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  1. Article: Probing the donor strength of yldiide ligands: synthesis, structure and reactivity of rhodium complexes with a PC

    Lapointe, Sébastien / Duari, Prakash / Gessner, Viktoria H

    Chemical science

    2023  Volume 14, Issue 14, Page(s) 3816–3825

    Abstract: Control of the metal ligand interaction by changes in the ligand protonation state is vital to many catalytic transformations based on metal-ligand cooperativity. Herein, we report on the coordination chemistry of a new ... ...

    Abstract Control of the metal ligand interaction by changes in the ligand protonation state is vital to many catalytic transformations based on metal-ligand cooperativity. Herein, we report on the coordination chemistry of a new PC
    Language English
    Publishing date 2023-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d2sc06759e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The Strain and the Clinical Outcome of

    Abou Chakra, Claire Nour / Gagnon, Anthony / Lapointe, Simon / Granger, Marie-Félixe / Lévesque, Simon / Valiquette, Louis

    Open forum infectious diseases

    2024  Volume 11, Issue 3, Page(s) ofae085

    Abstract: Background: The association between bacterial strains and clinical outcomes in : Methods: Five electronic databases were used to identify studies reporting CDI severity, complications, recurrence, or mortality according to strain type from inception ... ...

    Abstract Background: The association between bacterial strains and clinical outcomes in
    Methods: Five electronic databases were used to identify studies reporting CDI severity, complications, recurrence, or mortality according to strain type from inception to June 2022. Random effect meta-analyses were conducted to assess outcome proportions and risk ratios (RRs).
    Results: A total of 93 studies were included: 44 reported recurrences, 50 reported severity or complications, and 55 reported deaths. Pooled proportions of complications were statistically comparable between NAP1/BI/R027 and R001, R078, and R106. Pooled attributable mortality was 4.8% with a gradation in patients infected with R014/20 (1.7%), R001 (3.8%), R078 (5.3%), and R027 (10.2%). Higher 30-day all-cause mortality was observed in patients infected with R001, R002, R027, and R106 (range, 20%-25%).NAP1/BI/R027 was associated with several unfavorable outcomes: recurrence 30 days after the end of treatment (pooled RR, 1.98; 95% CI, 1.02-3.84); admission to intensive care, colectomy, or CDI-associated death (1.88; 1.09-3.25); and 30-day attributable mortality (1.96; 1.23-3.13). The association between harboring the binary toxin gene and 30-day all-cause mortality did not reach significance (RR, 1.6 [0.9-2.9]; 7 studies).
    Conclusions: Numerous studies were excluded due to discrepancies in the definition of the outcomes and the lack of reporting of important covariates. NAP1/BI/R027, the most frequently reported and assessed strain, was associated with unfavorable outcomes. However, there were not sufficient data to reach significant conclusions on other strains.
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofae085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: "Love thy neighbour"?

    Lapointe, Simon

    the effect of income and language differences on votes for municipal secessions

    (VATT working papers ; 107)

    2018  

    Author's details Simon Lapointe
    Series title VATT working papers ; 107
    Language English
    Size 1 Online-Ressource (circa 67 Seiten), Illustrationen
    Document type Book ; Online
    ISBN 9789522742186 ; 952274218X
    Database ECONomics Information System

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  4. Article ; Online: Correction: On the mechanism of Ni(ii)-promoted Michael-type hydroamination of acrylonitrile and its substituted derivatives.

    Lapointe, S / Zargarian, D

    Dalton transactions (Cambridge, England : 2003)

    2017  Volume 46, Issue 5, Page(s) 1714

    Abstract: Correction for 'On the mechanism of Ni(ii)-promoted Michael-type hydroamination of acrylonitrile and its substituted derivatives' by S. Lapointe et al., Dalton Trans., 2016, 45, 15800-15810. ...

    Abstract Correction for 'On the mechanism of Ni(ii)-promoted Michael-type hydroamination of acrylonitrile and its substituted derivatives' by S. Lapointe et al., Dalton Trans., 2016, 45, 15800-15810.
    Language English
    Publishing date 2017-01-18
    Publishing country England
    Document type Journal Article ; Published Erratum
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/c7dt90010d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Ylide-Substituted Phosphines: A Platform of Strong Donor Ligands for Gold Catalysis and Palladium-Catalyzed Coupling Reactions.

    Lapointe, Sébastien / Sarbajna, Abir / Gessner, Viktoria H

    Accounts of chemical research

    2022  Volume 55, Issue 5, Page(s) 770–782

    Abstract: The development of homogeneous catalysts is strongly connected to the design of new, sophisticated ligands, which resolve limitations of a given reaction protocol by manipulating the electronic properties of the metal and its spatial environment. ... ...

    Abstract The development of homogeneous catalysts is strongly connected to the design of new, sophisticated ligands, which resolve limitations of a given reaction protocol by manipulating the electronic properties of the metal and its spatial environment. Phosphines are a privileged class of ligands that find applications in many catalytic transformations, ranging from hydrogenation reactions to hydroformylation and coupling chemistry. For many years, chemists have been trying to improve the efficiency, selectivity, and application of coupling reactions. The use of highly electron-rich and bulky phosphines was often associated with increased selectivity and efficiency and led to the development of a vast variety of electron-rich alkyl-substituted phosphines. However, this concept of increasing the ligand donor strength reaches its limits with the use of trialkyl-substituted phosphines with tri-
    MeSH term(s) Catalysis ; Gold ; Ligands ; Palladium/chemistry ; Phosphines/chemistry
    Chemical Substances Ligands ; Phosphines ; Palladium (5TWQ1V240M) ; Gold (7440-57-5)
    Language English
    Publishing date 2022-02-16
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1483291-4
    ISSN 1520-4898 ; 0001-4842
    ISSN (online) 1520-4898
    ISSN 0001-4842
    DOI 10.1021/acs.accounts.1c00797
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: On the mechanism of Ni(ii)-promoted Michael-type hydroamination of acrylonitrile and its substituted derivatives.

    Lapointe, S / Zargarian, D

    Dalton transactions (Cambridge, England : 2003)

    2016  Volume 45, Issue 40, Page(s) 15800–15810

    Abstract: Michael-type hydroamination of acrylonitrile and its substituted derivatives promoted by Ni(ii) complexes is believed to proceed via an outer-sphere nucleophilic attack on the cationic adduct of the nitrile-coordinated substrate. As a test for the ... ...

    Abstract Michael-type hydroamination of acrylonitrile and its substituted derivatives promoted by Ni(ii) complexes is believed to proceed via an outer-sphere nucleophilic attack on the cationic adduct of the nitrile-coordinated substrate. As a test for the validity of this mechanistic postulate, we have sought to establish a correlation between the electrophilic character of the Ni(ii) center and the degree to which it can activate the substrate toward nucleophilic attack by amines. This has been done by screening the catalytic activities of the cationic acetonitrile adducts [(R-POCOP)Ni(NCCH
    Language English
    Publishing date 2016-10-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/c6dt02105k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Isolated Fetal Sinus Bradycardia as a First Sign of Congenital Hypopituitarism.

    Lapointe, Simon / Rottembourg, Diane / Dallaire, Frederic

    CJC open

    2020  Volume 2, Issue 5, Page(s) 420–422

    Abstract: We present a case of marked fetal sinus bradycardia as the sole presenting sign of congenital combined pituitary hormone deficiencies. Fetal sinus bradycardia < 120 beats/min was detected at 36 weeks of gestation during an otherwise uncomplicated ... ...

    Abstract We present a case of marked fetal sinus bradycardia as the sole presenting sign of congenital combined pituitary hormone deficiencies. Fetal sinus bradycardia < 120 beats/min was detected at 36 weeks of gestation during an otherwise uncomplicated pregnancy. Sinus bradycardia persisted after birth, and congenital hypothyroidism and growth hormone deficiencies were subsequently identified. Normal sinus rhythm was rapidly restored with hormone supplementation. Hypothyroidism and growth hormone deficiency should be considered in the differential diagnosis of unexplained perinatal sinus bradycardia because early diagnosis may help to avoid potential complications (ie, mental retardation, severe hypoglycemia, and growth anomaly).
    Language English
    Publishing date 2020-04-11
    Publishing country United States
    Document type Case Reports
    ISSN 2589-790X
    ISSN (online) 2589-790X
    DOI 10.1016/j.cjco.2020.04.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Food for thought: IP protection for nutraceuticals and functional foods.

    Lapointe, Serge

    Health law in Canada

    2008  Volume 28, Issue 3-4, Page(s) 101–111

    Abstract: Functional foods and nutraceuticals are one of the fastest growing segments of the food industry. The market is driven by an aging population, rising health care costs, advances in food production technology and a growing understanding within the ... ...

    Abstract Functional foods and nutraceuticals are one of the fastest growing segments of the food industry. The market is driven by an aging population, rising health care costs, advances in food production technology and a growing understanding within the customer population of the link between diet and health. Functional foods and nutraceutical products represent an excellent growth opportunity for the Canadian agri-food industry but, to stay competitive, companies must take appropriate actions to develop, preserve and protect their intellectual property rights. This article presents an overview of the different intellectual property (IP) rights which may be applicable to functional foods and nutraceuticals and provides stakeholders with a number of strategies on how to maximize their protection.
    MeSH term(s) Canada ; Dietary Supplements ; Food Supply/legislation & jurisprudence ; Government Regulation ; Intellectual Property
    Language English
    Publishing date 2008-06
    Publishing country Canada
    Document type Journal Article
    ISSN 0226-8841
    ISSN 0226-8841
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online: Effects of municipal mergers on voter turnout

    Lapointe, Simon / Saarimaa, Tuukka / Tukiainen, Janne

    (VATT working papers ; 106)

    2018  

    Author's details Simon Lapointe, Tuukka Saarimaa, Janne Tukiainen
    Series title VATT working papers ; 106
    Language English
    Size 1 Online-Ressource (circa 26 Seiten), Illustrationen
    Document type Book ; Online
    ISBN 9789522742162 ; 9522742163
    Database ECONomics Information System

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  10. Book ; Online: Bolzano's theoretical philosophy

    Lapointe, Sandra

    an introduction

    (History of analytic philosophy)

    2011  

    Abstract: The first book in English to offer a systematic survey of Bolzano's philosophical logic and theory of knowledge, it offers a reconstruction of Bolzano's views on a series of key issues: the analysis of meaning, generality, analyticity, logical ... ...

    Author's details Sandra Lapointe
    Series title History of analytic philosophy
    Abstract The first book in English to offer a systematic survey of Bolzano's philosophical logic and theory of knowledge, it offers a reconstruction of Bolzano's views on a series of key issues: the analysis of meaning, generality, analyticity, logical consequence, mathematical demonstration and knowledge by virtue of meaning
    Language English
    Size Online-Ressource
    Publisher Palgrave Macmillan
    Publishing place Basingstoke u.a.
    Document type Book ; Online
    Note Includes bibliographical references and index
    ISBN 9780230308640 ; 0230308643
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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