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  1. Article: PKV-Ombudsmann: Konflikte kreativ lösen.

    Lamping, M

    Versicherungsmedizin

    2007  Volume 59, Issue 3, Page(s) 144–145

    Title translation PKV-Ombudsman: resolving conflicts creatively .
    MeSH term(s) Conflict (Psychology) ; Creativity ; Insurance, Health ; Patient Advocacy ; Private Sector/organization & administration ; Problem Solving
    Language German
    Publishing date 2007-09-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 885025-2
    ISSN 0933-4548
    ISSN 0933-4548
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Project to Reduce Opioid Administration for Women in the Postpartum Period.

    Lamping, Michele / Gajus, Jaime / Gonzalez, Angela

    Nursing for women's health

    2020  Volume 24, Issue 5, Page(s) 325–331

    Abstract: Objective: To decrease the need for opioids for women in the postpartum period by using the PainPack Protocol to administer alternating acetaminophen and ibuprofen.: Design: Quality improvement project.: Setting: Southwestern Ohio Level II ... ...

    Abstract Objective: To decrease the need for opioids for women in the postpartum period by using the PainPack Protocol to administer alternating acetaminophen and ibuprofen.
    Design: Quality improvement project.
    Setting: Southwestern Ohio Level II community hospital with approximately 4,000 births per year.
    Participants: A pilot group of women who gave birth from July 2017 through December 2017 (n = 210). Full implementation included women who gave birth from January 2018 through June 2019 (n = 5,560).
    Intervention/measurements: The PainPack Protocol used in the outpatient setting was modified and implemented for use in the inpatient setting. Outcomes were measured via chart review and were based on morphine milligram equivalents (MMEs) given in the hospital and prescribed after discharge. Feedback from women during nurse leader rounds was also considered.
    Results: The average amount of MMEs administered in the hospital was reduced from 143.2 to 105.8 for women birthing via cesarean and from 32.8 to 26.1 for women birthing vaginally. The average amount of MMEs prescribed at discharge was reduced from 281.0 to 166.9 for women birthing via cesarean and from 99.0 to 45.0 for women birthing vaginally.
    Conclusion: This protocol was associated with reduced amounts of opioids administered to women during postpartum hospitalization and prescribed upon discharge. At the same time, women reported effective pain control during nurse leader rounds.
    MeSH term(s) Acetaminophen/administration & dosage ; Analgesics, Non-Narcotic/administration & dosage ; Analgesics, Opioid/administration & dosage ; Female ; Humans ; Ibuprofen/administration & dosage ; Ohio ; Pain Management/methods ; Patient Discharge ; Postpartum Period ; Pregnancy ; Quality Improvement
    Chemical Substances Analgesics, Non-Narcotic ; Analgesics, Opioid ; Acetaminophen (362O9ITL9D) ; Ibuprofen (WK2XYI10QM)
    Language English
    Publishing date 2020-09-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2275619-X
    ISSN 1751-486X ; 1751-4851
    ISSN (online) 1751-486X
    ISSN 1751-4851
    DOI 10.1016/j.nwh.2020.07.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Mechanical Power Differs Between Pressure-Controlled Ventilation and Different Volume-Controlled Ventilation Modes.

    Rietveld, Petra J / Snoep, Jacob W M / Lamping, Marjolein / van der Velde, Franciska / de Jonge, Evert / van Westerloo, David W / Schoe, Abraham

    Critical care explorations

    2022  Volume 4, Issue 8, Page(s) e0741

    Abstract: Objectives: Mechanical power (MP) is a way of estimating the energy delivered by the ventilator to the patient. For both volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV) methods have been described to calculate the MP. The ... ...

    Abstract Objectives: Mechanical power (MP) is a way of estimating the energy delivered by the ventilator to the patient. For both volume-controlled ventilation (VCV) and pressure-controlled ventilation (PCV) methods have been described to calculate the MP. The pressure-volume (PV) loop, from which the MP is calculated, is different for VCV compared with PCV. We aimed to compare the MP of VCV with zero pause time (VCV-0), VCV with 10% pause time (VCV-10), and PCV within patients in different patient categories based on severity of lung injury.
    Design: In a proof-of-concept study, we enrolled 46 mechanically ventilated patients without spontaneous breathing efforts. Baseline measurements were done in pressure-controlled mode. Subsequently, measurements were done in VCV-0 and VCV-10. Tidal volume and all other settings were kept the same.
    Setting: ICU, single university medical center.
    Patients: Fifty-eight cases in 46 patients on controlled ventilation modes.
    Interventions: Comparison between the MP of PCV, VCV-0, and VCV-10.
    Measurement and main results: The mean MP of VCV-0, VCV-10, and PCV was 19.30, 21.80, and 20.87 J/min, respectively (
    Conclusions: In patients ventilated in a controlled mode, VCV without pause time had the lowest MP followed by PCV. VCV with 10% pause time had the highest MP.
    Language English
    Publishing date 2022-08-15
    Publishing country United States
    Document type Journal Article
    ISSN 2639-8028
    ISSN (online) 2639-8028
    DOI 10.1097/CCE.0000000000000741
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Thesis: Patentschutz und Marktmacht

    Lamping, Matthias

    (Schriftenreihe zum gewerblichen Rechtsschutz ; 169)

    2010  

    Author's details von Matthias Lamping
    Series title Schriftenreihe zum gewerblichen Rechtsschutz ; 169
    Keywords Antitrust law ; Antitrust law (International law) ; Patent laws and legislation ; Patents (International law) ; Patentrecht ; Kartellrecht ; Deutschland ; Europäisches Kartellrecht ; Europäisches Patentrecht
    Language German
    Size XXVII, 508 S.
    Publisher Heymanns
    Publishing place Köln
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Zugl.: Diss
    ISBN 9783452274410 ; 3452274411
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  5. Article ; Online: Synthesis and conformational analysis of an expanded cyclic ketoxime-hexapeptide.

    Lamping, Matthias / Grell, Yvonne / Geyer, Armin

    Journal of peptide science : an official publication of the European Peptide Society

    2016  Volume 22, Issue 4, Page(s) 228–235

    Abstract: In this work the synthesis of a linear hexapeptide with a hydroxylamine functionality at the N-terminus and a ketone instead of the carboxylic acid at the C-terminus is described. Cyclization by ketoxime formation yields the 19-membered ring-expanded ... ...

    Abstract In this work the synthesis of a linear hexapeptide with a hydroxylamine functionality at the N-terminus and a ketone instead of the carboxylic acid at the C-terminus is described. Cyclization by ketoxime formation yields the 19-membered ring-expanded cyclic hexapeptide cyclo[Goly-Val-Ala-Pro-Leu-Kly] which adopts a main conformer with two intramolecular hydrogen bonds. The hydrolytic stability of a ketoxime lies between the inert amide and the labile imine. The substitution of an amide bond for an iminium bond transforms the irreversible macrocyclization into a reversible process, but macrocyclic imines are difficult to isolate because they are prone to hydrolysis. The enhanced chemical stability of the ketoxime justifies its application in ligation protocols. The detailed NMR analysis of a ketoxime linkage presented here identifies its local conformational preferences in a constrained peptide environment.
    MeSH term(s) Amino Acid Sequence ; Hydrogen Bonding ; Oligopeptides/chemical synthesis ; Oximes/chemical synthesis ; Peptides, Cyclic/chemical synthesis ; Protein Conformation
    Chemical Substances Oligopeptides ; Oximes ; Peptides, Cyclic
    Language English
    Publishing date 2016-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1234416-3
    ISSN 1099-1387 ; 1075-2617
    ISSN (online) 1099-1387
    ISSN 1075-2617
    DOI 10.1002/psc.2873
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Tumour mutational burden and survival with molecularly matched therapy.

    de Bortoli, Till / Benary, Manuela / Horak, Peter / Lamping, Mario / Stintzing, Sebastian / Tinhofer, Ingeborg / Leyvraz, Serge / Schäfer, Reinhold / Klauschen, Frederick / Keller, Ulrich / Stenzinger, Albrecht / Fröhling, Stefan / Kurzrock, Razelle / Keilholz, Ulrich / Rieke, Damian T / Jelas, Ivan

    European journal of cancer (Oxford, England : 1990)

    2023  Volume 190, Page(s) 112925

    Abstract: Background: The impact of tumour mutational burden (TMB) on outcome with molecularly matched therapy is unknown. Higher TMB could predict resistance to molecularly matched therapy through co-occurring driver mutations.: Methods: One hundred and four ... ...

    Abstract Background: The impact of tumour mutational burden (TMB) on outcome with molecularly matched therapy is unknown. Higher TMB could predict resistance to molecularly matched therapy through co-occurring driver mutations.
    Methods: One hundred and four patients with advanced cancers underwent molecular profiling in the DKTK-MASTER program. Fifty-five patients received systemic therapy excluding immunotherapy. Patients with molecularly matched (n = 35) or non-molecularly informed therapy (n = 20) were analysed for TMB and survival. Results were validated in an independent cohort of patients receiving molecularly matched (n = 68) or non-molecularly informed therapy (n = 40). Co-occurring driver mutations and TMB were analysed in the exploratory cohort and The Cancer Genome Atlas (TCGA) datasets.
    Results: Patients were stratified by the median TMB of 1.67 mutations per Megabase (mut/Mb) of 35 patients receiving molecularly matched therapy into TMB-high or TMB-low groups. Median overall survival (4 months [95% CI, 3.3-7.6] versus 12.8 months [95% CI, 10-not reached], p < 0.001) and progression-free survival (1.8 months [95% CI, 1.1-3.7] versus 7.9 months [95% CI, 2.8-17.0], p = 0.003) were significantly shorter in the TMB-high group compared to the TMB-low group. In the validation cohort, shorter OS and PFS were identified in the TMB-high group (TMB cut-off of 4 mut/Mb) treated with molecularly matched therapy. No differences were observed in patients receiving non-molecularly informed systemic therapy. A significant correlation between co-occurring driver mutations and TMB (n = 104, r = 0.78 [95% CI, 0.68-0.85], p < 0.001) was found in the exploratory cohort as well as the majority (24/33) of TCGA studies.
    Conclusion: A high TMB was associated with unfavourable outcome in patients receiving molecularly matched therapy, indicating untargeted resistance pathways. Therefore, TMB should be further investigated as a predictive biomarker in precision oncology programs.
    MeSH term(s) Humans ; Neoplasms/drug therapy ; Neoplasms/genetics ; Mutation ; Precision Medicine ; Progression-Free Survival ; Immunotherapy/methods ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2023-05-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 82061-1
    ISSN 1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
    ISSN (online) 1879-0852
    ISSN 0277-5379 ; 0959-8049 ; 0964-1947
    DOI 10.1016/j.ejca.2023.05.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Comparison of Treatment Recommendations by Molecular Tumor Boards Worldwide.

    Rieke, Damian T / Lamping, Mario / Schuh, Marissa / Le Tourneau, Christophe / Basté, Neus / Burkard, Mark E / Metzeler, Klaus H / Leyvraz, Serge / Keilholz, Ulrich

    JCO precision oncology

    2022  Volume 2, Page(s) 1–14

    Abstract: Purpose: Precision oncology holds the promise of improving patient outcome. It is based on the idea that the testing of genomic biomarkers can lead to the recommendation of a treatment option tailored to the specific patient. To derive treatment ... ...

    Abstract Purpose: Precision oncology holds the promise of improving patient outcome. It is based on the idea that the testing of genomic biomarkers can lead to the recommendation of a treatment option tailored to the specific patient. To derive treatment recommendations from molecular profiles, interdisciplinary molecular tumor boards (MTBs) have been established recently in many academic institutions. The recommendation process in MTBs, however, has not been well defined, which limits applicability to larger clinical trials and patient populations.
    Methods: We created four fictional patients on the basis of recent real cases with genomic information on mutations, fusions, copy numbers, and gene expression. We identified 29 tumor boards from nine countries worldwide and asked them to provide treatment recommendations for the sample patients. In addition, a questionnaire regarding the setup and methods used by MTBs was circulated.
    Results: Five MTBs from four countries provided treatment recommendations and answered the questionnaire. For one patient, three tumor board treatment recommendations were identical, and two tumor boards had identical treatment strategies for the other three patients. There was heterogeneity in the interpretation of tumor and germline aberrations as well as in standards of prioritization.
    Conclusion: Differences in the interpretation and recommendation process contribute to heterogeneity in MTB recommendations. Additional comparative analyses of recommendations could help improve rational decision making and lead to standardization.
    Language English
    Publishing date 2022-01-27
    Publishing country United States
    Document type Journal Article
    ISSN 2473-4284
    ISSN (online) 2473-4284
    DOI 10.1200/PO.18.00098
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: A High-Fidelity Human Patient Simulation Initiative to Enhance Communication and Teamwork Among a Maternity Care Team.

    Meeker, Katy / Brown, Susan K / Lamping, Michele / Moyer, Michael R / Dienger, M Joyce

    Nursing for women's health

    2018  Volume 22, Issue 6, Page(s) 454–462

    Abstract: Objective: To use high-fidelity human patient simulation to enhance teamwork and communication during maternity care emergencies.: Design: Quality improvement initiative.: Setting/local problem: The labor and delivery team at a large suburban ... ...

    Abstract Objective: To use high-fidelity human patient simulation to enhance teamwork and communication during maternity care emergencies.
    Design: Quality improvement initiative.
    Setting/local problem: The labor and delivery team at a large suburban Level 2 facility in the Midwestern United States sought to apply evidence and use simulation to improve communication and teamwork.
    Participants: Approximately 170 maternity care staff members, including nurses, anesthesia providers, and pediatric and obstetric physicians.
    Intervention/measurements: During each simulation, there were two scenarios with a debriefing session at the end of each. Teamwork and communication were evaluated using participant surveys.
    Results: Participants reported improved communication (p = .031) and teamwork (p = .041) after simulation. Additionally, 81% of respondents believed that their ability to perform clinical skills improved.
    Conclusion: Use of high-fidelity human patient simulation was associated with improved teamwork and communication for a maternity care team. Simulation has been incorporated into standard education. We hope to sustain successful outcomes by providing ongoing simulation experiences for labor and delivery staff annually.
    MeSH term(s) Delivery, Obstetric ; Emergencies ; Female ; Humans ; Interdisciplinary Communication ; Interprofessional Relations ; Patient Care Team/organization & administration ; Patient Simulation ; Pregnancy ; Program Evaluation ; Quality Improvement
    Language English
    Publishing date 2018-10-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2275619-X
    ISSN 1751-486X ; 1751-4851
    ISSN (online) 1751-486X
    ISSN 1751-4851
    DOI 10.1016/j.nwh.2018.10.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Conference proceedings: Fallbericht zur Behandlung eines NSCLC Patienten und aktivierender p.G469A BRAF-Mutation mit Dabrafenib und Trametinib

    Olive, E / Grohé, C / Sänger, K / Lamping, M / Leyvraz, S / Ochsenreither, S / Keilholz, U / Tessmer, A

    Pneumologie

    2018  Volume 72, Issue S 01

    Event/congress 59. Kongress der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin e.V., Dresden, 2018-03-14
    Language German
    Publishing date 2018-02-21
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 607630-0
    ISSN 1438-8790 ; 0934-8387
    ISSN (online) 1438-8790
    ISSN 0934-8387
    DOI 10.1055/s-0037-1619263
    Database Thieme publisher's database

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  10. Article ; Online: Feasibility and outcome of reproducible clinical interpretation of high-dimensional molecular data: a comparison of two molecular tumor boards.

    Rieke, Damian T / de Bortoli, Till / Horak, Peter / Lamping, Mario / Benary, Manuela / Jelas, Ivan / Rüter, Gina / Berger, Johannes / Zettwitz, Marit / Kagelmann, Niklas / Kind, Andreas / Fabian, Falk / Beule, Dieter / Glimm, Hanno / Brors, Benedikt / Stenzinger, Albrecht / Fröhling, Stefan / Keilholz, Ulrich

    BMC medicine

    2022  Volume 20, Issue 1, Page(s) 367

    Abstract: Background: Structured and harmonized implementation of molecular tumor boards (MTB) for the clinical interpretation of molecular data presents a current challenge for precision oncology. Heterogeneity in the interpretation of molecular data was shown ... ...

    Abstract Background: Structured and harmonized implementation of molecular tumor boards (MTB) for the clinical interpretation of molecular data presents a current challenge for precision oncology. Heterogeneity in the interpretation of molecular data was shown for patients even with a limited number of molecular alterations. Integration of high-dimensional molecular data, including RNA- (RNA-Seq) and whole-exome sequencing (WES), is expected to further complicate clinical application. To analyze challenges for MTB harmonization based on complex molecular datasets, we retrospectively compared clinical interpretation of WES and RNA-Seq data by two independent molecular tumor boards.
    Methods: High-dimensional molecular cancer profiling including WES and RNA-Seq was performed for patients with advanced solid tumors, no available standard therapy, ECOG performance status of 0-1, and available fresh-frozen tissue within the DKTK-MASTER Program from 2016 to 2018. Identical molecular profiling data of 40 patients were independently discussed by two molecular tumor boards (MTB) after prior annotation by specialized physicians, following independent, but similar workflows. Identified biomarkers and resulting treatment options were compared between the MTBs and patients were followed up clinically.
    Results: A median of 309 molecular aberrations from WES and RNA-Seq (n = 38) and 82 molecular aberrations from WES only (n = 3) were considered for clinical interpretation for 40 patients (one patient sequenced twice). A median of 3 and 2 targeted treatment options were identified per patient, respectively. Most treatment options were identified for receptor tyrosine kinase, PARP, and mTOR inhibitors, as well as immunotherapy. The mean overlap coefficient between both MTB was 66%. Highest agreement rates were observed with the interpretation of single nucleotide variants, clinical evidence levels 1 and 2, and monotherapy whereas the interpretation of gene expression changes, preclinical evidence levels 3 and 4, and combination therapy yielded lower agreement rates. Patients receiving treatment following concordant MTB recommendations had significantly longer overall survival than patients receiving treatment following discrepant recommendations or physician's choice.
    Conclusions: Reproducible clinical interpretation of high-dimensional molecular data is feasible and agreement rates are encouraging, when compared to previous reports. The interpretation of molecular aberrations beyond single nucleotide variants and preclinically validated biomarkers as well as combination therapies were identified as additional difficulties for ongoing harmonization efforts.
    MeSH term(s) Humans ; High-Throughput Nucleotide Sequencing/methods ; Neoplasms/diagnosis ; Neoplasms/genetics ; Neoplasms/therapy ; Precision Medicine/methods ; Feasibility Studies ; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use ; Retrospective Studies ; RNA ; Protein-Tyrosine Kinases ; Nucleotides/therapeutic use
    Chemical Substances Poly(ADP-ribose) Polymerase Inhibitors ; RNA (63231-63-0) ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; Nucleotides
    Language English
    Publishing date 2022-10-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2131669-7
    ISSN 1741-7015 ; 1741-7015
    ISSN (online) 1741-7015
    ISSN 1741-7015
    DOI 10.1186/s12916-022-02560-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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