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Conference proceedings ; Online: Antibiotic resistance in aquatic environments

Jampani, Mahesh / Mateo-Sagasta, Javier / Langan, Simon

priorities and knowledge for water quality modelling

2023

Keywords	resistance to antibiotics ; aquatic environment ; water quality ; modelling ; bacteria ; pollution ; transformation ; wastewater ; health hazards
Language	English
Publishing date	2023-12-11T05:37:33Z
Publishing country	fr
Document type	Conference proceedings ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Conference proceedings ; Online: Antibiotic resistance in aquatic environments

Jampani, Mahesh / Mateo-Sagasta, Javier / Langan, Simon

priorities and knowledge for water quality modelling [Abstract only].

2023

Keywords	resistance to antibiotics ; antibiotic resistance genes ; bacteria ; water quality ; modelling ; frameworks ; aquatic environment ; public health ; health hazards
Language	English
Publishing date	2023-12-11T09:25:16Z
Publishing country	fr
Document type	Conference proceedings ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Using the RECORD guidelines to improve transparent reporting of studies based on routinely collected data.

Harron, K / Benchimol, E / Langan, S

International journal of population data science

2018 Volume 3, Issue 1, Page(s) 2

Abstract: Transparent reporting of routinely-collected data studies is key to producing valid and reliable research that can inform decisions about patient care and health systems. This article discusses some of the unique challenges in using these data sources, ... ...

Abstract	Transparent reporting of routinely-collected data studies is key to producing valid and reliable research that can inform decisions about patient care and health systems. This article discusses some of the unique challenges in using these data sources, and explains how the REporting of studies Conducted using Observational Routinely-collected Data (RECORD) guidelines were developed to help researchers and journals to maintain a high level of quality in reporting of healthcare studies using routinely-collected data.
Language	English
Publishing date	2018-01-24
Publishing country	Wales
Document type	Journal Article
ISSN	2399-4908
ISSN (online)	2399-4908
DOI	10.23889/ijpds.v3i1.419
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Article ; Online: Cementless versus Cemented Total Knee Arthroplasty Using the Same Implant Design: A Mean 5-Year Follow-up Study.

Miller, Adam J / Nadar, Arun C / Granade, Charles M / Smith, Langan S / Yakkanti, Madhusudhan R / Malkani, Arthur L

The journal of knee surgery

2024

Abstract: Cementless implant use continues to increase primarily due to increased numbers of younger and obese patients opting for primary total knee arthroplasty (TKA). Given the increased use of cementless implants, the purpose of this study was to evaluate the ... ...

Abstract	Cementless implant use continues to increase primarily due to increased numbers of younger and obese patients opting for primary total knee arthroplasty (TKA). Given the increased use of cementless implants, the purpose of this study was to evaluate the midterm clinical performance of cementless TKA using a highly porous tibial baseplate compared with its cemented counterpart of the same system. We conducted a retrospective case-control study of 400 patients undergoing primary TKA that included 200 patients with cementless components matched for age and body mass index (BMI) to 200 patients with cemented implants of the same implant design with a 5-year follow-up. We evaluated clinical results, complications, revisions, and overall survivorship between the cohorts. Statistical analysis was performed using student
Language	English
Publishing date	2024-03-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2075354-8
ISSN	1938-2480 ; 1538-8506 ; 0899-7403
ISSN (online)	1938-2480
ISSN	1538-8506 ; 0899-7403
DOI	10.1055/s-0044-1785192
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Article ; Online: Results of Primary Total Knee Arthroplasty in Patients on Chronic Psychotropic Medications.

Smith, Nolan S / Abhari, Sarag / Smith, Langan S / Altman, Kyle M / Yakkanti, Madhusudhan R / Malkani, Arthur L

The Journal of arthroplasty

2024

Abstract: Background: Psychotropic medications are commonly used to treat several mental health conditions. The aim of this study was to determine the impact of psychotropic medications in patients undergoing primary total knee arthroplasty (TKA) with respect to ... ...

Abstract	Background: Psychotropic medications are commonly used to treat several mental health conditions. The aim of this study was to determine the impact of psychotropic medications in patients undergoing primary total knee arthroplasty (TKA) with respect to postoperative opioid use, complications, patient-reported outcome measures, and satisfaction. Methods: This is a retrospective cohort study of 514 consecutive patients undergoing primary TKA. There were 120 patients (23.3%) who were excluded due to preoperative opioid usage. The remaining 394 patients had a minimum 1-year follow-up. Of those, 133 (34%) were on psychotropic medications preoperatively and were compared to the remaining 261 (66%) patients who were not on psychotropics. Clinical data, satisfaction, Knee Society (KS) scores, Western Ontario McMaster Universities Arthritis Index, Patient-Reported Outcomes Measurement Index Score, Forgotten Joint Scores, Knee Injury and Osteoarthritis Outcome Score for Joint Replacement, postoperative opioid medication usage, and complications were compared. Results: The study cohort (psychotropic medications) had significantly lower postoperative KS Function, KS Knee, Forgotten Joint Scores, Knee Injury and Osteoarthritis Outcome Score for Joint Replacement, Western Ontario McMaster Universities Arthritis Index, and Patient-Reported Outcomes Measurement Index Score compared to the control group. The study group had a lower overall satisfaction score (Likert scale 1 to 5) and a lower percentage of patients either satisfied or very satisfied (4.55 versus 4.79, P < .001; 92.0 versus 97.24%, P = .03, respectively). Postoperative opioid usage was significantly greater in the study group at both 6.4 weeks (range, 4 to 8) and 12-month follow-up (52.76 versus 13.33%, P < .001; 5.51 versus 0.39%, P = .002, respectively). There were no differences in complications and revisions between the groups. Conclusions: Patients on psychotropic medications should be educated on the risk of increased opioid consumption, diminished satisfaction, and patient-reported outcome measures following primary TKA. Given the large number of patients on psychotropic medications undergoing TKA, additional studies are needed to further improve clinical outcomes in this group.
Language	English
Publishing date	2024-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	632770-9
ISSN	1532-8406 ; 0883-5403
ISSN (online)	1532-8406
ISSN	0883-5403
DOI	10.1016/j.arth.2024.02.037
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Article ; Online: Ask Me about My Pearls: Burn Care, Ethics, and Creative Writing.

Reilly, Debra Ann / Langan, Steve

AMA journal of ethics

2018 Volume 20, Issue 1, Page(s) 589–594

Abstract: Channeling feelings into the written word rather than the scalpel was at the heart of the creative writing challenge that the first author (DR) accepted when she joined the Seven Doctors Project at the University of Nebraska Medical Center in 2008. ... ...

Abstract	Channeling feelings into the written word rather than the scalpel was at the heart of the creative writing challenge that the first author (DR) accepted when she joined the Seven Doctors Project at the University of Nebraska Medical Center in 2008. Burnout has become recognized as a factor undermining physicians' quality of life, and the practice of creative writing helps mitigate stress and sustain a successful practice. When physicians partner with and are mentored by a seasoned creative writer, creative writing can serve as an exercise in ethical reflection, which is particularly valuable at mid-career; this is the subject of the following dialogue between one physician writer and the facilitator of the Seven Doctors Project creative writing class.
MeSH term(s)	Burnout, Professional/prevention & control ; Burns/therapy ; Creativity ; Curriculum ; Emotions ; Ethics, Medical ; Hospitals, University ; Humanities ; Humans ; Mentors ; Nebraska ; Occupational Stress/psychology ; Occupational Stress/therapy ; Physicians/psychology ; Quality of Life ; Thinking ; Writing
Language	English
Publishing date	2018-06-01
Publishing country	United States
Document type	Journal Article
ISSN	2376-6980
ISSN (online)	2376-6980
DOI	10.1001/journalofethics.2018.20.6.pnar1-1806
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Conference proceedings ; Online: Lessons from the results of smallholder irrigation technologies (IWMI)

Langan, Simon

2015

Abstract: Proceedings of the Launching Workshop of the Agricultural Water Management Platform, Addis Ababa, Ethiopia, 15-16 January 2015. Colombo, Sri Lanka: International Water Management Institute (IWMI). ...

Abstract	Proceedings of the Launching Workshop of the Agricultural Water Management Platform, Addis Ababa, Ethiopia, 15-16 January 2015. Colombo, Sri Lanka: International Water Management Institute (IWMI).
Keywords	Irrigation methods ; Technology ; Smallholders ; Farmers ; Pumps ; Productivity Analysis ; Research and Development/Tech Change/Emerging Technologies
Language	English
Publishing country	us
Document type	Conference proceedings ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Distribution of vitamin D status in the UK: a cross-sectional analysis of UK Biobank.

Lin, Liang-Yu / Smeeth, Liam / Langan, Sinead / Warren-Gash, Charlotte

BMJ open

2021 Volume 11, Issue 1, Page(s) e038503

Abstract: Objective: No recent large studies have described the distribution of vitamin D status in the UK. Understanding the epidemiology of vitamin D deficiency is important to inform targeted public health recommendations. This study aimed to investigate the ... ...

Abstract	Objective: No recent large studies have described the distribution of vitamin D status in the UK. Understanding the epidemiology of vitamin D deficiency is important to inform targeted public health recommendations. This study aimed to investigate the distribution of factors associated with serum vitamin D status in a large national cohort. Design: A cross-sectional study. Setting: The UK Biobank, a prospective cohort study following the health and well-being of middle-aged and older adults recruited between 2006 and 2010. Participants: A total of 449 943 participants aged 40-69 years with measured serum vitamin D status were eligible for the analysis. Participants completed a questionnaire about sex, age, ethnic background, vitamin D supplementation, smoking, drinking and socioeconomic status. Primary and secondary outcome measures: We investigated the distribution of serum vitamin D status and the association between demographic factors and vitamin D deficiency or insufficiency. Vitamin D deficiency was defined as a serum 25-hydroxyvitamin D level <25 nmol/L. Multivariable logistic regression was used to assess the association between demographic factors and vitamin D status. Results: Asian (n=4297/8000, 53.7%) and black (n=2459/7046, 34.9%) participants had a higher proportion of vitamin D deficiency than white participants (n=50 920/422 907, 12%). During spring and winter, the proportion of vitamin D deficiency was higher across the UK and higher in the north than in the south. Male sex, abnormal body mass index, non-white ethnic backgrounds, smoking and being more socioeconomically deprived were associated with higher odds of vitamin D deficiency. Increasing age, taking vitamin D supplements and drinking alcohol were associated with lower odds of deficiency. Conclusions: Vitamin D status varied among different ethnic groups and by season and geographical area within the UK. Taking supplements was associated with a lower risk of vitamin D deficiency. These findings support the vitamin D supplementation recommendations of Public Health England.
MeSH term(s)	Adult ; Aged ; Biological Specimen Banks ; Cross-Sectional Studies ; Dietary Supplements ; England ; Humans ; Male ; Middle Aged ; Prevalence ; Prospective Studies ; Seasons ; United Kingdom/epidemiology ; Vitamin D ; Vitamin D Deficiency/epidemiology
Chemical Substances	Vitamin D (1406-16-2)
Language	English
Publishing date	2021-01-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2020-038503
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Article ; Online: Perceived psychological stress and risk of herpes zoster: a nationwide population-based cohort study.

Schmidt, S A J / Sørensen, H T / Langan, S M / Vestergaard, M

The British journal of dermatology

2021 Volume 185, Issue 1, Page(s) 130–138

Abstract: Background: Psychological stress may reduce cellular immunity, but its role in triggering latent infections, including herpes zoster (HZ), is controversial.: Objectives: To examine the association between perceived psychological stress and risk of HZ. ...

Abstract	Background: Psychological stress may reduce cellular immunity, but its role in triggering latent infections, including herpes zoster (HZ), is controversial. Objectives: To examine the association between perceived psychological stress and risk of HZ. Methods: In a linked registry-based cohort study, we followed 77 310 persons aged 40 years or older who participated in the 2010 Danish National Health Survey from 1 May 2010 until HZ diagnosis, death, emigration or 1 July 2014, whichever occurred first. We computed hazard ratios (HRs) of HZ associated with Cohen's Perceived Stress Scale (PSS) score (range 0-40) using Cox regression with age as the timescale, adjusted for sex, immunosuppressive and selected chronic conditions, immunosuppressive drugs, and sociodemographic, lifestyle and anthropometric factors. The PSS measures chronic stress perceived by an individual in response to various demands of daily life. We modelled the PSS score using quintiles and a restricted cubic spline function. Results: The unadjusted rate of HZ varied from 5·53 to 7·20 per 1000 person-years from the lowest to the highest PSS score quintile. Compared with the lowest PSS score quintile, the adjusted HR for HZ was 1·00 [95% confidence interval (CI) 0·86-1·16], 1·08 (95% CI 0·92-1·26), 1·05 (95% CI 0·90-1·23) and 1·14 (95% CI 0·97-1·34) for the second to the fifth quintile, respectively. In cubic spline analyses, PSS scores < 20 were not associated with increased HR of HZ, but thereafter the HR increased linearly from 1·10 (95% CI 0·85-1·41) to 2·22 (95% CI 1·32-3·75). Conclusions: Our study indicated that high levels of psychological stress are associated with increased risk of HZ.
MeSH term(s)	Cohort Studies ; Herpes Zoster/epidemiology ; Herpesvirus 3, Human ; Humans ; Incidence ; Risk Factors ; Stress, Psychological/epidemiology
Language	English
Publishing date	2021-05-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1111/bjd.19832
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Article ; Online: Neutral Mechanical Alignment Alters the Native Distal Femoral Joint Line: A Virtual Three-Dimensional Planning Total Knee Arthroplasty Study.

Richards, Jarod A / Williams, Mark D / Gupta, Neil A / Smith, Langan S / Malkani, Arthur L

The Journal of arthroplasty

2022 Volume 38, Issue 3, Page(s) 484–490

Abstract: Background: Alternative alignment concepts have garnered great interest in an effort to improve patient satisfaction following primary total knee arthroplasty (TKA). The purpose of this study is to determine variation or deviation from an individual's ... ...

Abstract	Background: Alternative alignment concepts have garnered great interest in an effort to improve patient satisfaction following primary total knee arthroplasty (TKA). The purpose of this study is to determine variation or deviation from an individual's native joint line in primary TKA using neutral mechanical versus a restricted kinematic technique. Methods: An institutional review board-approved prospective cohort study was performed evaluating the effect of neutral mechanical alignment (nMA) versus a restricted kinematic alignment (rKA) on the native joint line in 100 consecutive patients undergoing primary TKA. Using preoperative computed tomography and intraoperative 3-dimensional software, 2 virtual preoperative plans were created: nMA and rKA. Templated bone resections were recorded. Change in joint line was calculated using known implant planar thickness and planned bone resection. Results: nMA yielded significantly greater deviation from the patient's native joint line along the lateral compartment of the knee (lateral distal femoral condyle, lateral posterior femoral condyle, lateral tibial resection). With nMA, the lateral distal femoral joint line was distalized by a mean 4.3 versus 2.6 mm using rKA technique (P < .001). In rKA, >60% of knees had <3 mm of deviation from the native lateral posterior femoral offset, whereas in nMA, >95% of knees had ≥3 mm change in the lateral posterior femoral condylar offset. Conclusion: nMA-TKA resulted in statistically larger joint line deviations compared to rKA-TKA, most notably along the lateral distal femoral condyle joint line. Further analysis is needed to determine the clinical consequences of joint line deviation from the native anatomy using nMA as the target for primary TKA.
MeSH term(s)	Humans ; Arthroplasty, Replacement, Knee/methods ; Prospective Studies ; Knee Joint/diagnostic imaging ; Knee Joint/surgery ; Femur/diagnostic imaging ; Femur/surgery ; Knee/surgery ; Osteoarthritis, Knee/surgery ; Biomechanical Phenomena
Language	English
Publishing date	2022-09-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	632770-9
ISSN	1532-8406 ; 0883-5403
ISSN (online)	1532-8406
ISSN	0883-5403
DOI	10.1016/j.arth.2022.09.013
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