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Article: Is Two Better Than One? A Retrospective Study on Colorectal Surgery Outcomes Using the Da Vinci

Landry, Dyllan / Quinn, Karson R / Helmer, Stephen D / Sanchez, Noel C

Kansas journal of medicine

2022 Volume 15, Page(s) 418–421

Abstract: Introduction: The da Vinci: Methods: A retrospective case-control study was conducted of patients who underwent various colorectal surgeries using either the single- or dual-console da Vinci: Results: Seventy-one patients (54.2%) utilized the ... ...

Abstract	Introduction: The da Vinci Methods: A retrospective case-control study was conducted of patients who underwent various colorectal surgeries using either the single- or dual-console da Vinci Results: Seventy-one patients (54.2%) utilized the single-console and 60 (45.8%) utilized the dual-console. There were no statistically significant differences in patient demographics, procedures performed, conversion to open, ICU admissions, total length of stay, need for blood transfusion, adequacy of surgical margin, number of lymph nodes harvested, anastomotic leak, discharge disposition, or readmission, wound infection, or need for reoperation within 30 days. There was a nonsignificant decrease in operative time with the dual-console system (200.6 vs. 220.2 minutes, p = 0.111). Conclusions: While this study showed no statistically significant differences between patient outcomes utilizing the single- versus dual-consoles, it showed that it is safe for use in training, and that more research is needed in this area.
Language	English
Publishing date	2022-11-28
Publishing country	United States
Document type	Journal Article
ISSN	1948-2035
ISSN	1948-2035
DOI	10.17161/kjm.vol15.18278
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Article ; Online: Tertiary treatment of a mixture of composting and landfill leachates using electrochemical processes.

Benguit, Alae / Tiwari, Bhagyashree / Drogui, Patrick / Landry, Dany

Chemosphere

2021 Volume 292, Page(s) 133379

Abstract: The study investigated the treatment efficiency of coupled electrocoagulation (EC) and electrooxidation (EO) processes for landfill leachate treatment in batch and continuous mode. The EC process (iron anode and graphite cathode) at 18.2 mA/ ... ...

Abstract	The study investigated the treatment efficiency of coupled electrocoagulation (EC) and electrooxidation (EO) processes for landfill leachate treatment in batch and continuous mode. The EC process (iron anode and graphite cathode) at 18.2 mA/cm
Language	English
Publishing date	2021-12-24
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2021.133379
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Article ; Online: Atypical anti-glomerular basement membrane glomerulonephritis in a patient with metastatic melanoma treated with mitogen-activated protein kinase and immune checkpoint inhibitors: a case report.

Kyriazis, Periklis / Tiwary, Abhinav / Freeman, Jonathan / Landry, Daniel / Braden, Gregory

Journal of medical case reports

2021 Volume 15, Issue 1, Page(s) 186

Abstract: Background: Immune checkpoint inhibitors and mitogen-activated protein kinase inhibitors have become the standard of care in patients with advanced melanoma bearing V600 mutations. However, little is known about their nephrotoxicity. To date, only two ... ...

Abstract	Background: Immune checkpoint inhibitors and mitogen-activated protein kinase inhibitors have become the standard of care in patients with advanced melanoma bearing V600 mutations. However, little is known about their nephrotoxicity. To date, only two cases of anti-glomerular basement membrane glomerulonephritis after exposure to checkpoint inhibitors have been documented. Herein, we report the first case of a patient with metastatic melanoma who developed linear Immunoglobulin G 3+, Immunoglobulin A 2+, kappa 2+, lambda 1+ anti-glomerular basement membrane glomerulonephritis with negative serology following treatment with checkpoint inhibitors and subsequently mitogen-activated protein kinase inhibitors. Case presentation: A 58-year-old Caucasian male was referred to our outpatient nephrology clinic with acute kidney injury and proteinuria. He had received three cycles of ipilimumab and nivolumab for recurrent melanoma positive for the BRAF V600E mutation with metastasis to the lungs. Immunotherapy had been discontinued in the setting of severe adverse effects including dermatitis, colitis, and hepatitis. Because of persistent bilateral lung metastases and left pleural metastases, the patient had been initiated on dabrafenib and trametinib until his presentation to our clinic 6 months later. On presentation, his blood pressure was 172/89 mm/Hg and had 2+ edema bilaterally. His creatinine level was 2.4 mg/dL from a previous normal baseline with a urinary protein-to-creatinine ratio of 2 g/g. His urinalysis showed dysmorphic erythrocytes and red blood cell casts. Serologic testing was negative for antineutrophilic cytoplasmic antibodies, proteinase 3 antigen, myeloperoxidase, and anti-glomerular basement membrane antibody. Complement levels were normal. A renal biopsy showed focal crescentic (2 of 15 glomeruli with cellular crescents), proliferative, and sclerosing glomerulonephritis with diffuse linear staining of glomerular capillary loops dominant for IgG (3+), IgA (2+), kappa (2+), and lambda (1+) minimal changes. He was initiated on oral cyclophosphamide and pulse intravenous methylprednisolone followed by oral prednisone for 6 months, which stabilized his renal function until reinitiation of immunotherapy. Conclusions: Acute kidney injury is an increasingly reported adverse effect of both drug classes, mostly affecting the tubulointerstitial compartment and infrequently the glomerulus. Although the biologic effect of these drugs on immune cells is not entirely understood, it is possible that BRAF-induced podocyte injury in combination with direct T-cell-mediated glomerular injury facilitated by checkpoint inhibitors led to the unmasking of cryptic antigens, loss of self-tolerance, and autoimmunity. More importantly, we show that treatment with corticosteroids and cyclophosphamide was able to improve and stabilize our patient's renal function until the reinitiation of immunotherapy.
MeSH term(s)	Anti-Glomerular Basement Membrane Disease ; Autoantibodies ; Glomerulonephritis ; Humans ; Immune Checkpoint Inhibitors ; Male ; Melanoma/drug therapy ; Middle Aged ; Mitogen-Activated Protein Kinases ; Neoplasm Recurrence, Local
Chemical Substances	Autoantibodies ; Immune Checkpoint Inhibitors ; Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2021-04-03
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2269805-X
ISSN	1752-1947 ; 1752-1947
ISSN (online)	1752-1947
ISSN	1752-1947
DOI	10.1186/s13256-021-02766-w
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Article ; Online: A Point Prevalence Survey of Antimicrobial Usage in New Brunswick Hospitals.

Cormier, Rachel / MacLaggan, Tim / Landry, Daniel / Harris, Rachel / Flewelling, Andrew

The Canadian journal of hospital pharmacy

2022 Volume 75, Issue 2, Page(s) 79–88

Abstract: Background: Prevalence surveys are useful tools for assessing the appropriateness of antimicrobial therapy.: Objectives: The primary objective was to assess patterns of antimicrobial utilization and appropriateness in New Brunswick hospitals. The ... ...

Abstract	Background: Prevalence surveys are useful tools for assessing the appropriateness of antimicrobial therapy. Objectives: The primary objective was to assess patterns of antimicrobial utilization and appropriateness in New Brunswick hospitals. The secondary objective was to assess the impact of hospital size and the presence of a penicillin allergy label on antimicrobial appropriateness. Methods: A point prevalence survey was conducted of inpatients taking 1 or more systemic antimicrobials during admission to hospitals in New Brunswick. A structured protocol and web-based data collection tool (National Antimicrobial Prescribing Survey) were used for this survey. Data regarding hospital size and presence of a penicillin allergy label were also collected. Antimicrobial utilization was assessed in terms of guideline compliance and appropriateness. Results were summarized descriptively. A χ Results: Ten hospitals participated, and a total of 2200 patients were admitted at the time of the survey. The overall prevalence of antimicrobial use was 22.7% (500/2200). A total of 648 antimicrobials were ordered. The most frequently prescribed antimicrobials by class were first-generation cephalosporins (14.0%, 91/648), third-generation cephalosporins (11.3%, 73/648), and piperacillin-tazobactam (10.2%, 66/648). The most common indications for antimicrobial therapy were respiratory tract infections (27.3%, 177/648), urinary tract infections (12.2%, 79/648), and intra-abdominal infections (11.4%, 74/648). Compliance with local or regional treatment guidelines, where applicable, was 66.2% (188/284). Provincially, 68.1% (441/648) of the antimicrobial orders were deemed appropriate. Larger centres had substantially higher rates of appropriateness ( Conclusions: Several opportunities for targeted interventions were identified to improve antimicrobial prescribing, including decreasing the use of broad-spectrum antimicrobials, increasing guideline compliance, and ensuring documentation of antimicrobial duration by prescribers.
Language	English
Publishing date	2022-04-04
Publishing country	Canada
Document type	Journal Article
ZDB-ID	413450-3
ISSN	1920-2903 ; 0008-4123
ISSN (online)	1920-2903
ISSN	0008-4123
DOI	10.4212/cjhp.v75i2.3093
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Article ; Online: Patient and Provider Satisfaction With Telehealth Preanesthesia Examinations.

Landry, David / Magee, Caleb / Nelson, Colby / Justice, Austin / McMullan, Susan

Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses

2022 Volume 38, Issue 3, Page(s) 394–397

Abstract: Purpose: Telehealth has become commonplace in many healthcare systems across the United States. Due to the COVID-19 pandemic, a large academic medical center in the southeast USA has increased the use of telehealth in the anesthesia department to ... ...

Abstract	Purpose: Telehealth has become commonplace in many healthcare systems across the United States. Due to the COVID-19 pandemic, a large academic medical center in the southeast USA has increased the use of telehealth in the anesthesia department to complete preanesthetic assessments before the patient's surgery. This has allowed high-risk patient populations to limit potential exposure to COVID-19 and limit the financial burden of traveling from neighboring counties to complete their preanesthetic assessment in person. The purpose of this quality improvement project was to evaluate the effectiveness of a preanesthetic assessment via telehealth among patients undergoing anesthesia. Design: A quality improvement project. Methods: Two separate surveys assessing patient and provider satisfaction with telehealth preanesthesia assessments were developed. Patients undergoing anesthesia at the medical center completed a telehealth preanesthesia assessment and received a satisfaction survey via email post-procedure. Certified registered nurse anesthetists (CRNAs) who cared for patients that completed a telehealth preanesthesia assessment also received an emailed satisfaction survey. Findings: Results demonstrate high satisfaction scores for both patients and providers. Conclusions: Current telehealth preanesthetic assessments prompt high satisfaction scores, supporting continued, and expanded use.
MeSH term(s)	Humans ; United States ; COVID-19 ; Pandemics ; Patient Satisfaction ; Telemedicine ; Personal Satisfaction
Language	English
Publishing date	2022-12-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1329844-6
ISSN	1532-8473 ; 0883-9433 ; 1089-9472
ISSN (online)	1532-8473
ISSN	0883-9433 ; 1089-9472
DOI	10.1016/j.jopan.2022.08.003
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Article ; Online: An NLR integrated domain toolkit to identify plant pathogen effector targets.

Landry, David / Mila, Isabelle / Sabbagh, Cyrus Raja Rubenstein / Zaffuto, Matilda / Pouzet, Cécile / Tremousaygue, Dominique / Dabos, Patrick / Deslandes, Laurent / Peeters, Nemo

The Plant journal : for cell and molecular biology

2023 Volume 115, Issue 5, Page(s) 1443–1457

Abstract: Plant immune receptors, known as NOD-like receptors (NLRs), possess unique integrated decoy domains that enable plants to attract pathogen effectors and initiate a specific immune response. The present study aimed to create a library of these integrated ... ...

Abstract	Plant immune receptors, known as NOD-like receptors (NLRs), possess unique integrated decoy domains that enable plants to attract pathogen effectors and initiate a specific immune response. The present study aimed to create a library of these integrated domains (IDs) and screen them with pathogen effectors to identify targets for effector virulence and NLR-effector interactions. This works compiles IDs found in NLRs from seven different plant species and produced a library of 78 plasmid clones containing a total of 104 IDs, representing 43 distinct InterPro domains. A yeast two-hybrid assay was conducted, followed by an in planta interaction test, using 32 conserved effectors from Ralstonia pseudosolanacearum type III. Through these screenings, three interactions involving different IDs (kinase, DUF3542, WRKY) were discovered interacting with two unrelated type III effectors (RipAE and PopP2). Of particular interest was the interaction between PopP2 and ID#85, an atypical WRKY domain integrated into a soybean NLR gene (GmNLR-ID#85). Using a Förster resonance energy transfer-fluorescence lifetime imaging microscopy technique to detect protein-protein interactions in living plant cells, PopP2 was demonstrated to physically associate with ID#85 in the nucleus. However, unlike the known WRKY-containing Arabidopsis RRS1-R NLR receptor, GmNLR-ID#85 could not be acetylated by PopP2 and failed to activate RPS4-dependent immunity when introduced into the RRS1-R immune receptor. The generated library of 78 plasmid clones, encompassing these screenable IDs, is publicly available through Addgene. This resource is expected to be valuable for the scientific community with respect to discovering targets for effectors and potentially engineering plant immune receptors.
MeSH term(s)	Crops, Agricultural ; Two-Hybrid System Techniques ; Cell Nucleus ; Transcription Factors ; NLR Proteins/metabolism ; Plants/metabolism ; Plants/microbiology ; Plant Proteins/metabolism ; Gene Library
Chemical Substances	Transcription Factors ; NLR Proteins ; Plant Proteins
Language	English
Publishing date	2023-07-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1088037-9
ISSN	1365-313X ; 0960-7412
ISSN (online)	1365-313X
ISSN	0960-7412
DOI	10.1111/tpj.16331
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Article ; Online: An NLR integrated domain toolkit to identify plant pathogen effector targets

Landry, David / Mila, Isabelle / Sabbagh, Cyrus Raja Rubenstein / Zaffuto, Matilda / Pouzet, Cécile / Tremousaygue, Dominique / Dabos, Patrick / Deslandes, Laurent / Peeters, Nemo

The Plant Journal. 2023 Sept., v. 115, no. 5 p.1443-1457

2023

Abstract: Plant immune receptors, known as NOD‐like receptors (NLRs), possess unique integrated decoy domains that enable plants to attract pathogen effectors and initiate a specific immune response. The present study aimed to create a library of these integrated ... ...

Abstract	Plant immune receptors, known as NOD‐like receptors (NLRs), possess unique integrated decoy domains that enable plants to attract pathogen effectors and initiate a specific immune response. The present study aimed to create a library of these integrated domains (IDs) and screen them with pathogen effectors to identify targets for effector virulence and NLR–effector interactions. This works compiles IDs found in NLRs from seven different plant species and produced a library of 78 plasmid clones containing a total of 104 IDs, representing 43 distinct InterPro domains. A yeast two‐hybrid assay was conducted, followed by an in planta interaction test, using 32 conserved effectors from Ralstonia pseudosolanacearum type III. Through these screenings, three interactions involving different IDs (kinase, DUF3542, WRKY) were discovered interacting with two unrelated type III effectors (RipAE and PopP2). Of particular interest was the interaction between PopP2 and ID#85, an atypical WRKY domain integrated into a soybean NLR gene (GmNLR‐ID#85). Using a Förster resonance energy transfer‐fluorescence lifetime imaging microscopy technique to detect protein–protein interactions in living plant cells, PopP2 was demonstrated to physically associate with ID#85 in the nucleus. However, unlike the known WRKY‐containing Arabidopsis RRS1‐R NLR receptor, GmNLR‐ID#85 could not be acetylated by PopP2 and failed to activate RPS4‐dependent immunity when introduced into the RRS1‐R immune receptor. The generated library of 78 plasmid clones, encompassing these screenable IDs, is publicly available through Addgene. This resource is expected to be valuable for the scientific community with respect to discovering targets for effectors and potentially engineering plant immune receptors.
Keywords	Arabidopsis ; Ralstonia ; energy ; genes ; immune response ; immunologic receptors ; microscopy ; plant pathogens ; plasmids ; soybeans ; two hybrid system techniques ; virulence
Language	English
Dates of publication	2023-09
Size	p. 1443-1457.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	1088037-9
ISSN	1365-313X ; 0960-7412
ISSN (online)	1365-313X
ISSN	0960-7412
DOI	10.1111/tpj.16331
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Article: Lifestyle changes do make a difference.

Landry, Donna

JAAPA : official journal of the American Academy of Physician Assistants

2009 Volume 21, Issue 12, Page(s) 45

MeSH term(s)	Aged, 80 and over ; Chronic Disease/prevention & control ; Health Promotion ; Humans ; Life Style ; Male ; Social Marketing
Language	English
Publishing date	2009-02-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2415226-2
ISSN	0893-7400 ; 1547-1896
ISSN (online)	0893-7400
ISSN	1547-1896
DOI	10.1097/01720610-200812000-00012
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Zs.A 6624: Show issues

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Article ; Online: A receptor required for chitin perception facilitates arbuscular mycorrhizal associations and distinguishes root symbiosis from immunity.

Zhang, Jingyi / Sun, Jongho / Chiu, Chai Hao / Landry, David / Li, Kangping / Wen, Jiangqi / Mysore, Kirankumar S / Fort, Sébastien / Lefebvre, Benoit / Oldroyd, Giles E D / Feng, Feng

Current biology : CB

2024 Volume 34, Issue 8, Page(s) 1705–1717.e6

Abstract: Plants establish symbiotic associations with arbuscular mycorrhizal fungi (AMF) to facilitate nutrient uptake, particularly in nutrient-limited conditions. This partnership is rooted in the plant's ability to recognize fungal signaling molecules, such as ...

Abstract	Plants establish symbiotic associations with arbuscular mycorrhizal fungi (AMF) to facilitate nutrient uptake, particularly in nutrient-limited conditions. This partnership is rooted in the plant's ability to recognize fungal signaling molecules, such as chitooligosaccharides (chitin) and lipo-chitooligosaccharides. In the legume Medicago truncatula, chitooligosaccharides trigger both symbiotic and immune responses via the same lysin-motif-receptor-like kinases (LysM-RLKs), notably CERK1 and LYR4. The nature of plant-fungal engagement is opposite according to the outcomes of immunity or symbiosis signaling, and as such, discrimination is necessary, which is challenged by the dual roles of CERK1/LYR4 in both processes. Here, we describe a LysM-RLK, LYK8, that is functionally redundant with CERK1 for mycorrhizal colonization but is not involved in chitooligosaccharides-induced immunity. Genetic mutation of both LYK8 and CERK1 blocks chitooligosaccharides-triggered symbiosis signaling, as well as mycorrhizal colonization, but shows no further impact on immunity signaling triggered by chitooligosaccharides, compared with the mutation of CERK1 alone. LYK8 interacts with CERK1 and forms a receptor complex that appears essential for chitooligosaccharides activation of symbiosis signaling, with the lyk8/cerk1 double mutant recapitulating the impact of mutations in the symbiosis signaling pathway. We conclude that this novel receptor complex allows chitooligosaccharides activation specifically of symbiosis signaling and helps the plant to differentiate between activation of these opposing signaling processes.
MeSH term(s)	Mycorrhizae/physiology ; Symbiosis ; Chitin/metabolism ; Medicago truncatula/microbiology ; Medicago truncatula/metabolism ; Medicago truncatula/immunology ; Medicago truncatula/genetics ; Plant Proteins/metabolism ; Plant Proteins/genetics ; Plant Immunity ; Oligosaccharides/metabolism ; Plant Roots/microbiology ; Plant Roots/metabolism ; Chitosan
Chemical Substances	Chitin (1398-61-4) ; Plant Proteins ; Oligosaccharides ; oligochitosan ; Chitosan (9012-76-4)
Language	English
Publishing date	2024-04-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1071731-6
ISSN	1879-0445 ; 0960-9822
ISSN (online)	1879-0445
ISSN	0960-9822
DOI	10.1016/j.cub.2024.03.015
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Article: Dual vs. single encoding in recognition memory as a function of lag, delay, and availability of semantic information.

Earhard, B / Landry, D

Memory & cognition

2011 Volume 4, Issue 5, Page(s) 609–615

Abstract: One objective of the study was to assess the view of Winograd and Raines (1972) that the absence of a difference between dual as opposed to single encodings of a word at long lags may be due to the fact that subjects can establish two independent ... ...

Abstract	One objective of the study was to assess the view of Winograd and Raines (1972) that the absence of a difference between dual as opposed to single encodings of a word at long lags may be due to the fact that subjects can establish two independent temporal tags when a to-be-remembered (TBRI word is presented at long lags. Winograd and Raines' argument that the effectiveness of any such temporal tags should diminish over time was examined. A second objective was to determine whether providing information about the semantic senses used during encoding operations would facilitate recognition, as "sense tagging" theories require. Words were presented twice in either the same low-frequency context or the same high-frequency context, or once in both a high- and low-frequency context at Lags 0 and 15. A recognition test was given immediately, or after a 1-week delay. The test was either context free or each word was accompanied by phrases which, in the case of TBR words, cued subjects with respect to the semantic senses of the word used in initial encoding. All manipulations influenced performance, but not in accordance with theoretical expectations.
Language	English
Publishing date	2011-02-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	185691-1
ISSN	1532-5946 ; 0090-502X
ISSN (online)	1532-5946
ISSN	0090-502X
DOI	10.3758/BF03213225
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