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  1. Article ; Online: Falsely decreased Abbott Alinity-c gamma-glutamyl transferase-2 result from paraprotein and heparin interference: case report and subsequent laboratory experiments.

    Sam, Khin M / Schneider, Hans-Gerhard / Choy, Kay Weng / Lam, Que T

    Clinical chemistry and laboratory medicine

    2024  Volume 62, Issue 6, Page(s) e126–e128

    MeSH term(s) Humans ; Heparin ; gamma-Glutamyltransferase/blood ; Paraproteins/analysis ; Male ; Female ; False Positive Reactions
    Chemical Substances Heparin (9005-49-6) ; gamma-Glutamyltransferase (EC 2.3.2.2) ; Paraproteins
    Language English
    Publishing date 2024-03-05
    Publishing country Germany
    Document type Case Reports ; Letter
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2024-0015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 121: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Article ; Online: The Presence of Diabetes and Higher HbA

    Yong, Priscilla H / Weinberg, Laurence / Torkamani, Niloufar / Churilov, Leonid / Robbins, Raymond J / Ma, Ronald / Bellomo, Rinaldo / Lam, Que T / Burns, James D / Hart, Graeme K / Lew, Jeremy F / Mårtensson, Johan / Story, David / Motley, Andrew N / Johnson, Douglas / Zajac, Jeffrey D / Ekinci, Elif I

    Diabetes care

    2018  Volume 41, Issue 6, Page(s) 1172–1179

    Abstract: Objective: Limited studies have examined the association between diabetes and HbA: Research design and methods: In this prospective, observational study, we measured the HbA: Results: Of 7,565 inpatients, 30% had diabetes, and 37% had prediabetes. ...

    Abstract Objective: Limited studies have examined the association between diabetes and HbA
    Research design and methods: In this prospective, observational study, we measured the HbA
    Results: Of 7,565 inpatients, 30% had diabetes, and 37% had prediabetes. After adjusting for age, Charlson comorbidity index (excluding diabetes and age), estimated glomerular filtration rate, and length of surgery, diabetes was associated with increased 6-month mortality (adjusted odds ratio [aOR] 1.29 [95% CI 1.05-1.58];
    Conclusions: Almost one-third of surgical inpatients age ≥54 years had diabetes. Diabetes and higher HbA
    MeSH term(s) Aged ; Aged, 80 and over ; Diabetes Complications/blood ; Diabetes Complications/epidemiology ; Diabetes Mellitus/blood ; Diabetes Mellitus/epidemiology ; Female ; Glycated Hemoglobin A/analysis ; Glycated Hemoglobin A/metabolism ; Hospitalization/statistics & numerical data ; Humans ; Inpatients ; Intensive Care Units ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Postoperative Complications/blood ; Postoperative Complications/epidemiology ; Postoperative Period ; Prediabetic State/blood ; Prediabetic State/epidemiology ; Risk Factors ; Surgical Procedures, Operative/adverse effects ; Surgical Procedures, Operative/statistics & numerical data
    Chemical Substances Glycated Hemoglobin A
    Language English
    Publishing date 2018-03-26
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    DOI 10.2337/dc17-2304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1434: Show issues Location:
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    Zs.MO 365: Show issues

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  3. Article ; Online: Incidence of post-operative troponin I rises and 1-year mortality after emergency orthopaedic surgery in older patients.

    Chong, Carol P / Lam, Que T / Ryan, Julie E / Sinnappu, Rabindra N / Lim, Wen Kwang

    Age and ageing

    2009  Volume 38, Issue 2, Page(s) 168–174

    Abstract: Objectives: to determine the incidence of post-operative troponin I rises and its association with 1-year all-cause mortality and cardiac events after emergency orthopaedic-geriatric surgery, which has not been studied before.: Methods: one hundred ... ...

    Abstract Objectives: to determine the incidence of post-operative troponin I rises and its association with 1-year all-cause mortality and cardiac events after emergency orthopaedic-geriatric surgery, which has not been studied before.
    Methods: one hundred and two patients over the age of 60 were recruited and followed up at 1 year. All consented to serial troponin I measurements peri-operatively.
    Results: the incidence of a troponin I rise post-operatively was 52.9%. Post-operative acute myocardial infarction was diagnosed in 9.8% and at 1 year, 70% of these patients were dead. At 1 year, 32.4% (33/102) had sustained a cardiac event (myocardial infarction, congestive cardiac failure, atrial fibrillation or major arrhythmia) and using multivariate analysis, post-operative troponin rise (OR 3.9, 95% CI 1.4-10.7, P = 0.008) was an independent predictor of this. Half of the patients with a troponin rise had a cardiac event compared to 18.8% without a rise. All-cause mortality was 20.6% at 1 year; 37% with an associated post-operative troponin rise died versus 2.1% without a rise (P < 0.0001). Using multivariate analysis, only two factors were associated with 1-year all-cause mortality: post-operative troponin rise (OR 12.0, 95% CI 1.4-104.8, P = 0.025) and sustaining a post-operative in-hospital cardiac event (OR 6.6, 95% CI 1.7-25.6, P = 0.006). Furthermore, patients with higher troponin levels had significantly worse survival.
    Conclusions: there is a high incidence of post-operative troponin I rises in older patients undergoing emergency orthopaedic surgery with 1-year mortality and cardiac events being significantly increased in these patients. Future studies are needed to determine whether any intervention can improve outcome for these patients.
    MeSH term(s) Aged ; Aged, 80 and over ; Aging ; Emergency Medical Services/statistics & numerical data ; Female ; Fractures, Bone/blood ; Fractures, Bone/mortality ; Fractures, Bone/surgery ; Heart Diseases/blood ; Heart Diseases/mortality ; Humans ; Incidence ; Inpatients/statistics & numerical data ; Male ; Middle Aged ; Orthopedic Procedures/mortality ; Outpatients/statistics & numerical data ; Postoperative Complications/blood ; Postoperative Complications/mortality ; Predictive Value of Tests ; Risk Factors ; Troponin I/blood
    Chemical Substances Troponin I
    Language English
    Publishing date 2009-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 186788-x
    ISSN 1468-2834 ; 0002-0729
    ISSN (online) 1468-2834
    ISSN 0002-0729
    DOI 10.1093/ageing/afn231
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 877: Show issues Location:
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    Zs.MO 448: Show issues

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  4. Article ; Online: Usefulness of N-terminal pro-brain natriuretic peptide to predict postoperative cardiac complications and long-term mortality after emergency lower limb orthopedic surgery.

    Chong, Carol P / Ryan, Julie E / van Gaal, William J / Lam, Que T / Sinnappu, Rabindra N / Burrell, Louise M / Savige, Judy / Lim, Wen Kwang

    The American journal of cardiology

    2010  Volume 106, Issue 6, Page(s) 865–872

    Abstract: After emergency orthopedic-geriatric surgery, cardiac complications are an important cause of morbidity and mortality. The utility of N-terminal pro-brain natriuretic peptide (NT-pro-BNP) for the prediction of cardiac complications and mortality was ... ...

    Abstract After emergency orthopedic-geriatric surgery, cardiac complications are an important cause of morbidity and mortality. The utility of N-terminal pro-brain natriuretic peptide (NT-pro-BNP) for the prediction of cardiac complications and mortality was evaluated. NT-pro-BNP was tested pre- and postoperatively in 89 patients >60 years of age. They were followed for 2 years for cardiac complications (defined as acute myocardial infarction, congestive cardiac failure, atrial fibrillation or major arrhythmia) or death. Receiver operating characteristic curves were constructed to determine the optimal discriminatory level for cardiac events and death using NT-pro-BNP. Twenty-three patients (25.8%) sustained an in-hospital postoperative cardiac complication. Total all-cause mortality was 3 of 89 (3.4%) in hospital, 21 of 89 (23.6%) at 1 year, and 27 of 89 (30.3%) at 2 years. Median preoperative and postoperative NT-pro-BNP levels were higher in patients who had an in-hospital cardiac event compared to those without (387 vs 1,969 pg/ml, p <0.001; and 676 vs 7,052 pg/ml, p <0.001 respectively). The optimal discriminatory level for preoperative NT-pro-BNP was 842 pg/ml and that for postoperative NT-pro-BNP was 1,401 pg/ml for the prediction of in-hospital cardiac events and 1- and 2-year mortality. Preoperative NT-pro-BNP >/=842 pg/ml (odds ratio 11.6, 95% confidence interval 2.1 to 65.0, p = 0.005) was an independent predictor of in-hospital cardiac complications using multivariate analysis and pre- and postoperative NT-pro-BNP levels were independent predictors of 2-year cardiovascular events. Patients who had preoperative NT-pro-BNP >/=842 pg/ml or postoperative NT-pro-BNP >/=1,401 pg/ml had significantly worse survival using log-rank testing (p <0.001) and these variables independently predicted 2-year mortality. In conclusion, increase pre- and postoperative NT-pro-BNP levels are independent predictors of in-hospital cardiac events and 1- and 2-year mortality in older patients undergoing emergency orthopedic surgery.
    MeSH term(s) Aged ; Aged, 80 and over ; Biomarkers/blood ; Confidence Intervals ; Emergencies ; Female ; Follow-Up Studies ; Frail Elderly ; Heart Diseases/blood ; Heart Diseases/diagnosis ; Heart Diseases/etiology ; Heart Diseases/mortality ; Heart Failure/diagnosis ; Heart Failure/mortality ; Humans ; Lower Extremity/surgery ; Male ; Natriuretic Peptide, Brain/blood ; Odds Ratio ; Orthopedic Procedures/adverse effects ; Peptide Fragments/blood ; Postoperative Period ; Predictive Value of Tests ; Preoperative Period ; Prospective Studies ; Survival Analysis
    Chemical Substances Biomarkers ; Peptide Fragments ; pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0)
    Language English
    Publishing date 2010-09-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2010.05.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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