suggests that during the growth, the field helps accumulate charges on graphene, which eventually changes the cohesive graphene layers into separate three-dimensional VG flakes. Furthermore, the field helps attract charged precursors to places sticking out from the substrate and makes them even sharper and turn into VG. Finally, we demonstrate that the VG-covered nanoparticles are benign to human blood leukocytes and could be considered for drug delivery. Our research may serve as a starting point for further vertical two-dimensional material growth mechanism studies.
Language	English
Publishing date	2022-01-10
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.1c21640
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Article ; Online: Multicenter Evaluation of Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) Spectroscopy-Based Method for Rapid Identification of Clinically Relevant Yeasts.

Lam, Lisa M T / Ismail, Ashraf A / Lévesque, Simon / Dufresne, Simon F / Cheng, Mathew P / Vallières, Émilie / Luong, Me-Linh / Sedman, Jacqueline / Dufresne, Philippe J

Journal of clinical microbiology

2021 Volume 60, Issue 1, Page(s) e0139821

Abstract: Fourier transform infrared (FTIR) spectroscopy has demonstrated applicability as a reagent-free whole-organism fingerprinting technique for both microbial identification and strain typing. For routine application of this technique in microbiology ... ...

Abstract	Fourier transform infrared (FTIR) spectroscopy has demonstrated applicability as a reagent-free whole-organism fingerprinting technique for both microbial identification and strain typing. For routine application of this technique in microbiology laboratories, acquisition of FTIR spectra in the attenuated total reflectance (ATR) mode simplifies the FTIR spectroscopy workflow, providing results within minutes after initial culture without prior sample preparation. In our previous central work, 99.7% correct species identification of clinically relevant yeasts was achieved by employing an ATR-FTIR-based method and spectral database developed by our group. In this study, ATR-FTIR spectrometers were placed in 6 clinical microbiology laboratories over a 16-month period and were used to collect spectra of routine yeast isolates for on-site identification to the species level. The identification results were compared to those obtained from conventional biochemical tests and/or matrix-assisted laser desorption/ionization-time of flight mass spectrometry. Isolates producing discordant results were reanalyzed by routine identification methods, ATR-FTIR spectroscopy, and PCR gene sequencing of the D1/D2 and internal transcribed spacer (ITS) regions. Among the 573 routine clinical yeast isolates collected and identified by the ATR-FTIR-based method, 564 isolates (98.4%) were correctly identified at the species level, while the remaining isolates were inconclusive with no misidentifications. Due to the low prevalence of Candida auris in routine isolates, additional randomly selected C. auris (
MeSH term(s)	Fourier Analysis ; Humans ; Spectroscopy, Fourier Transform Infrared/methods ; Yeasts/isolation & purification
Language	English
Publishing date	2021-10-20
Publishing country	United States
Document type	Evaluation Study ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	390499-4
ISSN	1098-660X ; 0095-1137
ISSN (online)	1098-660X
ISSN	0095-1137
DOI	10.1128/JCM.01398-21
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Article ; Online: A phase I study of pharmacokinetics of trastuzumab emtansine in Chinese patients with locally advanced inoperable or metastatic human epidermal growth factor receptor 2-positive breast cancer who have received prior trastuzumab-based therapy.

Ji, Dongmei / Shen, Weina / Zhang, Jian / Cao, Junning / Li, Wenhua / Lam, Lisa H / Wu, Fan / Wang, Bei / Li, Zao / Sun, Guofang / Hu, Xichun / Chen, Shang-Chiung

Medicine

2020 Volume 99, Issue 44, Page(s) e22886

Abstract: Background: Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate that retains the antitumor effects of trastuzumab while also delivering the cytotoxic antimicrotubule agent, DM1, directly to tumor cells that overexpress human epidermal growth ... ...

Abstract	Background: Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate that retains the antitumor effects of trastuzumab while also delivering the cytotoxic antimicrotubule agent, DM1, directly to tumor cells that overexpress human epidermal growth factor receptor 2. The pharmacokinetic (PK) profile of T-DM1 has been well characterized in Western, Asian, and Japanese patients; this single-center, phase I study (NCT03153163) examined the PK of T-DM1 and safety specifically in Chinese patients. Methods: Patients with locally advanced or metastatic breast cancer, previously treated with trastuzumab and a taxane, received open-label T-DM1 at 3.6 mg/kg every 3 weeks. Serum T-DM1 and total trastuzumab, and plasma DM1 were evaluated, and PK parameters were calculated using standard noncompartmental approaches. Adverse events (AEs) were assessed, and immunogenicity was evaluated by measuring antidrug antibodies to T-DM1. Results: Among 11 Chinese patients, mean (±standard deviation) PK parameters (maximum serum concentration, 77.6 ± 17.4 μg/mL; clearance 11.0 ± 2.6 mL/d/kg; terminal half-life 3.8 ± 1.0 days) were similar to those previously reported in Western and Japanese patients. One patient transiently developed antidrug antibodies, which did not appear to influence safety or PK. T-DM1 was generally well tolerated. Grade 3-4 AEs occurred in 7 patients (63.6%) and serious AEs occurred in 4 patients (36.4%). Platelet count decrease was the most common all-grade AE (10/11; 90.9%), grade 3-4 AE (5/11; 45.5%), and serious AE (3/11; 27.3%), but did not appear to be associated with any clinically significant bleeding events. Conclusions: T-DM1 PK in Chinese patients was consistent with those in global and Asian populations, supporting its use in patients with advanced human epidermal growth factor receptor 2-positive breast cancer following progression on trastuzumab and a taxane. The safety profile of T-DM1 was consistent with prior experience.
MeSH term(s)	Antineoplastic Agents, Immunological/administration & dosage ; Antineoplastic Agents, Immunological/adverse effects ; Antineoplastic Agents, Immunological/pharmacokinetics ; Breast Neoplasms/drug therapy ; Breast Neoplasms/immunology ; Breast Neoplasms/pathology ; China ; Drug Monitoring/methods ; Female ; Humans ; Middle Aged ; Neoplasm Staging ; Receptor, ErbB-2/analysis ; Trastuzumab/administration & dosage ; Trastuzumab/adverse effects ; Trastuzumab/pharmacokinetics ; Treatment Outcome
Chemical Substances	Antineoplastic Agents, Immunological ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1) ; Trastuzumab (P188ANX8CK)
Language	English
Publishing date	2020-11-24
Publishing country	United States
Document type	Clinical Trial ; Clinical Trial, Phase I ; Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000022886
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