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Book: Immunology and immunopathogenesis of malaria

Langhorne, Jean

with 6 tables

(Current topics in microbiology and immunology ; 297)

2005

Author's details	J. Langhorne (ed.)
Series title	Current topics in microbiology and immunology ; 297
Collection
Language	English
Size	VII, 231 S. : Ill.
Publisher	Springer
Publishing place	Berlin u.a.
Publishing country	Germany
Document type	Book
HBZ-ID	HT014503984
ISBN	3-540-25718-7 ; 978-3-540-25718-7 ; 978-3-540-25718-9
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
Ud II Zs 24 -297-	verfügbar in Königswinter	Königswinter

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Article ; Online: Gamma/Delta T Cells and Their Role in Protection Against Malaria.

Deroost, Katrien / Langhorne, Jean

Frontiers in immunology

2018 Volume 9, Page(s) 2973

Abstract: Whether and how γδT cells play a protective role in immunity ... ...

Abstract	Whether and how γδT cells play a protective role in immunity against
MeSH term(s)	Animals ; Antigens, Protozoan/immunology ; Antigens, Protozoan/metabolism ; Cytokines/immunology ; Cytokines/metabolism ; Disease Models, Animal ; Humans ; Immunologic Memory ; Intraepithelial Lymphocytes/immunology ; Intraepithelial Lymphocytes/metabolism ; Lymphocyte Activation ; Malaria/immunology ; Malaria/parasitology ; Mice ; Plasmodium/immunology ; Receptors, Antigen, T-Cell, gamma-delta/immunology ; Receptors, Antigen, T-Cell, gamma-delta/metabolism ; Sporozoites/immunology
Chemical Substances	Antigens, Protozoan ; Cytokines ; Receptors, Antigen, T-Cell, gamma-delta
Language	English
Publishing date	2018-12-20
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2018.02973
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Article ; Online: A New Link between γδ T Cells and Myeloid Cells in Malaria?

Lewis, Matthew D / Langhorne, Jean

Immunity

2018 Volume 48, Issue 2, Page(s) 193–195

Abstract: In malaria, the immune responses leading to protective immunity versus immunopathology are unclear. Mamedov et al. (2018) identify a subset of clonally expanded γδ T cells in late-stage infection that produce M-CSF and may interact with myeloid cells to ... ...

Abstract	In malaria, the immune responses leading to protective immunity versus immunopathology are unclear. Mamedov et al. (2018) identify a subset of clonally expanded γδ T cells in late-stage infection that produce M-CSF and may interact with myeloid cells to control recrudescent infection.
MeSH term(s)	Humans ; Immunity ; Malaria ; Myeloid Cells ; Receptors, Antigen, T-Cell, gamma-delta ; T-Lymphocytes
Chemical Substances	Receptors, Antigen, T-Cell, gamma-delta
Language	English
Publishing date	2018-02-19
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2018.02.003
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Article ; Online: Antibody-dependent immune responses elicited by blood stage-malaria infection contribute to protective immunity to the pre-erythrocytic stages.

Tumwine-Downey, Irene / Deroost, Katrien / Levy, Prisca / McLaughlin, Sarah / Hosking, Caroline / Langhorne, Jean

Current research in immunology

2022 Volume 4, Page(s) 100054

Abstract: Advances in transcriptomics and proteomics have revealed that different life-cycle stages of the malaria parasite, ...

Abstract	Advances in transcriptomics and proteomics have revealed that different life-cycle stages of the malaria parasite,
Language	English
Publishing date	2022-12-23
Publishing country	Netherlands
Document type	Journal Article
ISSN	2590-2555
ISSN (online)	2590-2555
DOI	10.1016/j.crimmu.2022.100054
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Article ; Online: Identification of gametocyte-associated pir genes in the rodent malaria parasite, Plasmodium chabaudi chabaudi AS.

Cunningham, Deirdre A / Reid, Adam J / Hosking, Caroline / Deroost, Katrien / Tumwine-Downey, Irene / Sanders, Mandy / Langhorne, Jean

BMC research notes

2023 Volume 16, Issue 1, Page(s) 56

Abstract: Objective: To analyse the transcriptional profiles of the pir multigene family of Plasmodium chabaudi chabaudi in male and female gametocytes isolated from the blood of infected mice.: Results: Infected red blood cells containing female and male P. ... ...

Abstract	Objective: To analyse the transcriptional profiles of the pir multigene family of Plasmodium chabaudi chabaudi in male and female gametocytes isolated from the blood of infected mice. Results: Infected red blood cells containing female and male P. chabaudi gametocytes transcribe a distinct set of genes encoded by the multigene family pir. The overall patterns are similar to what has been observed in the close relative P. berghei, but here we show that gametocyte-associated pir genes are distinct from those involved in chronic blood-stage infection and highlight a male-associated pir gene which should be the focus of future studies.
MeSH term(s)	Male ; Female ; Animals ; Mice ; Plasmodium chabaudi/genetics ; Parasites ; Malaria/parasitology
Language	English
Publishing date	2023-04-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2413336-X
ISSN	1756-0500 ; 1756-0500
ISSN (online)	1756-0500
ISSN	1756-0500
DOI	10.1186/s13104-023-06322-1
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Article ; Online: Distinct transcriptomic signatures define febrile malaria depending on initial infective states, asymptomatic or uninfected.

Kimenyi, Kelvin M / Akinyi, Mercy Y / Mwikali, Kioko / Gilmore, Tegan / Mwangi, Shaban / Omer, Elisha / Gichuki, Bonface / Wambua, Juliana / Njunge, James / Obiero, George / Bejon, Philip / Langhorne, Jean / Abdi, Abdirahman / Ochola-Oyier, Lynette Isabella

BMC infectious diseases

2024 Volume 24, Issue 1, Page(s) 140

Abstract: Background: Cumulative malaria parasite exposure in endemic regions often results in the acquisition of partial immunity and asymptomatic infections. There is limited information on how host-parasite interactions mediate the maintenance of chronic ... ...

Abstract	Background: Cumulative malaria parasite exposure in endemic regions often results in the acquisition of partial immunity and asymptomatic infections. There is limited information on how host-parasite interactions mediate the maintenance of chronic symptomless infections that sustain malaria transmission. Methods: Here, we determined the gene expression profiles of the parasite population and the corresponding host peripheral blood mononuclear cells (PBMCs) from 21 children (< 15 years). We compared children who were defined as uninfected, asymptomatic and those with febrile malaria. Results: Children with asymptomatic infections had a parasite transcriptional profile characterized by a bias toward trophozoite stage (~ 12 h-post invasion) parasites and low parasite levels, while early ring stage parasites were characteristic of febrile malaria. The host response of asymptomatic children was characterized by downregulated transcription of genes associated with inflammatory responses, compared with children with febrile malaria,. Interestingly, the host responses during febrile infections that followed an asymptomatic infection featured stronger inflammatory responses, whereas the febrile host responses from previously uninfected children featured increased humoral immune responses. Conclusions: The priming effect of prior asymptomatic infection may explain the blunted acquisition of antibody responses seen to malaria antigens following natural exposure or vaccination in malaria endemic areas.
MeSH term(s)	Child ; Humans ; Malaria, Falciparum/epidemiology ; Asymptomatic Infections/epidemiology ; Plasmodium falciparum ; Transcriptome ; Leukocytes, Mononuclear ; Malaria ; Gene Expression Profiling ; Fever
Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2041550-3
ISSN	1471-2334 ; 1471-2334
ISSN (online)	1471-2334
ISSN	1471-2334
DOI	10.1186/s12879-024-08973-2
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Article ; Online: Evidence of Plasmodium vivax circulation in western and eastern regions of Senegal: implications for malaria control.

Badiane, Aida S / Ngom, Bassirou / Ndiaye, Tolla / Cunningham, Deirdre / Campbell, James / Gaye, Amy / Sène, Aita / Sy, Mouhamad / Ndiaye, Daouda / Nwakanma, Davis / Langhorne, Jean

Malaria journal

2024 Volume 23, Issue 1, Page(s) 149

Abstract: Background: Malaria elimination in Senegal requires accurate diagnosis of all Plasmodium species. Plasmodium falciparum is the most prevalent species in Senegal, although Plasmodium malariae, Plasmodium ovale, and recently Plasmodium vivax have also ... ...

Abstract	Background: Malaria elimination in Senegal requires accurate diagnosis of all Plasmodium species. Plasmodium falciparum is the most prevalent species in Senegal, although Plasmodium malariae, Plasmodium ovale, and recently Plasmodium vivax have also been reported. Nonetheless, most malaria control tools, such as Histidine Rich Protein 2 rapid diagnosis test (PfHRP2-RDT,) can only diagnose P. falciparum. Thus, PfHRP2-RDT misses non-falciparum species and P. falciparum infections that fall below the limit of detection. These limitations can be addressed using highly sensitive Next Generation Sequencing (NGS). This study assesses the burden of the four different Plasmodium species in western and eastern regions of Senegal using targeted PCR amplicon sequencing. Methods: Three thousand samples from symptomatic and asymptomatic individuals in 2021 from three sites in Senegal (Sessene, Diourbel region; Parcelles Assainies, Kaolack region; Gabou, Tambacounda region) were collected. All samples were tested using PfHRP2-RDT and photoinduced electron transfer polymerase chain reaction (PET-PCR), which detects all Plasmodium species. Targeted sequencing of the nuclear 18S rRNA and the mitochondrial cytochrome B genes was performed on PET-PCR positive samples. Results: Malaria prevalence by PfHRP2-RDT showed 9.4% (94/1000) and 0.2% (2/1000) in Diourbel (DBL) and Kaolack (KL), respectively. In Tambacounda (TAM) patients who had malaria symptoms and had a negative PfHRP2-RDT were enrolled. The PET-PCR had a positivity rate of 23.5% (295/1255) overall. The PET-PCR positivity rate was 37.6%, 12.3%, and 22.8% in Diourbel, Kaolack, and Tambacounda, respectively. Successful sequencing of 121/295 positive samples detected P. falciparum (93%), P. vivax (2.6%), P. malariae (4.4%), and P. ovale wallikeri (0.9%). Plasmodium vivax was co-identified with P. falciparum in thirteen samples. Sequencing also detected two PfHRP2-RDT-negative mono-infections of P. vivax in Tambacounda and Kaolack. Conclusion: The findings demonstrate the circulation of P. vivax in western and eastern Senegal, highlighting the need for improved malaria control strategies and accurate diagnostic tools to better understand the prevalence of non-falciparum species countrywide.
MeSH term(s)	Senegal/epidemiology ; Humans ; Adolescent ; Adult ; Young Adult ; Child ; Middle Aged ; Male ; Female ; Plasmodium vivax/genetics ; Plasmodium vivax/isolation & purification ; Child, Preschool ; Malaria, Vivax/epidemiology ; Malaria, Vivax/parasitology ; Prevalence ; Aged ; Infant ; Polymerase Chain Reaction ; Plasmodium ovale/genetics ; Plasmodium ovale/isolation & purification
Language	English
Publishing date	2024-05-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2091229-8
ISSN	1475-2875 ; 1475-2875
ISSN (online)	1475-2875
ISSN	1475-2875
DOI	10.1186/s12936-024-04932-z
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Article ; Online: Expanding the antimalarial toolkit: Targeting host-parasite interactions.

Langhorne, Jean / Duffy, Patrick E

The Journal of experimental medicine

2016 Volume 213, Issue 2, Page(s) 143–153

Abstract: Recent successes in malaria control are threatened by drug-resistant Plasmodium parasites and insecticide-resistant Anopheles mosquitoes, and first generation vaccines offer only partial protection. New research approaches have highlighted host as well ... ...

Abstract	Recent successes in malaria control are threatened by drug-resistant Plasmodium parasites and insecticide-resistant Anopheles mosquitoes, and first generation vaccines offer only partial protection. New research approaches have highlighted host as well as parasite molecules or pathways that could be targeted for interventions. In this study, we discuss host-parasite interactions at the different stages of the Plasmodium life cycle within the mammalian host and the potential for therapeutics that prevent parasite migration, invasion, intracellular growth, or egress from host cells, as well as parasite-induced pathology.
MeSH term(s)	Animals ; Antimalarials/pharmacology ; Cytokines/immunology ; Drug Discovery ; Erythrocytes/parasitology ; Host-Parasite Interactions/drug effects ; Host-Parasite Interactions/immunology ; Host-Parasite Interactions/physiology ; Humans ; Inflammation/prevention & control ; Malaria/parasitology ; Malaria/prevention & control ; Malaria/therapy ; Malaria Vaccines/pharmacology ; Plasmodium/drug effects ; Plasmodium/growth & development ; Plasmodium/physiology ; T-Lymphocytes/immunology
Chemical Substances	Antimalarials ; Cytokines ; Malaria Vaccines
Language	English
Publishing date	2016-02-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	218343-2
ISSN	1540-9538 ; 0022-1007
ISSN (online)	1540-9538
ISSN	0022-1007
DOI	10.1084/jem.20151677
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Article ; Online: Distinct ontogenetic lineages dictate cDC2 heterogeneity.

Minutti, Carlos M / Piot, Cécile / Pereira da Costa, Mariana / Chakravarty, Probir / Rogers, Neil / Huerga Encabo, Hector / Cardoso, Ana / Loong, Jane / Bessou, Gilles / Mionnet, Cyrille / Langhorne, Jean / Bonnet, Dominique / Dalod, Marc / Tomasello, Elena / Reis E Sousa, Caetano

Nature immunology

2024 Volume 25, Issue 3, Page(s) 448–461

Abstract: Conventional dendritic cells (cDCs) include functionally and phenotypically diverse populations, such as cDC1s and cDC2s. The latter population has been variously subdivided into Notch-dependent cDC2s, KLF4-dependent cDC2s, T- ... ...

Abstract	Conventional dendritic cells (cDCs) include functionally and phenotypically diverse populations, such as cDC1s and cDC2s. The latter population has been variously subdivided into Notch-dependent cDC2s, KLF4-dependent cDC2s, T-bet
MeSH term(s)	Animals ; Mice ; Cell Differentiation ; Dendritic Cells ; Sialic Acid Binding Immunoglobulin-like Lectins
Chemical Substances	Sialic Acid Binding Immunoglobulin-like Lectins
Language	English
Publishing date	2024-02-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/s41590-024-01745-9
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Article ; Online: B-cell memory in malaria: Myths and realities.

Pérez-Mazliah, Damián / Ndungu, Francis M / Aye, Racheal / Langhorne, Jean

Immunological reviews

2019 Volume 293, Issue 1, Page(s) 57–69

Abstract: B-cell and antibody responses to Plasmodium spp., the parasite that causes malaria, are critical for control of parasitemia and associated immunopathology. Antibodies also provide protection to reinfection. Long-lasting B-cell memory has been shown to ... ...

Abstract	B-cell and antibody responses to Plasmodium spp., the parasite that causes malaria, are critical for control of parasitemia and associated immunopathology. Antibodies also provide protection to reinfection. Long-lasting B-cell memory has been shown to occur in response to Plasmodium spp. in experimental model infections, and in human malaria. However, there are reports that antibody responses to several malaria antigens in young children living with malaria are not similarly long-lived, suggesting a dysfunction in the maintenance of circulating antibodies. Some studies attribute this to the expansion of atypical memory B cells (AMB), which express multiple inhibitory receptors and activation markers, and are hyporesponsive to B-cell receptor (BCR) restimulation in vitro. AMB are also expanded in other chronic infections such as tuberculosis, hepatitis B and C, and HIV, as well as in autoimmunity and old age, highlighting the importance of understanding their role in immunity. Whether AMB are dysfunctional remains controversial, as there are also studies in other infections showing that AMB can produce isotype-switched antibodies and in mouse can contribute to protection against infection. In light of these controversies, we review the most recent literature on either side of the debate and challenge some of the currently held views regarding B-cell responses to Plasmodium infections.
MeSH term(s)	Antibody Formation/immunology ; Antigens, Protozoan/immunology ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Clonal Anergy ; Host-Parasite Interactions/immunology ; Humans ; Immunologic Memory ; Malaria/immunology ; Malaria/metabolism ; Malaria/parasitology ; Plasmodium/immunology ; Receptors, Antigen, B-Cell/metabolism ; Signal Transduction
Chemical Substances	Antigens, Protozoan ; Receptors, Antigen, B-Cell
Language	English
Publishing date	2019-11-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	391796-4
ISSN	1600-065X ; 0105-2896
ISSN (online)	1600-065X
ISSN	0105-2896
DOI	10.1111/imr.12822
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