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Article ; Online: Optimizing the diagnosis of pelvic lymph node metastasis in bladder cancer using computed tomography and magnetic resonance imaging.

Lam, Thomas B L

Cancer communications (London, England)

2018 Volume 38, Issue 1, Page(s) 2

MeSH term(s)	Humans ; Lymph Nodes ; Lymphatic Metastasis ; Magnetic Resonance Imaging ; Tomography, X-Ray Computed ; Urinary Bladder Neoplasms
Language	English
Publishing date	2018-03-12
Publishing country	United States
Document type	Journal Article ; Comment
ISSN	2523-3548
ISSN (online)	2523-3548
DOI	10.1186/s40880-018-0271-6
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Article ; Online: Prostate Cancer Detection Percentages of Repeat Biopsy in Patients with Positive Multiparametric Magnetic Resonance Imaging (Prostate Imaging Reporting and Data System/Likert 3-5) and Negative Initial Biopsy. A Mini Systematic Review.

Grivas, Nikolaos / Lardas, Michael / Espinós, Estefania Linares / Lam, Thomas B / Rouviere, Olivier / Mottet, Nicolas / van den Bergh, Roderick C N

European urology

2022 Volume 82, Issue 5, Page(s) 452–457

Abstract: Multiparametric magnetic resonance imaging (mpMRI) has high sensitivity but low specificity for prostate cancer (PCa) diagnosis. The aim of our systematic review was to investigate the proportion of PCa found at a repeat biopsy in patients with a ... ...

Abstract	Multiparametric magnetic resonance imaging (mpMRI) has high sensitivity but low specificity for prostate cancer (PCa) diagnosis. The aim of our systematic review was to investigate the proportion of PCa found at a repeat biopsy in patients with a negative initial prostate biopsy, despite initial positive mpMRI. Included patients had a Prostate Imaging Reporting and Data System (PI-RADS)/Likert 3-5 lesion on mpMRI prior to the initial mpMRI-targeted prostate biopsy, which was negative for PCa on histology. The main outcomes were the overall and clinically significant PCa (csPCa; International Society of Urological Pathology >1 or any provided definition) percentages at a repeat biopsy. Out of 1179 articles identified, nine studies were included (a total of 485 patients). For patients with PI-RADS 3 lesions, overall and csPCa detection percentages ranged from 0% to 80% and from 0% to 20%, respectively, while for patients with PI-RADS ≥4 lesions, the corresponding percentages were 15.4-86% and 7.7-57%. An overall cancer detection percentage of 87.5% was reported in patients with Likert 5 lesions. Limitation of our review is the small number of studies and the protocol revision that allowed studies with <50 patients. In patients with a positive MRI result and a negative initial MRI-targeted biopsy, we suggest MRI re-reading and follow-up with repeat mpMRI or the standard repeat biopsy in cases at the highest risk. PATIENT SUMMARY: Literature has shown that in men with an abnormal prostate magnetic resonance imaging (MRI) scan but a normal biopsy, a significant prostate cancer can be present. MRI scans should be double checked, followed by standard checkups or repeat prostate biopsy, especially in highly suspicious cases.
MeSH term(s)	Biopsy ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Multiparametric Magnetic Resonance Imaging ; Prostate/diagnostic imaging ; Prostate/pathology ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology
Language	English
Publishing date	2022-08-18
Publishing country	Switzerland
Document type	Journal Article ; Systematic Review
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2022.07.025
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Zs.A 1247: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Re: Neil E. Martin, Laura Massey, Caleb Stowell, et al. Defining a Standard Set of Patient-centered Outcomes for Men with Localized Prostate Cancer. Eur Urol 2015;67:460-7.

MacLennan, Steven / Williamson, Paula R / Lam, Thomas B

European urology

2015 Volume 68, Issue 6, Page(s) e123–4

MeSH term(s)	Health Status ; Health Status Indicators ; Humans ; Male ; Medical Oncology/standards ; Patient-Centered Care/standards ; Process Assessment, Health Care/standards ; Prostatic Neoplasms/therapy ; Quality Indicators, Health Care/standards
Language	English
Publishing date	2015-08-29
Publishing country	Switzerland
Document type	Letter ; Comment
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2015.08.015
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Zs.A 1247: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Significance of MUC1 in bladder cancer.

Ahmad, Sarfraz / Lam, Thomas B L / N'Dow, James

BJU international

2015 Volume 115, Issue 1, Page(s) 161–162

MeSH term(s)	Biomarkers, Tumor/metabolism ; Humans ; Mucin-1/metabolism ; Urinary Bladder Neoplasms/metabolism
Chemical Substances	Biomarkers, Tumor ; MUC1 protein, human ; Mucin-1
Language	English
Publishing date	2015-01
Publishing country	England
Document type	Journal Article
ZDB-ID	1462191-5
ISSN	1464-410X ; 1464-4096 ; 1358-8672
ISSN (online)	1464-410X
ISSN	1464-4096 ; 1358-8672
DOI	10.1111/bju.12727
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Ui VI Zs.107: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Between a rock and a hard place: the uncertainties in managing renal stones.

Lam, Thomas B L / McClinton, Sam

European urology

2014 Volume 67, Issue 1, Page(s) 138–139

MeSH term(s)	Humans ; Kidney Calculi/surgery ; Nephrostomy, Percutaneous/methods
Language	English
Publishing date	2014-07-31
Publishing country	Switzerland
Document type	Editorial ; Comment
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2014.07.016
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Zs.A 1247: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: European Association of Urology Guidelines on Renal Cell Carcinoma: The 2022 Update.

Ljungberg, Börje / Albiges, Laurence / Abu-Ghanem, Yasmin / Bedke, Jens / Capitanio, Umberto / Dabestani, Saeed / Fernández-Pello, Sergio / Giles, Rachel H / Hofmann, Fabian / Hora, Milan / Klatte, Tobias / Kuusk, Teele / Lam, Thomas B / Marconi, Lorenzo / Powles, Thomas / Tahbaz, Rana / Volpe, Alessandro / Bex, Axel

European urology

2022 Volume 82, Issue 4, Page(s) 399–410

Abstract: Context: The European Association of Urology (EAU) Renal Cell Carcinoma (RCC) Guideline Panel has prepared evidence-based guidelines and recommendations for the management of RCC.: Objective: To present a summary of the 2022 RCC guideline, which is ... ...

Abstract	Context: The European Association of Urology (EAU) Renal Cell Carcinoma (RCC) Guideline Panel has prepared evidence-based guidelines and recommendations for the management of RCC. Objective: To present a summary of the 2022 RCC guideline, which is based on a standardised methodology including systematic reviews (SRs) and provides transparent and reliable evidence for the management of RCC. Evidence acquisition: For the 2022 update, a new literature search was carried out with a cutoff date of May 28, 2021, covering the Medline, EMBASE, and Cochrane databases. The data search focused on randomised controlled trials (RCTs) and retrospective or controlled comparator-arm studies, SRs, and meta-analyses. Evidence synthesis was conducted using modified GRADE criteria as outlined for all the EAU guidelines. Evidence synthesis: All chapters of the RCC guideline were updated on the basis of a structured literature assessment, and clinical practice recommendations were developed. The majority of the studies included were retrospective with matched or unmatched cohorts and were based on single- or multi-institution data or national registries. The exception was systemic treatment of metastatic RCC, for which there are several large RCTs, resulting in recommendations that are based on higher levels of evidence. Conclusions: The 2022 RCC guidelines have been updated by a multidisciplinary panel of experts using the highest methodological standards. These guidelines provide the most reliable contemporary evidence base for the management of RCC in 2022. Patient summary: The European Association of Urology panel for guidelines on kidney cancer has thoroughly evaluated the research data available to establish up-to-date international standards for the care of patients with kidney cancer.
MeSH term(s)	Carcinoma, Renal Cell/therapy ; Humans ; Kidney Neoplasms/pathology ; Kidney Neoplasms/therapy ; Urology
Language	English
Publishing date	2022-03-26
Publishing country	Switzerland
Document type	Journal Article ; Practice Guideline
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2022.03.006
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Zs.A 1247: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: A randomized trial comparing three Delphi feedback strategies found no evidence of a difference in a setting with high initial agreement.

MacLennan, Steven / Kirkham, Jamie / Lam, Thomas B L / Williamson, Paula R

Journal of clinical epidemiology

2017 Volume 93, Page(s) 1–8

Abstract: Objectives: The objective of the study was to explore the impact of different feedback strategies on (1) subsequent agreement and (2) variability in Delphi studies.: Study design and setting: A two-round Delphi survey, with a list of outcomes ... ...

Abstract	Objectives: The objective of the study was to explore the impact of different feedback strategies on (1) subsequent agreement and (2) variability in Delphi studies. Study design and setting: A two-round Delphi survey, with a list of outcomes generated from the results of a systematic review and interviews, was undertaken while developing a core outcomes set for prostate cancer including two stakeholder groups (health professionals and patients). Seventy-nine outcomes were scored on a scale of one (not important) to nine (critically important). Participants were randomized in round 2 to receive round 1 feedback from peers only, multiple stakeholders separately, or multiple stakeholders combined. Results: Agreement on outcomes retained for all feedback groups was high (peer: 92%, multiple separate: 90%, multiple combined: 84%). There were no statistically significant reduction in variability for peer vs. multiple separate (0.016 [-0.035, 0.067]; P = 0.529), or multiple separate vs. multiple combined feedback (0.063 [-0.003, 0.129]; P = 0.062). Peer feedback statistically significantly reduced variability compared with multiple combined feedback (0.079 [0.001, 0.157]; P = 0.046). Conclusions: We found no evidence of a difference between different feedback strategies in terms of the number of outcomes retained or reduction in variability of opinion. However, this may be explained by the high level of existing agreement in round 1. Further methodological studies nested within Delphi surveys will help clarify the best strategy.
MeSH term(s)	Delphi Technique ; Feedback ; Female ; Health Personnel ; Humans ; Interviews as Topic ; Male ; Peer Group ; Research Design ; Systematic Reviews as Topic ; Treatment Outcome
Language	English
Publishing date	2017-10-07
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial
ZDB-ID	639306-8
ISSN	1878-5921 ; 0895-4356
ISSN (online)	1878-5921
ISSN	0895-4356
DOI	10.1016/j.jclinepi.2017.09.024
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Article ; Online: Reply to E. Jason Abel Letter to the Editor re: Lorenzo Marconi, Saeed Dabestani, Thomas B. Lam, et al. Systematic Review and Meta-analysis of Diagnostic Accuracy of Percutaneous Renal Tumour Biopsy. Eur Urol 2016;69:660-73.

Marconi, Lorenzo / Lam, Thomas B / Bex, Axel / Ljungberg, Börje / Volpe, Alessandro

European urology

2016 Volume 69, Issue 6, Page(s) e119–20

Language	English
Publishing date	2016-06
Publishing country	Switzerland
Document type	Letter
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2015.12.043
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Zs.A 1247: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Reply to Jae Heon Kim's Letter to the Editor re: Lorenzo Marconi, Saeed Dabestani, Thomas B. Lam, et al. Systematic Review and Meta-analysis of Diagnostic Accuracy of Percutaneous Renal Tumour Biopsy. Eur Urol 2016;69:660-73.

Marconi, Lorenzo / Lam, Thomas B / Bex, Axel / Ljungberg, Börje / Volpe, Alessandro

European urology

2016 Volume 70, Issue 5, Page(s) e141–e142

Language	English
Publishing date	2016-11
Publishing country	Switzerland
Document type	Letter
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2016.04.026
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Zs.A 1247: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Reprint - Bipolar vs. monopolar transurethral resection of the prostate for lower urinary tract symptoms secondary to benign prostatic obstruction: A Cochrane review.

Alexander, Cameron Edwin / Scullion, Malo M F / Omar, Muhammad Imran / Yuan, Yuhong / Mamoulakis, Charalampos / N'Dow, James M O / Chen, Changhao / Lam, Thomas B L

Canadian Urological Association journal = Journal de l'Association des urologues du Canada

2020 Volume 14, Issue 12, Page(s) 423–430

Abstract: Introduction: There remains uncertainty regarding the differences in patient outcomes between monopolar transurethral resection of the prostate (MTURP) and bipolar TURP (BTURP) in the management of lower urinary tract symptoms (LUTS) secondary to benign ...

Abstract	Introduction: There remains uncertainty regarding the differences in patient outcomes between monopolar transurethral resection of the prostate (MTURP) and bipolar TURP (BTURP) in the management of lower urinary tract symptoms (LUTS) secondary to benign prostatic obstruction (BPO). Methods: A systematic literature search was carried out up to March 19, 2019. Methods in the Cochrane Handbook were followed. Certainty of evidence (CoE) was assessed using the GRADE approach. Results: A total of 59 randomized controlled trials (RCTs) with 8924 participants were included. BTURP probably results in little to no difference in International Prostate Symptom Score (IPSS) at 12 months (mean difference -0.24, 95% confidence internal [CI] -0.39--0.09; participants=2531; RCTs=16; moderate CoE) or health-related quality of life (HRQOL) at 12 months (mean difference -0.12, 95% CI -0.25-0.02; participants=2004, RCTs=11; moderate CoE), compared to MTURP. BTURP probably reduces TUR syndrome (relative risk [RR] 0.17, 95% CI 0.09-0.30; participants= 6,745, RCTs=44; moderate CoE) and blood transfusions (RR 0.42, 95% CI 0.30-0.59; participants=5727, RCTs=38; moderate CoE), compared to MTURP. BTURP may carry similar risk of urinary incontinence at 12 months (RR 0.20, 95% CI 0.01-4.06; participants=751; RCTs=4; low CoE), re-TURP (RR 1.02, 95% CI 0.44-2.40; participants=652, RCTs=6, I Conclusions: BTURP and MTURP probably improve urological symptoms to a similar degree. BTURP probably reduces TUR syndrome and blood transfusion slightly postoperatively. The moderate certainty of evidence available for primary outcomes suggests no need for further RCTs comparing BTURP and MTURP.
Language	English
Publishing date	2020-07-25
Publishing country	Canada
Document type	Journal Article ; Review
ZDB-ID	2431403-1
ISSN	1911-6470
ISSN	1911-6470
DOI	10.5489/cuaj.6464
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