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Article ; Online: Rosai Dorfman Disease With Extensive Bony Involvement- A Diagnostic Dilemma.

Ahmed, Maria Zahid / Mahmood, Madiha / Langhani, Jawaharlal / Zohair, Muhammad / Virk, Mahnoor / Mubarak, Muhammad / Akhtar, Fazal / Ahmed, Ejaz

Journal of Ayub Medical College, Abbottabad : JAMC

2023  Volume 35, Issue 3, Page(s) 493–496

Abstract: Previously classified as Non Langerhan cell histiocytosis by the Working Group of Histiocytic Society in 1987 Rosai Dorfman Destombes disease was first described by Destombes in 1965 and later in 1969 by Rosai and Dorfman as a rare histiocytic disorder ... ...

Abstract Previously classified as Non Langerhan cell histiocytosis by the Working Group of Histiocytic Society in 1987 Rosai Dorfman Destombes disease was first described by Destombes in 1965 and later in 1969 by Rosai and Dorfman as a rare histiocytic disorder with sinus histiocytosis and massive lymphadenopathy. They exist in both nodal and extranodal forms. Immunohistochemistry is an essential part of diagnosis to differentiate between Langerhans cell histiocytosis and another malignant histiocytosis. Some overlap has also been reported with IgG4-related diseases. We hereby reflect upon a patient who presented to our facility with pyrexia of unknown origin, the challenges faced to reach a diagnosis and the management offered.
MeSH term(s) Humans ; Histiocytosis, Sinus/diagnostic imaging ; Histiocytosis, Sinus/pathology ; Lymphadenopathy ; Fever ; Immunohistochemistry ; Diagnosis, Differential
Language English
Publishing date 2023-12-06
Publishing country Pakistan
Document type Case Reports
ZDB-ID 2192473-9
ISSN 1819-2718 ; 1025-9589
ISSN (online) 1819-2718
ISSN 1025-9589
DOI 10.55519/JAMC-03-11450
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