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  1. AU="Lan, Li"
  2. AU="De Panfilis, Simone"
  3. AU="Barnestein, R"
  4. AU="Grafton, R. Quentin"
  5. AU="Lee, Cin-Ty Aeolus"
  6. AU="Tahmasbi, Fateme"
  7. AU="Marmolejo-Ramos, Fernando"
  8. AU="Michel, Christoph M"
  9. AU="Drury, Ashleigh"
  10. AU="Besson, François"
  11. AU="Lee, Seong-Min"
  12. AU=Fath Mohsen Karami AU=Fath Mohsen Karami
  13. AU="Isabel, P."
  14. AU="Melniker, Larry"
  15. AU="Wagner, Marlies"
  16. AU="Karina A. Dow"
  17. AU="Prieto, A. Fernández"
  18. AU=Arnaout Omar AU=Arnaout Omar
  19. AU="Holden, Joseph M."
  20. AU="Balcells, Ll"
  21. AU="Ho, Raymond W"
  22. AU="Richardson, Marcy"
  23. AU="Stephanie Fischinger"
  24. AU="Wilkinson, Michelle J"

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  1. Artikel ; Online: Cytoophidia Influence Cell Cycle and Size in Schizosaccharomyces pombe

    Ruolan Deng / Yi-Lan Li / Ji-Long Liu

    International Journal of Molecular Sciences, Vol 25, Iss 1, p

    2024  Band 608

    Abstract: Cytidine triphosphate synthase (CTPS) forms cytoophidia in all three domains of life. Here we focus on the function of cytoophidia in cell proliferation using Schizosaccharomyces pombe as a model system. We find that converting His 359 of CTPS into Ala ... ...

    Abstract Cytidine triphosphate synthase (CTPS) forms cytoophidia in all three domains of life. Here we focus on the function of cytoophidia in cell proliferation using Schizosaccharomyces pombe as a model system. We find that converting His 359 of CTPS into Ala 359 leads to cytoophidium disassembly. By reducing the level of CTPS protein or specific mutation, the loss of cytoophidia prolongs the G2 phase and expands cell size. In addition, the loss-filament mutant of CTPS leads to a decrease in the expression of genes related to G2/M transition and cell growth, including histone chaperone slm9 . The overexpression of slm9 alleviates the G2 phase elongation and cell size enlargement induced by CTPS loss-filament mutants. Overall, our results connect cytoophidia with cell cycle and cell size control in Schizosaccharomyces pombe .
    Schlagwörter cell cycle ; cell size ; CTP synthase ; cytoophidium ; G2 phase ; Schizosaccharomyces pombe ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Thema/Rubrik (Code) 612
    Sprache Englisch
    Erscheinungsdatum 2024-01-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
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  2. Artikel ; Online: Inferring Land Conditions in the Tumen River Basin by Trend Analysis Based on Satellite Imagery and Geoinformation

    Hangnan Yu / Lan Li

    Sustainability, Vol 14, Iss 5687, p

    2022  Band 5687

    Abstract: The aim of this study was to map the land condition within the area of the Tumen River Basin (TRB), located on the Sino–North Korean border, using trend analysis of environmental factors. The normalized difference vegetation index (NDVI) and land surface ...

    Abstract The aim of this study was to map the land condition within the area of the Tumen River Basin (TRB), located on the Sino–North Korean border, using trend analysis of environmental factors. The normalized difference vegetation index (NDVI) and land surface temperature (LST) trends over the past 30 years were analyzed to identify areas that have undergone degradation, restoration, and/or a transition. Landsat NDVI and LST were obtained using the Google Earth Engine (GEE) platform. Erosion was also gauged over the same period using the Revised Universal Soil Loss Equation (RUSLE). Our results showed that only 0.3% of the land within the TRB underwent change that can be characterized as statistically significant within the study period. We therefore infer that land degradation may not be a major concern in the study area. Areas with a significant upward trend of soil loss accounted for 0.8% of the basin’s footprint and were mainly distributed upstream of North Korea. However, more than 80% of the area was found to be suffering from water stress, 10% of these areas were statistically significant and most were located downstream.
    Schlagwörter land conditions ; Google Earth Engine ; Tumen River Basin ; Landsat ; trend analysis ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 550
    Sprache Englisch
    Erscheinungsdatum 2022-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Effects of acute exposure to hypoxia on sleep structure in healthy adults: A systematic review.

    Guo, Chao / Lan, Li / Yan, Yan / Kang, Mengyuan

    Sleep medicine reviews

    2024  Band 75, Seite(n) 101928

    Abstract: The sleep quality of lowlanders in hypoxic environments has become increasingly important with an increase in highland and alpine activities. This study aimed to identify the effects of acute exposure to hypoxia on the sleep structure of lowlanders and ... ...

    Abstract The sleep quality of lowlanders in hypoxic environments has become increasingly important with an increase in highland and alpine activities. This study aimed to identify the effects of acute exposure to hypoxia on the sleep structure of lowlanders and to analyze the changes in sleep indicators at varying levels of hypoxia. This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Twenty-three studies were screened and included in the quantitative analysis. The results showed that acute exposure to hypoxia reduced sleep quality in lowlanders. Post-sleep arousal events and the percentage of N1 were significantly increased, whereas total sleep time, sleep efficiency, and the percentage of N3 and rapid eye movement sleep were significantly decreased in hypoxic environments. Acute exposure to hypoxia had the greatest negative impact on wakefulness after sleep onset (WASO). In addition, a larger decrease in sleep efficiency and higher increase in the percentages of N1 and WASO were observed when lowlanders were exposed to higher levels of hypoxia. This study clarifies the quantitative effects of acute hypoxic exposure on sleep in lowlanders based on original studies and explains the sleep disorders faced by lowlanders in hypoxic environments.
    Sprache Englisch
    Erscheinungsdatum 2024-04-01
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1414211-9
    ISSN 1532-2955 ; 1087-0792
    ISSN (online) 1532-2955
    ISSN 1087-0792
    DOI 10.1016/j.smrv.2024.101928
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  4. Artikel ; Online: Eradicate first, or treat peptic ulcer disease?

    Xinjue He / Lan Li / Chao Lu

    SAGE Open Medicine, Vol

    2023  Band 11

    Abstract: Background: Helicobacter pylori infection is very common worldwide, and about 10%–16% of these patients develop peptic ulcer disease. However, there is limited research on the impact of H. pylori eradication and peptic ulcer disease treatment sequencing. ...

    Abstract Background: Helicobacter pylori infection is very common worldwide, and about 10%–16% of these patients develop peptic ulcer disease. However, there is limited research on the impact of H. pylori eradication and peptic ulcer disease treatment sequencing. Methods: We conducted a retrospective study of adult patients diagnosed with H. pylori infection and peptic ulcer disease between October 2020 and April 2021 at our center. Data on primary treatment outcomes, including H. pylori eradication and peptic ulcer disease healing, were collected, and factors that may influence treatment outcomes were analyzed. Results: A total of 306 patients were included in this study. The sequence of H. pylori eradication and peptic ulcer disease treatment did not significantly affect the outcomes of H. pylori eradication and peptic ulcer disease healing. In addition, patient age, peptic ulcer disease type, clinic type and treatment regimen (including choice of proton pump inhibitor) had no significant impact on H. pylori eradication. However, patient gender and the choice of antibiotic combination proved to be key factors, as eradication rates were lower in female patients compared to males, and the combination of levofloxacin and clarithromycin was the least effective in eradicating H. pylori . Regarding peptic ulcer disease healing, the peptic ulcer disease type was an important influencing factor, since gastric ulcers being more likely to get cured completely compared to duodenal ulcers. Conclusions: The sequence of H. pylori eradication and peptic ulcer disease treatment does not significantly affect the primary outcomes. Patient gender and the choice of antibiotic combination are important factors in H. pylori eradication, whereas peptic ulcer disease type plays a key role in ulcer healing.
    Schlagwörter Medicine (General) ; R5-920
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-12-01T00:00:00Z
    Verlag SAGE Publishing
    Dokumenttyp Artikel ; Online
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  5. Artikel ; Online: Immunostaining and Protein Pull-Down of Methyl-5-Cytosine-Marked RNA:DNA Hybrids.

    Yang, Haibo / Lan, Li

    Methods in molecular biology (Clifton, N.J.)

    2022  Band 2528, Seite(n) 271–276

    Abstract: RNA:DNA hybrids not only function in various physiological cellular processes but also represent a threat to genome integrity. The methyl-5-cytosine ( ... ...

    Abstract RNA:DNA hybrids not only function in various physiological cellular processes but also represent a threat to genome integrity. The methyl-5-cytosine (m
    Mesh-Begriff(e) Cytosine ; DNA/genetics ; RNA/genetics
    Chemische Substanzen RNA (63231-63-0) ; Cytosine (8J337D1HZY) ; DNA (9007-49-2)
    Sprache Englisch
    Erscheinungsdatum 2022-06-15
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2477-7_17
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  6. Artikel ; Online: Detection of miRNAs contents in cerebrospinal fluid and serum of patients with epilepsy and their regulating effect on related cytokines

    Lan Li

    Journal of Hainan Medical University, Vol 22, Iss 6, Pp 101-

    2016  Band 104

    Abstract: Objective: To study the contents of miRNAs in cerebrospinal fluid and serum of patients with epilepsy and their regulating effect on related cytokines. Methods: Serum and cerebrospinal fluid of epilepsy group and non-epilepsy group were collected to ... ...

    Abstract Objective: To study the contents of miRNAs in cerebrospinal fluid and serum of patients with epilepsy and their regulating effect on related cytokines. Methods: Serum and cerebrospinal fluid of epilepsy group and non-epilepsy group were collected to detect the contents of miR- 146a, miR-221, miR-222, miR-21 and miR-34a as well as inflammatory factors and apoptosis molecules. Results: miR-146a, miR-221, miR-222 and miR-21 contents in cerebrospinal fluid of epilepsy group were significantly lower than those of non-epilepsy group, and miR-34a content was higher than that of non-epilepsy group; miR-146a, miR-221, miR-222 and miR- 21 contents in serum were significantly higher than those of non-epilepsy group, and miR-34a content was lower than that of non-epilepsy group; TNF-α, IL-2, IL-6 and ICAM-1 contents in cerebrospinal fluid of epilepsy group were higher than those of non-epilepsy group and negatively correlated with miR-146a, miR-221 and miR-222 contents; Bax, Bim, Caspase-3 and Caspase-9 contents in cerebrospinal fluid of epilepsy group were higher than those of nonepilepsy group and negatively correlated with miR-21, and Bcl-2 content was lower than that of non-epilepsy group and negatively correlated with miR-34a. Conclusion: miR-146a, miR- 221, miR-222 and miR-21 contents decrease while miR-34a content increases in cerebrospinal fluid of patients with epilepsy, and miRNAs can regulate the expression of inflammatory factors and apoptosis molecules and be involved in the changes of neuron function.
    Schlagwörter Epilepsy ; microRNA ; Inflammatory factors ; Apoptosis ; Medicine ; R
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2016-03-01T00:00:00Z
    Verlag Editorial Board of Journal of Hainan Medical University
    Dokumenttyp Artikel ; Online
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  7. Artikel ; Online: Indoor thermal comfort research using human participants: Guidelines and a checklist for experimental design

    Lei, Tze-Huan / Lan, Li / Wang, Faming

    Journal of Thermal Biology. 2023 Apr., v. 113 p.103506-

    2023  

    Abstract: Thermal comfort dictates our alliesthesia and behavioural responses in indoor environments with the primary aim of maintaining the thermal homeostasis of our human body. The recent advances in neurophysiology research have suggested that thermal comfort ... ...

    Abstract Thermal comfort dictates our alliesthesia and behavioural responses in indoor environments with the primary aim of maintaining the thermal homeostasis of our human body. The recent advances in neurophysiology research have suggested that thermal comfort is a physiological response that is regulated by the deviations of both skin and core temperatures. Therefore, when conducting thermal comfort using indoor occupants in an indoor environment, proper experimental design and standardisation should be followed. However, there is no published source that provides an educational guideline on how to properly implement the thermal comfort experiment in an indoor environment using indoor occupants (normal occupational activities and during sleep in a home-based setting). Therefore, the primary purpose of this work is to illustrate how to conduct indoor thermal comfort related experiments using human trials in both normal occupational activities and during sleep in a home-based setting. Furthermore, we hope that the information presented in this article will result in better experimental design when conducting the experiment on thermal comfort using indoor occupants (occupational and home-based environments). Due to this reason, special emphasis will be focused on the experimental design, selection of participants and experimental standardisation. The key summary of this article is that thermal comfort related to indoor occupants in an indoor environment should perform priori sample analysis and follow the proper experimental design and standardisation as outlined in this article.
    Schlagwörter experimental design ; guidelines ; homeostasis ; humans ; physiological response ; sensation ; sleep ; Thermal comfort ; Experimental rigor ; Thermal perceptions ; Sleeping ; Cognitive test ; Productivity
    Sprache Englisch
    Erscheinungsverlauf 2023-04
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel ; Online
    Anmerkung Pre-press version
    ZDB-ID 1498364-3
    ISSN 1879-0992 ; 0306-4565
    ISSN (online) 1879-0992
    ISSN 0306-4565
    DOI 10.1016/j.jtherbio.2023.103506
    Datenquelle NAL Katalog (AGRICOLA)

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  8. Artikel ; Online: Karrikins, redox and plant abiotic stress tolerance

    Pinging Fang / Yannan Hu / Qinwei Guo / Lan Li / Pei Xu

    Plant Stress, Vol 9, Iss , Pp 100185- (2023)

    A focal review

    2023  

    Abstract: Karrikins (KARs) are bioactive butenolide molecules that were initially discovered as germination stimulants in the smoke generated from burned plant materials. The past decades have witnessed the unraveling of KARs as a group of potential plant hormones ...

    Abstract Karrikins (KARs) are bioactive butenolide molecules that were initially discovered as germination stimulants in the smoke generated from burned plant materials. The past decades have witnessed the unraveling of KARs as a group of potential plant hormones that impact various aspects of plant physiology, from regulation of light responses and controlling root morphology, to modulation of secondary metabolism. KARs share a similar structure with strigolactones (SLs), and they activate similar signaling pathways where the interaction of α/β hydrolases with the F-box protein MORE AXILLARY GROWTH 2 (MAX2) is involved. Upon binding with KARs, the α/β hydrolase KAI2 (KARRIKIN INSENSITIVE 2) interacts with MAX2, which in turn activates the downstream signals by promoting the degradation of SMAX1/SMXL2 (SUPPRESSOR OF MAX2 1/SMX1-LIKE). Recent accumulating evidence has proved that KARs act as a protective agent regulating plant adaptation to abiotic stresses, particularly drought, salinity, and extreme temperature; however, these functions have not been widely perceived. This review revisits the knowledge of the characteristics and signals transduction of KARs in plants, with a focus on the interplay of KARs and redox signals in modulating plant tolerance to abiotic stresses. This collection of information is valuable for better understanding plant-environment interactions and will help create stress-tolerant crops and achieve the goal of agricultural and ecological sustainability.
    Schlagwörter Karrikin ; Abiotic stress ; Redox ; Stress tolerance ; Plant ecology ; QK900-989
    Thema/Rubrik (Code) 580
    Sprache Englisch
    Erscheinungsdatum 2023-09-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
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  9. Artikel ; Online: Interactive effects of indoor environmental factors on work performance.

    Shi, Yongxiang / Wu, Jialin / Lan, Li / Lian, Zhiwei

    Ergonomics

    2023  , Seite(n) 1–16

    Abstract: Among a variety of environmental factors, operative temperature, relative humidity and ventilation rate are generally considered to be factors that significantly affect work performance, and the interactions among these three factors were quantitatively ... ...

    Abstract Among a variety of environmental factors, operative temperature, relative humidity and ventilation rate are generally considered to be factors that significantly affect work performance, and the interactions among these three factors were quantitatively studied in this paper. Eighteen participants were recruited to complete the neurobehavioral ability tests in different environments by central composite design, and their performance was analysed by regression fitting and multi-factor coupling analysis. By defining the interval coefficient β, the interaction effects between the factors were calculated quantitatively. The results showed that: for the performance of perception and expression tasks, there was an antagonistic effect between operative temperature and relative humidity (β = 0.50 ∼ 0.82), between operative temperature and ventilation rate (
    Sprache Englisch
    Erscheinungsdatum 2023-08-07
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1920-3
    ISSN 1366-5847 ; 0014-0139
    ISSN (online) 1366-5847
    ISSN 0014-0139
    DOI 10.1080/00140139.2023.2243407
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  10. Artikel: Indoor thermal comfort research using human participants: Guidelines and a checklist for experimental design.

    Lei, Tze-Huan / Lan, Li / Wang, Faming

    Journal of thermal biology

    2023  Band 113, Seite(n) 103506

    Abstract: Thermal comfort dictates our alliesthesia and behavioural responses in indoor environments with the primary aim of maintaining the thermal homeostasis of our human body. The recent advances in neurophysiology research have suggested that thermal comfort ... ...

    Abstract Thermal comfort dictates our alliesthesia and behavioural responses in indoor environments with the primary aim of maintaining the thermal homeostasis of our human body. The recent advances in neurophysiology research have suggested that thermal comfort is a physiological response that is regulated by the deviations of both skin and core temperatures. Therefore, when conducting thermal comfort using indoor occupants in an indoor environment, proper experimental design and standardisation should be followed. However, there is no published source that provides an educational guideline on how to properly implement the thermal comfort experiment in an indoor environment using indoor occupants (normal occupational activities and during sleep in a home-based setting). Therefore, the primary purpose of this work is to illustrate how to conduct indoor thermal comfort related experiments using human trials in both normal occupational activities and during sleep in a home-based setting. Furthermore, we hope that the information presented in this article will result in better experimental design when conducting the experiment on thermal comfort using indoor occupants (occupational and home-based environments). Due to this reason, special emphasis will be focused on the experimental design, selection of participants and experimental standardisation. The key summary of this article is that thermal comfort related to indoor occupants in an indoor environment should perform priori sample analysis and follow the proper experimental design and standardisation as outlined in this article.
    Mesh-Begriff(e) Humans ; Checklist ; Research Design ; Homeostasis ; Temperature
    Sprache Englisch
    Erscheinungsdatum 2023-02-10
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1498364-3
    ISSN 1879-0992 ; 0306-4565
    ISSN (online) 1879-0992
    ISSN 0306-4565
    DOI 10.1016/j.jtherbio.2023.103506
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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