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  1. Article ; Online: Rising trend in use of patient-reported outcomes in atrial fibrillation clinical trials.

    Lan, Roy H / Perez-Guerrero, Eduardo / Saeed, Mohammad / Perez, Marco V

    Heart rhythm

    2024  

    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2024.04.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Characteristics of contemporary atrial fibrillation clinical trials and their association with industry sponsorship.

    Lan, Roy H / Paranjpe, Ishan / Saeed, Mohammad / Perez, Marco V

    Heart rhythm

    2024  

    Abstract: Background: Industry sponsorship is an important source of funding for atrial fibrillation (AF) clinical trials, the implications of which have not been analyzed.: Objective: The purpose of this study was to determine the characteristics of ... ...

    Abstract Background: Industry sponsorship is an important source of funding for atrial fibrillation (AF) clinical trials, the implications of which have not been analyzed.
    Objective: The purpose of this study was to determine the characteristics of contemporary AF clinical trials and to evaluate their association with funding source.
    Methods: We systematically assessed all completed AF trials registered in the ClinicalTrials.gov database between conception to October 31, 2023, and extracted publicly available information including funding source, trial size, demographic distribution, intervention, location, and publication status. Trial characteristics were compared using the Wilcoxon rank-sum test and Fisher exact test for continuous and categorical variables, respectively.
    Results: Of the 253 clinical trials assessed, 171 (68%) reported industry funding. Industry funding was associated with a greater median number of patients enrolled (172 vs 80; P <.001), publication rate (56.7% vs 42.7%; P = .04), probability of being product-focused (48.0% vs 24.4%; P <.001), and multicontinental recruitment location (25.2% vs 2.4%; P <.001) when compared to nonindustry-funded trials. However, industry funding was not associated with a significant difference in median impact factor (7.7 vs 7.7; P = .723). The overall proportion of industry-funded trials did not change over time (P = 1).
    Conclusion: Industry-funded clinical trials in AF often are larger, more frequently published, multicontinental, and product-focused. Industry funding was found to be associated with significant differences in study enrollment and publication metrics.
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2229357-7
    ISSN 1556-3871 ; 1547-5271
    ISSN (online) 1556-3871
    ISSN 1547-5271
    DOI 10.1016/j.hrthm.2024.03.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Outcomes and care quality metrics for people living with rheumatic heart disease and atrial fibrillation in Uganda.

    Opara, Chinonso C / Lan, Roy H / Rwebembera, Joselyn / Okello, Emmy / Watkins, David A / Chang, Andrew Y / Longenecker, Chris T

    Heart rhythm O2

    2024  Volume 5, Issue 4, Page(s) 201–208

    Abstract: Background: Atrial fibrillation (AF) is a common complication of rheumatic heart disease (RHD) and is challenging to treat in lower-resourced settings in which RHD remains endemic.: Objective: We characterized demographics, treatment outcomes, and ... ...

    Abstract Background: Atrial fibrillation (AF) is a common complication of rheumatic heart disease (RHD) and is challenging to treat in lower-resourced settings in which RHD remains endemic.
    Objective: We characterized demographics, treatment outcomes, and factors leading to care retention for participants with RHD and AF in Uganda.
    Methods: We conducted a retrospective analysis of the Uganda national RHD registry between June 2009 and May 2018. Participants with AF or atrial flutter were included. Demographics, survival, and care metrics were compared with participants without AF. Multivariable logistic regression was used to identify factors associated with retention in care among participants with AF.
    Results: A total of 1530 participants with RHD were analyzed and 293 (19%) had AF. The median age was 24 (interquartile range 14-38) years. Mortality was similar in both groups (adjusted hazard ratio 1.183,
    Conclusion: Participants with RHD and AF in Uganda do not experience higher mortality than those without AF. Anticoagulation prescription rates are high. Although retention in care is poor among RHD participants, those with concurrent AF are more likely to be retained.
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article
    ISSN 2666-5018
    ISSN (online) 2666-5018
    DOI 10.1016/j.hroo.2024.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Resident Involvement in Posterior Lumbar Interbody Fusion is Associated With Increased Readmissions and Operative Time, But No Increased Short-term Risks.

    Lan, Roy H / Grits, Daniel / Samuel, Linsen T / Sultan, Assem A

    Clinical spine surgery

    2021  Volume 34, Issue 6, Page(s) E364–E369

    Abstract: Study design: A retrospective cohort study.: Objective: The aim was to compare rates of adverse events and additional posterior lumbar interbody fusion (PLIF) cases assisted by residents versus cases performed solely by an orthopedic attending.: ... ...

    Abstract Study design: A retrospective cohort study.
    Objective: The aim was to compare rates of adverse events and additional posterior lumbar interbody fusion (PLIF) cases assisted by residents versus cases performed solely by an orthopedic attending.
    Summary of background data: PLIF is a widely accepted surgical technique for the management of a variety of spinal conditions requiring spinal stabilization and fusion. However, no published studies have assessed the effects of resident involvement on intraoperative and postoperative outcomes in PLIF.
    Methods: This retrospective study utilized the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) registry from 2007 to 2012 to identify patients who underwent PLIF procedures. A propensity score matching model was utilized to reduce patient cohort variances. The perioperative data and outcomes in the matched population were analyzed using paired t test and the McNemar test in order to assess, based on resident presence, the rates of postoperative adverse events, readmission, reoperation within 30 days, and operative time.
    Results: In total, 1633 patients undergoing PLIF were included in the study, with 24.62% involving resident participation. The propensity score matching algorithm yielded 396 well-matched resident and nonresident pairs. Patients undergoing PLIF involving a resident were associated with a higher rate of readmission (1.77% vs. 0.00%; P=0.008), and longer operative time (245.7 vs. 197.7 min; P<0.001). However, these procedures were not associated with any significant difference in minor or severe adverse events.
    Conclusions: Resident involvement in PLIF was associated with an increased rate of readmissions, and operative time; however, was not associated with an increase in minor or severe adverse events. Further investigation is needed to characterize the role of resident involvement based on level of training experience, as well as methods to improve the learning curve to independence while reducing postoperative hospital length of stay.
    Level of evidence: Level III-retrospective comparative study.
    MeSH term(s) Humans ; Lumbar Vertebrae/surgery ; Operative Time ; Patient Readmission ; Postoperative Complications/etiology ; Retrospective Studies ; Spinal Fusion/adverse effects ; Treatment Outcome
    Language English
    Publishing date 2021-07-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2849646-2
    ISSN 2380-0194 ; 2380-0186
    ISSN (online) 2380-0194
    ISSN 2380-0186
    DOI 10.1097/BSD.0000000000001157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Contemporary Outpatient Arthroplasty Is Safe Compared with Inpatient Surgery: A Propensity Score-Matched Analysis of 574,375 Procedures.

    Lan, Roy H / Samuel, Linsen T / Grits, Daniel / Kamath, Atul F

    The Journal of bone and joint surgery. American volume

    2021  Volume 103, Issue 7, Page(s) 593–600

    Abstract: Background: Outpatient joint arthroplasty is a potential modality for increased case throughput and is rising in demand. However, we are aware of no study that has compared outcomes between risk-matched outpatient and inpatient procedures within the ... ...

    Abstract Background: Outpatient joint arthroplasty is a potential modality for increased case throughput and is rising in demand. However, we are aware of no study that has compared outcomes between risk-matched outpatient and inpatient procedures within the last 7 years. The aims of this study were to compare matched patient cohorts who underwent outpatient or inpatient joint arthroplasty in terms of 30-day adverse events and readmission rates.
    Methods: From the National Surgical Quality Improvement Program database, we identified patients who underwent primary total hip arthroplasty (THA), primary total knee arthroplasty (TKA), and primary unicompartmental knee arthroplasty (UKA) from 2009 to 2018. Using 10 perioperative variables, patients who underwent an outpatient procedure were 1:4 propensity score-matched with patients who underwent an inpatient procedure. The rates of 30-day adverse events and readmission were compared using the McNemar test. The risk factors for adverse events and readmissions were identified using multivariate regression.
    Results: Of 574,375 patients identified, 21,506 (3.74%) underwent an outpatient procedure. After propensity score matching, an outpatient joint arthroplasty was associated with a lower rate of adverse events (3.18% compared with 7.45%; p < 0.001). When assessed individually, outpatient TKA (3.15% compared with 8.11%; p < 0.001), THA (4.94% compared with 10.05%; p < 0.001), and UKA (1.78% compared with 3.39%; p < 0.001) were all associated with fewer adverse events overall and there was no difference in the rate of 30-day readmission, when compared with inpatient analogs. Outpatient joint arthroplasty was an independent factor for lower adverse events (odds ratio [OR], 0.407 [95% confidence interval (CI), 0.369 to 0.449]; p < 0.001), with no increase in the risk of readmission (OR, 1.004 [95% CI, 0.878 to 1.148]; p = 0.951).
    Conclusions: Contemporary outpatient joint arthroplasty demonstrated lower rates of adverse events with no increased rate of 30-day readmission when compared with risk-matched inpatient counterparts. Although multiple factors should guide the decision for the site of care, outpatient arthroplasty may be a safe alternative to inpatient arthroplasty.
    Level of evidence: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Ambulatory Surgical Procedures/adverse effects ; Ambulatory Surgical Procedures/methods ; Arthroplasty, Replacement, Hip/adverse effects ; Arthroplasty, Replacement, Hip/methods ; Arthroplasty, Replacement, Knee/adverse effects ; Arthroplasty, Replacement, Knee/methods ; Databases, Factual/statistics & numerical data ; Female ; Humans ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Patient Readmission/statistics & numerical data ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Propensity Score ; Registries/statistics & numerical data ; Risk Factors ; Young Adult
    Language English
    Publishing date 2021-02-28
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 220625-0
    ISSN 1535-1386 ; 0021-9355
    ISSN (online) 1535-1386
    ISSN 0021-9355
    DOI 10.2106/JBJS.20.01307
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Outcome measures in total hip arthroplasty: have our metrics changed over 15 years?

    Lan, Roy H / Bell, Jack W / Samuel, Linsen T / Kamath, Atul F

    Archives of orthopaedic and trauma surgery

    2021  Volume 142, Issue 8, Page(s) 1753–1762

    Abstract: Introduction: Consensus has not been reached regarding ideal outcome measures for total hip arthroplasty (THA) clinical evaluation and research. The goal of this review was to analyze the trends in outcome metrics within the THA literature and to ... ...

    Abstract Introduction: Consensus has not been reached regarding ideal outcome measures for total hip arthroplasty (THA) clinical evaluation and research. The goal of this review was to analyze the trends in outcome metrics within the THA literature and to discuss the potential impact of instrument heterogeneity on clinical practice.
    Materials and methods: A PubMed search of all manuscripts related to THA from January 2005 to December 2019 was performed. Statistical and linear regression analyses were performed for individual outcome metrics as a proportion of total THA publications over time.
    Results: There was a statistically significant increase in studies utilizing outcomes metrics between 2005 and 2019 (15.1-29.5%; P < 0.001; R
    Conclusions: The utilization of outcome-reporting metrics in THA has continued to increase, resulting in added complexity within the literature. The utilization rates of individual instruments have shifted over the past 15 years. Additional study is required to determine which specific instruments are recommended.
    MeSH term(s) Arthroplasty, Replacement, Hip/methods ; Humans ; Osteoarthritis, Hip/surgery ; Patient Reported Outcome Measures ; Quality of Life ; Treatment Outcome
    Language English
    Publishing date 2021-02-11
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 80407-1
    ISSN 1434-3916 ; 0003-9330 ; 0344-8444
    ISSN (online) 1434-3916
    ISSN 0003-9330 ; 0344-8444
    DOI 10.1007/s00402-021-03809-z
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  7. Article: Does the Timing of Pre-Operative Medical Evaluation Influence Perioperative Total Hip Arthroplasty Outcomes?

    Lan, Roy H / Kamath, Atul F

    The open orthopaedics journal

    2017  Volume 11, Page(s) 195–202

    Abstract: Background: Medical evaluation pre-operatively is an important component of risk stratification and potential risk optimization. However, the effect of timing prior to surgical intervention is not well-understood. We hypothesized that total hip ... ...

    Abstract Background: Medical evaluation pre-operatively is an important component of risk stratification and potential risk optimization. However, the effect of timing prior to surgical intervention is not well-understood. We hypothesized that total hip arthroplasty (THA) patients seen in pre-operative evaluation closer to the date of surgery would experience better perioperative outcomes.
    Methods: We retrospectively reviewed 167 elective THA patients to study the relationship between the number of days between pre-operative evaluation (range, 0-80 days) and surgical intervention. Patients' demographics, length of stay (LOS), ICU admission frequency, and rate of major complications were recorded.
    Results: When pre-operative evaluation carried out 4 days or less before the procedure date, there was a significant reduction in LOS (3.91 vs. 4.49; p=0.03). When pre-operative evaluation carried out 11 days or less prior to the procedure date, there was a four-fold decrease in rate of intensive care admission (p=0.04). Furthermore, the major complication rate also significantly reduced (p<0.05). However, when pre-operative evaluation took place 30 days or less before the procedure date compared to more than 30 days prior, there were no significant changes in the outcomes.
    Conclusion: From this study, pre-operative medical evaluation closer to the procedure date was correlated with improved selected peri-operative outcomes. However, further study on larger patient groups must be done to confirm this finding. More study is needed to define the effect on rare events like infection, and to analyze the subsets of THA patients with modifiable risk factors that may be time-dependent and need further time to optimization.
    Language English
    Publishing date 2017-03-22
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2395994-0
    ISSN 1874-3250
    ISSN 1874-3250
    DOI 10.2174/1874325001711010195
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  8. Article: Post-acute care disparities in total joint arthroplasty.

    Lan, Roy H / Kamath, Atul F

    Arthroplasty today

    2017  Volume 3, Issue 3, Page(s) 187–191

    Abstract: Background: Understanding the socioeconomic factors that influence hospitalization and post-discharge metrics after joint replacement is important for identifying key areas of improvement in the delivery of orthopaedic care.: Methods: An ... ...

    Abstract Background: Understanding the socioeconomic factors that influence hospitalization and post-discharge metrics after joint replacement is important for identifying key areas of improvement in the delivery of orthopaedic care.
    Methods: An institutional administrative data set of 2869 patients from an academic arthroplasty referral center was analyzed to quantify the relationship between socioeconomic factors and post-acute rehabilitation care received, length of stay, and cost of care. The study used International Classification of Disease, ninth edition coding in order to identify cohorts of patients who received joint arthroplasty of the knee and hip between January 2007 and May 2015.
    Results: The study found that females (odds ratio [OR], 2.07; 95% confidence interval [CI], 1.74-2.46), minorities (OR, 2.11; 95% CI, 1.78-2.51), and non-private insurance holders (OR, 1.56; 95% CI, 1.26-1.94) were more likely to be assigned to institutional care after discharge. The study also found that minorities (OR, 1.45; 95% CI, 1.24-1.70) and non-private insurance holders (OR, 1.43; 95% CI, 1.16-1.77) are more likely to exhibit longer length of stay. Mean charges were higher for males when compared to females ($80,010 vs $74,855;
    Conclusions: Socioeconomic factors such as gender, race, and insurance status should be further explored with respect to healthcare policies seeking to influence quality of care and health outcomes.
    Language English
    Publishing date 2017-03-06
    Publishing country United States
    Document type Journal Article
    ISSN 2352-3441
    ISSN 2352-3441
    DOI 10.1016/j.artd.2017.02.001
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  9. Article ; Online: Evolving Outcome Measures in Total Knee Arthroplasty: Trends and Utilization Rates Over the Past 15 Years.

    Lan, Roy H / Bell, Jack W / Samuel, Linsen T / Kamath, Atul F

    The Journal of arthroplasty

    2020  Volume 35, Issue 11, Page(s) 3375–3382

    Abstract: Background: Patient-reported outcome metrics and reporting are important for demonstrating value associated with total knee arthroplasty (TKA). This review studied the patient-reported outcome utilization trends as reported within the TKA literature ... ...

    Abstract Background: Patient-reported outcome metrics and reporting are important for demonstrating value associated with total knee arthroplasty (TKA). This review studied the patient-reported outcome utilization trends as reported within the TKA literature over a 15-year period.
    Methods: A PubMed search of all manuscripts related to TKA from January 2005 to December 2019 was performed. Descriptive statistics were used for individual outcome metrics as proportions of total article publications focusing on TKA outcomes. Linear regressions analysis was performed to demonstrate significant changes in utilization rates over time.
    Results: There was a significant overall increase in studies utilizing outcome metrics between 2005 and 2019 (16.1%-45.0%; P < .001; R
    Conclusion: Although utilization of outcome metrics has significantly increased over the last 15 years in the TKA literature, there still exists considerable heterogeneity of outcome metrics. This lack of consensus may impede comparisons of studies for clinical and research purposes, as well as hinder cross-walk of outcome tools over time. Further study is needed to identify ideal global and joint-specific tools, while balancing issues like ease of use and utility in specific populations such as the young and highly active.
    MeSH term(s) Arthroplasty, Replacement, Knee ; Humans ; Knee Joint/surgery ; Osteoarthritis, Knee/surgery ; Patient Reported Outcome Measures ; Quality of Life ; Treatment Outcome
    Language English
    Publishing date 2020-06-17
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 632770-9
    ISSN 1532-8406 ; 0883-5403
    ISSN (online) 1532-8406
    ISSN 0883-5403
    DOI 10.1016/j.arth.2020.06.036
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  10. Article ; Online: American Association of Hip and Knee Surgeons-Endorsed Comorbidity Coding for Total Joint Arthroplasty: How Often Did We Hit the Mark With International Classification of Diseases, Ninth Revision?

    Lan, Roy H / Kamath, Atul F

    The Journal of arthroplasty

    2016  Volume 31, Issue 12, Page(s) 2692–2695

    Abstract: Background: Initiatives led by the American Academy of Orthopaedic Surgeons and the American Association of Hip and Knee Surgeons (AAHKS) have indicated a number of clinical risk factors associated with total joint arthroplasty that might reflect the ... ...

    Abstract Background: Initiatives led by the American Academy of Orthopaedic Surgeons and the American Association of Hip and Knee Surgeons (AAHKS) have indicated a number of clinical risk factors associated with total joint arthroplasty that might reflect the complexity of contemporary hip and knee care. This study sought to examine the prevalence of specific International Classification of Diseases, Ninth Revision (ICD-9), coding with respect to an AAHKS-endorsed list of comorbidity codes.
    Methods: An administrative data set from an academic arthroplasty referral center was analyzed in an attempt to measure the prevalence of clinical risk factors (ICD-9) endorsed by AAHKS. Total, partial, and revision joint arthroplasty procedures from January 1, 2012, to April 27, 2015, were included. Demographic data, along with diagnosis and procedural coding data, were collected and analyzed.
    Results: Results analysis found a number of poorly coded variables. The following variables were omitted in the data: narcotic use, worker's compensation status, previous intra-articular infection, previous open reduction and internal fixation knee, and depression/psychiatric disease. Likewise, there was a discrepancy between the rate of ICD coding for obesity and body mass index measurements and categorization recorded in the clinic.
    Conclusion: From this single-center study, there remain opportunities for coding to adequately reflect the comorbidities and complexities of patients undergoing arthroplasty.
    MeSH term(s) Aged ; Aged, 80 and over ; Arthroplasty, Replacement, Hip ; Arthroplasty, Replacement, Knee ; Comorbidity ; Female ; Humans ; International Classification of Diseases ; Male ; Middle Aged ; Obesity ; Prevalence ; Risk Factors ; Surgeons ; United States
    Language English
    Publishing date 2016-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632770-9
    ISSN 1532-8406 ; 0883-5403
    ISSN (online) 1532-8406
    ISSN 0883-5403
    DOI 10.1016/j.arth.2016.05.051
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