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Article ; Online: Chronic intermittent hypoxia in obstructive sleep apnea: a narrative review from pathophysiological pathways to a precision clinical approach.

Labarca, Gonzalo / Gower, Jorge / Lamperti, Liliana / Dreyse, Jorge / Jorquera, Jorge

2019 Volume 24, Issue 2, Page(s) 751–760

Abstract: Obstructive sleep apnea syndrome (OSAS) is a prevalent condition caused by dynamic upper airway collapse during sleep. The pathological impact and consequences are due to chronic intermittent hypoxia (CIH). Hypoxia increases the expression of several ... ...

Abstract	Obstructive sleep apnea syndrome (OSAS) is a prevalent condition caused by dynamic upper airway collapse during sleep. The pathological impact and consequences are due to chronic intermittent hypoxia (CIH). Hypoxia increases the expression of several inflammatory stress markers and endothelial dysfunction. Recent studies suggest that patients with a similar AHI but with severe nocturnal hypoxia using oximetric parameters, such as the lowest saturation of oxygen during the night (min SaO2), percentage of total sleep time with oxygen saturation < 90% (T90) or the oxygen desaturation index (ODI-3%), commonly reported during the sleep study, are indicative of the increased expression of inflammatory markers due to severe nocturnal hypoxia and CIH during the night compared to subjects with moderate-severe OSAS without severe nocturnal hypoxia. The aim of this review is to describe physiological pathways involved in OSAS and their clinical consequences, focused in CIH and oximetric parameters showed in sleep study and their potential utility as inflammatory markers.
MeSH term(s)	Airway Obstruction/diagnosis ; Airway Obstruction/physiopathology ; Airway Obstruction/therapy ; Chronic Disease ; Correlation of Data ; Humans ; Hypoxia/physiopathology ; Inflammation Mediators/blood ; Multivariate Analysis ; Narrative Medicine ; Oxygen/blood ; Polysomnography ; Precision Medicine ; Sleep/physiology ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/physiopathology ; Sleep Apnea, Obstructive/therapy
Chemical Substances	Inflammation Mediators ; Oxygen (S88TT14065)
Language	English
Publishing date	2019-11-22
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1500381-4
ISSN	1522-1709 ; 1520-9512
ISSN (online)	1522-1709
ISSN	1520-9512
DOI	10.1007/s11325-019-01967-4
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Article ; Online: Validation of a Methodology for the Detection of Severe Acute Respiratory Syndrome Coronavirus 2 in Saliva by Real-Time Reverse Transcriptase-PCR.

Escobar, Daniel F / Díaz, Pablo / Díaz-Dinamarca, Diego / Puentes, Rodrigo / Alarcón, Pedro / Alarcón, Bárbara / Rodríguez, Iván / Manzo, Ricardo A / Soto, Daniel A / Lamperti, Liliana / Díaz, Janepsy / García-Escorza, Heriberto E / Vasquez, Abel E

Frontiers in public health

2021 Volume 9, Page(s) 743300

Abstract: In January 2021, the Chilean city of Concepción experienced a second wave of coronavirus 2019 (COVID-19) while in early April 2021, the entire country faced the same situation. This outbreak generated the need to modify and validate a method for ... ...

Abstract	In January 2021, the Chilean city of Concepción experienced a second wave of coronavirus 2019 (COVID-19) while in early April 2021, the entire country faced the same situation. This outbreak generated the need to modify and validate a method for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in saliva, thereby expanding the capacity and versatility of testing for COVID-19. This study was conducted in February 2021 in the Chilean city of Concepción during which time, the town was under total quarantine. The study participants were mostly symptomatic (87.4%), not hospitalized, and attended care centers because of their health status rather than being asked by the researchers. People coming to the health center in Concepción to be tested for COVID-19 (
MeSH term(s)	COVID-19/diagnosis ; COVID-19 Testing ; Chile ; Humans ; Reverse Transcriptase Polymerase Chain Reaction ; SARS-CoV-2/isolation & purification ; Saliva/virology ; Specimen Handling
Language	English
Publishing date	2021-12-02
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2021.743300
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Article: Impact of Obstructive Sleep Apnea (OSA) in COVID-19 Survivors, Symptoms Changes Between 4-Months and 1 Year After the COVID-19 Infection.

Labarca, Gonzalo / Henríquez-Beltrán, Mario / Lamperti, Liliana / Nova-Lamperti, Estefania / Sanhueza, Sergio / Cabrera, Camilo / Quiroga, Romina / Antilef, Barbara / Ormazábal, Valeska / Zúñiga, Felipe / Castillo, Daniela / Horta, Gloria / Enos, Daniel / Lastra, Jaime / Gonzalez, Jessica / Targa, Adriano / Barbe, Ferran

Frontiers in medicine

2022 Volume 9, Page(s) 884218

Abstract: Objective: To determine the association between Obstructive Sleep Apnea (OSA) with long-term symptoms and inflammatory cytokines, exploring the changes between 4-months and 1-year after COVID-19 infection.: Methods: We conducted an observational, ... ...

Abstract	Objective: To determine the association between Obstructive Sleep Apnea (OSA) with long-term symptoms and inflammatory cytokines, exploring the changes between 4-months and 1-year after COVID-19 infection. Methods: We conducted an observational, prospective cohort study, including patients ≥18 years old with confirmed diagnosis of COVID-19 between April to July 2020. All participants underwent two clinical follow-up visits, the first at 4-months (Visit 1) and the second at 1 year, after SARS-CoV-2 infection (Visit 2). Plasma glucose, total cholesterol, HDL, and triglycerides. Regarding pulmonary function, spirometry and lung diffusion capacity tests were assessed. For mental and neurocognitive evaluation, a short-form (SF-12), Beck depression and Hospital-Anxiety depression questionnaires were conducted at both time-points, whereas the Montreal Cognitive assessment was conducted during the second follow-up. Regarding to sleep evaluation, Epworth Sleepiness Scale, Insomnia Severity index and STOP-BANG questionnaire were conducted. Additionally, a home sleep apnea test and 7-day wrist actigraphy were performed in all participants. Inflammatory cytokines were measured using an inflammatory cytokine bead array kit. Results: A total of 60 patients were included in the first follow-up, from which 57 completed the second follow-up. The mean age was 46.4 years-old (SD ± 13.1) and 53.3% were male. 30% of cases reported mild COVID-19 infection, 28.3% with moderate illness, and 41.6% with severe illness. Moreover, 56.6% of them were admitted to the ICU. Regarding to metabolic values, the OSA group showed higher values of insulin resistance (IR) (27%), systolic blood pressure (SBP) 135.2 (±19.1), dyslipidemia (67.5%), total cholesterol 202.1 (±60.5), triglycerides 176.1 (±119.0) and HOMA-IR 9.0 (±18.8) in comparison with the non-OSA group. 1 year after COVID-19 infection, DLCO test remains abnormal in OSA patients (25% OSA vs. 3.6% non-OSA, Discussion: Among patients with previous COVID-19, OSA impact the development of incident glycemic, neurocognitive impairment, and abnormal functional pulmonary changes that persist up to 1 year since acute phase.
Language	English
Publishing date	2022-06-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.884218
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Article ; Online: Analysis of clinical symptoms, radiological changes and pulmonary function data 4 months after COVID-19.

Labarca, Gonzalo / Henríquez-Beltrán, Mario / Lastra, Jaime / Enos, Daniel / Llerena, Faryd / Cigarroa, Igor / Lamperti, Liliana / Ormazabal, Valeska / Ramirez, Carlos / Espejo, Eric / Canales, Nicole / Fuentes, Fabiola / Horta, Gloria / Fernandez-Bussy, Sebastian / Nova-Lamperti, Estefania

The clinical respiratory journal

2021 Volume 15, Issue 9, Page(s) 992–1002

Abstract: Background: Coronavirus disease 2019 (COVID-19) ranges from asymptomatic disease to respiratory failure and requires invasive mechanical ventilation (IMV). Data about the sequelae after infection are scarce. The study aims to describe the prevalence of ... ...

Abstract	Background: Coronavirus disease 2019 (COVID-19) ranges from asymptomatic disease to respiratory failure and requires invasive mechanical ventilation (IMV). Data about the sequelae after infection are scarce. The study aims to describe the prevalence of symptoms, pulmonary function tests (PFTs), and radiological changes after four months of follow-up. Methods: A prospective, cross-sectional, multicentre study was performed. Patients with different illness severities were consecutively included (mild; moderate: hospitalized without IMV; severe: hospitalized with IMV). Clinical variables, health-related quality of life (HRQoL), PFT (spirometry, diffusing capacity of the lungs for carbon monoxide (DLCO)), and (CT) scans of the chest were obtained. The association between the risk of sequelae (DLCO <80%) and altered CT was analysed using logistic regression adjusted for confounding variables. Results: 60 patients (18 mild, 17 moderate, and 25 severe) were included. Fatigue was found in 11% of the mild, 47% of the moderate and 36% of the severe group. Altered DLCO (mild: 5.5%, moderate: 41%, severe: 28%, p < .05) and change in HRQoL (mild: 50%, moderate: 94%, severe: 60%), while the severe group showed a higher prevalence of altered CT (88% vs. 64%). Awake prone position (APP) and high-flow nasal cannula (HFNC) was independently associated with altered DLCO, Odds ratio (OR) 7.28 (CI, 1.10-47.81; p < .05), and altered CT, OR 9.50 (CI, 1.26-71.5; p < .05). Besides, prolonged time in IMV was associated with altered CT, OR 1.24 (CI, 1.05-1.46; p < .05). Discussion: It is common to find sequelae in symptoms, radiology, and PFT. In our series, the use of APP+HFNC and days on IMV were associated with an increased risk of sequelae.
MeSH term(s)	COVID-19 ; Cross-Sectional Studies ; Humans ; Lung/diagnostic imaging ; Prospective Studies ; Quality of Life ; Radiology ; SARS-CoV-2
Language	English
Publishing date	2021-06-29
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	2442214-9
ISSN	1752-699X ; 1752-6981
ISSN (online)	1752-699X
ISSN	1752-6981
DOI	10.1111/crj.13403
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Article ; Online: Humoral immunity against SARS-CoV-2 evoked by heterologous vaccination groups using the CoronaVac (Sinovac) and BNT162b2 (Pfizer/BioNTech) vaccines in Chile.

Díaz-Dinamarca, Diego A / Díaz, Pablo / Barra, Gisselle / Puentes, Rodrigo / Arata, Loredana / Grossolli, Jonnathan / Riveros-Rodriguez, Boris / Ardiles, Luis / Santelises, Julio / Vasquez-Saez, Valeria / Escobar, Daniel F / Soto, Daniel / Canales, Cecilia / Díaz, Janepsy / Lamperti, Liliana / Castillo, Daniela / Urra, Mychel / Zuñiga, Felipe / Ormazabal, Valeska /

Nova-Lamperti, Estefanía / Benítez, Rosana / Rivera, Alejandra / Cortes, Claudia P / Valenzuela, María Teresa / García-Escorza, Heriberto E / Vasquez, Abel E

Frontiers in public health

2023 Volume 11, Page(s) 1229045

Abstract: Introduction: Severe acute respiratory syndrome virus 2 (SARS-CoV-2) has caused over million deaths worldwide, with more than 61,000 deaths in Chile. The Chilean government has implemented a vaccination program against SARS-CoV-2, with over 17.7 million ...

Abstract	Introduction: Severe acute respiratory syndrome virus 2 (SARS-CoV-2) has caused over million deaths worldwide, with more than 61,000 deaths in Chile. The Chilean government has implemented a vaccination program against SARS-CoV-2, with over 17.7 million people receiving a complete vaccination scheme. The final target is 18 million individuals. The most common vaccines used in Chile are CoronaVac (Sinovac) and BNT162b2 (Pfizer-Biotech). Given the global need for vaccine boosters to combat the impact of emerging virus variants, studying the immune response to SARS-CoV-2 is crucial. In this study, we characterize the humoral immune response in inoculated volunteers from Chile who received vaccination schemes consisting of two doses of CoronaVac [CoronaVac (2x)], two doses of CoronaVac plus one dose of BNT162b2 [CoronaVac (2x) + BNT162b2 (1x)], and three doses of BNT162b2 [BNT162b2 (3x)]. Methods: We recruited 469 participants from Clínica Dávila in Santiago and the Health Center Víctor Manuel Fernández in the city of Concepción, Chile. Additionally, we included participants who had recovered from COVID-19 but were not vaccinated (RCN). We analyzed antibodies, including anti-N, anti-S1-RBD, and neutralizing antibodies against SARS-CoV-2. Results: We found that antibodies against the SARS-CoV-2 nucleoprotein were significantly higher in the CoronaVac (2x) and RCN groups compared to the CoronaVac (2x) + BNT162b2 (1x) or BNT162b2 (3x) groups. However, the CoronaVac (2x) + BNT162b2 (1x) and BNT162b2 (3x) groups exhibited a higher concentration of S1-RBD antibodies than the CoronaVac (2x) group and RCN group. There were no significant differences in S1-RBD antibody titers between the CoronaVac (2x) + BNT162b2 (1x) and BNT162b2 (3x) groups. Finally, the group immunized with BNT162b2 (3x) had higher levels of neutralizing antibodies compared to the RCN group, as well as the CoronaVac (2x) and CoronaVac (2x) + BNT162b2 (1x) groups. Discussion: These findings suggest that vaccination induces the secretion of antibodies against SARS-CoV-2, and a booster dose of BNT162b2 is necessary to generate a protective immune response. In the current state of the pandemic, these data support the Ministry of Health of the Government of Chile's decision to promote heterologous vaccination as they indicate that a significant portion of the Chilean population has neutralizing antibodies against SARS-CoV-2.
MeSH term(s)	Humans ; Immunity, Humoral ; SARS-CoV-2 ; BNT162 Vaccine ; Chile ; COVID-19/prevention & control ; Vaccines ; Vaccination ; Antibodies, Neutralizing
Chemical Substances	BNT162 Vaccine ; sinovac COVID-19 vaccine ; Vaccines ; Antibodies, Neutralizing
Language	English
Publishing date	2023-08-24
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2023.1229045
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Article ; Online: Plasma from Patients with Rheumatoid Arthritis Reduces Nitric Oxide Synthesis and Induces Reactive Oxygen Species in A Cell-Based Biosensor.

Herlitz-Cifuentes, Herbert / Vejar, Camila / Flores, Alejandra / Jara, Paola / Bustos, Paulina / Castro, Irene / Poblete, Evelyn / Saez, Katia / Opazo, Marina / Gajardo, Jorge / Aguayo, Claudio / Nova-Lamperti, Estefania / Lamperti, Liliana

Biosensors

2019 Volume 9, Issue 1

Abstract: Rheumatoid arthritis (RA) has been associated with a higher risk of developing cardiovascular (CV) diseases. It has been proposed that systemic inflammation plays a key role in premature atherosclerosis development, and is therefore crucial to determine ... ...

Abstract	Rheumatoid arthritis (RA) has been associated with a higher risk of developing cardiovascular (CV) diseases. It has been proposed that systemic inflammation plays a key role in premature atherosclerosis development, and is therefore crucial to determine whether systemic components from RA patients promotes endothelial cell-oxidative stress by affecting reactive oxygen species (ROS) and nitric-oxide (NO) production. The aim of this study was to evaluate whether plasma from RA patients impair NO synthesis and ROS production by using the cell-line ECV-304 as a biosensor. NO synthesis and ROS production were measured in cells incubated with plasma from 73 RA patients and 52 healthy volunteers by fluorimetry. In addition, traditional CV risk factors, inflammatory molecules and disease activity parameters were measured. Cells incubated with plasma from RA patients exhibited reduced NO synthesis and increased ROS production compared to healthy volunteers. Furthermore, the imbalance between NO synthesis and ROS generation in RA patients was not associated with traditional CV risk factors. Our data suggest that ECV-304 cells can be used as a biosensor of systemic inflammation-induced endothelial cell-oxidative stress. We propose that both NO and ROS production are potential biomarkers aimed at improving the current assessment of CV risk in RA.
MeSH term(s)	Arthritis, Rheumatoid/blood ; Atherosclerosis/blood ; Atherosclerosis/pathology ; Biosensing Techniques ; Cell Line ; Endothelial Cells/drug effects ; Humans ; Inflammation/blood ; Inflammation/pathology ; Nitric Oxide/biosynthesis ; Nitric Oxide/isolation & purification ; Oxidative Stress/drug effects ; Plasma ; Reactive Oxygen Species/chemistry ; Reactive Oxygen Species/isolation & purification
Chemical Substances	Reactive Oxygen Species ; Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2019-02-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662125-3
ISSN	2079-6374 ; 2079-6374
ISSN (online)	2079-6374
ISSN	2079-6374
DOI	10.3390/bios9010032
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Article ; Online: Undiagnosed sleep disorder breathing as a risk factor for critical COVID-19 and pulmonary consequences at the midterm follow-up.

Labarca, Gonzalo / Henriquez-Beltran, Mario / Llerena, Faryd / Erices, Gustavo / Lastra, Jaime / Enos, Daniel / Castillo, Daniela / Fraga, Marco / Lamperti, Liliana / Ormazabal, Valeska / Riffo, Benilde / Rubilar, Daniel / Sanhueza, Rocio / Vasquez, Jaime / Villanueva, Carolina / Horta, Gloria / Sanhueza, Felipe / Melo, Pedro / Dreyse, Jorge /

Jorquera, Jorge / Fernandez-Bussy, Sebastian / Gonzalez, Jessica / Barbe, Ferran / Nova-Lamperti, Estefania

Sleep medicine

2021 Volume 91, Page(s) 196–204

Abstract: Introduction: Patients with severe COVID-19 develops an acute respiratory distress syndrome (ARDS), requiring admission to the intensive care unit. COVID-19 also reports an increased prevalence of comorbidities, similar to patients with Sleep disorder ... ...

Abstract	Introduction: Patients with severe COVID-19 develops an acute respiratory distress syndrome (ARDS), requiring admission to the intensive care unit. COVID-19 also reports an increased prevalence of comorbidities, similar to patients with Sleep disorder breathing (SDB). Objectives: To evaluate the association between undiagnosed SDB and the risk of ARDS and pulmonary abnormalities in a cohort of patients' survivors of COVID-19 between 3 and 6 months after diagnosis. Methods: Prospective cohort study of patients who developed ARDS during hospitalization due to COVID-19 compared with a control group of patients who had COVID-19 with mild to moderate symptoms. All patients were evaluated between the 12th and 24th week after SARS-CoV-2 infection. The evaluation includes persistent symptoms, lung diffusing capacity of carbon monoxide (DLCO), chest CT scan and home sleep apnea test. SDB was diagnosed by the respiratory disturbance index ≥5 ev/h. The association between SDB and ARDS, the hazards of lung impairment and the hazard ratios (HR) were analyzed. Results: A total of 60 patients were included (ARDS: 34 patients, Control: 26 patients). The mean follow-up was 16 weeks (range 12-24). ARDS reported a high prevalence of SDB (79% vs. 38% in control group). A total of 35% reported DLCO impairment, and 67.6% abnormal chest CT. SDB was independently associated to ARDS, OR 6.72 (CI, 1.56-28.93), p < 0.01, and abnormal Chest CT, HR 17.2 (CI, 1.68-177.4, p = 0.01). Besides, ARDS, days in mechanical ventilation, male gender were also associated with an increased risk of abnormal chest CT. Conclusion: Undiagnosed SDB is prevalent and independently associated with ARDS. In addition, undiagnosed SDB increased the hazard of abnormal Chest CT in the midterm. Study register: ISRCTN16865246.
MeSH term(s)	COVID-19/complications ; COVID-19/epidemiology ; Follow-Up Studies ; Humans ; Lung/diagnostic imaging ; Male ; Prospective Studies ; Respiratory Distress Syndrome/diagnosis ; Respiratory Distress Syndrome/epidemiology ; Respiratory Distress Syndrome/etiology ; Risk Factors ; SARS-CoV-2 ; Sleep Apnea Syndromes/diagnosis ; Sleep Apnea Syndromes/epidemiology
Language	English
Publishing date	2021-02-19
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2012041-2
ISSN	1878-5506 ; 1389-9457
ISSN (online)	1878-5506
ISSN	1389-9457
DOI	10.1016/j.sleep.2021.02.029
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Article ; Online: Apolipoprotein A-I enhances proliferation of human endothelial progenitor cells and promotes angiogenesis through the cell surface ATP synthase.

González-Pecchi, Valentina / Valdés, Sara / Pons, Véronique / Honorato, Paula / Martinez, Laurent O / Lamperti, Liliana / Aguayo, Claudio / Radojkovic, Claudia

Microvascular research

2015 Volume 98, Page(s) 9–15

Abstract: Background: Human endothelial progenitor cells (hEPC) correspond to a subtype of stem cells which, in the presence of angiogenic stimuli, can be mobilized from bone marrow to circulation and then recruited to the damaged endothelium, where they ... ...

Abstract	Background: Human endothelial progenitor cells (hEPC) correspond to a subtype of stem cells which, in the presence of angiogenic stimuli, can be mobilized from bone marrow to circulation and then recruited to the damaged endothelium, where they differentiate into mature endothelial cells. High-density lipoproteins (HDL) increase the level and functionality (proliferation, migration, differentiation, angiogenesis capacity) of circulating hEPC; however, the contribution of receptors for HDL and/or apolipoprotein A-I (apoA-I), the main HDL apolipoprotein, in these effects is still unclear. On mature endothelial cells, the cell surface F1-ATP synthase has been previously characterized as a high affinity receptor of apoA-I, whereas the scavenger receptor SR-BI mainly binds with fully lipidated HDL and displays a poor affinity for lipid-free apoA-I. Furthermore, it was shown that apoA-I binding to surface ATP synthase on mature endothelial cells promotes cell proliferation, whereas inhibits apoptosis. In this work, we aimed to determine the effect of apoA-I in the proliferation and the angiogenic capacity of early hEPC, and the contribution of the cell surface ATP synthase in these events. Results: We first evidenced that early hEPC express the ATP synthase at the surface of nonpermeabilized cells, where it is not colocalized with MitoTracker, a mitochondria marker. ApoA-I (50 μg/mL) increases hEPC proliferation (+14.5%, p<0.001) and potentiates the effect of hEPC on a cellular model of angiogenesis, with an increase of +31% (p<0.01) in branch point counting and in tubule length. These effects of apoA-I were totally reversed in the presence of ATP synthase inhibitors, such as IF1 or oligomycin, whereas the inhibition of the HDL receptor, SR-BI, partially inhibits these events. Conclusions: These results provide the first evidence that surface ATP synthase is expressed on early hEPC, where it mediates apoA-I effects in hEPC proliferation and in angiogenesis. This knowledge could be helpful for future investigations focused on the regulation of the number and functionality of these cells and in the development of new therapies for the treatment of diseases, such as cardiovascular disease.
MeSH term(s)	Adult ; Apolipoprotein A-I/physiology ; Apoptosis ; Cell Membrane/metabolism ; Cell Proliferation ; Endothelial Cells/metabolism ; Endothelial Progenitor Cells/metabolism ; Female ; Healthy Volunteers ; Humans ; Lipoproteins, HDL/metabolism ; Male ; Microscopy, Confocal ; Mitochondria/metabolism ; Neovascularization, Physiologic ; Proton-Translocating ATPases/metabolism ; Receptors, Lipoprotein/metabolism ; Stem Cells/cytology ; Young Adult
Chemical Substances	APOA1 protein, human ; Apolipoprotein A-I ; Lipoproteins, HDL ; Receptors, Lipoprotein ; high density lipoprotein receptors ; Proton-Translocating ATPases (EC 3.6.3.14)
Language	English
Publishing date	2015-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80307-8
ISSN	1095-9319 ; 0026-2862
ISSN (online)	1095-9319
ISSN	0026-2862
DOI	10.1016/j.mvr.2014.11.003
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Article ; Online: Role of lectin-like oxidized low density lipoprotein-1 in fetoplacental vascular dysfunction in preeclampsia.

Zuniga, Felipe A / Ormazabal, Valeska / Gutierrez, Nicolas / Aguilera, Valeria / Radojkovic, Claudia / Veas, Carlos / Escudero, Carlos / Lamperti, Liliana / Aguayo, Claudio

BioMed research international

2014 Volume 2014, Page(s) 353616

Abstract: The bioavailability of nitric oxide (NO) represents a key marker in vascular health. A decrease in NO induces a pathological condition denominated endothelial dysfunction, syndrome observed in different pathologies, such as obesity, diabetes, kidney ... ...

Abstract	The bioavailability of nitric oxide (NO) represents a key marker in vascular health. A decrease in NO induces a pathological condition denominated endothelial dysfunction, syndrome observed in different pathologies, such as obesity, diabetes, kidney disease, cardiovascular disease, and preeclampsia (PE). PE is one of the major risks for maternal death and fetal loss. Recent studies suggest that the placenta of pregnant women with PE express high levels of lectin-like oxidized LDL receptor-1 (LOX-1), which induces endothelial dysfunction by increasing reactive oxygen species (ROS) and decreasing intracellular NO. Besides LOX-1 activation induces changes in migration and apoptosis of syncytiotrophoblast cells. However, the role of this receptor in placental tissue is still unknown. In this review we will describes the physiological roles of LOX-1 in normal placenta development and the potential involvement of this receptor in the pathophysiology of PE.
MeSH term(s)	Female ; Fetus/blood supply ; Fetus/physiopathology ; Humans ; Lectins/metabolism ; Lipoproteins, LDL/metabolism ; Nitric Oxide/metabolism ; Placenta/blood supply ; Placenta/physiopathology ; Pre-Eclampsia/physiopathology ; Pregnancy
Chemical Substances	Lectins ; Lipoproteins, LDL ; oxidized low density lipoprotein ; Nitric Oxide (31C4KY9ESH)
Language	English
Publishing date	2014-07-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2014/353616
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Article: Clinical and pulmonary function analysis in long-COVID revealed that long-term pulmonary dysfunction is associated with vascular inflammation pathways and metabolic syndrome.

Sanhueza, Sergio / Vidal, Mabel A / Hernandez, Mauricio A / Henriquez-Beltran, Mario E / Cabrera, Camilo / Quiroga, Romina / Antilef, Bárbara E / Aguilar, Kevin P / Castillo, Daniela A / Llerena, Faryd J / Fraga Figueroa, Marco / Nazal, Mauricio / Castro, Eritson / Lagos, Paola / Moreno, Alexa / Lastra, Jaime J / Gajardo, Jorge / Garcés, Pamela / Riffo, Benilde /

Buchert, Jorge / Sanhueza, Rocío / Ormazába, Valeska / Saldivia, Pablo / Vargas, Cristian / Nourdin, Guillermo / Koch, Elard / Zuñiga, Felipe A / Lamperti, Liliana / Bustos, Paula / Guzmán-Gutiérrez, Enrique / Tapia, Claudio A / Ferrada, Luciano / Cerda, Gustavo / Woehlbier, Ute / Riquelme, Erick / Yuseff, Maria-Isabel / Muñoz Ramirez, Braulio A / Lombardi, Giovanna / De Gonzalo-Calvo, David / Salomon, Carlos / Verdugo, Ricardo A / Quiñones, Luis A / Colombo, Alicia / Barría, Maria I / Labarca, Gonzalo / Nova-Lamperti, Estefania

Frontiers in medicine

2023 Volume 10, Page(s) 1271863

Abstract: Introduction: Long-term pulmonary dysfunction (L-TPD) is one of the most critical manifestations of long-COVID. This lung affection has been associated with disease severity during the acute phase and the presence of previous comorbidities, however, the ...

Abstract	Introduction: Long-term pulmonary dysfunction (L-TPD) is one of the most critical manifestations of long-COVID. This lung affection has been associated with disease severity during the acute phase and the presence of previous comorbidities, however, the clinical manifestations, the concomitant consequences and the molecular pathways supporting this clinical condition remain unknown. The aim of this study was to identify and characterize L-TPD in patients with long-COVID and elucidate the main pathways and long-term consequences attributed to this condition by analyzing clinical parameters and functional tests supported by machine learning and serum proteome profiling. Methods: Patients with L-TPD were classified according to the results of their computer-tomography (CT) scan and diffusing capacity of the lungs for carbon monoxide adjusted for hemoglobin (DLCOc) tests at 4 and 12-months post-infection. Results: Regarding the acute phase, our data showed that L-TPD was favored in elderly patients with hypertension or insulin resistance, supported by pathways associated with vascular inflammation and chemotaxis of phagocytes, according to computer proteomics. Then, at 4-months post-infection, clinical and functional tests revealed that L-TPD patients exhibited a restrictive lung condition, impaired aerobic capacity and reduced muscular strength. At this time point, high circulating levels of platelets and CXCL9, and an inhibited FCgamma-receptor-mediated-phagocytosis due to reduced FcγRIII (CD16) expression in CD14+ monocytes was observed in patients with L-TPD. Finally, 1-year post infection, patients with L-TPD worsened metabolic syndrome and augmented body mass index in comparison with other patient groups. Discussion: Overall, our data demonstrated that CT scan and DLCOc identified patients with L-TPD after COVID-19. This condition was associated with vascular inflammation and impair phagocytosis of virus-antibody immune complexes by reduced FcγRIII expression. In addition, we conclude that COVID-19 survivors required a personalized follow-up and adequate intervention to reduce long-term sequelae and the appearance of further metabolic diseases.
Language	English
Publishing date	2023-10-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1271863
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