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  1. Article ; Online: A sheep in wolf's clothing: a rare case of erythema ab igne mimicking vasculitis.

    Gupta, Ankit / Arasu, Alexis / Landgren, Anthony / Howard, Anne

    Internal and emergency medicine

    2024  

    Language English
    Publishing date 2024-03-06
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-024-03575-x
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    Zs.A 6673: Show issues Location:
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  2. Article ; Online: Syphilis as the great mimicker: A case of full-house pattern membranous nephropathy.

    Fan, Shu Ling / Landgren, Anthony / Ruderman, Irene

    Nephrology (Carlton, Vic.)

    2023  Volume 29, Issue 1, Page(s) 18–20

    Abstract: Syphilis is a known cause of membranous nephropathy. We describe a case of a patient presenting with nephrotic syndrome whose renal biopsy demonstrated a 'full house' immunohistochemical pattern with positive IgG, IgM, C1q, IgA, C3c, and C4d staining. He ...

    Abstract Syphilis is a known cause of membranous nephropathy. We describe a case of a patient presenting with nephrotic syndrome whose renal biopsy demonstrated a 'full house' immunohistochemical pattern with positive IgG, IgM, C1q, IgA, C3c, and C4d staining. He was treated with immunosuppressive agents for minimal change nephropathy and subsequently class V lupus nephritis, before syphilis infection was confirmed. Following treatment with a single dose of intramuscular benzathine penicillin there was complete and rapid resolution of nephrotic syndrome. With progressive rising incidence in the western world, syphilis is an important and under-recognised differential diagnosis in cases of nephrotic syndrome.
    MeSH term(s) Male ; Humans ; Glomerulonephritis, Membranous/diagnosis ; Glomerulonephritis, Membranous/drug therapy ; Glomerulonephritis, Membranous/etiology ; Nephrotic Syndrome ; Syphilis/complications ; Syphilis/diagnosis ; Syphilis/drug therapy ; Lupus Nephritis/pathology ; Penicillin G Benzathine/therapeutic use
    Chemical Substances Penicillin G Benzathine (RIT82F58GK)
    Language English
    Publishing date 2023-09-18
    Publishing country Australia
    Document type Case Reports
    ZDB-ID 1303661-0
    ISSN 1440-1797 ; 1320-5358
    ISSN (online) 1440-1797
    ISSN 1320-5358
    DOI 10.1111/nep.14240
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  3. Article ; Online: Translation of a circulating miRNA signature of melanoma into a solid tissue assay to improve diagnostic accuracy and precision.

    Laar, Ryan Van / King, Samuel / McCoy, Richard / Saad, Mirette / Fereday, Sian / Winship, Ingrid / Uzzell, Catherine / Landgren, Anthony

    Biomarkers in medicine

    2021  Volume 15, Issue 13, Page(s) 1111–1122

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Adult ; Diagnosis, Differential ; Female ; Gene Expression Profiling/methods ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Melanoma/diagnosis ; Melanoma/genetics ; MicroRNAs/blood ; MicroRNAs/genetics ; Middle Aged ; Molecular Diagnostic Techniques/methods ; Nevus/diagnosis ; Nevus/genetics ; Reproducibility of Results ; Sensitivity and Specificity ; Skin Neoplasms/diagnosis ; Skin Neoplasms/genetics ; Translational Science, Biomedical/methods
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2021-06-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2481014-9
    ISSN 1752-0371 ; 1752-0363
    ISSN (online) 1752-0371
    ISSN 1752-0363
    DOI 10.2217/bmm-2021-0289
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  4. Article ; Online: Histological and Extended Clinical Outcomes After ABO-Incompatible Renal Transplantation Without Splenectomy or Rituximab.

    Chow, Kevin V / Flint, Shaun M / Shen, Angeline / Landgren, Anthony / Finlay, Moira / Murugasu, Anand / Masterson, Rosemary / Hughes, Peter / Cohney, Solomon J

    Transplantation

    2017  Volume 101, Issue 6, Page(s) 1433–1440

    Abstract: Background: Excellent short-term results have been reported in ABO-incompatible (ABOi) renal transplant recipients managed solely with antibody removal and conventional immunosuppression. However, long-term clinical outcomes with this regimen and ... ...

    Abstract Background: Excellent short-term results have been reported in ABO-incompatible (ABOi) renal transplant recipients managed solely with antibody removal and conventional immunosuppression. However, long-term clinical outcomes with this regimen and predictive information from protocol biopsies are lacking.
    Methods: We compared outcome data in ABOi and ABO-compatible (ABOc) recipients receiving this regimen approximately 4 years posttransplant, and histology from biopsies approximately 12 months posttransplant.
    Results: Patient and graft survivals among 54 ABOi recipients were 98.1% and 90.7%, respectively, at 4 years. Graft function was similar between ABOi (creatinine, 140.3 μmol/L) and ABOc recipients (creatinine, 140.2 μmol/L) (P = 0.99), with no significant change over the study period in either group (Δcreatinine, -0.83 vs 6.6 μmol/L) (P = 0.59). There was no transplant glomerulopathy in biopsies from either group. Interstitial fibrosis (IF) and tubular atrophy (TA) was present in 7 (28%) of 25 ABOi compared with 7 (20.6%) of 34 ABOc (P = 0.52). Progression of IF/TA from implantation was noted in 6 (24%) of 25 ABOi and 6 (17.6%) of 34 ABOc, respectively. C4d staining without antibody-mediated rejection was present in 13 (52%) 25 early posttransplant biopsies from ABOi recipients by immunohistochemistry, but in only 4 (16%) of 25 at 12 months.
    Conclusions: ABO-incompatible renal transplant performed with antibody removal and conventional immunosuppression continues to provide excellent patient and graft survival, and stable renal function over 4 years. Coupled with absent transplant glomerulopathy and low rates of progressive IF/TA on earlier biopsies, this suggests that ABOi with conventional immunosuppression and antibody removal, without rituximab or splenectomy, can achieve long-term outcomes comparable to ABO-compatible transplantation.
    MeSH term(s) ABO Blood-Group System/immunology ; Adult ; Biopsy ; Blood Group Incompatibility/immunology ; Female ; Graft Rejection/blood ; Graft Rejection/immunology ; Graft Rejection/mortality ; Graft Rejection/prevention & control ; Graft Survival ; Histocompatibility ; Histocompatibility Testing ; Humans ; Immunosuppressive Agents/therapeutic use ; Kidney Transplantation/adverse effects ; Kidney Transplantation/mortality ; Male ; Middle Aged ; Plasmapheresis ; Rituximab/therapeutic use ; Splenectomy ; Time Factors ; Treatment Outcome
    Chemical Substances ABO Blood-Group System ; Immunosuppressive Agents ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2017-06
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000001415
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  5. Article: Infective mesenteric adenitis masquerading as relapsed non-Hodgkin's lymphoma.

    Grigg, Andrew / Landgren, Anthony

    Leukemia & lymphoma

    2004  Volume 45, Issue 12, Page(s) 2517–2519

    Abstract: Bulky mesenteric lymphadenopathy and B symptoms in a patient with a prior history of relapsed histologically aggressive non-Hodgkin's lymphoma would usually be attributed to recurrent disease. In the case described here, recurrent lymphadenopathy was ... ...

    Abstract Bulky mesenteric lymphadenopathy and B symptoms in a patient with a prior history of relapsed histologically aggressive non-Hodgkin's lymphoma would usually be attributed to recurrent disease. In the case described here, recurrent lymphadenopathy was found to be due to probable Yersinia infection, highlighting the need for rebiopsy of tissue in these circumstances wherever possible.
    MeSH term(s) Adult ; Diagnosis, Differential ; Humans ; Lymphadenitis/diagnosis ; Lymphoma, Non-Hodgkin/diagnosis ; Male ; Recurrence ; Yersinia Infections/diagnosis
    Language English
    Publishing date 2004-12-15
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/1042-8190400001014
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    Zs.A 2997: Show issues Location:
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  6. Article ; Online: Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients.

    Allen, Nicholas C / Martin, Andrew J / Snaidr, Victoria A / Eggins, Renee / Chong, Alvin H / Fernandéz-Peñas, Pablo / Gin, Douglas / Sidhu, Shireen / Paddon, Vanessa L / Banney, Leith A / Lim, Adrian / Upjohn, Edward / Schaider, Helmut / Ganhewa, Aparna D / Nguyen, Jennifer / McKenzie, Catriona A / Prakash, Saurabh / McLean, Catriona / Lochhead, Alistair /
    Ibbetson, Jan / Dettrick, Andrew / Landgren, Anthony / Allnutt, Katherine J / Allison, Clare / Davenport, Rachael B / Mumford, Blake P / Wong, Brittany / Stagg, Brendan / Tedman, Alexander / Gribbin, Hannah / Edwards, Harrison A / De Rosa, Nicholas / Stewart, Thomas / Doolan, Brent J / Kok, Yonatan / Simpson, Kate / Low, Zhi M / Kovitwanichkanont, Tom / Scolyer, Richard A / Dhillon, Haryana M / Vardy, Janette L / Chadban, Steven J / Bowen, David G / Chen, Andrew C / Damian, Diona L

    The New England journal of medicine

    2023  Volume 388, Issue 9, Page(s) 804–812

    Abstract: Background: Immunosuppressed organ-transplant recipients have an increased incidence of, and mortality from, skin cancer. Nicotinamide (vitamin B: Methods: In this phase 3 trial, we randomly assigned, in a 1:1 ratio, organ-transplant recipients who ... ...

    Abstract Background: Immunosuppressed organ-transplant recipients have an increased incidence of, and mortality from, skin cancer. Nicotinamide (vitamin B
    Methods: In this phase 3 trial, we randomly assigned, in a 1:1 ratio, organ-transplant recipients who had had at least two keratinocyte cancers in the past 5 years to receive 500 mg of nicotinamide or placebo twice daily for 12 months. Participants were examined for skin lesions by dermatologists at 3-month intervals for 12 months. The primary end point was the number of new keratinocyte cancers during the 12-month intervention period. Secondary end points included the numbers of squamous-cell and basal-cell carcinomas during the 12-month intervention period, the number of actinic keratoses until 6 months after randomization, safety, and quality of life.
    Results: A total of 158 participants were enrolled, with 79 assigned to the nicotinamide group and 79 to the placebo group. The trial was stopped early owing to poor recruitment. At 12 months, there were 207 new keratinocyte cancers in the nicotinamide group and 210 in the placebo group (rate ratio, 1.0; 95% confidence interval, 0.8 to 1.3; P = 0.96). No significant between-group differences in squamous-cell and basal-cell carcinoma counts, actinic keratosis counts, or quality-of-life scores were observed. Adverse events and changes in blood or urine laboratory variables were similar in the two groups.
    Conclusions: In this 12-month, placebo-controlled trial, oral nicotinamide therapy did not lead to lower numbers of keratinocyte cancers or actinic keratoses in immunosuppressed solid-organ transplant recipients. (Funded by the National Health and Medical Research Council; ONTRANS Australian New Zealand Clinical Trials Registry number, ACTRN12617000599370.).
    MeSH term(s) Humans ; Australia ; Carcinoma, Basal Cell/etiology ; Carcinoma, Basal Cell/prevention & control ; Carcinoma, Squamous Cell/etiology ; Carcinoma, Squamous Cell/prevention & control ; Chemoprevention ; Keratosis, Actinic/etiology ; Keratosis, Actinic/prevention & control ; Niacinamide/administration & dosage ; Niacinamide/therapeutic use ; Quality of Life ; Skin Neoplasms/etiology ; Skin Neoplasms/prevention & control ; Transplant Recipients ; Immunocompromised Host ; Organ Transplantation/adverse effects ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/therapeutic use ; Ultraviolet Rays/adverse effects
    Chemical Substances Niacinamide (25X51I8RD4) ; Antineoplastic Agents
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Clinical Trial, Phase III ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMoa2203086
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  7. Article ; Online: Renal allograft re-use and herpetic re-infection.

    Setyapranata, Stella / Holt, Stephen G / Wiggins, Kate J / Mulley, William R / Kerr, Peter G / Landgren, Anthony J / Eisen, Damon P / Young, Andrew / Opdam, Helen / Robertson, Amanda / Asadi, Khashayar / Hughes, Peter D

    Nephrology (Carlton, Vic.)

    2015  Volume 20 Suppl 1, Page(s) 17–21

    Abstract: A middle-aged man received a kidney transplant from a deceased multi-organ donor. The recipient suffered cardiac arrest several days post-operatively and sustained hypoxic brain injury and was declared brain dead. Following the family's consent, the ... ...

    Abstract A middle-aged man received a kidney transplant from a deceased multi-organ donor. The recipient suffered cardiac arrest several days post-operatively and sustained hypoxic brain injury and was declared brain dead. Following the family's consent, the allograft kidney was retrieved and re-transplanted into a man with end-stage renal failure secondary to reflux nephropathy. The liver was not transplanted due to suspicion of fatty changes based on macroscopic appearance. After transplantation of other organs, liver histology revealed coagulative parenchymal necrosis with nuclear inclusions and moderate parenchymal cholestasis, suggestive of herpes viral hepatitis. Renal implantation biopsy showed histiocytes with enlarged nuclei containing viral inclusions in the capsular fibrous tissue, with positive immunostaining for herpes simplex virus (HSV). Anti-viral therapy was commenced immediately after obtaining histological evidence of donor HSV infection. Our recipient had pre-formed immunoglobulin G antibodies to HSV-1 and HSV-2, and was immunoglobulin M negative pre-transplant. HSV viraemia was detected day 5 post-transplant with a viral load of 7688 copies/mL by polymerase chain reaction assay. The recipient completed a 30 day course of intravenous ganciclovir before switching to oral valganciclovir as standard cytomegalovirus prophylaxis. The HSV polymerase chain reaction became undetectable on day 7 of intravenous ganciclovir and has remained undetectable. The patient remains well 9 months post-transplant with an estimated glomerular filtration rate of 61 mL/min per 1.73 m(2). Although renal allograft re-use has been shown to be technically possible with a good outcome in this recipient, this does raise issues including assessment of allografts that have undergone repeated severe ischaemic insults and the potential of transmission of infections.
    MeSH term(s) Allografts ; Antiviral Agents/administration & dosage ; Biopsy ; Donor Selection ; Ganciclovir/administration & dosage ; Ganciclovir/analogs & derivatives ; Herpes Simplex/diagnosis ; Herpes Simplex/drug therapy ; Herpes Simplex/transmission ; Herpes Simplex/virology ; Herpesvirus 2, Human/pathogenicity ; Humans ; Kidney Transplantation/adverse effects ; Male ; Middle Aged ; Reoperation ; Time Factors ; Treatment Outcome
    Chemical Substances Antiviral Agents ; valganciclovir (GCU97FKN3R) ; Ganciclovir (P9G3CKZ4P5)
    Language English
    Publishing date 2015-03
    Publishing country Australia
    Document type Case Reports ; Journal Article
    ZDB-ID 1303661-0
    ISSN 1440-1797 ; 1320-5358
    ISSN (online) 1440-1797
    ISSN 1320-5358
    DOI 10.1111/nep.12423
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