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  1. Book ; Online: Innovationsräume

    Lang, Thilo / Graffenberger, Martin / Vonnahme, Lukas

    (Dialektik des Globalen. Kernbegriffe)

    2019  

    Series title Dialektik des Globalen. Kernbegriffe
    Keywords Biography & True Stories ; Core concept
    Language German
    Size 1 electronic resource (41 pages)
    Publisher De Gruyter
    Document type Book ; Online
    Note German
    HBZ-ID HT030648090
    ISBN 9783110632873 ; 311063287X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Regional and Local Development in Times of Polarisation : Re-thinking Spatial Policies in Europe

    Lang, Thilo / Görmar, Franziska

    2019  

    Keywords Cultural studies ; Sociology ; Politics & government ; Human geography ; Social sciences ; Sociology, Urban ; Culture-Study and teaching ; Europe-Politics and government
    Size 1 electronic resource (382 pages)
    Publisher Springer Nature
    Publishing place Singapore
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021028691
    ISBN 978-981-13-1190-1 ; 981-13-1190-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book ; Thesis: Die Rolle der Mikro-RNA 342 und ihres Wirtsgens Evl in der Blutbildung

    Lang, Tonio

    2020  

    Author's details vorgelegt von Tonio Johannes Lukas Lang
    Language German
    Size 105 Blätter, Illustrationen, Diagramme, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2021
    HBZ-ID HT021471142
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2022 E 900 order for loan Magazin

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  4. Article ; Online: Tandem repeats structure of gel-forming mucin domains could be revealed by SMRT sequencing data.

    Lang, Tiange

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 20652

    Abstract: Mucins are large glycoproteins that cover and protect epithelial surface of the body. Mucin domains of gel-forming mucins are rich in proline, threonine, and serine that are heavily glycosylated. These domains show great complexity with tandem repeats, ... ...

    Abstract Mucins are large glycoproteins that cover and protect epithelial surface of the body. Mucin domains of gel-forming mucins are rich in proline, threonine, and serine that are heavily glycosylated. These domains show great complexity with tandem repeats, thus make it difficult to study the sequences. With the coming of single molecule real-time (SMRT) sequencing technologies, we manage to present sequence structure of mucin domains via SMRT long reads for gel-forming mucins MUC2, MUC5AC, MUC5B and MUC6. Our study shows that for different individuals, single nucleotide polymorphisms could be found in mucin domains of MUC2, MUC5AC, MUC5B and MUC6, while different number of tandem repeats could be found in mucin domains of MUC2 and MUC6. Furthermore, we get the sequence of MUC2, MUC5AC, and MUC5B mucin domain in a Chinese individual for each nucleotide at accuracy of possibly 99.98-99.99%, 99.93-99.99%, and 99.76-99.99%, respectively. We report a new method to obtain DNA sequence of gel-forming mucin domains. This method will provided new insights on getting the sequence for Tandem Repeat parts which locate in coding region. With the sequences we obtained through this method, we can give more information for people to study the sequences of gel-forming mucin domains.
    MeSH term(s) Humans ; Tandem Repeat Sequences/genetics ; Technology ; Threonine ; Asians ; Nucleotides
    Chemical Substances Threonine (2ZD004190S) ; Nucleotides
    Language English
    Publishing date 2022-11-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-25262-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Enabling evidence to tackle everyday diseases to mitigate another pandemic.

    Lang, Trudie

    Gates open research

    2022  Volume 6, Page(s) 45

    Abstract: The next emergent novel pathogen is likely to occur where the ability to undertake health research and collect life-saving data is lacking. Without embedded and ongoing research activities in place spotting and stopping a new threat is not possible, ... ...

    Abstract The next emergent novel pathogen is likely to occur where the ability to undertake health research and collect life-saving data is lacking. Without embedded and ongoing research activities in place spotting and stopping a new threat is not possible, thereby enabling undetected infection and unchecked transmission within a community. Without local existing capabilities to collect such data delay is catastrophic. Fundamental goals in pandemic preparedness should be to stop an outbreak before it becomes a pandemic. This requires immediate action from teams already in place with the right skills, this could be readily achieved if we shift our thinking and enable research capabilities to be present in every healthcare setting. Addressing fundamental gaps in health research capacity and equity could tackle this and then we would be better prepared, globally.
    Language English
    Publishing date 2022-04-07
    Publishing country United States
    Document type Journal Article
    ISSN 2572-4754
    ISSN (online) 2572-4754
    DOI 10.12688/gatesopenres.13497.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: UK food policy: implications for nutritionists.

    Lang, Tim

    The Proceedings of the Nutrition Society

    2022  Volume 81, Issue 2, Page(s) 176–189

    Abstract: Implications of the 'changing world' for nutrition and nutritionists are considered, using the UK within a global context as an illustration. The first section summarises the slow recognition by policy makers of the significance of the changing world of ... ...

    Abstract Implications of the 'changing world' for nutrition and nutritionists are considered, using the UK within a global context as an illustration. The first section summarises the slow recognition by policy makers of the significance of the changing world of food and nutrition. The second section 'Food system stress is now at a critical level' considers the present scale of global food system stress and the failure so far sufficiently to narrow the gap between evidence and policy change. The year 2021 was earmarked when three major UN conferences had the opportunity to chart food changes ahead. The third section 'Multi-criteria analysis helps frame 21st century nutrition science' proposes that multi-criteria analysis is an essential methodology for nutrition within this more complex policy world; nutrition studies can no long exclude social and environmental criteria. The penultimate section 'Nutrition science can reconnect its life science, social and environmental nutrition traditions to contribute to new paradigm formation' suggests that nutrition science can now recombine three traditions within its own history to address this complexity: social nutrition, environmental nutrition and life sciences. The final section 'Priorities ahead' concludes that this multi-criteria approach to nutrition offers new routes for science and policy influence. Five priorities are identified: (1) clarification of the features of a good food system; (2) new sustainable dietary guidelines which integrate different determinants of sustainability; (3) helping consumer engagement with change; (4) developing improved policy frameworks and (5) contributing to professional channels in these processes. In the UK, while the challenge of narrowing the gap between evidence, policy and change remains daunting, the risks of not attempting to improve the transition to an ecologically sound public health nutrition are even greater.
    MeSH term(s) Food Supply ; Humans ; Nutrition Policy ; Nutritionists ; Public Health ; United Kingdom
    Language English
    Publishing date 2022-02-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 391142-1
    ISSN 1475-2719 ; 0029-6651
    ISSN (online) 1475-2719
    ISSN 0029-6651
    DOI 10.1017/S0029665122000817
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ue I Zs.179: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Book ; Online: Clustering large 3D volumes

    Lang, Thomas

    A sampling-based approach

    2023  

    Abstract: In many applications of X-ray computed tomography, an unsupervised segmentation of the reconstructed 3D volumes forms an important step in the image processing chain for further investigation of the digitized object. Therefore, the goal is to train a ... ...

    Abstract In many applications of X-ray computed tomography, an unsupervised segmentation of the reconstructed 3D volumes forms an important step in the image processing chain for further investigation of the digitized object. Therefore, the goal is to train a clustering algorithm on the volume, which produces a voxelwise classification by assigning a cluster index to each voxel. However, clustering methods, e.g., K-Means, typically have an asymptotic polynomial runtime with respect to the dataset size, and thus, these techniques are rarely applicable to large volumes. In this work, we introduce a novel clustering technique based on random sampling, which allows for the voxelwise classification of arbitrarily large volumes. The presented method conducts efficient linear passes over the data to extract a representative random sample of a fixed size on which the classifier can be trained. Then, a final linear pass performs the segmentation and assigns a cluster index to each individual voxel. Quantitative and qualitative evaluations show that excellent results can be achieved even with a very small sample size. Consequently, the unsupervised segmentation by means of clustering becomes feasible for arbitrarily large volumes.

    Comment: 12 pages, 8 figures
    Keywords Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Information Retrieval ; 68W20 ; I.5.3 ; H.3.3
    Publishing date 2023-03-07
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Minimum retesting intervals in practice: 10 years experience.

    Lang, Tim

    Clinical chemistry and laboratory medicine

    2020  Volume 59, Issue 1, Page(s) 39–50

    Abstract: Background: Minimum retesting intervals (MRI) are a popular demand management solution for the identification and reduction of over-utilized tests. In 2011 Association of Clinical Biochemistry and Laboratory Medicines (ACB) published evidence-based ... ...

    Abstract Background: Minimum retesting intervals (MRI) are a popular demand management solution for the identification and reduction of over-utilized tests. In 2011 Association of Clinical Biochemistry and Laboratory Medicines (ACB) published evidence-based recommendations for the use of MRI.
    Aim: The aim of the paper was to review the use of MRI over the period since the introduction of these recommendations in 2011 to 2020 and compare it to previous published data between 2000-2010.
    Methods: A multi-source literature search was performed to identify studies that reported the use of a MRI in the management or identification of inappropriate testing between the years prior to (2000-2010) and after implementation (2011-2020) of these recommendations.
    Results: 31 studies were identified which met the acceptance criteria (2000-2010 n=4, 2011-2020 n=27). Between 2000 and 2010 4.6% of tests (203,104/4,425,311) were identified as failing a defined MRI which rose to 11.8% of tests (2,691,591/22,777,288) in the 2011-2020 period. For those studies between 2011 and 2020 reporting predicted savings (n=20), 14.3% of tests (1,079,972/750,580) were cancelled, representing a total saving of 2.9 M Euros or 2.77 Euro/test. The most popular rejected test was Haemoglobin A1c which accounted for nearly a quarter of the total number of rejected tests. 13 out 27 studies used the ACB recommendations.
    Conclusions: MRI are now an established, safe and sustainable demand management tool for the identification and management of inappropriate testing. Evidence based consensus recommendations have supported the adoption of this demand management tool into practice across multiple healthcare settings globally and harmonizing laboratory practice.
    MeSH term(s) Clinical Laboratory Techniques/standards ; Medical Overuse/prevention & control ; Time Factors
    Language English
    Publishing date 2020-09-07
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2020-0660
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 121: Show issues Location:
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  9. Article ; Online: Plug COVID-19 research gaps in detection, prevention and care.

    Lang, Trudie

    Nature

    2020  Volume 583, Issue 7816, Page(s) 333

    MeSH term(s) Animals ; Behavioral Research/organization & administration ; Behavioral Research/trends ; Biomedical Research/organization & administration ; Biomedical Research/trends ; COVID-19 ; Community Health Services ; Coronavirus Infections/diagnosis ; Coronavirus Infections/prevention & control ; Coronavirus Infections/therapy ; Coronavirus Infections/transmission ; Financing, Organized/organization & administration ; Healthcare Disparities/statistics & numerical data ; Humans ; International Cooperation ; Mental Health/statistics & numerical data ; Pandemics/prevention & control ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/therapy ; Pneumonia, Viral/transmission ; Public Health/methods ; Public Health Administration ; Public Opinion ; Qualitative Research ; Randomized Controlled Trials as Topic
    Keywords covid19
    Language English
    Publishing date 2020-07-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-020-02004-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 26: Show issues Location:
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  10. Article ; Online: Cervical wear pathobiology by robot-simulated 3-year toothbrushing - New methodological approach.

    Wilke, K / Nietzsche, S / Hemmleb, M / Mason, S / Varghese, R / Lang, T / Gaengler, P

    Archives of oral biology

    2024  Volume 163, Page(s) 105981

    Abstract: Objectives: An ex-vivo study was aimed at (i) programming clinically validated robot three-year random toothbrushing, (ii) evaluating cervical macro- and microwear patterns on all tooth groups of different functional age, (iii) documenting and ... ...

    Abstract Objectives: An ex-vivo study was aimed at (i) programming clinically validated robot three-year random toothbrushing, (ii) evaluating cervical macro- and microwear patterns on all tooth groups of different functional age, (iii) documenting and codificating wear related morphological features at the cemento-enamel junction in young teeth and on roots in older teeth.
    Design: Following ethical approval random toothbrushing (44 strokes per tooth horizontally, rotating, vertically; 2x/d) with manual toothbrushes and low-abrasive dentifrice was performed in an artificial oral cavity with brushing-force 3.5 N on 14 extracted human teeth. Morphological features were examined by SEM at baseline and after simulated 3 years using the replication technique. 3D-SEM analyses were carried out with a four-quadrant back scattered electron detector. Wilcoxon-Mann-Whitney-test was used for statistical analyses.
    Results: 3-year random toothbrushing with horizontal, rotating and vertical brushing movements revealed morphological features classified as four enamel patterns, one dentin pattern and three cervical patterns. Negative impacts were enamel, cementum and dentin loss. Positive impact on oral health was removing dental calculus and straightening cervical traumatic and iatrogenic damages. The volume loss varied from x̅=34.25nl to x̅=87.75nl. Wear extended apically from 100 to 1500 micrometres.
    Conclusion: Robot simulated toothbrushing in an artificial oral cavity, with subsequent SEM and 3D-SEM assessment, elucidated both negative and oral health-contributing micromorphology patterns of cervical wear after simulated 3-year random toothbrushing. Cervical macro- and microwear of cementum revealed, for the first time, what we describe as overhanging enamel peninsulas and enamel islands on roots in young teeth, but no enamel islands on roots from older teeth after root cementum loss. In contrast, many older teeth exhibited enamel peninsulas.
    MeSH term(s) Humans ; Toothbrushing ; Tooth Wear/etiology ; Tooth Cervix/pathology ; Microscopy, Electron, Scanning ; Robotics ; Dental Enamel ; Dental Cementum/pathology ; Dentin ; Dentifrices ; In Vitro Techniques
    Chemical Substances Dentifrices
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 80227-x
    ISSN 1879-1506 ; 0003-9969
    ISSN (online) 1879-1506
    ISSN 0003-9969
    DOI 10.1016/j.archoralbio.2024.105981
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    Ul III Zs.151: Show issues Location:
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