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  1. Article ; Online: NB-02 Protects Neurons and Astrocytes from Oligomeric Amyloid-β-Mediated Damage.

    Miller, Morgan R / Lariviere, Lavender / Pagnier, Guillaume J / Aygar, Sema / Wieckiewicz, Natalia / Maesako, Masato / Bacskai, Brian J / Kastanenka, Ksenia V

    Journal of Alzheimer's disease : JAD

    2024  Volume 99, Issue 2, Page(s) 477–483

    Abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disease with limited therapeutic strategies. NB-02 is a novel botanical drug that has shown promise as a protective and therapeutic treatment for AD in an APP/PS1 preclinical mouse model. In ... ...

    Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disease with limited therapeutic strategies. NB-02 is a novel botanical drug that has shown promise as a protective and therapeutic treatment for AD in an APP/PS1 preclinical mouse model. In this paper, we investigate the underlying mechanisms by which NB-02 provides these therapeutic advantages using in vitro neuron-astrocyte co-cultures. Pretreatment with NB-02 prevented pathological calcium elevations in neurons and astrocytes after application of toxic soluble amyloid-β (Aβ) oligomers. NB-02 also prevented cell death associated with the addition of soluble Aβ oligomers suggesting NB-02 is effective at protecting both neurons and astrocytes from Aβ-mediated damage.
    MeSH term(s) Animals ; Astrocytes/drug effects ; Astrocytes/metabolism ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Peptides/toxicity ; Neurons/drug effects ; Neurons/metabolism ; Neurons/pathology ; Coculture Techniques ; Neuroprotective Agents/pharmacology ; Mice ; Cells, Cultured ; Calcium/metabolism ; Peptide Fragments/toxicity ; Peptide Fragments/pharmacology ; Humans
    Language English
    Publishing date 2024-04-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1440127-7
    ISSN 1875-8908 ; 1387-2877
    ISSN (online) 1875-8908
    ISSN 1387-2877
    DOI 10.3233/JAD-231387
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6084: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Novel Botanical Therapeutic NB-02 Effectively Treats Alzheimer's Neuropathophysiology in an APP/PS1 Mouse Model.

    Lee, Yee Fun / Lariviere, Lavender / Russ, Alyssa N / Choi, Sang-Zin / Bacskai, Brian J / Kastanenka, Ksenia V

    eNeuro

    2021  Volume 8, Issue 3

    Abstract: Alzheimer's disease (AD) is an incurable neurodegenerative disorder and a major cause of dementia. Some of the hallmarks of AD include presence of amyloid plaques in brain parenchyma, calcium dysregulation within individual neurons, and neuroinflammation. ...

    Abstract Alzheimer's disease (AD) is an incurable neurodegenerative disorder and a major cause of dementia. Some of the hallmarks of AD include presence of amyloid plaques in brain parenchyma, calcium dysregulation within individual neurons, and neuroinflammation. A promising therapeutic would reverse or stymie these pathophysiologies in an animal model of AD. We tested the effect of NB-02, previously known as DA-9803, a novel multimodal therapeutic, on amyloid deposition, neuronal calcium regulation and neuroinflammation in 8- to 10-month-old APP/PS1 mice, an animal model of AD.
    MeSH term(s) Alzheimer Disease/drug therapy ; Amyloid beta-Peptides ; Amyloid beta-Protein Precursor/genetics ; Animals ; Disease Models, Animal ; Mice ; Mice, Transgenic ; Plaque, Amyloid/drug therapy
    Chemical Substances Amyloid beta-Peptides ; Amyloid beta-Protein Precursor
    Language English
    Publishing date 2021-05-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2800598-3
    ISSN 2373-2822 ; 2373-2822
    ISSN (online) 2373-2822
    ISSN 2373-2822
    DOI 10.1523/ENEURO.0389-20.2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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