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Article ; Online: Isolation strategy for controlling the spread of multidrug-resistant organisms: Is this still an essential option in hospitals?

Larrosa, María Nieves / Almirante, Benito

Enfermedades infecciosas y microbiologia clinica (English ed.)

2021

Language	Spanish
Publishing date	2021-06-18
Publishing country	Spain
Document type	Editorial
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/j.eimc.2021.04.010
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Article ; Online: Isolation strategy for controlling the spread of multidrug-resistant organisms: Is this still an essential option in hospitals?

Larrosa, María Nieves / Almirante, Benito

Enfermedades infecciosas y microbiologia clinica (English ed.)

2021 Volume 39, Issue 9, Page(s) 425–428

MeSH term(s)	Drug Resistance, Multiple, Bacterial ; Enterococcus ; Hospitals
Language	English
Publishing date	2021-11-04
Publishing country	Spain
Document type	Editorial ; Comment
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/j.eimce.2021.04.007
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Article ; Online: Secular trends in the epidemiology and clinical characteristics of Enterococcus faecalis infective endocarditis at a referral center (2007-2018).

Escolà-Vergé, Laura / Fernández-Hidalgo, Nuria / Larrosa, María Nieves / Fernandez-Galera, Ruben / Almirante, Benito

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

2021 Volume 40, Issue 6, Page(s) 1137–1148

Abstract: The aim of the study was to analyze the epidemiological and clinical changes in EFIE. All definite IE episodes treated at a referral center between 2007 and 2018 were registered prospectively, and a trend test was used to study etiologies over time. EFIE ...

Abstract	The aim of the study was to analyze the epidemiological and clinical changes in EFIE. All definite IE episodes treated at a referral center between 2007 and 2018 were registered prospectively, and a trend test was used to study etiologies over time. EFIE cases were divided into three periods, and clinical differences between them were analyzed. All episodes of E. faecalis monomicrobial bacteremia (EFMB) between 2010 and 2018 and the percentage of echocardiograms performed were retrospectively collected. Six hundred forty-eight IE episodes were studied. We detected an increase in the percentage of EFIE (15% in 2007, 25.3% in 2018, P = 0.038), which became the most prevalent causative agent of IE during the last study period. One hundred and eight EFIE episodes were analyzed (2007-2010, n = 30; 2011-2014, n = 22; 2015-2018, n = 56). The patients in the last period were older (median 70.9 vs 66.5 vs 76.3 years, P = 0.015) and more frequently had an abdominal origin of EFIE (20% vs 13.6% vs 42.9%, P = 0.014), fewer indications for surgery (63.3% vs 54.6% vs 32.1%, P = 0.014), and non-significantly lower in-hospital mortality (30% vs 18.2% vs 12.5%, P = 0.139). There was an increase in the percentage of echocardiograms performed in patients with EFMB (30% in 2010, 51.2% in 2018, P = 0.014) and EFIE diagnoses (15% in 2010, 32.6% in 2018, P = 0.004). E. faecalis is an increasing cause of IE in our center, most likely due to an increase in the percentage of echocardiograms performed. The factors involved in clinical changes in EFIE should be thoroughly studied.
MeSH term(s)	Aged ; Aged, 80 and over ; Bacteremia/epidemiology ; Bacteremia/microbiology ; Bacteremia/mortality ; Endocarditis, Bacterial/epidemiology ; Endocarditis, Bacterial/microbiology ; Endocarditis, Bacterial/mortality ; Enterococcus faecalis/classification ; Enterococcus faecalis/genetics ; Enterococcus faecalis/isolation & purification ; Enterococcus faecalis/physiology ; Female ; Hospitals, University/statistics & numerical data ; Humans ; Male ; Middle Aged ; Prospective Studies ; Referral and Consultation/statistics & numerical data ; Retrospective Studies ; Spain/epidemiology
Language	English
Publishing date	2021-01-06
Publishing country	Germany
Document type	Journal Article ; Observational Study
ZDB-ID	603155-9
ISSN	1435-4373 ; 0934-9723 ; 0722-2211
ISSN (online)	1435-4373
ISSN	0934-9723 ; 0722-2211
DOI	10.1007/s10096-020-04117-x
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Article: Use of Biomarkers to Improve 28-Day Mortality Stratification in Patients with Sepsis and SOFA ≤ 6.

Baldirà, Jaume / Ruiz-Rodríguez, Juan Carlos / Ruiz-Sanmartin, Adolfo / Chiscano, Luis / Cortes, Alejandro / Sistac, Diego Ángeles / Ferrer-Costa, Roser / Comas, Inma / Villena, Yolanda / Larrosa, Maria Nieves / González-López, Juan José / Ferrer, Ricard

Biomedicines

2023 Volume 11, Issue 8

Abstract: Early diagnosis and appropriate treatments are crucial to reducing mortality risk in septic patients. Low SOFA scores and current biomarkers may not adequately discern patients that could develop severe organ dysfunction or have an elevated mortality ... ...

Abstract	Early diagnosis and appropriate treatments are crucial to reducing mortality risk in septic patients. Low SOFA scores and current biomarkers may not adequately discern patients that could develop severe organ dysfunction or have an elevated mortality risk. The aim of this prospective observational study was to evaluate the predictive value of the biomarkers mid-regional pro-adrenomedullin (MR-proADM), procalcitonin (PCT), C-reactive protein (CRP), and lactate for 28-day mortality in patients with sepsis, and patients with a SOFA score ≤6. 284 were included, with a 28-day all-cause mortality of 8.45% (
Language	English
Publishing date	2023-07-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11082149
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Article ; Online: Recommendations of the Spanish Antibiogram Committee (COESANT) for in vitro susceptibility testing of antimicrobial agents by disk diffusion.

Rivera, Alba / Viñado, Belén / Benito, Natividad / Docobo-Pérez, Fernando / Fernández-Cuenca, Felipe / Fernández-Domínguez, Javier / Guinea, Jesús / López-Navas, Antonio / Moreno, Miguel Ángel / Larrosa, María Nieves / Oliver, Antonio / Navarro, Ferran

Enfermedades infecciosas y microbiologia clinica (English ed.)

2023 Volume 41, Issue 9, Page(s) 571–576

Abstract: Disk diffusion is a well standardized method that provides reliable categorical results to guide antimicrobial therapy in numerous types of infections. Based on the guidelines of the European Committee on Antimicrobial Susceptibility Testing (EUCAST), ... ...

Abstract	Disk diffusion is a well standardized method that provides reliable categorical results to guide antimicrobial therapy in numerous types of infections. Based on the guidelines of the European Committee on Antimicrobial Susceptibility Testing (EUCAST), which are widely implemented in Spain, the Spanish Antibiogram Committee (COESANT) has drawn up recommendations for antimicrobial selection by the disk diffusion technique, including selective reporting and its use for the detection of resistance mechanisms. Factors affecting disk diffusion results, along with advantages and shortcomings of the method, are also discussed.
MeSH term(s)	Anti-Infective Agents ; Microbial Sensitivity Tests ; Spain
Chemical Substances	Anti-Infective Agents
Language	English
Publishing date	2023-01-05
Publishing country	Spain
Document type	Journal Article ; Review
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/j.eimce.2022.12.009
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Article ; Online: Empirical use of β-lactam/β-lactamase inhibitor combinations does not increase mortality compared with cloxacillin and cefazolin in methicillin-susceptible Staphylococcus aureus bacteraemia: a propensity-weighted cohort study.

Willekens, Rein / Puig-Asensio, Mireia / Suanzes, Paula / Fernández-Hidalgo, Nuria / Larrosa, Maria N / González-López, Juan J / Rodríguez-Pardo, Dolors / Pigrau, Carles / Almirante, Benito

The Journal of antimicrobial chemotherapy

2022 Volume 77, Issue 8, Page(s) 2288–2295

Abstract: Objectives: To evaluate the effectiveness of empirical therapy with β-lactam/β-lactamase inhibitor combinations (BL/BLICs) for MSSA bacteraemia.: Methods: We conducted a post hoc analysis of all adult patients with MSSA bacteraemia who were ... ...

Abstract	Objectives: To evaluate the effectiveness of empirical therapy with β-lactam/β-lactamase inhibitor combinations (BL/BLICs) for MSSA bacteraemia. Methods: We conducted a post hoc analysis of all adult patients with MSSA bacteraemia who were hospitalized at a Spanish university hospital between 2013 and 2018. We compared 30 day mortality among patients receiving initial therapy with BL/BLICs (de-escalated to cloxacillin or cefazolin within 96 h) versus cloxacillin or cefazolin, using propensity score analysis with the inverse probability of treatment weighting (IPTW) method. Results: We evaluated 373 patients with MSSA bacteraemia. Among them, 198 patients met the eligibility criteria, including 127 patients in the BL/BLICs group and 71 patients in the cloxacillin/cefazolin group. Patients in the BL/BLICs group had a higher Charlson comorbidity index (median, 2 [IQR, 1-4.5] versus 2 [IQR, 0-4]); an increased proportion of high-risk sources (i.e. endocarditis, respiratory sources and bacteraemia of unknown origin [34.6% versus 18.3%]); and an earlier start of antibiotic treatment (median, 0 days [IQR, 0-0] versus 1 day [IQR, 1-2]). Thirty day mortality did not significantly differ between the BL/BLICs and the cloxacillin/cefazolin groups (27 patients [21.3%] versus 13 patients [18.3%]; IPTW-adjusted OR = 0.53 [95% CI, 0.18-1.51]). For secondary outcomes, 7 day mortality and 90 day relapse were not statistically different between study groups (8.7% versus 5.6% [P = 0.62] and 6.2% versus 3.8% [P = 0.81], respectively). Conclusions: BL/BLICs might be an effective empirical treatment for MSSA bacteraemia when de-escalated to cloxacillin or cefazolin within 96 h from the index blood culture.
MeSH term(s)	Adult ; Anti-Bacterial Agents/pharmacology ; Bacteremia/drug therapy ; Cefazolin/therapeutic use ; Cloxacillin/pharmacology ; Cloxacillin/therapeutic use ; Cohort Studies ; Humans ; Lactams/pharmacology ; Methicillin/pharmacology ; Retrospective Studies ; Staphylococcal Infections/drug therapy ; Staphylococcus aureus ; beta-Lactamase Inhibitors/pharmacology ; beta-Lactamase Inhibitors/therapeutic use ; beta-Lactams/pharmacology ; beta-Lactams/therapeutic use
Chemical Substances	Anti-Bacterial Agents ; Lactams ; beta-Lactamase Inhibitors ; beta-Lactams ; Cefazolin (IHS69L0Y4T) ; Cloxacillin (O6X5QGC2VB) ; Methicillin (Q91FH1328A)
Language	English
Publishing date	2022-05-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	191709-2
ISSN	1460-2091 ; 0305-7453
ISSN (online)	1460-2091
ISSN	0305-7453
DOI	10.1093/jac/dkac152
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Zs.A 1197: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 124: Show issues

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Article ; Online: Impact of

Suanzes, Paula / Willekens, Rein / Puig-Asensio, Mireia / Pizzi, María Nazarena / Roque, Albert / Barios, Marta / Simó, Marc / Rodríguez-Pardo, Dolors / Larrosa, María Nieves / Fernández-Hidalgo, Núria / Almirante, Benito

Enfermedades infecciosas y microbiologia clinica (English ed.)

2022 Volume 41, Issue 1, Page(s) 3–10

Abstract: Objectives: To assess the impact of : Methods: Post hoc analysis of a prospective cohort of consecutive adult patients diagnosed with SAB (January 2013-December 2017). Patients who underwent : Results: We included 39 patients (median age: 69 years, ...

Abstract	Objectives: To assess the impact of Methods: Post hoc analysis of a prospective cohort of consecutive adult patients diagnosed with SAB (January 2013-December 2017). Patients who underwent Results: We included 39 patients (median age: 69 years, IQR:60-79). Fifteen (39%) patients did not have an infectious focus identified before Conclusions: 18
MeSH term(s)	Adult ; Humans ; Aged ; Positron Emission Tomography Computed Tomography ; Staphylococcal Infections/diagnostic imaging ; Staphylococcal Infections/drug therapy ; Bacteremia/diagnostic imaging ; Bacteremia/drug therapy ; Fluorodeoxyglucose F18 ; Staphylococcus aureus ; Prospective Studies ; Anti-Bacterial Agents/therapeutic use
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Anti-Bacterial Agents
Language	English
Publishing date	2022-10-29
Publishing country	Spain
Document type	Observational Study ; Journal Article
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/j.eimce.2021.11.011
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Article ; Online: Spanish Antibiogram Committee (COESANT) recommendations for cumulative antibiogram reports.

Larrosa, María Nieves / Canut-Blasco, Andrés / Benito, Natividad / Cantón, Rafael / Cercenado, Emilia / Docobo-Pérez, Fernando / Fernández-Cuenca, Felipe / Fernández-Domínguez, Javier / Guinea, Jesús / López-Navas, Antonio / Moreno, Miguel Ángel / Morosini, Mª Isabel / Navarro, Ferran / Martínez-Martínez, Luis / Oliver, Antonio

Enfermedades infecciosas y microbiologia clinica (English ed.)

2022 Volume 41, Issue 7, Page(s) 430–435

Abstract: The Spanish Antibiogram Committee (Comité Español del Antibiograma, COESANT) presents in this document a series of recommendations intending to unify how cumulative antibiogram reports must be made in Clinical Microbiology Spanish laboratories. This ... ...

Abstract	The Spanish Antibiogram Committee (Comité Español del Antibiograma, COESANT) presents in this document a series of recommendations intending to unify how cumulative antibiogram reports must be made in Clinical Microbiology Spanish laboratories. This article is based on the information included in the Clinical Microbiology Procedure No. 51, «Preparation of cumulative reports on antimicrobial susceptibility» of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), published in 2014. The recommendations also include the modifications in the definition of clinical interpretive categories recently published by the European Committee on Antimicrobial Susceptibility Testing (EUCAST) in 2019. Its final objective is to establish a homogeneous way of preparing these summaries to compare results from different centers or aggregate the information from these in order to carry out an adequate local or even national surveillance regarding the evolution of antimicrobial susceptibility.
Language	English
Publishing date	2022-09-26
Publishing country	Spain
Document type	Journal Article ; Review
ISSN	2529-993X
ISSN (online)	2529-993X
DOI	10.1016/j.eimce.2022.09.002
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Article: COVID-19 pandemic, as experienced in the surgical service of a district hospital in Spain.

Pérez Lara, Francisco Javier / Jimenez Martinez, Maria Belen / Pozo Muñoz, Francisco / Fontalba Navas, Andres / Garcia Cisneros, Rogelio / Garcia Larrosa, Maria Jose / Garcia Delgado, Ignacio / Callejon Gil, Maria Del Mar

World journal of clinical cases

2021 Volume 9, Issue 23, Page(s) 6582–6590

Abstract: The coronavirus disease 2019, which is caused by severe acute respiratory syndrome coronavirus 2, was first identified in December 2019 in Wuhan, China, and has since spread rapidly, evolving into a full-blown pandemic. We would like to report our ... ...

Abstract	The coronavirus disease 2019, which is caused by severe acute respiratory syndrome coronavirus 2, was first identified in December 2019 in Wuhan, China, and has since spread rapidly, evolving into a full-blown pandemic. We would like to report our experience after 1 year of this pandemic in the surgical service of a district hospital in Spain. There have been many changes (including new protocols) that our service and the hospital have undergone, to adapt to the new situation. We believe that this experience can be useful for other professionals who have lived and are living a similar situation.
Language	English
Publishing date	2021-07-14
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v9.i23.6582
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Article ; Online: Mortality in Staphylococcus aureus bacteraemia remains high despite adherence to quality indicators: secondary analysis of a prospective cohort study.

Willekens, Rein / Puig-Asensio, Mireia / Suanzes, Paula / Fernández-Hidalgo, Nuria / Larrosa, Maria N / González-López, Juan J / Rodríguez-Pardo, Dolors / Pigrau, Carles / Almirante, Benito

The Journal of infection

2021 Volume 83, Issue 6, Page(s) 656–663

Abstract: Objectives: To evaluate the association between compliance with previously published quality indicators (QIs) for the management of Staphylococcus aureus bacteraemia (SAB) and 30-day mortality.: Methods: We conducted a post hoc analysis of all adult ... ...

Abstract	Objectives: To evaluate the association between compliance with previously published quality indicators (QIs) for the management of Staphylococcus aureus bacteraemia (SAB) and 30-day mortality. Methods: We conducted a post hoc analysis of all adult patients with SAB who were hospitalized at a Spanish university hospital between 2013 and 2018. We evaluated the compliance with 7 QIs of SAB management (i.e., Infectious Diseases consultation, follow-up blood cultures, early source control, echocardiography, early cloxacillin or cefazolin, vancomycin monitoring, and appropriate treatment duration). The QIs compliance rate was considered good if ≥75% of the QIs recommended in each patient were performed. We studied the impact of different risk factors (including QIs compliance) on 30-day all-cause mortality adjusting by multivariable modeling and propensity-matched analysis. Results: We included 441 patients with SAB. The QIs compliance rate was ≥75% in 361 patients (81.9%). A total of 95 patients (21.5%) died within 30 days after the index blood culture. In the multivariable model, the variables associated with 30-day mortality were: age (OR, 1.1; 95% CI, 1.0-1.1), Charlson comorbidity index (OR, 1.2; 95% CI, 1.1-1.4), persistent bacteraemia >72 h (OR, 6.0; 95% CI, 3.2-11.5), infective endocarditis (OR, 2.8; 95% CI, 1.2-6.7), and SAB of unknown source (OR, 3.3; 95% CI, 1.5-7.1). We did not find an association between a global QIs compliance rate of ≥75% or any individual QI with 30-day mortality. Conclusions: SAB 30-day mortality remains high despite good adherence to previously published QIs for the management of SAB. Future research should focus on additional factors to further improve SAB-related mortality.
MeSH term(s)	Adult ; Anti-Bacterial Agents/therapeutic use ; Bacteremia/drug therapy ; Humans ; Prospective Studies ; Quality Indicators, Health Care ; Staphylococcal Infections/drug therapy ; Staphylococcus aureus
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2021-10-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2021.10.001
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Zs.MG 48: Show issues

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