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  1. Article ; Online: KRAS mutation

    Lamei Huang / Zhixing Guo / Fang Wang / Liwu Fu

    Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-

    from undruggable to druggable in cancer

    2021  Volume 20

    Abstract: Abstract Cancer is the leading cause of death worldwide, and its treatment and outcomes have been dramatically revolutionised by targeted therapies. As the most frequently mutated oncogene, Kirsten rat sarcoma viral oncogene homologue (KRAS) has ... ...

    Abstract Abstract Cancer is the leading cause of death worldwide, and its treatment and outcomes have been dramatically revolutionised by targeted therapies. As the most frequently mutated oncogene, Kirsten rat sarcoma viral oncogene homologue (KRAS) has attracted substantial attention. The understanding of KRAS is constantly being updated by numerous studies on KRAS in the initiation and progression of cancer diseases. However, KRAS has been deemed a challenging therapeutic target, even “undruggable”, after drug-targeting efforts over the past four decades. Recently, there have been surprising advances in directly targeted drugs for KRAS, especially in KRAS (G12C) inhibitors, such as AMG510 (sotorasib) and MRTX849 (adagrasib), which have obtained encouraging results in clinical trials. Excitingly, AMG510 was the first drug-targeting KRAS (G12C) to be approved for clinical use this year. This review summarises the most recent understanding of fundamental aspects of KRAS, the relationship between the KRAS mutations and tumour immune evasion, and new progress in targeting KRAS, particularly KRAS (G12C). Moreover, the possible mechanisms of resistance to KRAS (G12C) inhibitors and possible combination therapies are summarised, with a view to providing the best regimen for individualised treatment with KRAS (G12C) inhibitors and achieving truly precise treatment.
    Keywords Medicine ; R ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: M2‐like macrophage‐derived exosomes facilitate metastasis in non‐small‐cell lung cancer by delivering integrin αVβ3

    Lamei Huang / Fang Wang / Xueping Wang / Chaoyue Su / Shaocong Wu / Chuan Yang / Min Luo / Jianye Zhang / Liwu Fu

    MedComm, Vol 4, Iss 1, Pp n/a-n/a (2023)

    2023  

    Abstract: Abstract Metastasis is the most prevalent cause of cancer deaths, and immunological components of the tumor microenvironment, especially tumor‐associated macrophages (TAMs), play a vital role in cancer metastasis. However, the underlying mechanisms of ... ...

    Abstract Abstract Metastasis is the most prevalent cause of cancer deaths, and immunological components of the tumor microenvironment, especially tumor‐associated macrophages (TAMs), play a vital role in cancer metastasis. However, the underlying mechanisms of TAMs on non‐small‐cell lung cancer (NSCLC) metastasis remain largely unexplored. Herein, we demonstrated that M2‐like TAMs facilitate the migration and invasion of cancer cells in vitro and in vivo through intercellular delivery of M2‐like macrophage‐derived exosomes (M2‐exos). Importantly, we found that M2‐exos had considerably higher levels of integrin (ITG) αV and β3. The impact of M2‐like macrophage‐mediated invasion and migration of NSCLC cells was clearly decreased when ITG αVβ3 was blocked. Mechanistically, exosomal ITG αVβ3 produced from M2‐like macrophages successfully triggered the focal adhesion kinase signaling pathway in recipient cells, boosting the migratory and invasive abilities of NSCLC cells. Clinically, we found that metastatic NSCLC patients had greater ITG αV and β3 expression, which was associated with a worse prognosis. This study reveals a novel mechanism by which M2‐exos significantly increased NSCLC cell migration and invasion by delivering integrin αVβ3. Exosomal ITG αVβ3 can be used as a potential prognostic marker, and blocking ITG αVβ3 could be a viable treatment option for preventing tumor metastasis.
    Keywords exosomes ; integrin αVβ3 ; M2‐like macrophage ; metastasis ; NSCLC ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Faulting controls on oil and gas composition in the Yingmai 2 Oilfield, Tarim Basin, NW China

    Wang, Yangyang / Guangping Luo / Guoqiang Zhang / Jianfa Chen / Lamei Huang / Xiongqi Pang / Yongfu Liu / Zeya Chen

    Organic geochemistry. 2018 Sept., v. 123

    2018  

    Abstract: The accumulation mechanism of hydrocarbons in the Yingmai 2 Oilfield of the Tabei Uplift in the Tarim Basin is not well understood. Here, the characteristics and formation of Paleozoic faults in the Yingmai 2 Oilfield are studied with new 3D seismic data ...

    Abstract The accumulation mechanism of hydrocarbons in the Yingmai 2 Oilfield of the Tabei Uplift in the Tarim Basin is not well understood. Here, the characteristics and formation of Paleozoic faults in the Yingmai 2 Oilfield are studied with new 3D seismic data and regional geologic data. Inclusion features and geochemical parameters are used to investigate the faults controlling the oil and gas compositions. The results indicate that three fault systems developed in the Yingmai 2 Oilfield: a NNW-trending strike-slip fault system that formed in the middle Caledonian, a NW-trending strike-slip fault system that formed in the Caledonian–late Hercynian and a NE-trending thrust fault system that formed in the late Hercynian–Indosinian, which was associated with volcanic activity. The two strike-slip fault systems were important early hydrocarbon migration pathways in the late Caledonian–early Hercynian, late Hercynian, and Himalayan accumulation periods. The NE-trending thrust faults were sealed by volcanics, and divided the originally uniform oilfield into two accumulation systems during the Himalayan. This finding is supported by the differences in the compositions of the oils and gases in the eastern (YM area) and the western (YG area) Yingmai 2 Oilfield. The oil density, iC4/nC4, Ph/nC18, and V/Ni ratios of the oils in the reservoirs in the YM area are lower than those in the YG area, whereas the TMNr, TeMNr, 4-1/DBT, Pr/Ph, C29-diasterane/C29-regular sterane ratios, H2S content, and the content of Himalayan hydrocarbon inclusions are higher. The hydrocarbon accumulation in the Yingmai 2 Oilfield is attributed to multiple episodes of hydrocarbon charging and suggests that the YM area has greater exploration potential than the YG area.
    Keywords basins ; gases ; geophysics ; hydrocarbons ; hydrogen sulfide ; nickel ; oil fields ; oils ; Paleozoic era ; vanadium ; volcanic activity ; China
    Language English
    Dates of publication 2018-09
    Size p. 48-66.
    Publishing place Elsevier Ltd
    Document type Article
    ISSN 0146-6380
    DOI 10.1016/j.orggeochem.2018.04.007
    Database NAL-Catalogue (AGRICOLA)

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