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  1. Book: A social history of medicine

    Lane, Joan

    health, healing and disease in England, 1750 - 1950

    2001  

    Author's details Joan Lane
    Keywords England ; Medizin ; Sozialgeschichte 1750-1950
    Subject Humanmedizin ; Heilkunst ; Medicine
    Language English
    Size IX, 233 S. : Ill.
    Publisher Routledge
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT013113679
    ISBN 0-415-20037-7 ; 0-415-20038-5 ; 978-0-415-20037-0 ; 978-0-415-20038-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2001 A 4049 order for loan Magazin

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  2. Book: John Hall and his patients

    Lane, Joan

    the medical practice of Shakespeare's son-in-law

    1996  

    Author's details Joan Lane
    Keywords Physicians / biography ; History of Medicine, 17th Cent. / Great Britain
    Language English
    Size XLII, 378 S. : Ill., Kt.
    Publisher Shakespeare Birthplace Trust u.a.
    Publishing place Stratford-upon-Avon
    Publishing country Great Britain
    Document type Book
    Note Bibliography: p357-361. - Includes index
    HBZ-ID HT007750396
    ISBN 0-7509-1095-X ; 978-0-7509-1095-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1997 A 7189 order for loan Magazin

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  3. Book: Worcester infirmary in the eighteenth century

    Lane, Joan

    (Occasional publications / Worcestershire Historical Society ; 6)

    1992  

    Author's details by Joan Lane
    Series title Occasional publications / Worcestershire Historical Society ; 6
    Collection
    Keywords Hospitals, Pediatric / history / Great Britain ; Hospitals, County / history / Great Britain ; History of Medicine, 18th Cent. / Great Britain
    Size 44 S.
    Publishing place S.l.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT004480140
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1993 B 330 order for loan Magazin

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  4. Article ; Online: Survival and Hematologic Benefits of Romiplostim After Acute Radiation Exposure Supported FDA Approval Under the Animal Rule.

    Bunin, Deborah I / Javitz, Harold S / Gahagen, Janet / Bakke, James / Lane, Joan H / Andrews, Dina A / Chang, Polly Y

    International journal of radiation oncology, biology, physics

    2023  Volume 117, Issue 3, Page(s) 705–717

    Abstract: Purpose: Patients exposed to acute high doses of ionizing radiation are susceptible to dose-dependent bone marrow depression with resultant pancytopenia. Romiplostim (RP; Nplate) is a recombinant thrombopoietin receptor agonist protein that promotes ... ...

    Abstract Purpose: Patients exposed to acute high doses of ionizing radiation are susceptible to dose-dependent bone marrow depression with resultant pancytopenia. Romiplostim (RP; Nplate) is a recombinant thrombopoietin receptor agonist protein that promotes progenitor megakaryocyte proliferation and platelet production and is an approved treatment for patients with chronic immune thrombocytopenia. The goal of our study was to evaluate the postirradiation survival and hematologic benefits of a single dose of RP with or without pegfilgrastim (PF; Neulasta, granulocyte colony stimulating factor) by conducting a well-controlled, treatment-concealed, good laboratory practice-compliant study in rhesus macaques that was compliant with the United States Food and Drug Administration Animal Rule regulatory approval pathway.
    Methods and materials: Irradiated male and female rhesus macaques (20/sex in each of 3 groups: control, RP, and RP + PF) were subcutaneously administered vehicle or RP (5 mg/kg, 10 mL/kg) on day 1 in the presence or absence of 2 doses of PF (0.3 mg/kg, 0.03 mL/kg, days 1 and 8). Total body radiation (680 cGy, 50 cGy/min from cobalt-60 gamma ray source) occurred 24 ± 2 hours previously at a dose targeting 70% lethality for the control cohort over 60 days. The study examined 60-day survival postirradiation as the primary endpoint. Secondary endpoints included incidence, severity, and duration of thrombocytopenia and neutropenia, other hematology parameters, coagulation parameters, and body weight change to provide insights into potential mechanisms of action.
    Results: Compared with sham-treated controls, treated animals demonstrated a 40% to 55% survival benefit compared with controls, less severe clinical signs, reduced incidence of thrombocytopenia and/or neutropenia, earlier hematologic recovery, and reduced morbidity from bacterial infection.
    Conclusions: These results were pivotal in obtaining Food and Drug Administration approval in January 2021 for RP's new indication as a single administration therapy to increase survival in adults and pediatric patients acutely exposed to myelosuppressive doses of radiation.
    MeSH term(s) Adult ; Animals ; Humans ; Male ; Female ; Child ; Macaca mulatta ; Recombinant Proteins ; Thrombocytopenia/drug therapy ; Thrombocytopenia/etiology ; Neutropenia/drug therapy ; Hematology ; Radiation Exposure
    Chemical Substances romiplostim (GN5XU2DXKV) ; Recombinant Proteins
    Language English
    Publishing date 2023-05-22
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2023.05.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1218: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Recovery Animals in Toxicology Studies: An Innovation and Quality Consortium Perspective on Best Practices With Case Study Examples.

    Salian-Mehta, Smita / Smith, James D / Flandre, Thierry D / Lambert, Amy L / Lane, Joan H / Stokes, Alan H / Orsted, Kathy / Bratcher-Petersen, Natalie A / Janardhan, Kyathanahalli S / Tonkin, Elizabeth G

    International journal of toxicology

    2024  , Page(s) 10915818241243350

    Abstract: The inclusion of recovery animals in nonclinical safety studies that support clinical trials is undertaken with a wide diversity of approaches even while operating under harmonized regulatory guidance. While empirical evaluation of reversibility may ... ...

    Abstract The inclusion of recovery animals in nonclinical safety studies that support clinical trials is undertaken with a wide diversity of approaches even while operating under harmonized regulatory guidance. While empirical evaluation of reversibility may enhance the overall nonclinical risk assessment, there are often overlooked opportunities to reduce recovery animal use by leveraging robust scientific and regulatory information. In the past, there were several attempts to benchmark recovery practices; however, recommendations have not been consistently applied across the pharmaceutical industry. A working group (WG) sponsored by the 3Rs Translational and Predictive Sciences Leadership Group of the IQ Consortium conducted a survey of current industry practice related to the evaluation of reversibility/recovery in repeat dose toxicity studies. Discussion among the WG representatives included member company strategies and case studies that highlight challenges and opportunities for continuous refinements in the use of recovery animals. The case studies presented in this paper demonstrate increasing alignment with the Society of Toxicologic Pathology recommendations (2013) towards (1) excluding recovery phase cohorts by default (include only when scientifically justified), (2) minimizing the number of recovery groups (e.g., control and one dose level), and (3) excluding controls in the recovery cohort by leveraging external and/or dosing phase data. Recovery group exclusion and decisions regarding the timing of reversibility evaluation may be driven by indication, modality, and/or other scientific or strategic factors using a weight of evidence approach. The results and recommendations discussed present opportunities to further decrease animal use without impacting the quality of human risk assessment.
    Language English
    Publishing date 2024-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1379845-5
    ISSN 1092-874X ; 1091-5818
    ISSN (online) 1092-874X
    ISSN 1091-5818
    DOI 10.1177/10915818241243350
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1870: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Points to consider regarding the use and implementation of virtual controls in nonclinical general toxicology studies.

    Palazzi, Xavier / Anger, Lennart T / Boulineau, Theresa / Grevot, Armelle / Guffroy, Magali / Henson, Kristin / Hoepp, Natalie / Jacobsen, Matt / Kale, Vijay P / Kreeger, John / Lane, Joan H / Li, Dingzhou / Muster, Wolfgang / Paisley, Brianna / Ramaiah, Lila / Robertson, Nicola / Shultz, Valerie / Steger Hartmann, Thomas / Westhouse, Richard

    Regulatory toxicology and pharmacology : RTP

    2024  Volume 150, Page(s) 105632

    Abstract: The replacement of a proportion of concurrent controls by virtual controls in nonclinical safety studies has gained traction over the last few years. This is supported by foundational work, encouraged by regulators, and aligned with societal expectations ...

    Abstract The replacement of a proportion of concurrent controls by virtual controls in nonclinical safety studies has gained traction over the last few years. This is supported by foundational work, encouraged by regulators, and aligned with societal expectations regarding the use of animals in research. This paper provides an overview of the points to consider for any institution on the verge of implementing this concept, with emphasis given on database creation, risks, and discipline-specific perspectives.
    Language English
    Publishing date 2024-04-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 604672-1
    ISSN 1096-0295 ; 0273-2300
    ISSN (online) 1096-0295
    ISSN 0273-2300
    DOI 10.1016/j.yrtph.2024.105632
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1711: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Wilkies, Richard

    Lane, Joan

    Oxford dictionary of national biography v.58

    2004  

    Author's details Joan Lane
    MeSH term(s) Physicians ; History, 18th Century ; History of Medicine
    Keywords England
    Language English
    Size p. 960-961.
    Publisher Oxford University Press
    Publishing place Oxford ; New York
    Document type Article
    ISBN 019861411X ; 9780198614111
    Database Catalogue of the US National Library of Medicine (NLM)

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  8. Article: Wintringham, Clifton

    Lane, Joan

    Oxford dictionary of national biography v.59

    2004  

    Author's details Joan Lane
    MeSH term(s) Physicians ; History, 18th Century ; History of Medicine
    Keywords England
    Language English
    Size p. 814-815.
    Publisher Oxford University Press
    Publishing place Oxford ; New York
    Document type Article
    ISBN 019861411X ; 9780198614111
    Database Catalogue of the US National Library of Medicine (NLM)

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  9. Article: Willughby, Percival

    Lane, Joan

    Oxford dictionary of national biography v.59

    2004  

    Author's details Joan Lane
    MeSH term(s) Physicians ; History, 17th Century ; History of Medicine
    Keywords England
    Language English
    Size p. 450.
    Publisher Oxford University Press
    Publishing place Oxford ; New York
    Document type Article
    ISBN 019861411X ; 9780198614111
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Article: Pearson, Richard

    Lane, Joan

    Oxford dictionary of national biography v.43

    2004  

    Author's details Joan Lane
    MeSH term(s) Physicians ; Pharmacists ; History, 18th Century ; History, 19th Century ; History of Medicine
    Keywords England
    Language English
    Size p. 340-341.
    Publisher Oxford University Press
    Publishing place Oxford ; New York
    Document type Article
    ISBN 019861411X ; 9780198614111
    Database Catalogue of the US National Library of Medicine (NLM)

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