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  1. Article ; Online: Management and outcomes of 27 pregnancies in women with myeloproliferative neoplasms.

    Lapoirie, Joëlle / Contis, Anne / Guy, Alexandre / Lifermann, François / Viallard, Jean-François / Sentilhes, Loïc / James, Chloé / Duffau, Pierre

    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

    2018  Volume 33, Issue 1, Page(s) 49–56

    Abstract: Introduction: ...

    Abstract Introduction:
    MeSH term(s) Abortion, Spontaneous/epidemiology ; Adult ; Female ; Fetal Growth Retardation/epidemiology ; France/epidemiology ; Hematologic Neoplasms/epidemiology ; Humans ; Myeloproliferative Disorders/epidemiology ; Myeloproliferative Disorders/therapy ; Pre-Eclampsia/epidemiology ; Pregnancy ; Pregnancy Complications, Neoplastic/epidemiology ; Pregnancy Complications, Neoplastic/therapy ; Pregnancy Outcome/epidemiology ; Pregnancy, High-Risk ; Premature Birth/epidemiology ; Retrospective Studies ; Risk Assessment ; Stillbirth/epidemiology
    Language English
    Publishing date 2018-06-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2077261-0
    ISSN 1476-4954 ; 1057-0802 ; 1476-7058
    ISSN (online) 1476-4954
    ISSN 1057-0802 ; 1476-7058
    DOI 10.1080/14767058.2018.1484097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3510: Show issues Location:
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  2. Article ; Online: Safety of hydroxychloroquine and darunavir or lopinavir in COVID-19 infection.

    Meriglier, Etienne / Rivoisy, Claire / Hessamfar, Mojgan / Bernard, Noelle / Aureau, Ines / Lapoirie, Joelle / Contis, Anne / Sacher, Frédéric / Sacristan, Benjamin / Lahouati, Marin / Pedeboscq, Stéphane / Vandenhende, Marie-Anne / Bouchet, Stéphane / Bonnet, Fabrice

    The Journal of antimicrobial chemotherapy

    2020  Volume 76, Issue 2, Page(s) 482–486

    Abstract: Background: Combination therapy with hydroxychloroquine and darunavir/ritonavir or lopinavir/ritonavir has been suggested as an approach to improve the outcome of patients with moderate/severe COVID-19 infection.: Objectives: To examine the safety of ...

    Abstract Background: Combination therapy with hydroxychloroquine and darunavir/ritonavir or lopinavir/ritonavir has been suggested as an approach to improve the outcome of patients with moderate/severe COVID-19 infection.
    Objectives: To examine the safety of combination therapy with hydroxychloroquine and darunavir/ritonavir or lopinavir/ritonavir.
    Methods: This was an observational cohort study of patients hospitalized for COVID-19 pneumonia treated with hydroxychloroquine and darunavir/ritonavir or lopinavir/ritonavir. Clinical evaluations, electrocardiograms and the pharmacokinetics of hydroxychloroquine, darunavir and lopinavir were examined according to clinical practice and guidelines.
    Results: Twenty-one patients received hydroxychloroquine with lopinavir/ritonavir (median age 68 years; 10 males) and 25 received hydroxychloroquine with darunavir/ritonavir (median age 71 years; 15 males). During treatment, eight patients (17.4%) developed ECG abnormalities. Ten patients discontinued treatment, including seven for ECG abnormalities a median of 5 (range 2-6) days after starting treatment. All ECG abnormalities reversed 1-2 days after interrupting treatment. Four patients died within 14 days. ECG abnormalities were significantly associated with age over 70 years, coexisting conditions (such as hypertension, chronic cardiovascular disease and kidney failure) and initial potential drug interactions, but not with the hydroxychloroquine concentration.
    Conclusions: Of the patients with COVID-19 who received hydroxychloroquine with lopinavir or darunavir, 17% had ECG abnormalities, mainly related to age or in those with a history of cardiovascular disease.
    MeSH term(s) Antiviral Agents/administration & dosage ; Antiviral Agents/adverse effects ; Antiviral Agents/blood ; Antiviral Agents/therapeutic use ; COVID-19/drug therapy ; COVID-19/epidemiology ; Cohort Studies ; Darunavir/administration & dosage ; Darunavir/adverse effects ; Darunavir/blood ; Darunavir/therapeutic use ; Drug Therapy, Combination ; Electrocardiography ; France ; Humans ; Hydroxychloroquine/administration & dosage ; Hydroxychloroquine/adverse effects ; Hydroxychloroquine/blood ; Hydroxychloroquine/therapeutic use ; Long QT Syndrome/chemically induced ; Long QT Syndrome/epidemiology ; Lopinavir/administration & dosage ; Lopinavir/adverse effects ; Lopinavir/blood ; Lopinavir/therapeutic use ; SARS-CoV-2 ; Severity of Illness Index ; Treatment Outcome
    Chemical Substances Antiviral Agents ; Lopinavir (2494G1JF75) ; Hydroxychloroquine (4QWG6N8QKH) ; Darunavir (YO603Y8113)
    Language English
    Publishing date 2020-11-22
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkaa441
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1197: Show issues Location:
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    Zs.MO 124: Show issues

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  3. Article ; Online: Interleukin-1β-Activated Microvascular Endothelial Cells Promote DC-SIGN-Positive Alternatively Activated Macrophages as a Mechanism of Skin Fibrosis in Systemic Sclerosis.

    Laurent, Paôline / Lapoirie, Joelle / Leleu, Damien / Levionnois, Emeline / Grenier, Cyrielle / Jurado-Mestre, Blanca / Lazaro, Estibaliz / Duffau, Pierre / Richez, Christophe / Seneschal, Julien / Pellegrin, Jean-Luc / Constans, Joel / Schaeverbeke, Thierry / Douchet, Isabelle / Duluc, Dorothée / Pradeu, Thomas / Chizzolini, Carlo / Blanco, Patrick / Truchetet, Marie-Elise /
    Contin-Bordes, Cécile

    Arthritis & rheumatology (Hoboken, N.J.)

    2022  Volume 74, Issue 6, Page(s) 1013–1026

    Abstract: Objective: To characterize the role of interleukin-1β (IL-1β) and microvascular endothelial cells (MVECs) in the generation of alternatively activated macrophages in the skin, and to explore their role in the development of skin fibrosis in patients ... ...

    Abstract Objective: To characterize the role of interleukin-1β (IL-1β) and microvascular endothelial cells (MVECs) in the generation of alternatively activated macrophages in the skin, and to explore their role in the development of skin fibrosis in patients with systemic sclerosis (SSc; scleroderma).
    Methods: Conditioned medium prepared with MVECs purified from the skin of healthy donors and the skin of SSc patients was used to generate monocyte-derived macrophages. Flow cytometry, multiplex protein assessment, real-time quantitative polymerase chain reaction, and tissue immunofluorescence were used to characterize MVEC-induced polarization of alternatively activated macrophages. Coculture experiments were conducted to assess the role of MVEC-induced alternatively activated macrophages in fibroblast activation. Alternatively activated macrophages were characterized in the skin of healthy donors and SSc patients using multiparametric immunofluorescence and multiplex immunostaining for gene expression. Based on our in vitro data, we defined a supervised macrophage gene signature score to assess correlation between the macrophage score and clinical features in patients with SSc, using the Spearman's test.
    Results: IL-1β-activated MVECs from SSc patients induced monocytes to differentiate into DC-SIGN+ alternatively activated macrophages producing high levels of CCL18, CCL2, and CXCL8 but low levels of IL-10. DC-SIGN+ alternatively activated macrophages showed significant enhancing effects in promoting the production of proinflammatory fibroblasts and were found to be enriched in perivascular regions of the skin of SSc patients who had a high fibrosis severity score. A novel skin transcriptomic macrophage signature, defined from our in vitro findings, correlated with the extent of skin fibrosis (Spearman's r = 0.6, P = 0.0018) and was associated with early disease manifestations and lung involvement in patients with SSc.
    Conclusion: Our findings shed new light on the vicious circle implicating unabated IL-1β secretion, MVEC activation, and the generation of DC-SIGN+ alternatively activated macrophages in the development of skin fibrosis in patients with SSc.
    MeSH term(s) Cell Adhesion Molecules/immunology ; Endothelial Cells/metabolism ; Fibrosis ; Humans ; Interleukin-1beta/immunology ; Lectins, C-Type/immunology ; Macrophage Activation ; Macrophages ; Receptors, Cell Surface/immunology ; Scleroderma, Systemic/pathology ; Skin/pathology
    Chemical Substances Cell Adhesion Molecules ; DC-specific ICAM-3 grabbing nonintegrin ; Interleukin-1beta ; Lectins, C-Type ; Receptors, Cell Surface
    Language English
    Publishing date 2022-05-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.42061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 24: Show issues Location:
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  4. Article ; Online: Improving Adherence to Adjuvant Endocrine Therapy in Breast Cancer Through a Therapeutic Educational Approach: A Feasibility Study
.

    Bourmaud, Aurélie / Rousset, Vanessa / Regnier-Denois, Véronique / Collard, Olivier / Jacquin, Jean-Philippe / Merrouche, Yacine / Lapoirie, Joelle / Tinquaut, Fabien / Lataillade, Laurence / Chauvin, Franck

    Oncology nursing forum

    2016  Volume 43, Issue 3, Page(s) E94–E103

    Abstract: Purpose/objectives: To develop and test the feasibility of a tailored therapeutic educational program, with the aim of improving adherence to oral endocrine adjuvant chemotherapy in women with breast cancer. 
.: Design: A qualitative study to ... ...

    Abstract Purpose/objectives: To develop and test the feasibility of a tailored therapeutic educational program, with the aim of improving adherence to oral endocrine adjuvant chemotherapy in women with breast cancer. 
.
    Design: A qualitative study to identify educational needs and a feasibility study assessing the efficacy of the program.
.
    Setting: A comprehensive cancer center, the Lucien Neuwirth Cancer Institute in Saint-Priest-en-Jarez, France.
.
    Sample: Two consecutive samples (N = 11, N = 6) of women taking adjuvant oral endocrine chemotherapy for breast cancer. 
.
    Methods: A mixed qualitative and quantitative method was used. The participants' representations of disease and treatment were explored through one-on-one interviews and then translated into educational needs, which were used to develop a tailored therapeutic education program. The pilot study evaluated the reach and efficacy using before-and-after comparisons. 
.
    Main research variables: Educational objectives, knowledge, trust in the treatment, and anxiety.
.
    Findings: Five educational objectives (acquiring knowledge, improving communication skills, managing anxiety, managing side effects, and improving adherence) were identified through 11 interviews. A three-session program was developed. Eight of the 23 patients invited to participate in a pilot study accepted, and six completed the intervention. Knowledge improved from 38.9 of 100 preintervention to 69.4 of 100 postintervention (p = 0.045). Trust in treatment showed a trend to improvement from 5.5 of 10 to 8 of 10 (p = 0.14), but anxiety did not change significantly; anxiety went from 6 to 7 (p = 0.88).
.
    Conclusions: Results from the feasibility study showed promising efficacy for the educational objectives and provided information about how the program could be improved. 
.
    Implications for nursing: Tailored educational programs conducted by trained nurses may help patients to adhere to and live with the effects of endocrine therapy.
    MeSH term(s) Administration, Oral ; Adult ; Aged ; Aged, 80 and over ; Breast Neoplasms/drug therapy ; Chemotherapy, Adjuvant ; Endocrine Disruptors/administration & dosage ; Feasibility Studies ; Female ; France ; Humans ; Middle Aged ; Oncology Nursing/methods ; Patient Compliance/psychology ; Patient Education as Topic ; Pilot Projects
    Chemical Substances Endocrine Disruptors
    Language English
    Publishing date 2016-05-01
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 604886-9
    ISSN 1538-0688 ; 0190-535X ; 1538-0688
    ISSN (online) 1538-0688 ; 0190-535X
    ISSN 1538-0688
    DOI 10.1188/16.ONF.E94-E103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1818: Show issues Location:
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    Zs.MO 414: Show issues

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  5. Article ; Online: Central nervous system involvement in eosinophilic granulomatosis with polyangiitis (Churg-Strauss): Report of 26 patients and review of the literature.

    André, Raphaël / Cottin, Vincent / Saraux, Jean-Luc / Blaison, Gilles / Bienvenu, Boris / Cathebras, Pascal / Dhote, Robin / Foucher, Aurélie / Gil, Helder / Lapoirie, Joëlle / Launay, David / Loustau, Valentine / Maurier, François / Pertuiset, Edouard / Zénone, Thierry / Seebach, Jörg / Costedoat-Chalumeau, Nathalie / Puéchal, Xavier / Mouthon, Luc /
    Guillevin, Loïc / Terrier, Benjamin

    Autoimmunity reviews

    2017  Volume 16, Issue 9, Page(s) 963–969

    Abstract: Background: Although peripheral nervous system involvement is common in eosinophilic granulomatosis with polyangiitis (EGPA), central nervous system (CNS) manifestations are poorly described. This study aimed to describe CNS involvement in EGPA.: ... ...

    Abstract Background: Although peripheral nervous system involvement is common in eosinophilic granulomatosis with polyangiitis (EGPA), central nervous system (CNS) manifestations are poorly described. This study aimed to describe CNS involvement in EGPA.
    Patients and methods: This retrospective, observational, multicenter study included patients with EGPA and CNS involvement affecting cranial nerves, brain and/or spinal cord. We also undertook a systematic literature review.
    Results: We analyzed 26 personal cases and 62 previously reported cases. At EGPA diagnosis, asthma was noted in 97%, eosinophilia in 98%, peripheral neuropathy in 55% and cardiac involvement in 41%. 38/71 (54%) were ANCA-positive, with a perinuclear-labeling pattern and/or anti-MPO specificity. CNS was involved in 86% at EGPA diagnosis, preceded EGPA in 2%, and occurred during follow-up in 12% after a median of 24months. Main neurological manifestations were ischemic cerebrovascular lesions in 46 (52%), intracerebral hemorrhage and/or subarachnoid hemorrhage in 21 (24%), loss of visual acuity in 28 (33%) (15 with optic neuritis, 9 with central retinal artery occlusion, 4 with cortical blindness), and cranial nerves palsies in 18 (21%), with 25 patients having ≥1 of these clinical CNS manifestations. Among the 81 patients with assessable neurological responses, 43% had complete responses without sequelae, 43% had partial responses with long-term sequelae and 14% refractory disease. After a mean follow-up of 36months, 11 patients died including 5 from intracerebral hemorrhages.
    Conclusion: EGPA-related CNS manifestations form 4 distinct neurological pictures: ischemic lesions, intracerebral hemorrhages, cranial nerve palsies and loss of visual acuity. Such manifestation should prompt practitioners to consider EGPA in such conditions. Long-term neurological sequelae were common, and intracerebral hemorrhages had the worst prognostic impact.
    Language English
    Publishing date 2017-09
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2144145-5
    ISSN 1873-0183 ; 1568-9972
    ISSN (online) 1873-0183
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2017.07.007
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