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  1. Article ; Online: The role of nutrition, food allergies, and gut dysbiosis in immune-mediated inflammatory skin disease: a narrative review.

    Bourkas, Adrienn N / Lara-Corrales, Irene

    Current opinion in pediatrics

    2023  Volume 35, Issue 4, Page(s) 452–459

    Abstract: Purpose of review: This review focuses on the emerging roles of nutrition, food allergies, and gut dysbiosis, and their influence on pediatric skin conditions such as psoriasis, hidradenitis suppurativa, and alopecia areata. As the prevalence of these ... ...

    Abstract Purpose of review: This review focuses on the emerging roles of nutrition, food allergies, and gut dysbiosis, and their influence on pediatric skin conditions such as psoriasis, hidradenitis suppurativa, and alopecia areata. As the prevalence of these conditions increases, understanding the underlying mechanisms and potential therapeutic targets is crucial for clinical practice and research.
    Recent findings: The review covers 32 recent articles that highlight the significance of the gut microbiome, nutrition, and gut dysbiosis in the pathogenesis and progression of inflammatory and immune-related pediatric skin conditions. The data suggest that food allergies and gut dysbiosis play a crucial role in disease pathogenesis.
    Summary: This review emphasizes the need for larger-scale studies to determine the effectiveness of dietary changes in preventing or treating inflammatory and immune-related skin conditions. Clinicians must maintain a balanced approach when implementing dietary changes in children with skin diseases like atopic dermatitis to avoid potential nutritional deficiencies and growth impairments. Further research into the complex interplay between environmental and genetic factors is warranted to develop tailored therapeutic strategies for these skin conditions in children.
    MeSH term(s) Humans ; Child ; Dysbiosis/complications ; Food Hypersensitivity ; Dermatitis, Atopic/etiology ; Dermatitis, Atopic/therapy ; Psoriasis ; Hidradenitis Suppurativa ; Skin
    Language English
    Publishing date 2023-06-12
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1049374-8
    ISSN 1531-698X ; 1040-8703
    ISSN (online) 1531-698X
    ISSN 1040-8703
    DOI 10.1097/MOP.0000000000001262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3049: Show issues Location:
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  2. Article ; Online: Hidradenitis Suppurativa in Children and Adolescents: An Update on Pharmacologic Treatment Options.

    Chiang, Nicholas / Sibbald, Cathryn / Levy, Rebecca / Lara-Corrales, Irene

    Paediatric drugs

    2023  Volume 25, Issue 6, Page(s) 659–676

    Abstract: Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory skin condition that manifests as painful, deep-seated, inflamed nodules and abscesses in the axillary, groin, perianal, perineal, and inframammary regions. The associated pain, malodour, ...

    Abstract Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory skin condition that manifests as painful, deep-seated, inflamed nodules and abscesses in the axillary, groin, perianal, perineal, and inframammary regions. The associated pain, malodour, and disfigurement contribute to its profound negative impact on psychosocial spheres and overall quality of life in affected individuals. Although the symptoms of HS classically begin in the second or third decade of life, HS affects children and adolescents as well. Despite this, there are limited pediatric data on treatment, which are largely based on expert opinion, extrapolation of efficacy data in adults with HS, and safety information from medication use in other pediatric diseases. On this basis, there exist several pharmacological modalities in the treatment of children and adolescents with HS including topical therapies, systemic therapies, and biologics. The goals of this review article are to: (1) review the efficacy of different pharmacological treatment modalities in children and adolescents with HS, and (2) review the safety and monitoring considerations of the different treatment options in children and adolescents with HS.
    MeSH term(s) Adult ; Humans ; Child ; Adolescent ; Quality of Life ; Hidradenitis Suppurativa/drug therapy ; Hidradenitis Suppurativa/diagnosis ; Pain
    Language English
    Publishing date 2023-10-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1492748-2
    ISSN 1179-2019 ; 1174-5878
    ISSN (online) 1179-2019
    ISSN 1174-5878
    DOI 10.1007/s40272-023-00595-6
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  3. Article ; Online: Vascular anomalies: clinical perspectives.

    Amaral, Joao Guilherme / Lara-Corrales, Irene

    Pediatric radiology

    2022  Volume 52, Issue 2, Page(s) 249–261

    Abstract: Vascular anomalies are classified as vascular tumors or vascular malformations according to their cellular features and biological behavior. Detailed history and clinical assessment allow for the proper clinical diagnosis of most vascular anomalies and ... ...

    Abstract Vascular anomalies are classified as vascular tumors or vascular malformations according to their cellular features and biological behavior. Detailed history and clinical assessment allow for the proper clinical diagnosis of most vascular anomalies and guide the choice of imaging to evaluate them. This article discusses the general information needed from a clinical history and physical exam to formulate a diagnosis of vascular anomaly. Then, the authors review the clinical findings from the most common vascular tumors and vascular malformations.
    MeSH term(s) Humans ; Vascular Malformations/diagnostic imaging
    Language English
    Publishing date 2022-01-05
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 124459-0
    ISSN 1432-1998 ; 0301-0449
    ISSN (online) 1432-1998
    ISSN 0301-0449
    DOI 10.1007/s00247-021-05260-z
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  4. Article ; Online: Updated Approach to Patients with Multiple Café au Lait Macules.

    Albaghdadi, Mohammed / Thibodeau, My Linh / Lara-Corrales, Irene

    Dermatologic clinics

    2021  Volume 40, Issue 1, Page(s) 9–23

    Abstract: Café au lait macules (CALMs) are a normal and frequent finding in the general population, but multiple CALMs raise the possibility of an underlying neurocutaneous disease like neurofibromatosis type I. Certain features of CALMs like number, size, shape, ... ...

    Abstract Café au lait macules (CALMs) are a normal and frequent finding in the general population, but multiple CALMs raise the possibility of an underlying neurocutaneous disease like neurofibromatosis type I. Certain features of CALMs like number, size, shape, and distribution are important in identifying children at higher risk of having a neurocutaneous disorder or another genetic disorder. Genetic testing can be especially helpful in establishing a diagnosis in atypical presentations, or when the child is young and other features of the disease aside from CALMs have not manifested.
    MeSH term(s) Cafe-au-Lait Spots/genetics ; Child ; Genetic Testing ; Humans ; Neurofibromatosis 1/complications ; Neurofibromatosis 1/genetics
    Language English
    Publishing date 2021-10-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 82798-8
    ISSN 1558-0520 ; 0733-8635
    ISSN (online) 1558-0520
    ISSN 0733-8635
    DOI 10.1016/j.det.2021.08.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Prescribing patterns and preferences for moderate-to-severe pediatric (<12 years of age) atopic dermatitis: A survey of Canadian practitioners.

    Ramien, Michele L / Jain, Vipul / Bergman, James / Marcoux, Danielle / Lara-Corrales, Irene

    JAAD international

    2023  Volume 14, Page(s) 87–89

    Language English
    Publishing date 2023-10-28
    Publishing country United States
    Document type Journal Article
    ISSN 2666-3287
    ISSN (online) 2666-3287
    DOI 10.1016/j.jdin.2023.10.003
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  6. Article ; Online: Early diagnosis of ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis syndrome: A case report.

    Bourkas, Adrienn N / Pope, Elena / Mendoza-Londono, Roberto / Kamath, Binita M / Lara-Corrales, Irene

    Pediatric dermatology

    2023  Volume 40, Issue 4, Page(s) 710–712

    Abstract: Congenital ichthyosis is a genodermatosis characterized by abnormal epidermal differentiation. The neonatal period is critical for patients with ichthyosis because of the risk for significant comorbidities and associated mortality, with most ... ...

    Abstract Congenital ichthyosis is a genodermatosis characterized by abnormal epidermal differentiation. The neonatal period is critical for patients with ichthyosis because of the risk for significant comorbidities and associated mortality, with most complications resulting from impaired barrier function. Early recognition can significantly alter the clinical course of this rare disease. Here we present a neonate with ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis syndrome (ILVASC), a rare inherited disease, to highlight how an interdisciplinary approach led to prompt assessment, confirmation of a genetic diagnosis and management of potential complications.
    MeSH term(s) Infant, Newborn ; Humans ; Alopecia/genetics ; Ichthyosis/diagnosis ; Ichthyosis/genetics ; Leukocyte Disorders/genetics ; Ichthyosis, Lamellar ; Syndrome ; Early Diagnosis
    Language English
    Publishing date 2023-01-19
    Publishing country United States
    Document type Case Reports
    ZDB-ID 605539-4
    ISSN 1525-1470 ; 0736-8046
    ISSN (online) 1525-1470
    ISSN 0736-8046
    DOI 10.1111/pde.15255
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    Zs.A 1882: Show issues Location:
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  7. Article ; Online: Hidradenitis Suppurativa in Pediatric Patients.

    Cotton, Colleen H / Chen, Stella X / Hussain, Sadaf H / Lara-Corrales, Irene / Zaenglein, Andrea L

    Pediatrics

    2023  Volume 151, Issue 5

    Abstract: Hidradenitis suppurativa is a chronic inflammatory skin disorder primarily affecting apocrine gland-bearing areas, including the axillae, groin, and buttocks. It is reported in up to 2% of Western populations and with increasing incidence in children and ...

    Abstract Hidradenitis suppurativa is a chronic inflammatory skin disorder primarily affecting apocrine gland-bearing areas, including the axillae, groin, and buttocks. It is reported in up to 2% of Western populations and with increasing incidence in children and adults. Nearly one-third of hidradenitis suppurativa cases occur in pediatric patients and nearly half of patients endorse initial symptoms in childhood. To date, there are few clinical studies and guidelines for pediatric hidradenitis suppurativa. Here, we review the epidemiology, clinical presentation, comorbidities, and management of pediatric hidradenitis suppurativa. We discuss barriers contributing to delays in diagnosis and the significant physical and emotional impact of the disease on children and adolescents.
    MeSH term(s) Adult ; Humans ; Child ; Adolescent ; Hidradenitis Suppurativa/diagnosis ; Hidradenitis Suppurativa/epidemiology ; Hidradenitis Suppurativa/therapy ; Comorbidity ; Groin ; Pelvis
    Language English
    Publishing date 2023-04-26
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2022-061049
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  8. Article ; Online: Use of topical rapamycin in acral pseudolymphomatous angiokeratoma of children (APACHE): A report of two cases and review of the literature.

    Park, Seiwon / Lara-Corrales, Irene / Pope, Elena

    Pediatric dermatology

    2020  Volume 37, Issue 5, Page(s) 877–880

    Abstract: Acral pseudolymphomatous angiokeratoma of children (APACHE) is a rare, benign disease characterized clinically by multiple, asymptomatic, erythematous papules in the acral regions. We report APACHE in a 12-year-old girl with erythematous-violaceous ... ...

    Abstract Acral pseudolymphomatous angiokeratoma of children (APACHE) is a rare, benign disease characterized clinically by multiple, asymptomatic, erythematous papules in the acral regions. We report APACHE in a 12-year-old girl with erythematous-violaceous papules on the lateral dorsum of her foot and toes, and a 3-year-old girl with erythematous papules on the plantar aspect of her foot. Topical rapamycin ointment improved the lesions and both patients tolerated the medication well. Topical rapamycin appears to be a potentially efficacious, well-tolerated, non-invasive therapy in APACHE, although further studies are needed.
    MeSH term(s) APACHE ; Angiokeratoma/drug therapy ; Child ; Child, Preschool ; Female ; Humans ; Pseudolymphoma/diagnosis ; Pseudolymphoma/drug therapy ; Sirolimus ; Skin Neoplasms/drug therapy
    Chemical Substances Sirolimus (W36ZG6FT64)
    Language English
    Publishing date 2020-06-26
    Publishing country United States
    Document type Case Reports ; Review
    ZDB-ID 605539-4
    ISSN 1525-1470 ; 0736-8046
    ISSN (online) 1525-1470
    ISSN 0736-8046
    DOI 10.1111/pde.14240
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  9. Article ; Online: Mechanisms of Cannabinoids and Potential Applicability to Skin Diseases.

    Cintosun, Amber / Lara-Corrales, Irene / Pope, Elena

    Clinical drug investigation

    2020  Volume 40, Issue 4, Page(s) 293–304

    Abstract: The legalisation of cannabis in a growing number of jurisdictions has led to increasing interest in its potential therapeutic effects in a range of disorders, including cutaneous conditions. Cannabinoids have been used as natural medicines for centuries; ...

    Abstract The legalisation of cannabis in a growing number of jurisdictions has led to increasing interest in its potential therapeutic effects in a range of disorders, including cutaneous conditions. Cannabinoids have been used as natural medicines for centuries; however, their biological activity in the skin is a new area of study. Recent data suggest that cannabinoids are involved in neuro-immuno-endocrine modulation of skin functioning, yet their effect on the features of dermatologic conditions is unclear. This article sought to review the mechanisms by which cannabinoids regulate skin functioning through the lens of relevance to treatment of dermatologic diseases looking at the effects of cannabinoids on a range of cellular activities and dermatologic conditions both in vitro and in vivo. We identified studies demonstrating an inhibitory effect of cannabinoids on skin inflammation, proliferation, fibrosis, pain, and itch-biological mechanisms involved in the pathogenesis of many dermatologic conditions. Cannabinoids have the potential to expand the therapeutic repertoire of a wide spectrum of skin disorders. Given their widespread unregulated use by the general public, basic and clinical studies are required to elucidate the effectiveness and long-term effects of topical and systemic cannabinoids in cutaneous disorders.
    MeSH term(s) Cannabinoids/therapeutic use ; Humans ; Skin Diseases/drug therapy
    Chemical Substances Cannabinoids
    Language English
    Publishing date 2020-02-13
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 1220136-4
    ISSN 1179-1918 ; 0114-2402 ; 1173-2563
    ISSN (online) 1179-1918
    ISSN 0114-2402 ; 1173-2563
    DOI 10.1007/s40261-020-00894-7
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    Zs.A 2807: Show issues Location:
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  10. Article ; Online: Suction Blisters.

    Vella, Kimberly M / Lara-Corrales, Irene / Rai, Brij Kishore / Kukreti, Vinay

    JAMA dermatology

    2021  Volume 156, Issue 11, Page(s) 1248

    MeSH term(s) Blister/diagnosis ; Blister/etiology ; Blister/pathology ; Breast Feeding ; Diagnosis, Differential ; Epidermolysis Bullosa/diagnosis ; Female ; Fingers/pathology ; Humans ; Infant, Newborn ; Skin/pathology ; Skin Diseases, Infectious/diagnosis ; Sucking Behavior
    Language English
    Publishing date 2021-02-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2701761-8
    ISSN 2168-6084 ; 2168-6068
    ISSN (online) 2168-6084
    ISSN 2168-6068
    DOI 10.1001/jamadermatol.2020.2675
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