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Article: Morphology and Molecular Phylogeny of the Genus

Liu, Benwen / Lan, Qiumei / Dai, Qingyu / Zhu, Huan / Liu, Guoxiang

2024 Volume 13, Issue 5

Abstract: ... ...

Abstract	Stigeoclonium
Language	English
Publishing date	2024-03-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants13050748
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Article ; Online: Mechanistic complement of autosomal dominant polycystic kidney disease: the role of aquaporins.

Lan, Qiumei / Li, Jie / Zhang, Hanqing / Zhou, Zijun / Fang, Yaxuan / Yang, Bo

Journal of molecular medicine (Berlin, Germany)

2024

Abstract: Autosomal dominant polycystic kidney disease is a genetic kidney disease caused by mutations in the genes PKD1 or PKD2. Its course is characterized by the formation of progressively enlarged cysts in the renal tubules bilaterally. The basic genetic ... ...

Abstract	Autosomal dominant polycystic kidney disease is a genetic kidney disease caused by mutations in the genes PKD1 or PKD2. Its course is characterized by the formation of progressively enlarged cysts in the renal tubules bilaterally. The basic genetic explanation for autosomal dominant polycystic kidney disease is the double-hit theory, and many of its mechanistic issues can be explained by the cilia doctrine. However, the precise molecular mechanisms underpinning this condition's occurrence are still not completely understood. Experimental evidence suggests that aquaporins, a class of transmembrane channel proteins, including aquaporin-1, aquaporin-2, aquaporin-3, and aquaporin-11, are involved in the mechanism of autosomal dominant polycystic kidney disease. Aquaporins are either a potential new target for the treatment of autosomal dominant polycystic kidney disease, and further study into the physiopathological role of aquaporins in autosomal dominant polycystic kidney disease will assist to clarify the disease's pathophysiology and increase the pool of potential treatment options. We primarily cover pertinent findings on aquaporins in autosomal dominant polycystic kidney disease in this review.
Language	English
Publishing date	2024-04-26
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1223802-8
ISSN	1432-1440 ; 0946-2716
ISSN (online)	1432-1440
ISSN	0946-2716
DOI	10.1007/s00109-024-02446-4
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Article ; Online: Microgel Encapsulated Nanoparticles for Intra-articular Disulfiram Delivery to Treat Osteoarthritis.

Liu, Yisi / Yao, Jun / Deng, Guotao / Zhong, Gang / Zhao, Jianping / Lan, Qiumei / Meng, Jinzhi / Yu, Yin / Chen, Fei

Molecular pharmaceutics

2023 Volume 21, Issue 1, Page(s) 87–101

Abstract: Osteoarthritis (OA) affects numerous patients worldwide, and there are no approved disease-modifying drugs. Repurposing FDA-approved small molecular drugs could be a promising alternative strategy to treat OA. Disulfiram (DSF), a clinically approved drug ...

Abstract	Osteoarthritis (OA) affects numerous patients worldwide, and there are no approved disease-modifying drugs. Repurposing FDA-approved small molecular drugs could be a promising alternative strategy to treat OA. Disulfiram (DSF), a clinically approved drug for treatment of alcoholism, inhibits inflammasome activation and exhibits a protective role in interleukin-1β-induced cardiac injury. However, its efficacy in treating OA remains to be explored due to its poor water solubility and stability, which limit its use in OA treatment. Here, the anti-inflammatory effect of DSF is evaluated in vitro, and a double-layer encapsulation approach is developed for intra-articular delivery of DSF for OA treatment
MeSH term(s)	Humans ; Rats ; Animals ; Disulfiram/pharmacology ; Microgels ; Osteoarthritis/drug therapy ; Osteoarthritis/metabolism ; Nanoparticles ; Cytokines ; Cartilage, Articular/metabolism
Chemical Substances	Disulfiram (TR3MLJ1UAI) ; Microgels ; Cytokines
Language	English
Publishing date	2023-12-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2138405-8
ISSN	1543-8392 ; 1543-8384
ISSN (online)	1543-8392
ISSN	1543-8384
DOI	10.1021/acs.molpharmaceut.3c00462
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Article: Correction: Natural products: potential drugs for the treatment of renal fibrosis.

Zhou, Zijun / Qiao, Yanheng / Zhao, Yanru / Chen, Xin / Li, Jie / Zhang, Hanqing / Lan, Qiumei / Yang, Bo

Chinese medicine

2022 Volume 17, Issue 1, Page(s) 121

Language	English
Publishing date	2022-10-24
Publishing country	England
Document type	Published Erratum
ZDB-ID	2260322-0
ISSN	1749-8546
ISSN	1749-8546
DOI	10.1186/s13020-022-00668-7
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Article: Natural products: potential drugs for the treatment of renal fibrosis.

Zhou, Zijun / Qiao, Yanheng / Zhao, Yanru / Chen, Xin / Li, Jie / Zhang, Hanqing / Lan, Qiumei / Yang, Bo

Chinese medicine

2022 Volume 17, Issue 1, Page(s) 98

Abstract: With the increasing prevalence and mortality, chronic kidney disease (CKD) has become a world public health problem. As the primary pathological manifestation in CKD, renal fibrosis is often used as a critical target for the treatment of CKD and inhibits ...

Abstract	With the increasing prevalence and mortality, chronic kidney disease (CKD) has become a world public health problem. As the primary pathological manifestation in CKD, renal fibrosis is often used as a critical target for the treatment of CKD and inhibits the progression of CKD to end-stage renal disease (ESRD). As a potential drug, natural products have been confirmed to have the potential as a routine or supplementary therapy for chronic kidney disease, which may target renal fibrosis and act through various pharmacological activities such as anti-inflammatory and anti-oxidation of natural products. This article briefly introduces the pathological mechanism of renal fibrosis and systematically summarizes the latest research on the treatment of renal fibrosis with natural products of Chinese herbal medicines.
Language	English
Publishing date	2022-08-17
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2260322-0
ISSN	1749-8546
ISSN	1749-8546
DOI	10.1186/s13020-022-00646-z
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Article ; Online: Reactive oxygen species (ROS)-responsive nanoprobe for bioimaging and targeting therapy of osteoarthritis.

Shen, Chong / Gao, Ming / Chen, Haimin / Zhan, Yanting / Lan, Qiumei / Li, Zhimin / Xiong, Wei / Qin, Zainen / Zheng, Li / Zhao, Jinmin

Journal of nanobiotechnology

2021 Volume 19, Issue 1, Page(s) 395

Abstract: Stimulus-responsive therapy that allows precise imaging-guided therapy is limited for osteoarthritis (OA) therapy due to the selection of proper physiological markers as stimulus. Based on that the over-production of Reactive Oxygen Species (ROS) is ... ...

Abstract	Stimulus-responsive therapy that allows precise imaging-guided therapy is limited for osteoarthritis (OA) therapy due to the selection of proper physiological markers as stimulus. Based on that the over-production of Reactive Oxygen Species (ROS) is associated with the progression in OA, we selected ROS as markers and designed a cartilage targeting and ROS-responsive theranostic nanoprobe that can be used for effective bioimaging and therapy of OA. This nanoprobe was fabricated by using PEG micelles modified with ROS-sensitive thioketal linkers (TK) and cartilage-targeting peptide, termed TKCP, which was then encapsulated with Dexamethasone (DEX) to form TKCP@DEX nanoparticles. Results showed that the nanoprobe can smartly "turn on" in response to excessive ROS and "turn off" in the normal joint. By applying different doses of ROS inducer and ROS inhibitor, this nanoprobe can emit ROS-dependent fluorescence according to the degree of OA severity, helpful to precise disease classification in clinic. Specifically targeting cartilage, TKCP@DEX could effectively respond to ROS and sustained release DEX to remarkably reduce cartilage damage in the OA joints. This smart, sensitive and endogenously activated ROS-responsive nanoprobe is promising for OA theranostics.
MeSH term(s)	Animals ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Probes/chemistry ; Molecular Probes/metabolism ; Nanoparticles/chemistry ; Osteoarthritis/diagnostic imaging ; Osteoarthritis/drug therapy ; Reactive Oxygen Species/chemistry ; Reactive Oxygen Species/metabolism ; Theranostic Nanomedicine/methods
Chemical Substances	Molecular Probes ; Reactive Oxygen Species
Language	English
Publishing date	2021-11-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2100022-0
ISSN	1477-3155 ; 1477-3155
ISSN (online)	1477-3155
ISSN	1477-3155
DOI	10.1186/s12951-021-01136-4
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Article ; Online: Cartilage-targeting poly(ethylene glycol) (PEG)-formononetin (FMN) nanodrug for the treatment of osteoarthritis.

Xiong, Wei / Lan, Qiumei / Liang, Xiaonan / Zhao, Jinmin / Huang, Hanji / Zhan, Yanting / Qin, Zainen / Jiang, Xianfang / Zheng, Li

Journal of nanobiotechnology

2021 Volume 19, Issue 1, Page(s) 197

Abstract: Intra-articular (IA) injection is an efficient treatment for osteoarthritis, which will minimize systemic side effects. However, the joint experiences rapid clearance of therapeutics after intra-articular injection. Delivering system modified through ... ...

Abstract	Intra-articular (IA) injection is an efficient treatment for osteoarthritis, which will minimize systemic side effects. However, the joint experiences rapid clearance of therapeutics after intra-articular injection. Delivering system modified through active targeting strategies to facilitate localization within specific joint tissues such as cartilage is hopeful to increase the therapeutic effects. In this study, we designed a nanoscaled amphiphilic and cartilage-targeting polymer-drug delivery system by using formononetin (FMN)-poly(ethylene glycol) (PEG) (denoted as PCFMN), which was prepared by PEGylation of FMN followed by coupling with cartilage-targeting peptide (CollBP). Our results showed that PCFMN was approximately regular spherical with an average diameter about 218 nm. The in vitro test using IL-1β stimulated chondrocytes indicated that PCFMN was biocompatible and upregulated anabolic genes while simultaneously downregulated catabolic genes of the articular cartilage. The therapeutic effects in vivo indicated that PCFMN could effectively attenuate the progression of OA as evidenced by immunohistochemical staining and histological analysis. In addition, PCFMN showed higher intention time in joints and better anti-inflammatory effects than FMN, indicating the efficacy of cartilage targeting nanodrug on OA. This study may provide a reference for clinical OA therapy.
MeSH term(s)	Animals ; Anti-Inflammatory Agents ; Cartilage, Articular/drug effects ; Cartilage, Articular/metabolism ; Cartilage, Articular/pathology ; Chondrocytes/drug effects ; Chondrocytes/metabolism ; Chondrocytes/pathology ; Disease Models, Animal ; Drug Delivery Systems ; Interleukin-1beta/metabolism ; Isoflavones/chemistry ; Isoflavones/pharmacology ; Male ; Nanoparticles ; Osteoarthritis/drug therapy ; Osteoarthritis/metabolism ; Osteoarthritis/pathology ; Peptides ; Polyethylene Glycols/chemistry ; Polyethylene Glycols/pharmacology ; Rats, Sprague-Dawley ; Rats
Chemical Substances	Anti-Inflammatory Agents ; IL1B protein, human ; Interleukin-1beta ; Isoflavones ; Peptides ; formononetin (295DQC67BJ) ; Polyethylene Glycols (3WJQ0SDW1A)
Language	English
Publishing date	2021-07-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2100022-0
ISSN	1477-3155 ; 1477-3155
ISSN (online)	1477-3155
ISSN	1477-3155
DOI	10.1186/s12951-021-00945-x
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Article ; Online: pH-responsive and hyaluronic acid-functionalized metal-organic frameworks for therapy of osteoarthritis.

Xiong, Feng / Qin, Zainen / Chen, Haimin / Lan, Qiumei / Wang, Zetao / Lan, Nihan / Yang, Yuan / Zheng, Li / Zhao, Jinmin / Kai, Dan

Journal of nanobiotechnology

2020 Volume 18, Issue 1, Page(s) 139

Abstract: Drug therapy of osteoarthritis (OA) is limited by the short retention and lacking of stimulus-responsiveness after intra-articular (IA) injection. The weak acid microenvironment in joint provides a potential trigger for controlled drug release systems in ...

Abstract	Drug therapy of osteoarthritis (OA) is limited by the short retention and lacking of stimulus-responsiveness after intra-articular (IA) injection. The weak acid microenvironment in joint provides a potential trigger for controlled drug release systems in the treatment of OA. Herein, we developed an pH-responsive metal - organic frameworks (MOFs) system modified by hyaluronic acid (HA) and loaded with an anti-inflammatory protocatechuic acid (PCA), designated as MOF@HA@PCA, for the therapy of OA. Results demonstrated that MOF@HA@PCA could smartly respond to acidic conditions in OA microenvironment and gradually release PCA, which could remarkably reduce synovial inflammation in both IL-1β induced chondrocytes and the OA joints. MOF@HA@PCA also down-regulated the expression of inflammatory markers of OA and promoted the expression of cartilage-specific makers. This work may provide a new insight for the design of efficient nanoprobes for precision theranostics of OA .
MeSH term(s)	Animals ; Anti-Inflammatory Agents/therapeutic use ; Biomarkers ; Cell Survival/drug effects ; Chondrocytes/metabolism ; Hyaluronic Acid/chemistry ; Hyaluronic Acid/pharmacology ; Hydrogen-Ion Concentration ; Hydroxybenzoates ; Inflammation/drug therapy ; Injections, Intra-Articular ; Interleukin-1beta ; Male ; Metal-Organic Frameworks/chemistry ; Metal-Organic Frameworks/pharmacology ; Osteoarthritis/drug therapy ; Osteoarthritis/pathology ; Rats ; Rats, Sprague-Dawley ; Reactive Oxygen Species
Chemical Substances	Anti-Inflammatory Agents ; Biomarkers ; Hydroxybenzoates ; Interleukin-1beta ; Metal-Organic Frameworks ; Reactive Oxygen Species ; protocatechuic acid (36R5QJ8L4B) ; Hyaluronic Acid (9004-61-9)
Language	English
Publishing date	2020-09-29
Publishing country	England
Document type	Journal Article
ISSN	1477-3155
ISSN (online)	1477-3155
DOI	10.1186/s12951-020-00694-3
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Article ; Online: MMP-13 enzyme and pH responsive theranostic nanoplatform for osteoarthritis.

Lan, Qiumei / Lu, Rongbin / Chen, Haimin / Pang, Yunfen / Xiong, Feng / Shen, Chong / Qin, Zainen / Zheng, Li / Xu, Guojie / Zhao, Jinmin

Journal of nanobiotechnology

2020 Volume 18, Issue 1, Page(s) 117

Abstract: Stimulus-responsive therapy permits precise control of therapeutic effect only at lesion of interest, which determines it a promising method for diagnosis and imaging-guided precision therapy. The acid environment and overexpressed matrix ... ...

Abstract	Stimulus-responsive therapy permits precise control of therapeutic effect only at lesion of interest, which determines it a promising method for diagnosis and imaging-guided precision therapy. The acid environment and overexpressed matrix metalloproteinases-13 (MMP-13) are typical markers in osteoarthritis (OA), which enables the development of stimulus-responsive drug delivery system with high specificity for OA. We herein demonstrate a nano-micelle based stimuli-responsive theranostic strategy with reporting and drug release controlled by acidic pH and MMP-13 for OA therapy. Such nanoplatform is incorporated with a motif specifically targeting on cartilage, a motif responsive to matrix metalloproteinases-13 to specifically report OA condition and biodynamics of nano-micelles, an anti-inflammatory drug (e.g., psoralidin (PSO)) from traditional Chinese medicine, and a biocompatible polymeric skeleton for sustainable drug release in response to the acidic OA condition. The high effectiveness of this targeted precision therapy is demonstrated comprehensively by both in vitro and vivo evidences.
MeSH term(s)	Animals ; Benzofurans ; Cells, Cultured ; Chondrocytes/metabolism ; Coumarins ; Hydrogen-Ion Concentration ; Matrix Metalloproteinase 13/metabolism ; Mice ; Mice, Inbred C57BL ; Osteoarthritis/metabolism ; Theranostic Nanomedicine/methods
Chemical Substances	Benzofurans ; Coumarins ; Matrix Metalloproteinase 13 (EC 3.4.24.-) ; psoralidin (G16ZUQ069L)
Language	English
Publishing date	2020-08-27
Publishing country	England
Document type	Journal Article
ISSN	1477-3155
ISSN (online)	1477-3155
DOI	10.1186/s12951-020-00666-7
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Article: Osteogenic Potential of Electrospun Poly(3-hydroxybutyrate-co-4-hydroxybutyrate)/ Poly(ethylene glycol) Nanofiber Membranes.

Wang, Zetao / Liang, Ruiming / Cheng, Xiaoming / Lan, Qiumei / Xie, Jiali / He, Mingwei / Pang, Yunfen / Xiong, Feng / Lei, Danqing / Zheng, Li / Zhao, Jinmin

Journal of biomedical nanotechnology

2019 Volume 15, Issue 6, Page(s) 1280–1289

Abstract: Nanofibers as niche-biomimetic scaffolds exhibit potential in bone tissue engineering (BTE). Here, poly(3-hydroxybutyrate-co-4-hydroxybutyrate) co-polymer (P34HB)/poly(ethylene glycol) (PEG) nanofiber membranes with a high hydrophilicity and mechanical ... ...

Abstract	Nanofibers as niche-biomimetic scaffolds exhibit potential in bone tissue engineering (BTE). Here, poly(3-hydroxybutyrate-co-4-hydroxybutyrate) co-polymer (P34HB)/poly(ethylene glycol) (PEG) nanofiber membranes with a high hydrophilicity and mechanical properties were fabricated by introducing PEG to P34HB via electrospinning. The P34HB/PEG nanofibrous scaffolds were investigated for their potential in the osteogenic differentiation and mineralization of bone marrow mesenchymal stem cells (BMSCs). By adjusting the ratio of PEG to P34HB, three scaffolds, including P34HB, P34HB/10 wt%PEG, and P34HB/30 wt%PEG, were successfully fabricated. The composite P34HB/PEG nanofiber membranes showed an enhanced hydrophilicity, a decreased fiber size, and an increased mechanical strength compared with those of P34HB.
MeSH term(s)	Cell Differentiation ; Cell Proliferation ; Hydroxybutyrates ; Mesenchymal Stem Cells ; Nanofibers ; Osteogenesis ; Polyesters ; Polyethylene Glycols ; Tissue Engineering ; Tissue Scaffolds
Chemical Substances	Hydroxybutyrates ; Polyesters ; poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (117068-64-1) ; Polyethylene Glycols (3WJQ0SDW1A)
Language	English
Publishing date	2019-05-06
Publishing country	United States
Document type	Journal Article
ISSN	1550-7033
ISSN	1550-7033
DOI	10.1166/jbn.2019.2757
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