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  1. Article ; Online: Erratum: Directional Bistability and Nonreciprocal Lasing with Cold Atoms in a Ring Cavity [Phys. Rev. Lett. 121, 163603 (2018)].

    Megyeri, B / Harvie, G / Lampis, A / Goldwin, J

    Physical review letters

    2019  Volume 123, Issue 15, Page(s) 159901

    Abstract: This corrects the article DOI: 10.1103/PhysRevLett.121.163603. ...

    Abstract This corrects the article DOI: 10.1103/PhysRevLett.121.163603.
    Language English
    Publishing date 2019-11-18
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.123.159901
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  2. Book ; Online: Bridging the Gap

    Lampis, Andrea / Lomurno, Eugenio / Matteucci, Matteo

    Enhancing the Utility of Synthetic Data via Post-Processing Techniques

    2023  

    Abstract: Acquiring and annotating suitable datasets for training deep learning models is challenging. This often results in tedious and time-consuming efforts that can hinder research progress. However, generative models have emerged as a promising solution for ... ...

    Abstract Acquiring and annotating suitable datasets for training deep learning models is challenging. This often results in tedious and time-consuming efforts that can hinder research progress. However, generative models have emerged as a promising solution for generating synthetic datasets that can replace or augment real-world data. Despite this, the effectiveness of synthetic data is limited by their inability to fully capture the complexity and diversity of real-world data. To address this issue, we explore the use of Generative Adversarial Networks to generate synthetic datasets for training classifiers that are subsequently evaluated on real-world images. To improve the quality and diversity of the synthetic dataset, we propose three novel post-processing techniques: Dynamic Sample Filtering, Dynamic Dataset Recycle, and Expansion Trick. In addition, we introduce a pipeline called Gap Filler (GaFi), which applies these techniques in an optimal and coordinated manner to maximise classification accuracy on real-world data. Our experiments show that GaFi effectively reduces the gap with real-accuracy scores to an error of 2.03%, 1.78%, and 3.99% on the Fashion-MNIST, CIFAR-10, and CIFAR-100 datasets, respectively. These results represent a new state of the art in Classification Accuracy Score and highlight the effectiveness of post-processing techniques in improving the quality of synthetic datasets.
    Keywords Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Artificial Intelligence ; Computer Science - Machine Learning
    Subject code 006
    Publishing date 2023-05-17
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Directional Bistability and Nonreciprocal Lasing with Cold Atoms in a Ring Cavity.

    Megyeri, B / Harvie, G / Lampis, A / Goldwin, J

    Physical review letters

    2018  Volume 121, Issue 16, Page(s) 163603

    Abstract: We demonstrate lasing into counterpropagating modes of a ring cavity using a gas of cold atoms as a gain medium. The laser operates under the usual conditions of magneto-optical trapping with no additional fields. We characterize the threshold behavior ... ...

    Abstract We demonstrate lasing into counterpropagating modes of a ring cavity using a gas of cold atoms as a gain medium. The laser operates under the usual conditions of magneto-optical trapping with no additional fields. We characterize the threshold behavior of the laser and measure the second-order optical coherence. The laser emission exhibits directional bistability, switching randomly between clockwise and counterclockwise modes, and a tunable nonreciprocity is observed as the atoms are displaced along the cavity axis.
    Language English
    Publishing date 2018-12-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.121.163603
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  4. Article ; Online: Vault RNAs: hidden gems in RNA and protein regulation.

    Hahne, Jens Claus / Lampis, Andrea / Valeri, Nicola

    Cellular and molecular life sciences : CMLS

    2020  Volume 78, Issue 4, Page(s) 1487–1499

    Abstract: Non-coding RNAs are important regulators of differentiation during embryogenesis as well as key players in the fine-tuning of transcription and furthermore, they control the post-transcriptional regulation of mRNAs under physiological conditions. ... ...

    Abstract Non-coding RNAs are important regulators of differentiation during embryogenesis as well as key players in the fine-tuning of transcription and furthermore, they control the post-transcriptional regulation of mRNAs under physiological conditions. Deregulated expression of non-coding RNAs is often identified as one major contribution in a number of pathological conditions. Non-coding RNAs are a heterogenous group of RNAs and they represent the majority of nuclear transcripts in eukaryotes. An evolutionary highly conserved sub-group of non-coding RNAs is represented by vault RNAs, named since firstly discovered as component of the largest known ribonucleoprotein complexes called "vault". Although they have been initially described 30 years ago, vault RNAs are largely unknown and their molecular role is still under investigation. In this review we will summarize the known functions of vault RNAs and their involvement in cellular mechanisms.
    MeSH term(s) Cell Differentiation/genetics ; Eukaryota/genetics ; Gene Expression Regulation/genetics ; Humans ; Proteins/genetics ; RNA/classification ; RNA/genetics ; RNA, Messenger/genetics ; RNA, Untranslated/genetics ; Transcription Factors/genetics
    Chemical Substances Proteins ; RNA, Messenger ; RNA, Untranslated ; Transcription Factors ; RNA (63231-63-0)
    Language English
    Publishing date 2020-10-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-020-03675-9
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    Zs.A 195: Show issues Location:
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  5. Article ; Online: MicroRNAs as mediators of drug resistance mechanisms.

    Lampis, Andrea / Hahne, Jens C / Hedayat, Somaieh / Valeri, Nicola

    Current opinion in pharmacology

    2020  Volume 54, Page(s) 44–50

    Abstract: MicroRNAs are small RNA transcripts involved in fine-tuning of several cellular mechanisms and pathways crucial for maintaining cells' homeostasis like apoptosis, differentiation, inflammation and cell-cycle regulation. They act by regulation of gene ... ...

    Abstract MicroRNAs are small RNA transcripts involved in fine-tuning of several cellular mechanisms and pathways crucial for maintaining cells' homeostasis like apoptosis, differentiation, inflammation and cell-cycle regulation. They act by regulation of gene expression at post-transcriptional level through fine-tuning of target proteins expression. Expression of microRNAs is cell-type specific and since their discovery they have been proven to be deregulated in various disorders including cancer. Several lines of evidence are emerging that link microRNAs to drug resistance mechanisms in tumours given their important role in modulating oncogenic and tumour suppressive mechanisms. This review will focus on latest knowledge of the roles and mechanisms of microRNAs as mediators to drug resistance and the implications for future therapies.
    MeSH term(s) Animals ; Apoptosis ; Cell Cycle ; Drug Resistance, Multiple/genetics ; Drug Resistance, Neoplasm/genetics ; Epithelial-Mesenchymal Transition ; Humans ; MicroRNAs ; Neoplasms/drug therapy ; Neoplasms/genetics ; Neoplastic Stem Cells
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2020-09-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2037057-X
    ISSN 1471-4973 ; 1471-4892
    ISSN (online) 1471-4973
    ISSN 1471-4892
    DOI 10.1016/j.coph.2020.08.004
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  6. Article ; Online: Italian state museums during the COVID-19 crisis

    Agostino, Deborah / Arnaboldi, Michela / Lampis, Antonio

    Museum Management and Curatorship

    from onsite closure to online openness

    2020  Volume 35, Issue 4, Page(s) 362–372

    Keywords Tourism, Leisure and Hospitality Management ; Business and International Management ; Visual Arts and Performing Arts ; covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ISSN 0964-7775
    DOI 10.1080/09647775.2020.1790029
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Italian state museums during the COVID-19 crisis: from onsite closure to online openness

    Agostino, Deborah / Arnaboldi, Michela / Lampis, Antonio

    Museum Manage. Curatorship

    Abstract: This study investigates the reaction of Italian state museums to the closure of their physical sites caused by the COVID-19 pandemic, taking the perspective of their online activity on social media. The study explores the type and amount of content ... ...

    Abstract This study investigates the reaction of Italian state museums to the closure of their physical sites caused by the COVID-19 pandemic, taking the perspective of their online activity on social media. The study explores the type and amount of content published by museums on their social media webpages, as well as the level of online engagement that is generated by their activity. Empirically, this study investigated the 100 largest Italian state museums, showing that, during the weeks of lockdown, their cultural initiatives did not come to a stop but, on the contrary, there has been a sharp rise in online cultural material and initiatives taking place through social media, with museums doubling their online activity. This online evidence has stimulated further reflections on the future direction of digitally enabled approaches to culture and its enjoyment.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #669610
    Database COVID19

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  8. Article ; Online: Truncation of the constant domain drives amyloid formation by immunoglobulin light chains.

    Lavatelli, Francesca / Natalello, Antonino / Marchese, Loredana / Ami, Diletta / Corazza, Alessandra / Raimondi, Sara / Mimmi, Maria Chiara / Malinverni, Silvia / Mangione, P Patrizia / Palmer, Manel Terrones / Lampis, Alessio / Concardi, Monica / Verona, Guglielmo / Canetti, Diana / Arbustini, Eloisa / Bellotti, Vittorio / Giorgetti, Sofia

    The Journal of biological chemistry

    2024  Volume 300, Issue 4, Page(s) 107174

    Abstract: AL amyloidosis is a life-threatening disease caused by deposition of immunoglobulin light chains. While the mechanisms underlying light chains amyloidogenesis in vivo remain unclear, several studies have highlighted the role that tissue environment and ... ...

    Abstract AL amyloidosis is a life-threatening disease caused by deposition of immunoglobulin light chains. While the mechanisms underlying light chains amyloidogenesis in vivo remain unclear, several studies have highlighted the role that tissue environment and structural amyloidogenicity of individual light chains have in the disease pathogenesis. AL natural deposits contain both full-length light chains and fragments encompassing the variable domain (V
    MeSH term(s) Amyloid/metabolism ; Amyloid/chemistry ; Humans ; Immunoglobulin Light Chains/metabolism ; Immunoglobulin Light Chains/chemistry ; Immunoglobulin Light Chains/genetics ; Molecular Dynamics Simulation ; Immunoglobulin Constant Regions/metabolism ; Immunoglobulin Constant Regions/genetics ; Immunoglobulin Constant Regions/chemistry ; Immunoglobulin Light-chain Amyloidosis/metabolism ; Immunoglobulin Light-chain Amyloidosis/pathology ; Kinetics ; Protein Domains
    Chemical Substances Amyloid ; Immunoglobulin Light Chains ; Immunoglobulin Constant Regions
    Language English
    Publishing date 2024-03-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2024.107174
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  9. Article ; Online: Challenges and perspectives for immunotherapy in oesophageal cancer: A look to the future (Review).

    Lampis, Andrea / Ratti, Margherita / Ghidini, Michele / Mirchev, Milko B / Okuducu, Ali Fuat / Valeri, Nicola / Hahne, Jens Claus

    International journal of molecular medicine

    2021  Volume 47, Issue 6

    Abstract: Oesophageal cancer is one of the most aggressive malignancies with limited treatment options, thus resulting in a high morbidity and mortality. With 5‑year survival rates of only 5‑10%, oesophageal cancer holds a dismal prognosis for patients. In order ... ...

    Abstract Oesophageal cancer is one of the most aggressive malignancies with limited treatment options, thus resulting in a high morbidity and mortality. With 5‑year survival rates of only 5‑10%, oesophageal cancer holds a dismal prognosis for patients. In order to improve overall survival, the early diagnosis and tools for patient stratification for personalized treatment are urgent needs. A minority of oesophageal cancers belong to the spectrum of Lynch syndrome‑associated cancers and are characterized by microsatellite instability (MSI). Microsatellite instability is a consequence of defective mismatch repair protein functions and it has been well characterized in other gastrointestinal tumours, such as colorectal and gastric cancer. In the latter, high levels of MSI are associated with a better prognosis and with an increased benefit to immune‑based therapies. Therefore, similar therapeutic approaches could offer an opportunity of treatment for oesophageal cancer patients with MSI. Apart from immune checkpoint inhibitors, other immunotherapies such as adoptive T‑cell transfer, peptide vaccine and oncolytic viruses are under investigation in oesophageal cancer patients. In the present review, the rationale and current knowledge about immunotherapies in oesophageal cancer are summarised.
    MeSH term(s) Animals ; Cancer Vaccines/therapeutic use ; Esophageal Neoplasms/immunology ; Esophageal Neoplasms/therapy ; Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Immunotherapy/methods ; Oncolytic Virotherapy/methods
    Chemical Substances Cancer Vaccines ; Immune Checkpoint Inhibitors
    Language English
    Publishing date 2021-04-13
    Publishing country Greece
    Document type Journal Article ; Review
    ZDB-ID 1444428-8
    ISSN 1791-244X ; 1107-3756
    ISSN (online) 1791-244X
    ISSN 1107-3756
    DOI 10.3892/ijmm.2021.4930
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    Zs.A 4942: Show issues Location:
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  10. Article ; Online: NTRK fusions in colorectal cancer: clinical meaning and future perspective.

    Ratti, Margherita / Grizzi, Giulia / Passalacqua, Rodolfo / Lampis, Andrea / Cereatti, Fabrizio / Grassia, Roberto / Hahne, Jens Claus

    Expert opinion on therapeutic targets

    2021  Volume 25, Issue 8, Page(s) 677–683

    Abstract: Introduction: Despite the efforts of the scientific community, the prognosis of metastatic colorectal cancer (mCRC) remains poor. Actionable gene fusions such as Neurotrophic Tropomyosin Receptor Kinases : Areas covered: This review aims to report ... ...

    Abstract Introduction: Despite the efforts of the scientific community, the prognosis of metastatic colorectal cancer (mCRC) remains poor. Actionable gene fusions such as Neurotrophic Tropomyosin Receptor Kinases
    Areas covered: This review aims to report the current knowledge and the available evidence on
    Expert opinion: Considering the limited options associated with the treatment of mCRC patients, the possibility of identifying new molecular biomarkers is an urgent clinical need. The availability of new molecular targets and the combinations of different agents might represent the true breakthrough point, allowing for change in the clinical course of colorectal cancer patients.
    MeSH term(s) Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Gene Fusion ; Humans ; Neoplasms/pathology ; Oncogene Proteins, Fusion/genetics ; Protein Kinase Inhibitors/pharmacology
    Chemical Substances Oncogene Proteins, Fusion ; Protein Kinase Inhibitors
    Language English
    Publishing date 2021-09-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2055208-7
    ISSN 1744-7631 ; 1472-8222
    ISSN (online) 1744-7631
    ISSN 1472-8222
    DOI 10.1080/14728222.2021.1978070
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