LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 7 of total 7

Search options

  1. Article ; Online: New Postmortem Perspective on Emerging SARS-CoV-2 Variants of Concern, Germany.

    Heinrich, Fabian / Huter, Tobias / Mertens, Sophie / Lange, Philine / Vering, Jessica / Heinemann, Axel / Nörz, Dominik Sebastian / Hoffmann, Armin / Aepfelbacher, Martin / Ondruschka, Benjamin / Krasemann, Susanne / Lütgehetmann, Marc

    Emerging infectious diseases

    2023  Volume 29, Issue 3, Page(s) 652–656

    Abstract: We performed autopsies on persons in Germany who died from COVID-19 and observed higher nasopharyngeal SARS-CoV-2 viral loads for variants of concern (VOC) compared with non-VOC lineages. Pulmonary inflammation and damage appeared higher in non-VOC than ... ...

    Abstract We performed autopsies on persons in Germany who died from COVID-19 and observed higher nasopharyngeal SARS-CoV-2 viral loads for variants of concern (VOC) compared with non-VOC lineages. Pulmonary inflammation and damage appeared higher in non-VOC than VOC lineages until adjusted for vaccination status, suggesting COVID-19 vaccination may mitigate pulmonary damage.
    MeSH term(s) Humans ; Autopsy ; SARS-CoV-2 ; COVID-19 Vaccines ; COVID-19 ; Germany
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-02-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2903.221297
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4778: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: SARS-CoV-2-assoziierte Hamburger Sterbefalle in der zweiten Pandemiewelle - Vergleich der bekannt gewordenen Todesfälle in den Gesundheitsämtern und der Rechtsmedizin (Mit 3 Tabellen)

    Ondruschka, Benjamin / Püschel, Klaus / Länge, Philine / Becker, Inga Kristina / Rieger-Ndakorerwa, Gudrun / Schröder, Ann Sophie

    Archiv für Kriminologie

    2021  Volume 248, Issue 5/6, Page(s) 180

    Language German
    Document type Article
    ZDB-ID 470-4
    ISSN 0003-9225
    Database Current Contents Medicine

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4770: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Postmortem Antigen-Detecting Rapid Diagnostic Tests to Predict Infectivity of SARS-CoV-2-Associated Deaths.

    Heinrich, Fabian / Schröder, Ann Sophie / Gerberding, Anna-Lina / Gerling, Moritz / Langenwalder, Felicia / Lange, Philine / Heinemann, Axel / Bibiza-Freiwald, Eric / Nörz, Dominik Sebastian / Aepfelbacher, Martin / Pfefferle, Susanne / Ondruschka, Benjamin / Lütgehetmann, Marc

    Emerging infectious diseases

    2021  Volume 28, Issue 1, Page(s) 244–247

    Abstract: We investigated the infectivity of 128 severe acute respiratory disease coronavirus 2-associated deaths and evaluated predictive values of standard diagnostic procedures. Maintained infectivity (20%) did not correlate with viral RNA loads but correlated ... ...

    Abstract We investigated the infectivity of 128 severe acute respiratory disease coronavirus 2-associated deaths and evaluated predictive values of standard diagnostic procedures. Maintained infectivity (20%) did not correlate with viral RNA loads but correlated well with anti-S antibody levels. Sensitivity >90% for antigen-detecting rapid diagnostic tests supports their usefulness for assessment.
    MeSH term(s) Autopsy ; COVID-19 ; Diagnostic Tests, Routine ; Humans ; SARS-CoV-2 ; Sensitivity and Specificity ; Viral Load
    Language English
    Publishing date 2021-11-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2801.211749
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4778: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Replication of SARS-CoV-2 in adipose tissue determines organ and systemic lipid metabolism in hamsters and humans.

    Zickler, Martin / Stanelle-Bertram, Stephanie / Ehret, Sandra / Heinrich, Fabian / Lange, Philine / Schaumburg, Berfin / Kouassi, Nancy Mounogou / Beck, Sebastian / Jaeckstein, Michelle Y / Mann, Oliver / Krasemann, Susanne / Schroeder, Maria / Jarczak, Dominik / Nierhaus, Axel / Kluge, Stefan / Peschka, Manuela / Schlüter, Hartmut / Renné, Thomas / Pueschel, Klaus /
    Kloetgen, Andreas / Scheja, Ludger / Ondruschka, Benjamin / Heeren, Joerg / Gabriel, Guelsah

    Cell metabolism

    2021  Volume 34, Issue 1, Page(s) 1–2

    Abstract: Zickler et al. describe SARS-CoV-2 RNA in post-mortem samples of human adipose tissue. In the hamster model, SARS-CoV-2 propagation in adipose tissue leads to specific changes in lipid metabolism, which are reflected in lipidome patterns of hamster and ... ...

    Abstract Zickler et al. describe SARS-CoV-2 RNA in post-mortem samples of human adipose tissue. In the hamster model, SARS-CoV-2 propagation in adipose tissue leads to specific changes in lipid metabolism, which are reflected in lipidome patterns of hamster and human plasma.
    MeSH term(s) Adipose Tissue/metabolism ; Adipose Tissue/virology ; Animals ; COVID-19/metabolism ; COVID-19/virology ; Cricetinae ; Female ; Humans ; Lipid Metabolism ; Liver/metabolism ; Liver/virology ; Lung/metabolism ; Lung/virology ; Male ; SARS-CoV-2/isolation & purification ; Virus Replication
    Language English
    Publishing date 2021-12-10
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2176834-1
    ISSN 1932-7420 ; 1550-4131
    ISSN (online) 1932-7420
    ISSN 1550-4131
    DOI 10.1016/j.cmet.2021.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6169: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Prospective postmortem evaluation of 735 consecutive SARS-CoV-2-associated death cases.

    Fitzek, Antonia / Schädler, Julia / Dietz, Eric / Ron, Alexandra / Gerling, Moritz / Kammal, Anna L / Lohner, Larissa / Falck, Carla / Möbius, Dustin / Goebels, Hanna / Gerberding, Anna-Lina / Schröder, Ann Sophie / Sperhake, Jan-Peter / Klein, Anke / Fröb, Daniela / Mushumba, Herbert / Wilmes, Sandra / Anders, Sven / Kniep, Inga /
    Heinrich, Fabian / Langenwalder, Felicia / Meißner, Kira / Lange, Philine / Zapf, Antonia / Püschel, Klaus / Heinemann, Axel / Glatzel, Markus / Matschke, Jakob / Aepfelbacher, Martin / Lütgehetmann, Marc / Steurer, Stefan / Thorns, Christoph / Edler, Carolin / Ondruschka, Benjamin

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 19342

    Abstract: Coronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic with significant mortality. Accurate information on the specific circumstances of death and whether patients died from ...

    Abstract Coronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic with significant mortality. Accurate information on the specific circumstances of death and whether patients died from or with SARS-CoV-2 is scarce. To distinguish COVID-19 from non-COVID-19 deaths, we performed a systematic review of 735 SARS-CoV-2-associated deaths in Hamburg, Germany, from March to December 2020, using conventional autopsy, ultrasound-guided minimally invasive autopsy, postmortem computed tomography and medical records. Statistical analyses including multiple logistic regression were used to compare both cohorts. 84.1% (n = 618) were classified as COVID-19 deaths, 6.4% (n = 47) as non-COVID-19 deaths, 9.5% (n = 70) remained unclear. Median age of COVID-19 deaths was 83.0 years, 54.4% were male. In the autopsy group (n = 283), the majority died of pneumonia and/or diffuse alveolar damage (73.6%; n = 187). Thromboses were found in 39.2% (n = 62/158 cases), pulmonary embolism in 22.1% (n = 56/253 cases). In 2020, annual mortality in Hamburg was about 5.5% higher than in the previous 20 years, of which 3.4% (n = 618) represented COVID-19 deaths. Our study highlights the need for mortality surveillance and postmortem examinations. The vast majority of individuals who died directly from SARS-CoV-2 infection were of advanced age and had multiple comorbidities.
    MeSH term(s) Adult ; Age Factors ; Aged ; Aged, 80 and over ; Alveolar Epithelial Cells/pathology ; Alveolar Epithelial Cells/virology ; Autopsy ; COVID-19/diagnosis ; COVID-19/epidemiology ; Comorbidity ; Female ; Germany/epidemiology ; Humans ; Lung/pathology ; Male ; Middle Aged ; Mortality ; Pneumonia ; Prospective Studies ; Pulmonary Embolism ; SARS-CoV-2 ; Thrombosis
    Language English
    Publishing date 2021-09-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-98499-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: CYP19A1 mediates severe SARS-CoV-2 disease outcome in males.

    Stanelle-Bertram, Stephanie / Beck, Sebastian / Mounogou, Nancy Kouassi / Schaumburg, Berfin / Stoll, Fabian / Al Jawazneh, Amirah / Schmal, Zoé / Bai, Tian / Zickler, Martin / Beythien, Georg / Becker, Kathrin / de la Roi, Madeleine / Heinrich, Fabian / Schulz, Claudia / Sauter, Martina / Krasemann, Susanne / Lange, Philine / Heinemann, Axel / van Riel, Debby /
    Leijten, Lonneke / Bauer, Lisa / van den Bosch, Thierry P P / Lopuhaä, Boaz / Busche, Tobias / Wibberg, Daniel / Schaudien, Dirk / Goldmann, Torsten / Lüttjohann, Anna / Ruschinski, Jenny / Jania, Hanna / Müller, Zacharias / Pinho Dos Reis, Vinicius / Krupp-Buzimkic, Vanessa / Wolff, Martin / Fallerini, Chiara / Baldassarri, Margherita / Furini, Simone / Norwood, Katrina / Käufer, Christopher / Schützenmeister, Nina / von Köckritz-Blickwede, Maren / Schroeder, Maria / Jarczak, Dominik / Nierhaus, Axel / Welte, Tobias / Kluge, Stefan / McHardy, Alice C / Sommer, Frank / Kalinowski, Jörn / Krauss-Etschmann, Susanne / Richter, Franziska / von der Thüsen, Jan / Baumgärtner, Wolfgang / Klingel, Karin / Ondruschka, Benjamin / Renieri, Alessandra / Gabriel, Gülsah

    Cell reports. Medicine

    2023  Volume 4, Issue 9, Page(s) 101152

    Abstract: Male sex represents one of the major risk factors for severe COVID-19 outcome. However, underlying mechanisms that mediate sex-dependent disease outcome are as yet unknown. Here, we identify the CYP19A1 gene encoding for the testosterone-to-estradiol ... ...

    Abstract Male sex represents one of the major risk factors for severe COVID-19 outcome. However, underlying mechanisms that mediate sex-dependent disease outcome are as yet unknown. Here, we identify the CYP19A1 gene encoding for the testosterone-to-estradiol metabolizing enzyme CYP19A1 (also known as aromatase) as a host factor that contributes to worsened disease outcome in SARS-CoV-2-infected males. We analyzed exome sequencing data obtained from a human COVID-19 cohort (n = 2,866) using a machine-learning approach and identify a CYP19A1-activity-increasing mutation to be associated with the development of severe disease in men but not women. We further analyzed human autopsy-derived lungs (n = 86) and detect increased pulmonary CYP19A1 expression at the time point of death in men compared with women. In the golden hamster model, we show that SARS-CoV-2 infection causes increased CYP19A1 expression in the lung that is associated with dysregulated plasma sex hormone levels and reduced long-term pulmonary function in males but not females. Treatment of SARS-CoV-2-infected hamsters with a clinically approved CYP19A1 inhibitor (letrozole) improves impaired lung function and supports recovery of imbalanced sex hormones specifically in males. Our study identifies CYP19A1 as a contributor to sex-specific SARS-CoV-2 disease outcome in males. Furthermore, inhibition of CYP19A1 by the clinically approved drug letrozole may furnish a new therapeutic strategy for individualized patient management and treatment.
    MeSH term(s) Female ; Humans ; Male ; Aromatase/genetics ; Letrozole ; SARS-CoV-2 ; COVID-19/genetics ; Estradiol ; Testosterone
    Chemical Substances Aromatase (EC 1.14.14.1) ; Letrozole (7LKK855W8I) ; Estradiol (4TI98Z838E) ; Testosterone (3XMK78S47O) ; CYP19A1 protein, human (EC 1.14.14.1)
    Language English
    Publishing date 2023-08-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2666-3791
    ISSN (online) 2666-3791
    DOI 10.1016/j.xcrm.2023.101152
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  7. Article ; Online: CYP19A1 mediates severe SARS-CoV-2 disease outcome in males

    Stanelle-Bertram, Stephanie / Beck, Sebastian / Mounogou, Nancy Kouassi / Schaumburg, Berfin / Stoll, Fabian / Jawazneh, Amirah Al / Schmal, Zoé / Bai, Tian / Zickler, Martin / Beythien, Georg / Becker, Kathrin / Roi, Madeleine de la / Heinrich, Fabian / Schulz, Claudia / Sauter, Martina / Krasemann, Susanne / Lange, Philine / Heinemann, Axel / Riel, Debby van /
    Leijten, Lonneke / Bauer, Lisa / Bosch, Thierry P.P. van den / Lopuhaä, Boaz / Busche, Tobias / Wibberg, Daniel / Schaudien, Dirk / Goldmann, Torsten / Lüttjohann, Anna / Ruschinski, Jenny / Jania, Hanna / Müller, Zacharias / Reis, Vinicius Pinho dos / Krupp-Buzimkic, Vanessa / Wolff, Martin / Fallerini, Chiara / Baldassarri, Margherita / Furini, Simone / Norwood, Katrina / Käufer, Christopher / Schützenmeister, Nina / Köckritz-Blickwede, Maren von / Schroeder, Maria / Jarczak, Dominik / Nierhaus, Axel / Welte, Tobias / Kluge, Stefan / McHardy, Alice C. / Sommer, Frank / Kalinowski, Jörn / Krauss-Etschmann, Susanne / Richter, Franziska / Thüsen, Jan von der / Baumgärtner, Wolfgang / Klingel, Karin / Ondruschka, Benjamin / Renieri, Alessandra / Gabriel, Gülsah

    2023  

    Abstract: Male sex represents one of the major risk factors for severe COVID-19 outcome. However, underlying mechanisms that mediate sex-dependent disease outcome are as yet unknown. Here, we identify the CYP19A1 gene encoding for the testosterone-to-estradiol ... ...

    Abstract Male sex represents one of the major risk factors for severe COVID-19 outcome. However, underlying mechanisms that mediate sex-dependent disease outcome are as yet unknown. Here, we identify the CYP19A1 gene encoding for the testosterone-to-estradiol metabolizing enzyme CYP19A1 (also known as aromatase) as a host factor that contributes to worsened disease outcome in SARS-CoV-2-infected males. We analyzed exome sequencing data obtained from a human COVID-19 cohort (n = 2,866) using a machine-learning approach and identify a CYP19A1-activity-increasing mutation to be associated with the development of severe disease in men but not women. We further analyzed human autopsy-derived lungs (n = 86) and detect increased pulmonary CYP19A1 expression at the time point of death in men compared with women. In the golden hamster model, we show that SARS-CoV-2 infection causes increased CYP19A1 expression in the lung that is associated with dysregulated plasma sex hormone levels and reduced long-term pulmonary function in males but not females. Treatment of SARS-CoV-2-infected hamsters with a clinically approved CYP19A1 inhibitor (letrozole) improves impaired lung function and supports recovery of imbalanced sex hormones specifically in males. Our study identifies CYP19A1 as a contributor to sex-specific SARS-CoV-2 disease outcome in males. Furthermore, inhibition of CYP19A1 by the clinically approved drug letrozole may furnish a new therapeutic strategy for individualized patient management and treatment.

    4

    9
    Subject code 610
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top