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Article ; Online: Predictive Factors of Stent Patency in Iliofemoral Venous Diseases in a Multicentre Cohort Study.

Espitia, Olivier / Douane, Frédéric / Hersant, Jeanne / Abbadie, Fabrice / Sobocinski, Jonathan / Heautot, Jean-François / Miossec, Annaïg / Lapébie, François-Xavier / Hartung, Olivier

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

2023 Volume 65, Issue 4, Page(s) 564–572

Abstract: Objective: This study assessed primary stent patency predictive factors in three groups of patients with history of lower limb (LL) vein thrombosis: non-thrombotic iliac vein lesion (NIVL), acute deep vein thrombosis (aDVT), and post-thrombotic syndrome ...

Abstract	Objective: This study assessed primary stent patency predictive factors in three groups of patients with history of lower limb (LL) vein thrombosis: non-thrombotic iliac vein lesion (NIVL), acute deep vein thrombosis (aDVT), and post-thrombotic syndrome (PTS). Methods: Consecutive patients from January 2014 to December 2020 with history of LL vein stenting from seven hospitals were included. All patients received an iliac or common femoral venous stent and had at least a six month follow up available with stent imaging. Anticoagulant and antiplatelet therapy strategies employed after venous stenting are reported and compared between groups. Results: This study included 377 patients: 134 NIVL, 55 aDVT, and 188 PTS. Primary patency was statistically significantly higher in the NIVL group (99.3%) compared with the PTS group (68.6%) (p < .001) and the aDVT group (83.6%) (p = .002). PTS patients received a statistically significantly greater number of stents (p < .001) and had more stents below the inguinal ligament (p < .001). Median follow up was 28.8 months (IQR 16, 47). Discontinuation of antiplatelet therapy at the last assessment was 83.6% for NIVL, 100% for aDVT, and 95.7% for the PTS group (p < .001). Discontinuation of anticoagulation therapy at the last assessment was 93.2% for NIVL, 25.0% for aDVT, and 70.3% for the PTS group (p < .001). The only predictor of worse primary patency in the aDVT group was long term anticoagulation before stenting. Conclusion: Patients with NIVL have better primary patency after venous stenting than patients with venous thrombotic disorders. Long term anticoagulation before stenting was the only factor associated with poorer primary patency in patients with aDVT.
MeSH term(s)	Humans ; Platelet Aggregation Inhibitors/therapeutic use ; Treatment Outcome ; Postthrombotic Syndrome/diagnostic imaging ; Postthrombotic Syndrome/etiology ; Postthrombotic Syndrome/surgery ; Venous Thrombosis/diagnostic imaging ; Venous Thrombosis/therapy ; Stents ; Anticoagulants/therapeutic use ; Iliac Vein/diagnostic imaging ; Cohort Studies ; Vascular Patency ; Retrospective Studies
Chemical Substances	Platelet Aggregation Inhibitors ; Anticoagulants
Language	English
Publishing date	2023-01-13
Publishing country	England
Document type	Multicenter Study ; Journal Article
ZDB-ID	1225869-6
ISSN	1532-2165 ; 1078-5884
ISSN (online)	1532-2165
ISSN	1078-5884
DOI	10.1016/j.ejvs.2023.01.005
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Article ; Online: Prise en charge de l'artériopathie athéromateuse

Lapébie, François-Xavier / Bura-Rivière, Alessandra

La Revue du praticien

2018 Volume 66, Issue 1, Page(s) 92–97

Abstract: Managing the atherosclerotic arterial disease. Peripheral arterial disease is currently detected by measuring the ratio of the systolic pressures between the ankle and at the arm (ABI). It is a powerful marker of cardiovascular mortality. Arterial ... ...

Title translation	Managing the atherosclerotic arterial disease
Abstract	Managing the atherosclerotic arterial disease. Peripheral arterial disease is currently detected by measuring the ratio of the systolic pressures between the ankle and at the arm (ABI). It is a powerful marker of cardiovascular mortality. Arterial doppler ultrasound is the imaging test to perform in first intention for a morphological and hemodynamic assessment of the lesions. The management is based on prevention of cardiovascular mortality, obtained by the control of risk factors and the use of antiplatelet agents, statins and renin-angiotensin system inhibitors. A supervised walking training is useful at the stage of intermittent claudication to reduce functional disability. Revascularization should be considered systematically at the stage of critical ischemia, due to the major risk of amputation at this stage. In case of intermittent claudication, the risk of amputation is low and revascularization can be considered in the presence of aorto- iliac lesions or in case of persistent functional disability, despite the medical treatment and rehabilitation.
MeSH term(s)	Amputation ; Humans ; Intermittent Claudication/complications ; Intermittent Claudication/therapy ; Ischemia ; Peripheral Arterial Disease/complications ; Peripheral Arterial Disease/therapy ; Walking
Language	French
Publishing date	2018-12-03
Publishing country	France
Document type	Journal Article
ZDB-ID	205365-2
ISSN	2101-017X ; 0035-2640
ISSN (online)	2101-017X
ISSN	0035-2640
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Article: Inter and intra-observer agreement of arterial wall contrast-enhanced ultrasonography in giant cell arteritis.

Espitia, Olivier / Robin, Olivier / Hersant, Jeanne / Roncato, Christophe / Théry, Arthur / Vibet, Marie-Anne / Gautier, Giovanni / Raimbeau, Alizée / Lapébie, François-Xavier

Frontiers in medicine

2022 Volume 9, Page(s) 1042366

Abstract: Objective: The aim of this study was to analyze inter- and intra-observer agreement for contrast-enhanced ultrasonography (CEUS) for monitoring disease activity in Giant Cell Arteritis (GCA) in the wall of axillary arteries, and common carotid arteries.! ...

Abstract	Objective: The aim of this study was to analyze inter- and intra-observer agreement for contrast-enhanced ultrasonography (CEUS) for monitoring disease activity in Giant Cell Arteritis (GCA) in the wall of axillary arteries, and common carotid arteries. Methods: Giant cell arteritis patients have CEUS of axillary arteries and common carotid. These images were rated by seven vascular medicine physicians from four hospitals who were experienced in duplex ultrasonography of GCA patients. Two weeks later, observers again rated the same images. GCA patients were recruited in from December 2019 to February 2021. An analysis of the contrast of the ultrasound images with a gradation in three classes (grade 0, 1, and 2) was performed. Grade 0 corresponds to no contrast, grade 1 to moderate wall contrast and grade 2 to intense contrast. A new analysis in 2 classes: positive or negative wall contrast; was then performed on new series of images. Results: Sixty arterial segments were evaluated in 30 patients. For the three-class scale, intra-rater agreement was substantial: κ 0.70; inter-rater agreement was fair: κ from 0.22 to 0.27. Thirty-four videos had a wall thickness of less than 2 mm and 26 videos had a wall thickness greater than 2 mm. For walls with a thickness lower than 2 mm: intra-rater agreement was substantial: κ 0.69; inter-rater agreement was fair: κ 0.35. For walls with a thickness of 2 mm or more: intra-rater agreement was substantial: κ 0.53; inter-rater agreement was fair: κ 0.25. For analysis of parietal contrast uptake in two classes: inter-rater agreement was fair to moderate: κ from 0.35 to 0.41; and for walls with a thickness of 2 mm or more: inter-rater agreement was fair to substantial κ from 0.22 to 0.63. Conclusion: The visual analysis of contrast uptake in the wall of the axillary and common carotid arteries showed good intra-rater agreement in GCA patients. The inter-rater agreement was low, especially when contrast was analyzed in three classes. The inter-rater agreement for the analysis in two classes was also low. The inter-rater agreement was higher in two-class analysis for walls of 2 mm thickness or more.
Language	English
Publishing date	2022-11-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.1042366
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Article ; Online: Predictors of recurrence of cancer-associated venous thromboembolism after discontinuation of anticoagulant therapy: a multicenter cohort study.

Lapébie, François-Xavier / Bura-Rivière, Alessandra / Espitia, Olivier / Bongard, Vanina / Ciammaichella, Maurizio M / Martínez, José González / Sigüenza, Patricia / Giménez, Joaquín Castro / Bertoletti, Laurent / Monreal, Manuel

Journal of thrombosis and haemostasis : JTH

2023 Volume 21, Issue 8, Page(s) 2189–2201

Abstract: Background: Data on recurrence after the end of anticoagulation for a first event of cancer-associated venous thromboembolism (VTE) are scarce.: Objectives: Our aim was to assess predictors of VTE recurrence during a 1-year follow-up period.: ... ...

Abstract	Background: Data on recurrence after the end of anticoagulation for a first event of cancer-associated venous thromboembolism (VTE) are scarce. Objectives: Our aim was to assess predictors of VTE recurrence during a 1-year follow-up period. Methods: This study is an analysis of RIETE, an international, multicenter, prospective cohort study of patients diagnosed with VTE. Patients had to have active cancer at the time of VTE and to have withdrawn from anticoagulation after 3 months of full treatment. Analyses were performed using Fine and Gray models, with death as a competing risk, and multiple imputation of missing data was performed by chained equations. Results: Among 14 318 patients with cancer-associated VTE, 3414 had undergone time-limited anticoagulation for at least 3 months. The cumulative incidence function for recurrent VTE was 10.2% (95% CI, 9.1-11.5) at 1 year. Chronic kidney disease (a subhazard ratio [sHR] of 1.08 for 10-mL/min decrease in glomerular filtration rate; 95% CI, 1.02-1.14); cancer of the lung, brain, stomach, esophagus, liver, or ovary (sHR, 3.56; 95% CI, 1.07-11.80; compared with cancer of the oropharynx, larynx, or melanoma); cancer of the pancreas, the biliary tract, or of unknown origin (sHR, 6.86; 95% CI, 1.89-24.85); inferior vena cava filter (sHR, 3.16; 95% CI, 1.75-5.71); postthrombotic syndrome (sHR, 2.09; 95% CI, 1.06-4.15); and residual pulmonary thrombotic obstruction (sHR, 2.58; 95% CI, 1.38-4.82) were predictive of recurrence. Surgery during the 2 months before VTE was predictive of absence of recurrence (sHR, 0.60; 95% CI, 0.40-0.92). Conclusion: One year after anticoagulant cessation for cancer-associated VTE, approximately 10% of patients experienced recurrence. Discontinuing anticoagulant therapy seems safe, mainly in surgery-associated VTE.
MeSH term(s)	Female ; Humans ; Anticoagulants/therapeutic use ; Neoplasms/complications ; Prospective Studies ; Recurrence ; Risk Factors ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/epidemiology
Chemical Substances	Anticoagulants
Language	English
Publishing date	2023-04-15
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2112661-6
ISSN	1538-7836 ; 1538-7933
ISSN (online)	1538-7836
ISSN	1538-7933
DOI	10.1016/j.jtha.2023.04.010
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Zs.MO 295: Show issues

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Article: Left ventricular pseudoaneurysm revealing a Behçet's disease: a case report.

Lapébie, François-Xavier / Robin, Guillaume / Adoue, Daniel / Bura-Rivière, Alessandra / Marcheix, Bertrand

Clinical and experimental rheumatology

2020 Volume 38 Suppl 127, Issue 5, Page(s) 127–128

MeSH term(s)	Aneurysm, False/diagnostic imaging ; Aneurysm, False/etiology ; Behcet Syndrome/complications ; Behcet Syndrome/diagnosis ; Behcet Syndrome/drug therapy ; Heart Ventricles/diagnostic imaging ; Humans
Language	English
Publishing date	2020-12-10
Publishing country	Italy
Document type	Case Reports ; Letter
ZDB-ID	605886-3
ISSN	1593-098X ; 0392-856X
ISSN (online)	1593-098X
ISSN	0392-856X
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Article ; Online: Real-world effect of iloprost in patients with chronic limb-threatening ischemia (CLTI): A cohort study.

Dari, Loubna / Constans, Joël / Boulon, Carine / Caradu, Caroline / Lapébie, François-Xavier / Bura-Rivière, Alessandra / Chastaingt, Lucie / Lacroix, Philippe / Bezin, Julien / Pariente, Antoine

Vascular medicine (London, England)

2023 Volume 29, Issue 1, Page(s) 67–69

MeSH term(s)	Humans ; Chronic Limb-Threatening Ischemia ; Iloprost/adverse effects ; Cohort Studies ; Peripheral Arterial Disease/diagnosis ; Peripheral Arterial Disease/drug therapy ; Peripheral Arterial Disease/etiology ; Ischemia/diagnosis ; Ischemia/drug therapy ; Ischemia/etiology ; Limb Salvage ; Treatment Outcome ; Retrospective Studies ; Chronic Disease ; Endovascular Procedures/adverse effects
Chemical Substances	Iloprost (JED5K35YGL)
Language	English
Publishing date	2023-11-07
Publishing country	England
Document type	Letter
ZDB-ID	1311628-9
ISSN	1477-0377 ; 1358-863X
ISSN (online)	1477-0377
ISSN	1358-863X
DOI	10.1177/1358863X231209263
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Article: Comparison between conventional duplex ultrasonography and the dual-gate Doppler mode for hemodynamic measurements of the carotid arteries.

Hersant, Jeanne / Ramondou, Pierre / Douillet, Delphine / Abrard, Stanislas / Vandeputte, Patrick / Lapébie, François-Xavier / Abraham, Pierre / Henni, Samir

Ultrasonography (Seoul, Korea)

2021 Volume 41, Issue 2, Page(s) 373–381

Abstract: Purpose: This study investigated the correlations of hemodynamic parameters measured to quantify stenosis between the gold-standard duplex ultrasonography and the dual-gate Doppler mode.: Methods: Patients examined due to suspicion of carotid artery ... ...

Abstract	Purpose: This study investigated the correlations of hemodynamic parameters measured to quantify stenosis between the gold-standard duplex ultrasonography and the dual-gate Doppler mode. Methods: Patients examined due to suspicion of carotid artery stenosis or for surveillance of known stenosis were invited to participate in this prospective single-center study. Upon acceptance, the hemodynamic characteristics of the carotid arteries were determined successively in standard duplex and dual-gate Doppler modes. The correlations between the two modes were analyzed by computing Pearson coefficients (r2) and Lin concordance coefficients (ρc). The degree of agreement between the two methods was visualized using Bland-Altman graphical representations. Results: The correlation between internal carotid artery peak systolic velocity measured by standard duplex ultrasonography and dual-gate Doppler mode was good (r2=0.642). The same high level of correlation was observed for the carotid ratio (r2=0.544). However, the Bland-Altman graphical representation and the Lin concordance coefficients (ρc=0.75 and ρc=0.74 for the internal carotid artery peak systolic velocity and carotid ratio, respectively) showed that a lack of precision generated some discrepancies between the two measurement methods. Conclusion: Although some discrepancies were observed, the hemodynamic measurements were closely correlated between the two ultrasonography modes. Therefore, the dual-gate Doppler mode may have obvious advantages over conventional ultrasonography, offering interesting development possibilities.
Language	English
Publishing date	2021-11-10
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2775801-1
ISSN	2288-5943 ; 2288-5919
ISSN (online)	2288-5943
ISSN	2288-5919
DOI	10.14366/usg.21175
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Article ; Online: Editor's Choice - External Applicability of the COMPASS and VOYAGER-PAD Trials on Patients with Symptomatic Lower Extremity Artery Disease in France: The COPART Registry.

Lapébie, François-Xavier / Aboyans, Victor / Lacroix, Philippe / Constans, Joël / Boulon, Carine / Messas, Emmanuel / Ferrières, Jean / Bongard, Vanina / Bura-Rivière, Alessandra

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery

2021 Volume 62, Issue 3, Page(s) 439–449

Abstract: Objective: The aim of this study was to examine the external applicability of the COMPASS and the VOYAGER-PAD trials in patients with lower extremity artery disease (LEAD) in the real world.: Methods: This was a multicentre retrospective analysis of ... ...

Abstract	Objective: The aim of this study was to examine the external applicability of the COMPASS and the VOYAGER-PAD trials in patients with lower extremity artery disease (LEAD) in the real world. Methods: This was a multicentre retrospective analysis of prospectively collected COPART data, a French multicentre registry of patients hospitalised for symptomatic LEAD. The proportion of patients eligible for the combination of rivaroxaban 2.5 mg twice daily plus aspirin based on either COMPASS or VOYAGER-PAD criteria is reported. The one year cumulative incidence of outcomes between eligible and non-eligible patients, as well as eligible patients vs. control arms of the COMPASS (LEAD patient subgroup) and the VOYAGER-PAD trials were compared. Analyses were performed using Cox models. Results: Of 2 259 evaluable patients, only 679 (30.1%) were eligible for a low dose rivaroxaban plus aspirin regimen. Others were not eligible because of the need for anticoagulant (48.5% and 38.9% of patients meeting COMPASS and VOYAGER-PAD exclusion criteria, respectively) or dual antiplatelet therapy use (15.7% and 16.5%, respectively), high bleeding risk (14.4% and 11.6%, respectively), malignancy (26.1% and 21.0%, respectively), history of ischaemic/haemorrhagic stroke (21.1% and 19.8%, respectively), and severe renal failure (13.2% and 10.5%, respectively). COMPASS and VOYAGER-PAD eligible and ineligible patients were at higher risk of ischaemic events than participants in these trials. The one year cumulative incidences were 6.0% (95% CI 4.3 - 8.1) in the COMPASS eligible subset vs. 3.5% (95% CI 2.9 - 4.3) in the COMPASS control arm for major adverse cardiovascular events, and 27.9% (95% CI 19.9 - 38.3) in the VOYAGER-PAD eligible subset vs. 6.0% (95% CI 5.3 - 6.9) in the VOYAGER-PAD control arm for major adverse limb events. Conclusion: Many patients hospitalised for symptomatic LEAD in France are not eligible for the low dose rivaroxaban plus aspirin combination. In turn, those eligible may potentially have greater absolute benefit because of higher risk than those enrolled in the trials.
Language	English
Publishing date	2021-07-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1225869-6
ISSN	1532-2165 ; 1078-5884
ISSN (online)	1532-2165
ISSN	1078-5884
DOI	10.1016/j.ejvs.2021.05.028
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Article ; Online: Platelet

Garcia, Cédric / Compagnon, Baptiste / Poëtte, Michaël / Gratacap, Marie-Pierre / Lapébie, François-Xavier / Voisin, Sophie / Minville, Vincent / Payrastre, Bernard / Vardon-Bounes, Fanny / Ribes, Agnès

Cells

2022 Volume 11, Issue 9

Abstract: Platelets are mainly known for their key role in hemostasis and thrombosis. However, studies over the last two decades have shown their strong implication in mechanisms associated with inflammation, thrombosis, and the immune system in various neoplastic, ...

Abstract	Platelets are mainly known for their key role in hemostasis and thrombosis. However, studies over the last two decades have shown their strong implication in mechanisms associated with inflammation, thrombosis, and the immune system in various neoplastic, inflammatory, autoimmune, and infectious diseases. During sepsis, platelets amplify the recruitment and activation of innate immune cells at the site of infection and contribute to the elimination of pathogens. In certain conditions, these mechanisms can lead to thromboinflammation resulting in severe organ dysfunction. Here, we discuss the interactions of platelets with leukocytes, neutrophil extracellular traps (NETs), and endothelial cells during sepsis. The intrinsic properties of platelets that generate an inflammatory signal through the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome are discussed. As an example of immunothrombosis, the implication of platelets in vaccine-induced immune thrombotic thrombocytopenia is documented. Finally, we discuss the role of megakaryocytes (MKs) in thromboinflammation and their adaptive responses.
MeSH term(s)	Blood Platelets ; Endothelial Cells ; Humans ; Inflammation ; Megakaryocytes ; Sepsis ; Thromboinflammation ; Thrombosis
Language	English
Publishing date	2022-04-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11091507
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Article ; Online: Finger Systolic Blood Pressure Index Measurement: A Useful Tool for the Evaluation of Arterial Disease in Patients With Systemic Sclerosis.

Blaise, Sophie / Boulon, Carine / Mangin, Marion / Senet, Patricia / Lazareth, Isabelle / Imbert, Bernard / Lapebie, François-Xavier / Lacroix, Philippe / Constans, Joël / Carpentier, Patrick

Arthritis care & research

2022 Volume 74, Issue 5, Page(s) 828–832

Abstract: Objective: To evaluate the prevalence and clinical correlates of peripheral arterial disease of the upper limbs in patients with systemic sclerosis (SSc), as detected with finger brachial pressure index (FBPI) measurements.: Methods: This work is ... ...

Abstract	Objective: To evaluate the prevalence and clinical correlates of peripheral arterial disease of the upper limbs in patients with systemic sclerosis (SSc), as detected with finger brachial pressure index (FBPI) measurements. Methods: This work is based on the baseline data of the SCLEROCAP multicenter cohort of SSc patients. Finger systolic blood pressure was measured with laser Doppler flowmetry, and the FBPI was obtained as its ratio over the ipsilateral brachial systolic blood pressure. An FBPI of <0.70 was used as the diagnostic criterion for occlusive arterial disease of the upper limbs. Thus, the prevalence of defined arterial disease as well as its clinical, biologic, and capillaroscopic correlates were evaluated. Results: Among 326 enrolled patients, 177 (54.3%) met the criterion for arterial disease (FBPI <0.70). No association was found with the type of SSc nor with the type of associated antinuclear antibodies, but a significant association was found with the duration of the disease (P < 0.001), the capillaroscopic pattern (P < 0.001), and most strikingly with the presence of digital ulcers (42.9% versus 13.4%; P < 0.001). A quantitative relationship was found between the FBPI and the prevalence of digital ulcers and was shown to be independent from the capillaroscopic pattern. Conclusion: This cross-sectional study shows a high prevalence of arterial disease of the upper limbs in patients with SSc. FBPI appears to be a strong and independent predictor of digital ulcers. This study suggests that both macro- and microangiopathy are contributing to the ischemic damage of the fingertips.
MeSH term(s)	Blood Pressure ; Cross-Sectional Studies ; Humans ; Microscopic Angioscopy ; Scleroderma, Systemic/complications ; Scleroderma, Systemic/diagnosis ; Scleroderma, Systemic/epidemiology ; Skin Ulcer/diagnosis ; Ulcer/complications
Language	English
Publishing date	2022-03-17
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	645059-3
ISSN	2151-4658 ; 0893-7524 ; 2151-464X
ISSN (online)	2151-4658
ISSN	0893-7524 ; 2151-464X
DOI	10.1002/acr.24527
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