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  1. Article ; Online: Donor Age, Donor-Recipient Size Mismatch, and Kidney Graft Survival.

    Lepeytre, Fanny / Delmas-Frenette, Catherine / Zhang, Xun / Larivière-Beaudoin, Stéphanie / Sapir-Pichhadze, Ruth / Foster, Bethany J / Cardinal, Héloïse

    Clinical journal of the American Society of Nephrology : CJASN

    2020  Volume 15, Issue 10, Page(s) 1455–1463

    Abstract: Background and objectives: Small donor and/or kidney sizes relative to recipient size are associated with a higher risk of kidney allograft failure. Donor and recipient ages are associated with graft survival and may modulate the relationship between ... ...

    Abstract Background and objectives: Small donor and/or kidney sizes relative to recipient size are associated with a higher risk of kidney allograft failure. Donor and recipient ages are associated with graft survival and may modulate the relationship between size mismatch and the latter. The aim of this study was to determine whether the association between donor-recipient size mismatch and graft survival differs by donor and recipient age.
    Design, setting, participants, & measurement: We performed a retrospective cohort study of first adult deceased donor kidney transplantations performed between 2000 and 2018 recorded in the Scientific Registry of Transplant Recipients. We used multivariable Cox proportional hazards models to assess the association between donor-recipient body surface area ratio and death-censored graft survival, defined as return to dialysis or retransplantation. We considered interactions between donor-recipient body surface area ratio and each of recipient and donor age.
    Results: Among the 136,321 kidney transplant recipients included in this study, 23,614 (17%) experienced death-censored graft loss over a median follow-up of 4.3 years (interquartile range, 1.9-7.8 years). The three-way donor-recipient body surface area ratio by donor age by recipient age interaction was statistically significant (
    Conclusions: The association of donor-recipient size mismatch on long-term graft survival is modulated by recipient and donor age. Size-mismatched kidneys yield excellent graft survival when the donor is young. Donor age was more strongly associated with graft survival than size mismatch.
    MeSH term(s) Adolescent ; Adult ; Age Factors ; Allografts ; Body Surface Area ; Female ; Graft Survival ; Humans ; Kidney Transplantation ; Male ; Middle Aged ; Proportional Hazards Models ; Registries ; Retrospective Studies ; Time Factors ; Tissue Donors ; United States ; Young Adult
    Language English
    Publishing date 2020-08-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.02310220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6584: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Natural Antibodies Are Associated With Rejection and Long-term Renal Allograft Loss in a Multicenter International Cohort.

    See, Sarah B / Yang, Xue / Burger, Carole / Lamarthée, Baptiste / Snanoudj, Renaud / Shihab, Ronzon / Tsapepas, Demetra S / Roy, Poulomi / Larivière-Beaudoin, Stéphanie / Hamelin, Katia / Mendoza Rojas, Aleixandra / van Besouw, Nicole M / Bartosic, Amanda / Daniel, Nikita / Rodica, Vasilescu E / Mohan, Sumit / Cohen, David / Ratner, Lloyd / Baan, Carla C /
    Bromberg, Jonathan S / Cardinal, Héloïse / Anglicheau, Dany / Sun, Yifei / Zorn, Emmanuel

    Transplantation

    2023  Volume 107, Issue 7, Page(s) 1580–1592

    Abstract: Background: Potentially harmful nonhuman leukocyte antigen antibodies have been identified in renal transplantation, including natural immunoglobulin G antibodies (Nabs) reactive to varied antigenic structures, including apoptotic cells.: Methods: In ...

    Abstract Background: Potentially harmful nonhuman leukocyte antigen antibodies have been identified in renal transplantation, including natural immunoglobulin G antibodies (Nabs) reactive to varied antigenic structures, including apoptotic cells.
    Methods: In this retrospective, multicenter study, we assessed Nabs by reactivity to apoptotic cells in sera collected from 980 kidney transplant recipients across 4 centers to determine their association with graft outcomes.
    Results: Elevated pretransplant Nabs were associated with graft loss (hazard ratio [HR] 2.71; 95% confidence interval [CI], 1.15-6.39; P   =  0.0232), the composite endpoint of graft loss or severe graft dysfunction (HR 2.40; 95% CI, 1.13-5.10; P  = 0.0232), and T cell-mediated rejection (odds ratio [OR] 1.77; 95% CI, 1.07-3.02; P  = 0.0310). High pretransplant Nabs together with donor-specific antibodies (DSAs) were associated with increased risk of composite outcomes (HR 6.31; 95% CI, 1.81-22.0; P  = 0.0039). In patients with high pretransplant Nabs, the subsequent development of posttransplant Nabs was associated with both T cell-mediated rejection (OR 3.64; 95% CI, 1.61-8.36; P  = 0.0021) and mixed rejection (OR 3.10; 95% CI, 1.02-9.75; P  = 0.0473). Finally, elevated pre- and posttransplant Nabs combined with DSAs were associated with increased risk of composite outcomes (HR 3.97; 95% CI, 1.51-10.43; P  = 0.0052) and T cell-mediated rejection (OR 7.28; 95% CI, 2.16-25.96; P  = 0.0016).
    Conclusions: The presence of pre- and posttransplant Nabs, together with DSAs, was associated with increased risk of poor graft outcomes and rejection after renal transplantation.
    MeSH term(s) Humans ; Kidney Transplantation/adverse effects ; Retrospective Studies ; Transplantation, Homologous ; Immunoglobulin G ; HLA Antigens ; Allografts ; Graft Rejection ; Graft Survival
    Chemical Substances Immunoglobulin G ; HLA Antigens
    Language English
    Publishing date 2023-06-20
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000004472
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 488: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 509: Show issues

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  3. Article ; Online: Acute Kidney Injury, Microvascular Rarefaction, and Estimated Glomerular Filtration Rate in Kidney Transplant Recipients.

    Doreille, Alice / Azzi, Féryel / Larivière-Beaudoin, Stéphanie / Karakeussian-Rimbaud, Annie / Trudel, Dominique / Hébert, Marie-Josée / Dieudé, Mélanie / Patey, Natacha / Cardinal, Héloïse

    Clinical journal of the American Society of Nephrology : CJASN

    2021  Volume 16, Issue 3, Page(s) 415–426

    Abstract: Background and objectives: Animal studies suggest that microvascular rarefaction is a key factor in the acute kidney disease to CKD transition. Hence, delayed graft function appears as a unique human model of AKI to further explore the role of ... ...

    Abstract Background and objectives: Animal studies suggest that microvascular rarefaction is a key factor in the acute kidney disease to CKD transition. Hence, delayed graft function appears as a unique human model of AKI to further explore the role of microvascular rarefaction in kidney transplant recipients. Here, we assessed whether delayed graft function is associated with peritubular capillary loss and evaluated the association between this loss and long-term kidney graft function.
    Design, setting, participants, & measurements: This observational, retrospective cohort study included 61 participants who experienced delayed graft function and 130 who had immediate graft function. We used linear regression models to evaluate associations between delayed graft function and peritubular capillary density expressed as the percentage of efficient cortical area occupied by peritubular capillaries in pre- and post-transplant graft biopsies. eGFRs 1 and 3 years post-transplant were secondary outcomes.
    Results: Post-transplant biopsies were performed at a median of 113 days (interquartile range, 101-128) after transplantation. Peritubular capillary density went from 15.4% to 11.5% in patients with delayed graft function (median change, -3.7%; interquartile range, -6.6% to -0.8%) and from 19.7% to 15.1% in those with immediate graft function (median change, -4.5%; interquartile range, -8.0% to -0.8%). Although the unadjusted change in peritubular capillary density was similar between patients with and without delayed graft function, delayed graft function was associated with more peritubular capillary loss in the multivariable analysis (adjusted difference in change, -2.9%; 95% confidence interval, -4.0 to -1.8). Pretransplant peritubular capillary density and change in peritubular capillary density were associated with eGFR 1 and 3 years post-transplantation.
    Conclusions: Perioperative AKI is associated with lower density in peritubular capillaries before transplantation and with loss of peritubular capillaries following transplantation. Lower peritubular capillary density is linked to lower long-term eGFR.
    MeSH term(s) Acute Kidney Injury/physiopathology ; Adult ; Cohort Studies ; Female ; Glomerular Filtration Rate ; Humans ; Kidney Transplantation ; Male ; Microvascular Rarefaction/physiopathology ; Middle Aged ; Postoperative Complications/physiopathology ; Retrospective Studies
    Language English
    Publishing date 2021-03-01
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.07270520
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6584: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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