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  1. AU="Landa-Moreno, Cinthia"
  2. AU="Kuntner, Matjaz"
  3. AU="Lemes, Robertha Mariana Rodrigues"
  4. AU="Riccioni, M E"
  5. AU="Traer, Colin J"
  6. AU="Cao, Xuejie"
  7. AU="Chen, Zishuo"
  8. AU="Kalachikov, Sergey"
  9. AU="Das, Tilak"
  10. AU="Bessat, Cécile"
  11. AU="Galina Velikova"
  12. AU="Greene, Sharrell"
  13. AU="Chen, Kallie J"
  14. AU="Schwab, Jörg O."
  15. AU="Ke Chen"
  16. AU="Hewei Liang"
  17. AU="Abreu, Cristina"
  18. AU="Mamani Ortiz, Yercin"
  19. AU="Castro, Lucíola de Fátima Albuquerque Almeida Peixoto"
  20. AU="Šimůnek, Tomáš"
  21. AU="Ong, Lizhen"
  22. AU="Chai, Chaoqing"
  23. AU="Maheswaran Kesavan"
  24. AU="Mehta, Mrunal"
  25. AU=Paredes Sergio D
  26. AU=Ghosh Nilanjan AU=Ghosh Nilanjan
  27. AU="Hofmann, Alexander"
  28. AU="Radici, Marco"
  29. AU="Noro, Fabrizia"
  30. AU="Wang, Jianzhao"
  31. AU="Divya Jeyam"
  32. AU="Wolf, Lisette"
  33. AU="Marjanovic, Nemanja Despot"
  34. AU="Jitxin, Lim"

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  1. Artikel ; Online: Antioxidant effects of silver nanoparticles obtained by green synthesis from the aqueous extract of Eryngium carlinae on the brain mitochondria of streptozotocin-induced diabetic rats.

    Lemus-de la Cruz, Jenaro / Trejo-Hurtado, Mitchell / Landa-Moreno, Cinthia / Peña-Montes, Donovan / Landeros-Páramo, José Luis / Cortés-Rojo, Christian / Montoya-Pérez, Rocío / Rosas, Gerardo / Saavedra-Molina, Alfredo

    Journal of bioenergetics and biomembranes

    2023  Band 55, Heft 2, Seite(n) 123–135

    Abstract: Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia that affects practically all tissues and organs, being the brain one of most susceptible, due to overproduction of reactive oxygen species induced by diabetes. Eryngium ... ...

    Abstract Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia that affects practically all tissues and organs, being the brain one of most susceptible, due to overproduction of reactive oxygen species induced by diabetes. Eryngium carlinae is a plant used in traditional Mexican medicine to treat diabetes, which has already been experimentally shown have hypoglycemic, antioxidant and hypolipidemic properties. The green synthesis of nanoparticles is a technique that combines plant extracts with metallic nanoparticles, so that the nanoparticles reduce the absorption and distribution time of drugs or compounds, increasing their effectiveness. In this work, the antioxidant effects and mitochondrial function in the brain were evaluated, as well as the hypoglycemic and hypolipidemic effect in serum of both the aqueous extract of the aerial part of E. carlinae, as well as its combination with silver nanoparticles of green synthesis. Administration with both, extract and the combination significantly decreased the production of reactive oxygen species, lipid peroxidation, and restored the activity of superoxide dismutase 2, glutathione peroxidase, and electron transport chain complexes in brain, while that the extract-nanoparticle combination decreased blood glucose and triglyceride levels. The results obtained suggest that both treatments have oxidative activity and restore mitochondrial function in the brain of diabetic rats.
    Mesh-Begriff(e) Rats ; Animals ; Antioxidants/pharmacology ; Antioxidants/metabolism ; Streptozocin/metabolism ; Streptozocin/pharmacology ; Streptozocin/therapeutic use ; Eryngium/metabolism ; Silver/pharmacology ; Silver/metabolism ; Silver/therapeutic use ; Reactive Oxygen Species/metabolism ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Metal Nanoparticles ; Oxidative Stress ; Rats, Wistar ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Hypoglycemic Agents/metabolism ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Lipid Peroxidation ; Brain/metabolism ; Mitochondria/metabolism
    Chemische Substanzen Antioxidants ; Streptozocin (5W494URQ81) ; Silver (3M4G523W1G) ; Reactive Oxygen Species ; Hypoglycemic Agents ; Plant Extracts
    Sprache Englisch
    Erscheinungsdatum 2023-03-29
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 198499-8
    ISSN 1573-6881 ; 0145-479X ; 0449-5705
    ISSN (online) 1573-6881
    ISSN 0145-479X ; 0449-5705
    DOI 10.1007/s10863-023-09963-w
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: An Ethyl Acetate Extract of

    Trejo-Hurtado, Cristian M / Landa-Moreno, Cinthia I / la Cruz, Jenaro Lemus-de / Peña-Montes, Donovan J / Montoya-Pérez, Rocío / Salgado-Garciglia, Rafael / Manzo-Avalos, Salvador / Cortés-Rojo, Christian / Monribot-Villanueva, Juan Luis / Guerrero-Analco, José Antonio / Saavedra-Molina, Alfredo

    Antioxidants (Basel, Switzerland)

    2023  Band 12, Heft 6

    Abstract: Secondary metabolites such as flavonoids are promising in the treatment of non-alcoholic fatty liver disease (NAFLD), which is one of the complications of diabetes due to oxidative stress and inflammation. Some plants, such ... ...

    Abstract Secondary metabolites such as flavonoids are promising in the treatment of non-alcoholic fatty liver disease (NAFLD), which is one of the complications of diabetes due to oxidative stress and inflammation. Some plants, such as
    Sprache Englisch
    Erscheinungsdatum 2023-06-07
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12061235
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: An Ethyl Acetate Extract of Eryngium carlinae Inflorescences Attenuates Oxidative Stress and Inflammation in the Liver of Streptozotocin-Induced Diabetic Rats

    Trejo-Hurtado, Cristian M. / Landa-Moreno, Cinthia I. / la Cruz, Jenaro Lemus-de / Peña-Montes, Donovan J. / Montoya-Pérez, Rocío / Salgado-Garciglia, Rafael / Manzo-Avalos, Salvador / Cortés-Rojo, Christian / Monribot-Villanueva, Juan Luis / Guerrero-Analco, José Antonio / Saavedra-Molina, Alfredo

    Antioxidants. 2023 June 07, v. 12, no. 6

    2023  

    Abstract: Secondary metabolites such as flavonoids are promising in the treatment of non-alcoholic fatty liver disease (NAFLD), which is one of the complications of diabetes due to oxidative stress and inflammation. Some plants, such as Eryngium carlinae, have ... ...

    Abstract Secondary metabolites such as flavonoids are promising in the treatment of non-alcoholic fatty liver disease (NAFLD), which is one of the complications of diabetes due to oxidative stress and inflammation. Some plants, such as Eryngium carlinae, have been investigated regarding their medicinal properties in in vitro and in vivo assays, showing favorable results for the treatment of various diseases such as diabetes and obesity. The present study examined the antioxidant and anti-inflammatory effects of the phenolic compounds present in an ethyl acetate extract of the inflorescences of Eryngium carlinae on liver homogenates and mitochondria from streptozotocin (STZ)-induced diabetic rats. Phenolic compounds were identified and quantified by UHPLC-MS. In vitro assays were carried out to discover the antioxidant potential of the extract. Male Wistar rats were administered with a single intraperitoneal injection of STZ (45 mg/kg) and were given the ethyl acetate extract at a level of 30 mg/kg for 60 days. Phytochemical assays showed that the major constituents of the extract were flavonoids; in addition, the in vitro antioxidant activity was dose dependent with IC50 = 57.97 mg/mL and IC50 = 30.90 mg/mL in the DPPH and FRAP assays, respectively. Moreover, the oral administration of the ethyl acetate extract improved the effects of NAFLD, decreasing serum and liver triacylglycerides (TG) levels and oxidative stress markers and increasing the activity of the antioxidant enzymes. Likewise, it attenuated liver damage by decreasing the expression of NF-κB and iNOS, which lead to inflammation and liver damage. We hypothesize that solvent polarity and consequently chemical composition of the ethyl acetate extract of E. carlinae, exert the beneficial effects due to phenolic compounds. These results suggest that the phenolic compounds of the ethyl acetate extract of E. carlinae have antioxidant, anti-inflammatory, hypolipidemic, and hepatoprotective activity.
    Schlagwörter Eryngium carlinae ; antioxidant activity ; antioxidants ; blood serum ; chemical composition ; diabetes ; dose response ; ethyl acetate ; fatty liver ; flavonoids ; hepatoprotective effect ; inflammation ; inhibitory concentration 50 ; intraperitoneal injection ; liver ; males ; mitochondria ; obesity ; oral administration ; oxidative stress ; secondary metabolites ; solvents ; streptozotocin ; triacylglycerols
    Sprache Englisch
    Erscheinungsverlauf 2023-0607
    Erscheinungsort Multidisciplinary Digital Publishing Institute
    Dokumenttyp Artikel ; Online
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12061235
    Datenquelle NAL Katalog (AGRICOLA)

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  4. Artikel: Antioxidant Effect of the Ethyl Acetate Extract of

    Landa-Moreno, Cinthia I / Trejo-Hurtado, Cristian M / Lemus-de la Cruz, Jenaro / Peña-Montes, Donovan J / Murillo-Villicaña, Marina / Huerta-Cervantes, Maribel / Montoya-Pérez, Rocío / Salgado-Garciglia, Rafael / Manzo-Avalos, Salvador / Cortés-Rojo, Christian / Monribot-Villanueva, Juan Luis / Guerrero-Analco, José Antonio / Saavedra-Molina, Alfredo

    Plants (Basel, Switzerland)

    2023  Band 12, Heft 18

    Abstract: Diabetes mellitus (DM) is a metabolic disorder characterized by persistent hyperglycemia. This state may lead to an increase in oxidative stress, which contributes to the development of diabetes complications, including diabetic kidney disease. ...

    Abstract Diabetes mellitus (DM) is a metabolic disorder characterized by persistent hyperglycemia. This state may lead to an increase in oxidative stress, which contributes to the development of diabetes complications, including diabetic kidney disease.
    Sprache Englisch
    Erscheinungsdatum 2023-09-07
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12183196
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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