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  1. Book: Essen und Trinken bei Lebensmittelallergien

    Lämmel, Sonja

    (DGE-Infothek)

    2012  

    Author's details [Autorin: Sonja Lämmel. Hrsg.: Deutsche Gesellschaft für Ernährung e.V.]
    Series title DGE-Infothek
    Language German
    Size 30 S. : Ill., 21 cm
    Edition 4., vollst. überarb. Aufl.
    Publisher DGE-MedienService
    Publishing place Bonn
    Publishing country Germany
    Document type Book
    HBZ-ID HT018635990
    ISBN 978-3-88749-204-5 ; 3-88749-204-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 9073 order for loan Magazin

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  2. Article ; Online: Head-mounted central venous access during optical recordings and manipulations of neural activity in mice.

    Liu, Christine / Freeman, Daniel J / Lammel, Stephan

    Nature protocols

    2023  Volume 19, Issue 3, Page(s) 960–983

    Abstract: Establishing reliable intravenous catheterization in mice with optical implants allows the combination of neural manipulations and recordings with rapid, time-locked delivery of pharmacological agents. Here we present a procedure for handmade jugular ... ...

    Abstract Establishing reliable intravenous catheterization in mice with optical implants allows the combination of neural manipulations and recordings with rapid, time-locked delivery of pharmacological agents. Here we present a procedure for handmade jugular vein catheters designed for head-mounted intravenous access and provide surgical and postoperative guidance for improved survival and patency. A head-mounted vascular access point eliminates the need for a back-mounted button in animals already receiving neural implants, thereby reducing sites of implantation. This protocol, which is readily adoptable by experimenters with previous training and experience in mouse surgery, enables repeated fiber photometry recordings or optogenetic manipulation during drug delivery in adult mice that are awake and behaving, whether head fixed or freely moving. With practice, an experienced surgeon requires ~30 min to perform catheterization on each mouse. Altogether, these techniques facilitate the reliable and repeated delivery of pharmacological agents in mouse models while simultaneously recording at high temporal resolution and/or manipulating neural populations.
    MeSH term(s) Mice ; Animals ; Prostheses and Implants ; Optogenetics
    Language English
    Publishing date 2023-12-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2244966-8
    ISSN 1750-2799 ; 1754-2189
    ISSN (online) 1750-2799
    ISSN 1754-2189
    DOI 10.1038/s41596-023-00928-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: State and rate-of-change encoding in parallel mesoaccumbal dopamine pathways.

    de Jong, Johannes W / Liang, Yilan / Verharen, Jeroen P H / Fraser, Kurt M / Lammel, Stephan

    Nature neuroscience

    2024  Volume 27, Issue 2, Page(s) 309–318

    Abstract: The nervous system uses fast- and slow-adapting sensory detectors in parallel to enable neuronal representations of external states and their temporal dynamics. It is unknown whether this dichotomy also applies to internal representations that have no ... ...

    Abstract The nervous system uses fast- and slow-adapting sensory detectors in parallel to enable neuronal representations of external states and their temporal dynamics. It is unknown whether this dichotomy also applies to internal representations that have no direct correlation in the physical world. Here we find that two distinct dopamine (DA) neuron subtypes encode either a state or its rate-of-change. In mice performing a reward-seeking task, we found that the animal's behavioral state and rate-of-change were encoded by the sustained activity of DA neurons in medial ventral tegmental area (VTA) DA neurons and transient activity in lateral VTA DA neurons, respectively. The neural activity patterns of VTA DA cell bodies matched DA release patterns within anatomically defined mesoaccumbal pathways. Based on these results, we propose a model in which the DA system uses two parallel lines for proportional-differential encoding of a state variable and its temporal dynamics.
    MeSH term(s) Mice ; Animals ; Dopamine/metabolism ; Dopaminergic Neurons/physiology ; Reward ; Ventral Tegmental Area/physiology
    Chemical Substances Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1420596-8
    ISSN 1546-1726 ; 1097-6256
    ISSN (online) 1546-1726
    ISSN 1097-6256
    DOI 10.1038/s41593-023-01547-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4891: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 67: Show issues

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  4. Article ; Online: Mesoaccumbal Dopamine Heterogeneity: What Do Dopamine Firing and Release Have to Do with It?

    de Jong, Johannes W / Fraser, Kurt M / Lammel, Stephan

    Annual review of neuroscience

    2022  Volume 45, Page(s) 109–129

    Abstract: Ventral tegmental area (VTA) dopamine (DA) neurons are often thought to uniformly encode reward prediction errors. Conversely, DA release in the nucleus accumbens (NAc), the prominent projection target of these neurons, has been implicated in ... ...

    Abstract Ventral tegmental area (VTA) dopamine (DA) neurons are often thought to uniformly encode reward prediction errors. Conversely, DA release in the nucleus accumbens (NAc), the prominent projection target of these neurons, has been implicated in reinforcement learning, motivation, aversion, and incentive salience. This contrast between heterogeneous functions of DA release versus a homogeneous role for DA neuron activity raises numerous questions regarding how VTA DA activity translates into NAc DA release. Further complicating this issue is increasing evidence that distinct VTA DA projections into defined NAc subregions mediate diverse behavioral functions. Here, we evaluate evidence for heterogeneity within the mesoaccumbal DA system and argue that frameworks of DA function must incorporate the precise topographic organization of VTA DA neurons to clarify their contribution to health and disease.
    MeSH term(s) Dopamine ; Dopaminergic Neurons ; Motivation ; Nucleus Accumbens/physiology ; Reward ; Ventral Tegmental Area/physiology
    Chemical Substances Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2022-02-28
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 282459-0
    ISSN 1545-4126 ; 0147-006X
    ISSN (online) 1545-4126
    ISSN 0147-006X
    DOI 10.1146/annurev-neuro-110920-011929
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1433: Show issues Location:
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  5. Article ; Online: A computational analysis of mouse behavior in the sucrose preference test.

    Verharen, Jeroen P H / de Jong, Johannes W / Zhu, Yichen / Lammel, Stephan

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 2419

    Abstract: The sucrose preference test (SPT) measures the relative preference of sucrose over water to assess hedonic behaviors in rodents. Yet, it remains uncertain to what extent the SPT reflects other behavioral components, such as learning, memory, motivation, ... ...

    Abstract The sucrose preference test (SPT) measures the relative preference of sucrose over water to assess hedonic behaviors in rodents. Yet, it remains uncertain to what extent the SPT reflects other behavioral components, such as learning, memory, motivation, and choice. Here, we conducted an experimental and computational decomposition of mouse behavior in the SPT and discovered previously unrecognized behavioral subcomponents associated with changes in sucrose preference. We show that acute and chronic stress have sex-dependent effects on sucrose preference, but anhedonia was observed only in response to chronic stress in male mice. Additionally, reduced sucrose preference induced by optogenetics is not always indicative of anhedonia but can also reflect learning deficits. Even small variations in experimental conditions influence behavior, task outcome and interpretation. Thus, an ostensibly simple behavioral task can entail high levels of complexity, demonstrating the need for careful dissection of behavior into its subcomponents when studying the underlying neurobiology.
    MeSH term(s) Mice ; Male ; Animals ; Sucrose/pharmacology ; Anhedonia ; Motivation ; Food Preferences ; Uncertainty ; Behavior, Animal
    Chemical Substances Sucrose (57-50-1)
    Language English
    Publishing date 2023-04-27
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-38028-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book: Heizkostenverordnung

    Lammel, Siegbert

    Verordnung über die verbrauchsabhängige Abrechnung der Heiz- und Warmwasserkosten ; (Verordnung über Heizkostenabrechnung - HeizkostenV) ; Kommentar

    2015  

    Title variant HeizkV
    Author's details von Siegbert Lammel
    Language German
    Size XII, 392 S
    Edition 4., neu bearb. Aufl.
    Publisher Beck
    Publishing place München
    Document type Book
    ISBN 3406636454 ; 9783406636455
    Database Former special subject collection: coastal and deep sea fishing

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  7. Book: Heizkostenverordnung

    Lammel, Siegbert

    Verordnung über die verbrauchsabhängige Abrechnung der Heiz- und Warmwasserkosten ; (Verordnung über Heizkostenabrechnung - HeizkostenV) ; Kommentar

    2015  

    Title variant HeizkV
    Author's details von Siegbert Lammel
    Keywords Energieversorgungsrecht ; Mietnebenkosten
    Language German
    Size XII, 392 S
    Edition 4., neu bearb. Aufl.
    Publisher Beck
    Publishing place München
    Document type Book
    ISBN 3406636454 ; 9783406636455
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  8. Book ; Online: Heizkostenverordnung

    Lammel, Siegbert

    Verordnung über die verbrauchsabhängige Abrechnung der Heiz- und Warmwasserkosten (Verordnung über Heizkostenabrechnung - Heizkosten V) ; Kommentar

    2015  

    Author's details von Siegbert Lammel
    Language German
    Size Online-Ressource (XII, 392 S.)
    Edition 4., neu bearb. Aufl
    Publisher Beck-Online ; Beck
    Publishing place München
    Document type Book ; Online
    Database Former special subject collection: coastal and deep sea fishing

    Full text online

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  9. Article ; Online: Aversion hot spots in the dopamine system.

    Verharen, J P H / Zhu, Yichen / Lammel, Stephan

    Current opinion in neurobiology

    2020  Volume 64, Page(s) 46–52

    Abstract: Through the development of optogenetics and other viral vector-based technologies, our view of the dopamine system has substantially advanced over the last decade. In particular, progress has been made in the reclassification of dopamine neurons based on ...

    Abstract Through the development of optogenetics and other viral vector-based technologies, our view of the dopamine system has substantially advanced over the last decade. In particular, progress has been made in the reclassification of dopamine neurons based on subtypes displaying specific projections, which are associated with different features at the anatomical, molecular and behavioral level. Together, these discoveries have raised the possibility that individual groups of dopamine cells make a unique contribution to the processing of reward and aversion. Here, we review recent studies that have identified non-canonical dopamine pathways that are excited in response to aversive stimuli, including dopamine projections to the ventromedial shell of the nucleus accumbens, prefrontal cortex, tail of the striatum, and amygdala.
    MeSH term(s) Corpus Striatum ; Dopamine ; Dopaminergic Neurons ; Nucleus Accumbens ; Reward
    Chemical Substances Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2020-03-05
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1078046-4
    ISSN 1873-6882 ; 0959-4388
    ISSN (online) 1873-6882
    ISSN 0959-4388
    DOI 10.1016/j.conb.2020.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3260: Show issues Location:
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  10. Article ; Online: Hot topic in optogenetics: new implications of in vivo tissue heating.

    Cardozo Pinto, Daniel F / Lammel, Stephan

    Nature neuroscience

    2019  Volume 22, Issue 7, Page(s) 1039–1041

    MeSH term(s) Heating ; Hot Temperature ; Optogenetics
    Language English
    Publishing date 2019-06-17
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1420596-8
    ISSN 1546-1726 ; 1097-6256
    ISSN (online) 1546-1726
    ISSN 1097-6256
    DOI 10.1038/s41593-019-0426-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4891: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
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