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  1. Book ; Thesis: Viral infecion causes reduction of IRF8 and CD9 expression on cells of immune system

    Kuang, Fei / Lang, Karl Sebastian

    2022  

    Institution Universität Duisburg-Essen
    Author's details vorgelegt von Fei Kuang ; 1. Gutachter/in: Herr Univ.-Prof. Dr. med. K. S. Lang, 2. Gutachter/in: Herr Prof. Dr. med. S. Dolff
    Language English
    Size 53 Seiten, Illustrationen
    Publishing place Duisburg ; Essen
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Duisburg-Essen, 2023
    HBZ-ID HT030000522
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2023 E 787 order for loan Magazin

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  2. Book ; Online ; Thesis: The generation and characterization of a beneficial anti-tumoral Lymphocytic choriomeningitis virus strain

    Bergerhausen, Michael [Verfasser] / Lang, Karl Sebastian [Akademischer Betreuer]

    2024  

    Author's details Michael Bergerhausen ; Betreuer: Karl Sebastian Lang
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Duisburg ; Universität Duisburg-Essen
    Publishing place Essen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  3. Book ; Online ; Thesis: Mechanisms and systemic relevance of immune cell specific virus replication

    Friedrich, Sarah-Kim [Verfasser] / Lang, Karl Sebastian [Akademischer Betreuer]

    2022  

    Author's details Sarah-Kim Friedrich-Becker ; Betreuer: Karl Sebastian Lang
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Duisburg ; Universität Duisburg-Essen
    Publishing place Essen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  4. Article ; Online: Expression of Interferon Regulatory Factor 8 (IRF8) and Its Association with Infections in Dialysis Patients.

    Friebus-Kardash, Justa / Kuang, Fei / Peitz, Tobias / Hamdan, Thamer A / Eisenberger, Ute / Boss, Kristina / Kribben, Andreas / Lang, Karl Sebastian / Jahn, Michael

    Cells

    2023  Volume 12, Issue 14

    Abstract: Patients on dialysis have dysfunctions of innate and adaptive immune system responses. The transcriptional factor IRF8 (interferon regulatory factor 8) is primarily expressed in plasmacytoid cells (pDCs) and myeloid dendritic cells (mDCs), playing a ... ...

    Abstract Patients on dialysis have dysfunctions of innate and adaptive immune system responses. The transcriptional factor IRF8 (interferon regulatory factor 8) is primarily expressed in plasmacytoid cells (pDCs) and myeloid dendritic cells (mDCs), playing a crucial role in the maturation of dendritic cells, monocytes, and macrophages, and contributing to protection against bacterial infections. The current study analyzed the expression patterns of IRF8 and assessed its association with the risk of infections in 79 dialysis patients compared to 44 healthy controls. Different subsets of leukocytes and the intracellular expression of IRF8 were measured using flow cytometry. Compared to the healthy controls, the dialysis patients showed significantly reduced numbers of pDCs and significantly increased numbers of natural killer cells and classical and intermediate monocytes. The dialysis patients exhibited decreased numbers of IRF8-positive dendritic cells (pDC
    MeSH term(s) Humans ; Renal Dialysis ; Interferon Regulatory Factors/genetics ; Interferon Regulatory Factors/metabolism ; Monocytes/metabolism ; Lymphocytes/metabolism
    Chemical Substances interferon regulatory factor-8 ; Interferon Regulatory Factors
    Language English
    Publishing date 2023-07-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12141892
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Online ; Thesis: NK cells negatively regulate CD8+ T cells during chronic viral infection in FcεRIγ-dependent manner

    Hamdan, Thamer A. [Verfasser] / Lang, Karl Sebastian [Akademischer Betreuer]

    2020  

    Author's details Thamer A. Hamdan ; Betreuer: Karl Sebastian Lang
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language English
    Publisher Duisburg ; Universität Duisburg-Essen
    Publishing place Essen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Article: Usp22 Deficiency Leads to Downregulation of PD-L1 and Pathological Activation of CD8

    Friebus-Kardash, Justa / Christ, Theresa Charlotte / Dietlein, Nikolaus / Elwy, Abdelrahman / Abdelrahman, Hossam / Holnsteiner, Lisa / Hu, Zhongwen / Rodewald, Hans-Reimer / Lang, Karl Sebastian

    Vaccines

    2023  Volume 11, Issue 10

    Abstract: Ubiquitin-specific peptidase 22 (Usp22) cleaves ubiquitin moieties from numerous proteins, including histone H2B and transcription factors. Recently, it was reported that Usp22 acts as a negative regulator of interferon-dependent responses. In the ... ...

    Abstract Ubiquitin-specific peptidase 22 (Usp22) cleaves ubiquitin moieties from numerous proteins, including histone H2B and transcription factors. Recently, it was reported that Usp22 acts as a negative regulator of interferon-dependent responses. In the current study, we investigated the role of Usp22 deficiency in acute viral infection with lymphocytic choriomeningitis virus (LCMV). We found that the lack of Usp22 on bone marrow-derived cells (Usp22
    Language English
    Publishing date 2023-10-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11101563
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: CD107a

    Wiechmann, Anika / Wilde, Benjamin / Tyczynski, Bartosz / Amann, Kerstin / Abdulahad, Wayel H / Kribben, Andreas / Lang, Karl Sebastian / Witzke, Oliver / Dolff, Sebastian

    Frontiers in medicine

    2021  Volume 8, Page(s) 556776

    Abstract: Cytotoxic ... ...

    Abstract Cytotoxic CD8
    Language English
    Publishing date 2021-03-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.556776
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The acid ceramidase/ceramide axis controls parasitemia in

    Günther, Anne / Hose, Matthias / Abberger, Hanna / Schumacher, Fabian / Veith, Ylva / Kleuser, Burkhard / Matuschewski, Kai / Lang, Karl Sebastian / Gulbins, Erich / Buer, Jan / Westendorf, Astrid M / Hansen, Wiebke

    eLife

    2022  Volume 11

    Abstract: Acid ceramidase (Ac) is part of the sphingolipid metabolism and responsible for the degradation of ceramide. As bioactive molecule, ceramide is involved in the regulation of many cellular processes. However, the impact of cell-intrinsic Ac activity and ... ...

    Abstract Acid ceramidase (Ac) is part of the sphingolipid metabolism and responsible for the degradation of ceramide. As bioactive molecule, ceramide is involved in the regulation of many cellular processes. However, the impact of cell-intrinsic Ac activity and ceramide on the course of
    MeSH term(s) Acid Ceramidase ; Animals ; Ceramides/pharmacology ; Erythropoiesis ; Malaria/drug therapy ; Mice ; Parasitemia ; Plasmodium yoelii
    Chemical Substances Ceramides ; Acid Ceramidase (EC 3.5.1.23)
    Language English
    Publishing date 2022-09-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.77975
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online ; Thesis: Mechanistical and therapeutical aspects of preventing diabetes

    Shaabani, Namir / Lang, Karl Sebastian / Proksch, Peter

    2014  

    Author's details Namir Shaabani. Gutachter: Karl Sebastian Lang; Peter Proksch
    Language English
    Size Online-Ressource
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Düsseldorf, Heinrich-Heine-Universität, Diss., 2014
    Database Former special subject collection: coastal and deep sea fishing

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  10. Book ; Online ; Thesis: Die Bedeutung einer forcierenden Virusreplikation auf die Aktivierung des adaptiven Immunsystems und Zerstörung der Selbsttoleranz

    Honke, Nadine / Lang, Karl Sebastian / Willbold, Dieter

    2014  

    Title variant The role of enforced virus replication in the activation of the adaptive immune system and breaking tolerance
    Author's details Nadine Honke. Gutachter: Karl Sebastian Lang; Dieter Willbold
    Language German
    Size Online-Ressource
    Publisher Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf
    Publishing place Düsseldorf
    Document type Book ; Online ; Thesis
    Thesis / German Habilitation thesis Düsseldorf, Heinrich-Heine-Universität, Diss., 2014
    Database Former special subject collection: coastal and deep sea fishing

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