Article ; Online: The Diagnosis and Treatment of Osteosarcoma and Ewing's Sarcoma in Children and Adolescents.
Deutsches Arzteblatt international
2023 Volume 120, Issue 24, Page(s) 405–412
Abstract: Background: Osteosarcoma and Ewing's sarcoma in children and adolescents require age-specific interdisciplinary diagnosis and treatment to achieve optimal therapeutic outcomes.: Methods: The diagnosis and treatment of malignant bone tumors in ... ...
| Abstract | Background: Osteosarcoma and Ewing's sarcoma in children and adolescents require age-specific interdisciplinary diagnosis and treatment to achieve optimal therapeutic outcomes. Methods: The diagnosis and treatment of malignant bone tumors in childhood and adolescence are presented in the light of publications retrieved by a selective search, pertinent guidelines, and the authors' extensive experience in an interdisciplinary cancer center. Results: Bone sarcomas make up approximately 5% of all malignancies in children and adolescents; the most common types are Ewing's sarcoma and osteosarcoma. Patients are often not referred to a specialized center until long after the onset of symptoms, as they and their physicians rarely consider the possibility of a bone tumor, and the symptoms are often trivialized. Bone pain of unknown origin, swelling, and functional limitations should be investigated with conventional x-rays. Lesions of unclear origin should be biopsied after a meticulous clinical and radiologic evaluation. Multimodal treatment consists of neo - adjuvant chemotherapy, limb-preserving resection if possible, and radiotherapy where indicated. In multicenter studies, patients with osteosarcoma achieve event-free survival in 64% of cases if their disease is localized, and 28% if it is metastatic; the corresponding figures for patients with Ewing's sarcoma are 80% and 27%, respectively. Conclusion: With implementation of the current treatment recommendations, most children and adolescents with malignant bone tumors can be treated successfully with curative intent. These patients should be referred to a sarcoma center for diagnosis and treatment. |
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| MeSH term(s) | Humans ; Child ; Adolescent ; Sarcoma, Ewing/therapy ; Sarcoma, Ewing/drug therapy ; Osteosarcoma/therapy ; Osteosarcoma/drug therapy ; Bone Neoplasms/therapy ; Bone Neoplasms/drug therapy ; Combined Modality Therapy |
| Language | English |
| Publishing date | 2023-04-24 |
| Publishing country | Germany |
| Document type | Journal Article |
| ZDB-ID | 2406159-1 |
| ISSN | 1866-0452 ; 1866-0452 |
| ISSN (online) | 1866-0452 |
| ISSN | 1866-0452 |
| DOI | 10.3238/arztebl.m2023.0079 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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