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  1. Article ; Online: Esketamine Nasal Spray versus Quetiapine for Resistant Depression.

    Lan, Chiao-Hsin / Wei, James C-C

    The New England journal of medicine

    2024  Volume 390, Issue 1, Page(s) 93–94

    MeSH term(s) Humans ; Quetiapine Fumarate/therapeutic use ; Nasal Sprays ; Depression/drug therapy ; Antidepressive Agents/therapeutic use
    Chemical Substances Quetiapine Fumarate (2S3PL1B6UJ) ; Nasal Sprays ; Esketamine (50LFG02TXD) ; Antidepressive Agents
    Language English
    Publishing date 2024-01-01
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2313230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Effects of intravascular photobiomodulation on motor deficits and brain perfusion images in intractable myasthenia gravis: A case report.

    Lan, Chiao-Hsin / Wu, Yu-Che / Chiang, Cheng-Chun / Chang, Shin-Tsu

    World journal of clinical cases

    2022  Volume 10, Issue 24, Page(s) 8718–8727

    Abstract: Background: Myasthenia gravis (MG) is an autoimmune disorder caused by neuromuscular junction failure characterized by muscle weakness and fatigability. We herein report a case of MG that received intravascular laser irradiation of blood (ILIB) ... ...

    Abstract Background: Myasthenia gravis (MG) is an autoimmune disorder caused by neuromuscular junction failure characterized by muscle weakness and fatigability. We herein report a case of MG that received intravascular laser irradiation of blood (ILIB) interventions and regained muscle power and better quality of life. To our knowledge, no previous study has investigated the benefits of ILIB treatment on patients with MG. We also evaluated the changes in brain perfusion scan and the MG activities of daily living (MG-ADL) and quantitative MG (QMG) scales.
    Case summary: A 59-year-old man presented to our outpatient hospital experiencing ptosis, diplopia, fibromyalgia, muscle fatigue, and fluctuating weakness in his limbs for 1 year. Based on his history, physical examination, and laboratory investigations, the final diagnosis was a flare-up of MG with poor endurance and muscle fatigue. The patient agreed to receive ILIB. Brain single-photon emission computed tomography (SPECT) was performed both before and after ILIB therapy. After receiving three courses of ILIB, the brain SPECT images showed greatly increased perfusion of the frontal lobe and anterior cingulate gyri. The patient's MG-ADL scale score decreased markedly from 17/24 to 3/24. The QMG scale score also decreased remarkably from 32/39 to 9/39. The symptoms of MG became barely detectable and the patient was able to perform his activities of daily living and regain muscle power.
    Conclusion: ILIB might have beneficial effects on MG, and brain SPECT images provided direct evidence of a positive correlation between ILIB and clinical performance.
    Language English
    Publishing date 2022-09-17
    Publishing country United States
    Document type Case Reports
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v10.i24.8718
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Exploring CNS Involvement in Pain Insensitivity in Hereditary Sensory and Autonomic Neuropathy Type 4: Insights from Tc-99m ECD SPECT Imaging.

    Chiang, Cheng-Chun / Wu, Yu-Che / Lan, Chiao-Hsin / Wang, Kuan-Chieh / Tang, Hsuan-Ching / Chang, Shin-Tsu

    Tomography (Ann Arbor, Mich.)

    2023  Volume 9, Issue 6, Page(s) 2261–2269

    Abstract: Hereditary sensory and autonomic neuropathy type 4 (HSAN4), also known as congenital insensitivity to pain with anhidrosis (CIPA), is a rare genetic disorder caused by NTRK1 gene mutations, affecting nerve growth factor signaling. This study investigates ...

    Abstract Hereditary sensory and autonomic neuropathy type 4 (HSAN4), also known as congenital insensitivity to pain with anhidrosis (CIPA), is a rare genetic disorder caused by NTRK1 gene mutations, affecting nerve growth factor signaling. This study investigates the central nervous system's (CNS) involvement and its relation to pain insensitivity in HSAN4. We present a 15-year-old girl with HSAN4, displaying clinical signs suggestive of CNS impact, including spasticity and a positive Babinski's sign. Using Technetium-99m ethyl cysteinate dimer single-photon emission computed tomography (Tc-99m ECD SPECT) imaging, we discovered perfusion deficits in key brain regions, notably the cerebellum, thalamus, and postcentral gyrus. These regions process pain signals, providing insights into HSAN4's pain insensitivity. This study represents the first visualization of CNS perfusion abnormality in an HSAN4 patient. It highlights the intricate relationship between the peripheral and central nervous systems in HSAN4. The complexity of HSAN4 diagnosis, involving potential unidentified genes, underscores the need for continued research to refine diagnostic approaches and develop comprehensive treatments.
    MeSH term(s) Female ; Humans ; Adolescent ; Organotechnetium Compounds ; Tomography, Emission-Computed, Single-Photon ; Hereditary Sensory and Autonomic Neuropathies/diagnostic imaging ; Hereditary Sensory and Autonomic Neuropathies/genetics ; Pain/diagnostic imaging ; Pain/etiology
    Chemical Substances technetium Tc 99m bicisate (H25WJA31XE) ; Organotechnetium Compounds
    Language English
    Publishing date 2023-12-18
    Publishing country Switzerland
    Document type Case Reports
    ISSN 2379-139X
    ISSN (online) 2379-139X
    DOI 10.3390/tomography9060175
    Database MEDical Literature Analysis and Retrieval System OnLINE

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