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Article ; Online: Updating the ethical guidance for gene and cell therapy research participation.

Cargill, Stephanie Solomon / Eidsvik, Andrea / Lamm, Marilyn

Molecular therapy : the journal of the American Society of Gene Therapy

2021 Volume 29, Issue 8, Page(s) 2394–2395

MeSH term(s)	Cell- and Tissue-Based Therapy/ethics ; Clinical Trials as Topic/ethics ; Genetic Therapy/ethics ; Humans ; Patient Selection/ethics ; Practice Guidelines as Topic
Language	English
Publishing date	2021-07-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2010592-7
ISSN	1525-0024 ; 1525-0016
ISSN (online)	1525-0024
ISSN	1525-0016
DOI	10.1016/j.ymthe.2021.07.009
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Article ; Online: Low-Temperature Molten Salt Electrochemical CO

Thapaliya, Bishnu P / Ivanov, Alexander S / Chao, Hsin-Yun / Lamm, Meghan / Meyer, Harry M / Chi, Miaofang / Sun, Xiao-Guang / Aytug, Tolga / Dai, Sheng / Mahurin, Shannon M

ACS applied materials & interfaces

2024 Volume 16, Issue 2, Page(s) 2251–2262

Abstract: One strategy for addressing the climate crisis caused by ... ...

Abstract	One strategy for addressing the climate crisis caused by CO
Language	English
Publishing date	2024-01-05
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c14858
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Article ; Online: Impact of Helicobacter pylori Infection and Treatment on Colorectal Cancer in a Large, Nationwide Cohort.

Shah, Shailja C / Camargo, M Constanza / Lamm, Mark / Bustamante, Ranier / Roumie, Christianne L / Wilson, Otis / Halvorson, Alese E / Greevy, Robert / Liu, Lin / Gupta, Samir / Demb, Joshua

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2024 , Page(s) JCO2300703

Abstract: Purpose: Helicobacter pylori: Patients: US Veterans who completed H. pylori testing between 1999 and 2018.: Methods: We conducted a retrospective cohort analysis among adults within the Veterans Health Administration who completed testing for H. ... ...

Abstract	Purpose: Helicobacter pylori Patients: US Veterans who completed H. pylori testing between 1999 and 2018. Methods: We conducted a retrospective cohort analysis among adults within the Veterans Health Administration who completed testing for H. pylori. The primary exposures were (1) H. pylori test result (positive/negative) and (2) H. pylori treatment (untreated/treated) among H. pylori-positive individuals. The primary outcomes were CRC incidence and mortality. Follow-up started at the first H. pylori testing and continued until the earliest of incident or fatal CRC, non-CRC death, or December 31, 2019. Results: Among 812,736 individuals tested for H. pylori, 205,178 (25.2%) tested positive. Being H. pylori-positive versus H. pylori-negative was associated with higher CRC incidence and mortality. H. pylori treatment versus no treatment was associated with lower CRC incidence and mortality (absolute risk reduction 0.23%-0.35%) through 15-year follow-up. Being H. pylori-positive versus H. pylori-negative was associated with an 18% (adjusted hazard ratio [adjusted HR], 1.18 [95% CI, 1.12 to 1.24]) and 12% (adjusted HR, 1.12 [95% CI, 1.03 to 1.21]) higher incident and fatal CRC risk, respectively. Individuals with untreated versus treated H. pylori infection had 23% (adjusted HR, 1.23 [95% CI, 1.13 to 1.34]) and 40% (adjusted HR, 1.40 [95% CI, 1.24 to 1.58]) higher incident and fatal CRC risk, respectively. The results were more pronounced in the analysis restricted to individuals with nonserologic testing. Conclusion: H. pylori positivity may be associated with small but statistically significant higher CRC incidence and mortality; untreated individuals, especially those with confirmed active infection, appear to be most at risk.
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.23.00703
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Book ; Online: Retrieval-guided Counterfactual Generation for QA

Paranjape, Bhargavi / Lamm, Matthew / Tenney, Ian

2021

Abstract: Deep NLP models have been shown to learn spurious correlations, leaving them brittle to input perturbations. Recent work has shown that counterfactual or contrastive data -- i.e. minimally perturbed inputs -- can reveal these weaknesses, and that data ... ...

Abstract	Deep NLP models have been shown to learn spurious correlations, leaving them brittle to input perturbations. Recent work has shown that counterfactual or contrastive data -- i.e. minimally perturbed inputs -- can reveal these weaknesses, and that data augmentation using counterfactuals can help ameliorate them. Proposed techniques for generating counterfactuals rely on human annotations, perturbations based on simple heuristics, and meaning representation frameworks. We focus on the task of creating counterfactuals for question answering, which presents unique challenges related to world knowledge, semantic diversity, and answerability. To address these challenges, we develop a Retrieve-Generate-Filter(RGF) technique to create counterfactual evaluation and training data with minimal human supervision. Using an open-domain QA framework and question generation model trained on original task data, we create counterfactuals that are fluent, semantically diverse, and automatically labeled. Data augmentation with RGF counterfactuals improves performance on out-of-domain and challenging evaluation sets over and above existing methods, in both the reading comprehension and open-domain QA settings. Moreover, we find that RGF data leads to significant improvements in a model's robustness to local perturbations. Comment: ACL 2022 Camera-ready version
Keywords	Computer Science - Computation and Language ; Computer Science - Artificial Intelligence
Subject code	006
Publishing date	2021-10-14
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Equivalent hip stem fixation by Hi-Fatigue G and Palacos R + G bone cement: a randomized radiostereometric controlled trial of 52 patients with 2 years' follow-up.

Jørgensen, Peter B / Lamm, Martin / Søballe, Kjeld / Stilling, Maiken

Acta orthopaedica

2019 Volume 90, Issue 3, Page(s) 237–242

Abstract: Background and purpose - Long-term fixation of cemented femoral stems relies on several factors including cement adhesion and fatigue. Hi-Fatigue is a newer third-generation bone cement with low-viscosity properties at room temperature, good mechanical ... ...

Abstract	Background and purpose - Long-term fixation of cemented femoral stems relies on several factors including cement adhesion and fatigue. Hi-Fatigue is a newer third-generation bone cement with low-viscosity properties at room temperature, good mechanical strength, and stable bone-cement interface in a laboratory testing environment. Palacos bone cement has excellent 10-year survival and is considered gold standard. We compared stem subsidence after fixation with Hi-Fatigue and Palacos bone cements using radiostereometry. Patients and methods - In a patient-blinded randomized controlled trial, 52 patients (30 women) at mean age 76 years (71-87) with osteoarthrosis and no osteoporosis received Hi-Fatigue G or Palacos R + G cement fixation of collarless, polished, double-tapered stems (CPT). Tantalum beads were inserted in the periprosthetic bone. Supine stereoradiographs were obtained postoperatively, 3 months, 6 months, 1 year, and 2 years after surgery. Oxford Hip Score (OHS) and VAS pain were recorded preoperatively and 1 and 2 years after surgery. Cement working times and properties were registered. Results - At 2 years, mean stem subsidence of 1.12 mm (95% CI 0.96-1.29) for Hi-Fatigue and 1.19 mm (CI 1.03-1.34) for Palacos was similar. Likewise, stem version was comparable between cement groups. Mean OHS and VAS pain were similar between cement groups. Cement working times were similar between cement groups, but the mean curing time was longer for Hi-Fatigue (13.7 min) than for Palacos (11.6 min). Interpretation - We found similar and generally low migration of CPT femoral stems inserted with Hi-Fatigue and Palacos bone cement until 2 years' follow-up, which indicates a good long-term survival of polished taper femoral stems inserted with both cement types.
MeSH term(s)	Aged ; Aged, 80 and over ; Arthroplasty, Replacement, Hip/methods ; Bone Cements/therapeutic use ; Female ; Hip Joint/diagnostic imaging ; Hip Joint/surgery ; Humans ; Male ; Osteoarthritis, Hip/surgery ; Polymethyl Methacrylate/therapeutic use ; Radiostereometric Analysis
Chemical Substances	Bone Cements ; Palacos R+G ; Polymethyl Methacrylate (9011-14-7)
Language	English
Publishing date	2019-04-01
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2180677-9
ISSN	1745-3682 ; 1745-3674
ISSN (online)	1745-3682
ISSN	1745-3674
DOI	10.1080/17453674.2019.1595390
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Article: Periprosthetic hip infection treated with two-stage stage-one Select Spacer- complication rate and restoration of anatomy.

Kipp, Josephine Olsen / Lamm, Martin / Søballe, Kjeld / Jakobsen, Stig Storgaard

Journal of orthopaedics

2019 Volume 18, Page(s) 138–142

Abstract: Two-stage revision with 'StageOne™ Select Hip Cement Spacer' is used as treatment of periprosthetic hip joint infection. The aim is to evaluate complications and restoration the joint with the StageOne Select Spacer. From 2013 to 2018 twenty-nine ... ...

Abstract	Two-stage revision with 'StageOne™ Select Hip Cement Spacer' is used as treatment of periprosthetic hip joint infection. The aim is to evaluate complications and restoration the joint with the StageOne Select Spacer. From 2013 to 2018 twenty-nine StageOne Select Spacers was inserted. Data was obtained through medical records and radiographs. 3.5% dislocated the spacer, 6.9% sustained a femoral fracture, 6.9% got reinfected and 6.9% failed to control the infection. Leg length discrepancy was 1.5 mm (-4,25-5.25) and offset discrepancy was 4 mm (-0.5-9). The spacer shows promising results with a low reinfection and dislocation rate and allowance of restoration of the joint.
Language	English
Publishing date	2019-09-11
Publishing country	India
Document type	Journal Article
ZDB-ID	2240839-3
ISSN	0972-978X
ISSN	0972-978X
DOI	10.1016/j.jor.2019.09.016
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Book ; Online: GNSS signal-based snow water equivalent determination for different snowpack conditions along a steep elevation gradient

Capelli, Achille / Koch, Franziska / Henkel, Patrick / Lamm, Markus / Appel, Florian / Marty, Christoph / Schweizer, Jürg

eISSN: 1994-0424

2022

Abstract: Snow water equivalent (SWE) can be measured using low-cost Global Navigation Satellite System (GNSS) sensors with one antenna placed below the snowpack and another one serving as a reference above the snow. The underlying GNSS signal-based algorithm for ... ...

Abstract	Snow water equivalent (SWE) can be measured using low-cost Global Navigation Satellite System (GNSS) sensors with one antenna placed below the snowpack and another one serving as a reference above the snow. The underlying GNSS signal-based algorithm for SWE determination for dry- and wet-snow conditions processes the carrier phases and signal strengths and additionally derives liquid water content (LWC) and snow depth (HS). So far, the algorithm was tested intensively for high-alpine conditions with distinct seasonal accumulation and ablation phases. In general, snow occurrence, snow amount, snow density and LWC can vary considerably with climatic conditions and elevation. Regarding alpine regions, lower elevations mean generally earlier and faster melting, more rain-on-snow events, and shallower snowpack. Therefore, we assessed the applicability of the GNSS-based SWE measurement at four stations along a steep elevation gradient (820, 1185, 1510 and 2540 m a.s.l.) in the eastern Swiss Alps during two winter seasons (2018–2020). Reference data of SWE, LWC and HS were collected manually and with additional automated sensors at all locations. The GNSS-derived SWE estimates agreed very well with manual reference measurements along the elevation gradient, and the accuracy (RMSE = 34 mm, RMSRE = 11 %) was similar under wet- and dry-snow conditions, although significant differences in snow density and meteorological conditions existed between the locations. The GNSS-derived SWE was more accurate than measured with other automated SWE sensors. However, with the current version of the GNSS algorithm, the determination of daily changes of SWE was found to be less suitable compared to manual measurements or pluviometer recordings and needs further refinement. The values of the GNSS-derived LWC were robust and within the precision of the manual and radar measurements. The additionally derived HS correlated well with the validation data. We conclude that SWE can reliably be determined using low-cost GNSS sensors under a broad range of climatic conditions, and LWC and HS are valuable add-ons.
Subject code	551
Language	English
Publishing date	2022-02-11
Publishing country	de
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Up-regulation of GLI1 in vincristine-resistant rhabdomyosarcoma and Ewing sarcoma.

Yoon, Joon Won / Lamm, Marilyn / Chandler, Christopher / Iannaccone, Philip / Walterhouse, David

BMC cancer

2020 Volume 20, Issue 1, Page(s) 511

Abstract: Background: The clinical significance of GLI1 expression either through canonical Hedgehog signal transduction or through non-canonical mechanisms in rhabdomyosarcoma (RMS) or Ewing sarcoma (EWS) is incompletely understood. We tested a role for Hedgehog ...

Abstract	Background: The clinical significance of GLI1 expression either through canonical Hedgehog signal transduction or through non-canonical mechanisms in rhabdomyosarcoma (RMS) or Ewing sarcoma (EWS) is incompletely understood. We tested a role for Hedgehog (HH) signal transduction and GL11 expression in development of vincristine (VCR) resistance in RMS and EWS. Methods: We characterized baseline expression and activity of HH pathway components in 5 RMS (RD, Rh18, Ruch-2, Rh30, and Rh41) and 5 EWS (CHLA9, CHLA10, TC32, CHLA258, and TC71) cell lines. We then established VCR-resistant RMS and EWS cell lines by exposing cells to serially increasing concentrations of VCR and determining the IC Results: We found evidence for HH pathway activity and GLI1 expression in RMS and EWS cell lines at baseline, and evidence that GLI1 contributes to survival and proliferation of these sarcoma cells. We were able to establish 4 VCR-resistant cell lines (Ruch-2VR, Rh30VR, Rh41VR, and TC71VR). GLI1 was significantly up-regulated in the Rh30VR, Rh41VR, and TC71VR cells. The only other gene in the drug resistance panel that was significantly up-regulated in each of these VCR-resistant cell lines compared with their corresponding parental cells was the GLI1 direct target and multidrug resistance gene, ATP-binding cassette sub-family B member 1 (MDR1). We established major vault protein (MVP), which was up-regulated in both vincristine-resistant alveolar RMS cell lines (Rh30VR and Rh41VR), as another direct target of GLI1 during development of drug resistance. Treatment of the VCR-resistant cell lines with the small molecule inhibitor GANT61 or GLI1 siRNA together with VCR significantly decreased cell viability at doses that did not reduce viability individually. Conclusions: These experiments demonstrate that GLI1 up-regulation contributes to VCR resistance in RMS and EWS cell lines and suggest that targeting GLI1 may benefit patients with RMS or EWS by reducing multidrug resistance.
MeSH term(s)	ATP Binding Cassette Transporter, Subfamily B/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/genetics ; Drug Resistance, Multiple/drug effects ; Drug Resistance, Multiple/genetics ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Gene Expression Regulation, Neoplastic ; Hedgehog Proteins/metabolism ; Humans ; Inhibitory Concentration 50 ; Pyridines/pharmacology ; Pyrimidines/pharmacology ; RNA, Small Interfering/metabolism ; Rhabdomyosarcoma/drug therapy ; Rhabdomyosarcoma/genetics ; Rhabdomyosarcoma/pathology ; Sarcoma, Ewing/drug therapy ; Sarcoma, Ewing/genetics ; Sarcoma, Ewing/pathology ; Signal Transduction/drug effects ; Signal Transduction/genetics ; Up-Regulation ; Vincristine/pharmacology ; Vincristine/therapeutic use ; Zinc Finger Protein GLI1/antagonists & inhibitors ; Zinc Finger Protein GLI1/genetics ; Zinc Finger Protein GLI1/metabolism
Chemical Substances	ABCB1 protein, human ; ATP Binding Cassette Transporter, Subfamily B ; GANT 61 ; GLI1 protein, human ; Hedgehog Proteins ; Pyridines ; Pyrimidines ; RNA, Small Interfering ; Zinc Finger Protein GLI1 ; Vincristine (5J49Q6B70F)
Language	English
Publishing date	2020-06-03
Publishing country	England
Document type	Journal Article
ISSN	1471-2407
ISSN (online)	1471-2407
DOI	10.1186/s12885-020-06985-0
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Article ; Online: [Treatment of external snapping hip with targeted resistance training intervention].

Kjeldsen, Troels / Dalgas, Ulrik / Lamm, Martin / Reimer, Lisa Cecilie Urup / Mechlenburg, Inger

Ugeskrift for laeger

2020 Volume 181, Issue 18

Abstract: This case report describes an 18-year-old woman, who had symptomatic bilateral external and internal snapping hip and completed 28 of 30 training sessions during a 12-week resistance training intervention. The intervention proved to be feasible and ... ...

Abstract	This case report describes an 18-year-old woman, who had symptomatic bilateral external and internal snapping hip and completed 28 of 30 training sessions during a 12-week resistance training intervention. The intervention proved to be feasible and improved maximal strength in hip abduction and extension measured with Isokinetic Dynamometry. Improvements were also seen in The Copenhagen Hip and Groin Outcome Score, and The Forgotten Joint Score. Furthermore, visual analog scale pain markedly decreased after the intervention.
MeSH term(s)	Adolescent ; Exercise Therapy ; Female ; Groin ; Hip Joint/diagnostic imaging ; Humans ; Joint Diseases ; Muscle Strength ; Pain Measurement ; Resistance Training
Language	Danish
Publishing date	2020-08-04
Publishing country	Denmark
Document type	Case Reports ; Journal Article
ZDB-ID	124102-3
ISSN	1603-6824 ; 0041-5782
ISSN (online)	1603-6824
ISSN	0041-5782
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Book ; Online: Consolation

Lamm, Maurice

The Spiritual Journey Beyond Grief

2010

Abstract: In this, his sequel to the best-selling The Jewish Way in Death and Mourning (over 350,000 copies sold), Rabbi Lamm helps mourners not just get through their grief, but also grow through it. He gently steers mourners on the path that allows their sorrow ... ...

Abstract	In this, his sequel to the best-selling The Jewish Way in Death and Mourning (over 350,000 copies sold), Rabbi Lamm helps mourners not just get through their grief, but also grow through it. He gently steers mourners on the path that allows their sorrow to teach them important lessons about life. And he shows consolers how to listen and speak with their hearts so that they can provide real comfort to others. His marvelous insights on the days of shiva, the year of kaddish, and the lovingkindness of others reveal the richness and true purpose of Jewish mourning rituals and customs. They prepare
Language	English
Size	Online-Ressource (359 p)
Publisher	JPS
Publishing place	Philadelphia
Document type	Book ; Online
Note	Description based upon print version of record
ISBN	9780827607644 ; 0827607644
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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