Article ; Online: Preclinical Antitumor Activity and Biodistribution of a Novel Anti-GCC Antibody-Drug Conjugate in Patient-derived Xenografts.
2020 Volume 19, Issue 10, Page(s) 2079–2088
Abstract: Guanylyl cyclase C (GCC) is a unique therapeutic target with expression restricted to the apical side of epithelial cell tight junctions thought to be only accessible by intravenously administered agents on malignant tissues where GCC expression is ... ...
| Abstract | Guanylyl cyclase C (GCC) is a unique therapeutic target with expression restricted to the apical side of epithelial cell tight junctions thought to be only accessible by intravenously administered agents on malignant tissues where GCC expression is aberrant. In this study, we sought to evaluate the therapeutic potential of a second-generation investigational antibody-dug conjugate (ADC), TAK-164, comprised of a human anti-GCC mAb conjugated via a peptide linker to the highly cytotoxic DNA alkylator, DGN549. The |
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| MeSH term(s) | Animals ; Female ; HEK293 Cells ; Humans ; Immunoconjugates/pharmacology ; Immunoconjugates/therapeutic use ; Mice ; Mice, Nude ; Tissue Distribution ; Xenograft Model Antitumor Assays | |||||
| Chemical Substances | Immunoconjugates | |||||
| Language | English | |||||
| Publishing date | 2020-08-11 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 2063563-1 | |||||
| ISSN | 1538-8514 ; 1535-7163 | |||||
| ISSN (online) | 1538-8514 | |||||
| ISSN | 1535-7163 | |||||
| DOI | 10.1158/1535-7163.MCT-19-1102 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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