LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 5 of total 5

Search options

  1. Article ; Online: Characterization of Biomarkers of Thrombo-Inflammation in Patients with First-Diagnosed Atrial Fibrillation.

    Friebel, Julian / Wegner, Max / Blöbaum, Leon / Schencke, Philipp-Alexander / Jakobs, Kai / Puccini, Marianna / Ghanbari, Emily / Lammel, Stella / Thevathasan, Tharusan / Moos, Verena / Witkowski, Marco / Landmesser, Ulf / Rauch-Kröhnert, Ursula

    International journal of molecular sciences

    2024  Volume 25, Issue 7

    Abstract: Patients with first-diagnosed atrial fibrillation (FDAF) exhibit major adverse cardiovascular events (MACEs) during follow-up. Preclinical models have demonstrated that thrombo-inflammation mediates adverse cardiac remodeling and atherothrombotic events. ...

    Abstract Patients with first-diagnosed atrial fibrillation (FDAF) exhibit major adverse cardiovascular events (MACEs) during follow-up. Preclinical models have demonstrated that thrombo-inflammation mediates adverse cardiac remodeling and atherothrombotic events. We have hypothesized that thrombin activity (FIIa) links coagulation with inflammation and cardiac fibrosis/dysfunction. Surrogate markers of the thrombo-inflammatory response in plasma have not been characterized in FDAF. In this prospective longitudinal study, patients presenting with FDAF (
    MeSH term(s) Humans ; Atrial Fibrillation/diagnosis ; Longitudinal Studies ; Prospective Studies ; Receptor, PAR-1 ; Biomarkers ; Fibrosis
    Chemical Substances Receptor, PAR-1 ; Biomarkers
    Language English
    Publishing date 2024-04-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25074109
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Quantitative Gas Exchange in Extracorporeal Membrane Oxygenation-A New Device: Accuracy, Approach-based Difficulties, and Caloric Targeting.

    Müller, Michael C / Wilke, Sarah K / Dobbermann, Andrej / Carbon, Niklas M / Lammel, Stella / Russ, Martin / Weber-Carstens, Steffen / Wollersheim, Tobias

    ASAIO journal (American Society for Artificial Internal Organs : 1992)

    2022  Volume 69, Issue 1, Page(s) 61–68

    Abstract: Measurement of oxygen uptake (VO 2 ) and carbon dioxide removal (VCO 2 ) on membrane lungs (MLs) during extracorporeal membrane oxygenation (ECMO) provides potential for improved and safer therapy. Real-time monitoring of ML function and degradation, ... ...

    Abstract Measurement of oxygen uptake (VO 2 ) and carbon dioxide removal (VCO 2 ) on membrane lungs (MLs) during extracorporeal membrane oxygenation (ECMO) provides potential for improved and safer therapy. Real-time monitoring of ML function and degradation, calculating caloric needs as well as cardiac output, and weaning algorithms are among the future possibilities. Our study compared the continuous measurement of the standalone Quantum Diagnostics System (QDS) with the published Measuring Energy Expenditure in ECMO patients (MEEP) approach, which calculates sequential VO 2 and VCO 2 values via blood gas analysis and a physiologic gas content model. Thirty-nine datasets were acquired during routine venovenous ECMO intensive care treatment and analyzed. VO 2 was clinically relevant underestimated via the blood-sided measurement of the QDS compared to the MEEP approach (mean difference -42.61 ml/min, limits of agreement [LoA] -2.49/-87.74 ml), which could be explained by the missing dissolved oxygen fraction of the QDS equation. Analysis of VCO 2 showed scattered values with wide limits of agreement (mean difference 54.95 ml/min, LoA 231.26/-121.40 ml/min) partly explainable by a calculation error of the QDS. We described potential confounders of gas-sided measurements in general which need further investigation and recommendations for enhanced devices.
    MeSH term(s) Humans ; Extracorporeal Membrane Oxygenation ; Lung/metabolism ; Oxygen ; Carbon Dioxide ; Cardiac Output
    Chemical Substances Oxygen (S88TT14065) ; Carbon Dioxide (142M471B3J)
    Language English
    Publishing date 2022-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 759982-1
    ISSN 1538-943X ; 0162-1432 ; 1058-2916
    ISSN (online) 1538-943X
    ISSN 0162-1432 ; 1058-2916
    DOI 10.1097/MAT.0000000000001662
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uk I Zs.199: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.B 2435: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Intestinal Barrier Dysfunction and Microbial Translocation in Patients with First-Diagnosed Atrial Fibrillation.

    Blöbaum, Leon / Witkowski, Marco / Wegner, Max / Lammel, Stella / Schencke, Philipp-Alexander / Jakobs, Kai / Puccini, Marianna / Reißner, Daniela / Steffens, Daniel / Landmesser, Ulf / Rauch, Ursula / Friebel, Julian

    Biomedicines

    2023  Volume 11, Issue 1

    Abstract: Background: According to the leaky gut concept, microbial products (e.g., lipopolysaccharide, LPS) enter the circulation and mediate pro-inflammatory immunological responses. Higher plasma LPS levels have been reported in patients with various ... ...

    Abstract Background: According to the leaky gut concept, microbial products (e.g., lipopolysaccharide, LPS) enter the circulation and mediate pro-inflammatory immunological responses. Higher plasma LPS levels have been reported in patients with various cardiovascular diseases, but not specifically during early atrial fibrillation (AF).
    Methods: We studied data and blood samples from patients presenting with first-diagnosed AF (FDAF) (
    Results: Circulating biomarkers that are suggestive of mucosal inflammation (zonulin, mucosal adhesion molecule MAdCAM-1) and intestinal epithelium damage (intestinal fatty acid binding protein, IFABP) were increased in the plasma of patients with FDAF when compared to patients with chronic cardiovascular diseases but without AF. Surrogate plasma markers of increased intestinal permeability (LPS, CD14, LPS-binding protein, gut-derived LPS-neutralising IgA antibodies, EndoCAbs) were detected during early AF. A reduced ratio of IgG/IgM EndoCAbs titres indicated chronic endotoxaemia. Collagen turnover biomarkers, which corresponded to the LPS values, suggested an association of gut-derived low-grade endotoxaemia with adverse structural remodelling. The LPS concentrations were higher in FDAF patients who experienced a major adverse cardiovascular event.
    Conclusions: Intestinal barrier dysfunction and microbial translocation accompany FDAF. Improving gut permeability and low-grade endotoxaemia might be a potential therapeutic approach to reducing the disease progression and cardiovascular complications in FDAF.
    Language English
    Publishing date 2023-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11010176
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Cytotoxic CD8

    Friebel, Julian / Witkowski, Marco / Wegner, Max / Blöbaum, Leon / Lammel, Stella / Schencke, Philipp-Alexander / Jakobs, Kai / Puccini, Marianna / Reißner, Daniela / Steffens, Daniel / Moos, Verena / Schutheiss, Heinz-Peter / Landmesser, Ulf / Rauch, Ursula

    Cells

    2022  Volume 12, Issue 1

    Abstract: Background: Atrial myopathy and atrial fibrillation (AF) accompany thrombo-inflammation. This facilitates disease progression and promotes major adverse cardiovascular events (MACEs). Thrombin receptor (protease-activated receptor 1, PAR1) signalling is ...

    Abstract Background: Atrial myopathy and atrial fibrillation (AF) accompany thrombo-inflammation. This facilitates disease progression and promotes major adverse cardiovascular events (MACEs). Thrombin receptor (protease-activated receptor 1, PAR1) signalling is central in mediating thrombo-inflammation. We hypothesised that PAR1 signalling links coagulation and inflammation through cytotoxic CD8
    Methods: A total of 210 patients were studied. We included data and blood samples from patients presenting with FDAF (
    Results: During early AF, a pro-inflammatory and cytotoxic subset of T lymphocytes (CD8
    Conclusions: In patients with FDAF, the TF-factor Xa-factor IIa-axis contributes to thrombo-inflammation via PAR1 in CD8
    MeSH term(s) Humans ; Atrial Fibrillation ; Receptor, PAR-1 ; CD8-Positive T-Lymphocytes ; Inflammation/complications ; Disease Progression
    Chemical Substances Receptor, PAR-1
    Language English
    Publishing date 2022-12-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12010141
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Pleiotropic Effects of the Protease-Activated Receptor 1 (PAR1) Inhibitor, Vorapaxar, on Atherosclerosis and Vascular Inflammation.

    Friebel, Julian / Moritz, Eileen / Witkowski, Marco / Jakobs, Kai / Strässler, Elisabeth / Dörner, Andrea / Steffens, Daniel / Puccini, Marianna / Lammel, Stella / Glauben, Rainer / Nowak, Franziska / Kränkel, Nicolle / Haghikia, Arash / Moos, Verena / Schutheiss, Heinz-Peter / Felix, Stephan B / Landmesser, Ulf / Rauch, Bernhard H / Rauch, Ursula

    Cells

    2021  Volume 10, Issue 12

    Abstract: Background: Protease-activated receptor 1 (PAR1) and toll-like receptors (TLRs) are inflammatory mediators contributing to atherogenesis and atherothrombosis. Vorapaxar, which selectively antagonizes PAR1-signaling, is an approved, add-on antiplatelet ... ...

    Abstract Background: Protease-activated receptor 1 (PAR1) and toll-like receptors (TLRs) are inflammatory mediators contributing to atherogenesis and atherothrombosis. Vorapaxar, which selectively antagonizes PAR1-signaling, is an approved, add-on antiplatelet therapy for secondary prevention. The non-hemostatic, platelet-independent, pleiotropic effects of vorapaxar have not yet been studied.
    Methods and results: Cellular targets of PAR1 signaling in the vasculature were identified in three patient cohorts with atherosclerotic disease. Evaluation of plasma biomarkers (
    Conclusions: PAR1 inhibition with vorapaxar may be effective in reducing residual thrombo-inflammatory event risk in patients with atherosclerosis independent of its effect on platelets.
    MeSH term(s) Animals ; Apolipoproteins E/genetics ; Atherosclerosis/drug therapy ; Atherosclerosis/genetics ; Atherosclerosis/pathology ; Female ; Humans ; Inflammation/drug therapy ; Inflammation/genetics ; Inflammation/pathology ; Intercellular Adhesion Molecule-1/genetics ; Lactones/administration & dosage ; Lactones/adverse effects ; Male ; Mice ; Mice, Knockout ; Myocardium/metabolism ; Myocardium/pathology ; Platelet Aggregation/drug effects ; Pyridines/administration & dosage ; Pyridines/adverse effects ; Receptor, PAR-1/antagonists & inhibitors ; Receptor, PAR-1/genetics ; Thrombin/genetics ; Toll-Like Receptor 2/genetics ; Toll-Like Receptor 4/genetics ; Vascular Cell Adhesion Molecule-1/genetics ; Vascular Diseases/drug therapy ; Vascular Diseases/genetics ; Vascular Diseases/pathology
    Chemical Substances Apolipoproteins E ; ICAM1 protein, human ; Lactones ; Pyridines ; Receptor, PAR-1 ; TLR2 protein, human ; TLR4 protein, human ; Toll-Like Receptor 2 ; Toll-Like Receptor 4 ; Vascular Cell Adhesion Molecule-1 ; Intercellular Adhesion Molecule-1 (126547-89-5) ; Thrombin (EC 3.4.21.5) ; vorapaxar (ZCE93644N2)
    Language English
    Publishing date 2021-12-13
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10123517
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top