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  1. Article ; Online: Region-specific associations between gamma-aminobutyric acid A receptor binding and cortical thickness in high-functioning autistic adults.

    James, David / Lam, Vicky T / Jo, Booil / Fung, Lawrence K

    Autism research : official journal of the International Society for Autism Research

    2022  Volume 15, Issue 6, Page(s) 1068–1082

    Abstract: The neurobiology of autism has been shown to involve alterations in cortical morphology and gamma-aminobutyric acid A ( ... ...

    Abstract The neurobiology of autism has been shown to involve alterations in cortical morphology and gamma-aminobutyric acid A (GABA
    MeSH term(s) Adult ; Autism Spectrum Disorder ; Autistic Disorder/diagnostic imaging ; Autistic Disorder/pathology ; Brain/pathology ; Brain Mapping/methods ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Male ; gamma-Aminobutyric Acid
    Chemical Substances gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2022-03-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2481338-2
    ISSN 1939-3806 ; 1939-3792
    ISSN (online) 1939-3806
    ISSN 1939-3792
    DOI 10.1002/aur.2703
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Thalamocortical connectivity is associated with autism symptoms in high-functioning adults with autism and typically developing adults.

    Ayub, Rafi / Sun, Kevin L / Flores, Ryan E / Lam, Vicky T / Jo, Booil / Saggar, Manish / Fung, Lawrence K

    Translational psychiatry

    2021  Volume 11, Issue 1, Page(s) 93

    Abstract: Alterations in sensorimotor functions are common in individuals with autism spectrum disorder (ASD). Such aberrations suggest the involvement of the thalamus due to its key role in modulating sensorimotor signaling in the cortex. Although previous ... ...

    Abstract Alterations in sensorimotor functions are common in individuals with autism spectrum disorder (ASD). Such aberrations suggest the involvement of the thalamus due to its key role in modulating sensorimotor signaling in the cortex. Although previous research has linked atypical thalamocortical connectivity with ASD, investigations of this association in high-functioning adults with autism spectrum disorder (HFASD) are lacking. Here, for the first time, we investigated the resting-state functional connectivity of the thalamus, medial prefrontal, posterior cingulate, and left dorsolateral prefrontal cortices and its association with symptom severity in two matched cohorts of HFASD. The principal cohort consisted of 23 HFASD (mean[SD] 27.1[8.9] years, 39.1% female) and 20 age- and sex-matched typically developing controls (25.1[7.2] years, 30.0% female). The secondary cohort was a subset of the ABIDE database consisting of 58 HFASD (25.4[7.8] years, 37.9% female) and 51 typically developing controls (24.4[6.7] years, 39.2% female). Using seed-based connectivity analysis, between-group differences were revealed as hyperconnectivity in HFASD in the principal cohort between the right thalamus and bilateral precentral/postcentral gyri and between the right thalamus and the right superior parietal lobule. The former was associated with autism-spectrum quotient in a sex-specific manner, and was further validated in the secondary ABIDE cohort. Altogether, we present converging evidence for thalamocortical hyperconnectivity in HFASD that is associated with symptom severity. Our results fill an important knowledge gap regarding atypical thalamocortical connectivity in HFASD, previously only reported in younger cohorts.
    MeSH term(s) Adult ; Autism Spectrum Disorder ; Autistic Disorder ; Cerebral Cortex/diagnostic imaging ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Thalamus/diagnostic imaging
    Language English
    Publishing date 2021-02-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2609311-X
    ISSN 2158-3188 ; 2158-3188
    ISSN (online) 2158-3188
    ISSN 2158-3188
    DOI 10.1038/s41398-021-01221-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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