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  1. Article: The SF3b Complex is an Integral Component of the Spliceosome and Targeted by Natural Product-Based Inhibitors.

    Larsen, Nicholas A

    Sub-cellular biochemistry

    2020  Volume 96, Page(s) 409–432

    Abstract: In this chapter, the essential role of the SF3b multi-protein complex will be discussed in the context of the overall spliceosome. SF3b is critical during spliceosome assembly for recognition of the branch point (BP) adenosine and, by de facto, selection ...

    Abstract In this chapter, the essential role of the SF3b multi-protein complex will be discussed in the context of the overall spliceosome. SF3b is critical during spliceosome assembly for recognition of the branch point (BP) adenosine and, by de facto, selection of the 3' splice site. This complex is highly dynamic, undergoing significant conformational changes upon loading of the branch duplex RNA and in its relative positioning during spliceosomal remodeling from the A, pre-B, B, B
    MeSH term(s) Biological Products/pharmacology ; Hematologic Neoplasms/drug therapy ; Humans ; Multiprotein Complexes/antagonists & inhibitors ; Multiprotein Complexes/genetics ; RNA Precursors/genetics ; RNA Precursors/metabolism ; RNA Splicing ; Spliceosomes/chemistry ; Spliceosomes/drug effects ; Spliceosomes/genetics ; Spliceosomes/metabolism
    Chemical Substances Biological Products ; Multiprotein Complexes ; RNA Precursors
    Language English
    Publishing date 2020-11-02
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 0306-0225 ; 0096-8757
    ISSN 0306-0225 ; 0096-8757
    DOI 10.1007/978-3-030-58971-4_12
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: A Mathematical Framework for Causally Structured Dilations and its Relation to Quantum Self-Testing

    Houghton-Larsen, Nicholas Gauguin

    2021  

    Abstract: The motivation for this thesis was to recast quantum self-testing [MY98,MY04] in operational terms. The result is a category-theoretic framework for discussing the following general question: How do different implementations of the same input-output ... ...

    Abstract The motivation for this thesis was to recast quantum self-testing [MY98,MY04] in operational terms. The result is a category-theoretic framework for discussing the following general question: How do different implementations of the same input-output process compare to each other? In the proposed framework, an input-output process is modelled by a causally structured channel in some fixed theory, and its implementations are modelled by causally structured dilations formalising hidden side-computations. These dilations compare through a pre-order formalising relative strength of side-computations. Chapter 1 reviews a mathematical model for physical theories as semicartesian symmetric monoidal categories. Many concrete examples are discussed, in particular quantum and classical information theory. The key feature is that the model facilitates the notion of dilations. Chapter 2 is devoted to the study of dilations. It introduces a handful of simple yet potent axioms about dilations, one of which (resembling the Purification Postulate [CDP10]) entails a duality theorem encompassing a large number of classic no-go results for quantum theory. Chapter 3 considers metric structure on physical theories, introducing in particular a new metric for quantum channels, the purified diamond distance, which generalises the purified distance [TCR10,Tom12] and relates to the Bures distance [KSW08a]. Chapter 4 presents a category-theoretic formalism for causality in terms of '(constructible) causal channels' and 'contractions'. It simplifies aspects of the formalisms [CDP09,KU17] and relates to traces in monoidal categories [JSV96]. The formalism allows for the definition of 'causal dilations' and the establishment of a non-trivial theory of such dilations. Chapter 5 realises quantum self-testing from the perspective of chapter 4, thus pointing towards the first known operational foundation for self-testing.

    Comment: PhD thesis submitted to the University of Copenhagen (ISBN 978-87-7125-039-8). Advised by prof. Matthias Christandl, submitted 1st of December 2020, defended 11th of February 2021. Keywords: dilations, applied category theory, quantum foundations, causal structure, quantum self-testing. 242 pages, 1 figure. Comments are welcome
    Keywords Quantum Physics ; Computer Science - Logic in Computer Science ; Mathematics - Category Theory
    Subject code 190
    Publishing date 2021-03-03
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Implantable neurostimulators for neurogenic orthostatic hypotension: the wave of the future? and other updates on recent autonomic research.

    Miglis, Mitchell G / Larsen, Nicholas / Muppidi, Srikanth

    Clinical autonomic research : official journal of the Clinical Autonomic Research Society

    2022  Volume 32, Issue 3, Page(s) 159–161

    MeSH term(s) Autonomic Nervous System ; Baroreflex ; Humans ; Hypotension, Orthostatic/diagnosis ; Implantable Neurostimulators
    Language English
    Publishing date 2022-06-03
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 1080007-4
    ISSN 1619-1560 ; 0959-9851
    ISSN (online) 1619-1560
    ISSN 0959-9851
    DOI 10.1007/s10286-022-00871-4
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  4. Article ; Online: Imaging in autonomic failure: a window into real-time physiological mechanisms and other updates on recent autonomic research.

    Miglis, Mitchell G / Larsen, Nicholas / Muppidi, Srikanth

    Clinical autonomic research : official journal of the Clinical Autonomic Research Society

    2022  Volume 32, Issue 6, Page(s) 405–407

    MeSH term(s) Humans ; Pure Autonomic Failure ; Autonomic Nervous System/diagnostic imaging
    Language English
    Publishing date 2022-11-21
    Publishing country Germany
    Document type Editorial
    ZDB-ID 1080007-4
    ISSN 1619-1560 ; 0959-9851
    ISSN (online) 1619-1560
    ISSN 0959-9851
    DOI 10.1007/s10286-022-00910-0
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  5. Article ; Online: Mechanisms of post-prandial symptoms in postural tachycardia syndrome and other updates on recent autonomic research.

    Miglis, Mitchell G / Larsen, Nicholas / Muppidi, Srikanth

    Clinical autonomic research : official journal of the Clinical Autonomic Research Society

    2022  Volume 32, Issue 2, Page(s) 87–89

    MeSH term(s) Autonomic Nervous System ; Heart Rate ; Humans ; Postprandial Period ; Postural Orthostatic Tachycardia Syndrome/diagnosis
    Language English
    Publishing date 2022-03-22
    Publishing country Germany
    Document type Editorial
    ZDB-ID 1080007-4
    ISSN 1619-1560 ; 0959-9851
    ISSN (online) 1619-1560
    ISSN 0959-9851
    DOI 10.1007/s10286-022-00863-4
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  6. Article ; Online: Inappropriate sinus tachycardia in long-COVID and other updates on recent autonomic research.

    Miglis, Mitchell G / Larsen, Nicholas / Muppidi, Srikanth

    Clinical autonomic research : official journal of the Clinical Autonomic Research Society

    2022  Volume 32, Issue 2, Page(s) 91–94

    MeSH term(s) Autonomic Nervous System ; COVID-19/complications ; Humans ; Tachycardia, Sinus/diagnosis
    Language English
    Publishing date 2022-02-07
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 1080007-4
    ISSN 1619-1560 ; 0959-9851
    ISSN (online) 1619-1560
    ISSN 0959-9851
    DOI 10.1007/s10286-022-00854-5
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  7. Article ; Online: Preparing for the long-haul: Autonomic complications of COVID-19.

    Larsen, Nicholas W / Stiles, Lauren E / Miglis, Mitchell G

    Autonomic neuroscience : basic & clinical

    2021  Volume 235, Page(s) 102841

    Abstract: As global numbers of COVID-19 grow, chronic neurological symptoms, including those of autonomic dysfunction, are being reported with increasing frequency. Mounting evidence suggests that many patients experience chronic and sometimes debilitating ... ...

    Abstract As global numbers of COVID-19 grow, chronic neurological symptoms, including those of autonomic dysfunction, are being reported with increasing frequency. Mounting evidence suggests that many patients experience chronic and sometimes debilitating symptoms long after their acute infectious period, leading to the new diagnostic category of post-acute COVID syndrome. Many symptoms of post-acute COVID syndrome appear autonomic in nature, suggesting that autonomic impairment may play a central role in the underlying pathophysiology. In this review, we discuss the autonomic symptoms and manifestations of post-acute COVID syndrome, potential mechanisms involved, and future directions for a better understanding of this novel condition.
    MeSH term(s) Autonomic Nervous System Diseases/physiopathology ; Autonomic Nervous System Diseases/virology ; COVID-19/complications ; COVID-19/physiopathology ; Humans
    Language English
    Publishing date 2021-07-03
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2020105-9
    ISSN 1872-7484 ; 1566-0702
    ISSN (online) 1872-7484
    ISSN 1566-0702
    DOI 10.1016/j.autneu.2021.102841
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  8. Article ; Online: RT-QUiC in multiple system atrophy: the biomarker of the future? and other updates on recent autonomic research.

    Miglis, Mitchell G / Larsen, Nicholas / Muppidi, Srikanth

    Clinical autonomic research : official journal of the Clinical Autonomic Research Society

    2021  Volume 31, Issue 1, Page(s) 47–49

    MeSH term(s) Autonomic Nervous System ; Biomarkers ; Humans ; Lewy Body Disease ; Multiple System Atrophy/diagnosis ; alpha-Synuclein
    Chemical Substances Biomarkers ; alpha-Synuclein
    Language English
    Publishing date 2021-01-29
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 1080007-4
    ISSN 1619-1560 ; 0959-9851
    ISSN (online) 1619-1560
    ISSN 0959-9851
    DOI 10.1007/s10286-021-00767-9
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  9. Article ; Online: Do not sweat it: we test while you rest and other updates on recent autonomic research.

    Miglis, Mitchell G / Larsen, Nicholas / Muppidi, Srikanth

    Clinical autonomic research : official journal of the Clinical Autonomic Research Society

    2021  Volume 31, Issue 3, Page(s) 361–363

    MeSH term(s) Autonomic Nervous System ; Humans ; Sweat ; Sweating
    Language English
    Publishing date 2021-05-12
    Publishing country Germany
    Document type Editorial ; Comment
    ZDB-ID 1080007-4
    ISSN 1619-1560 ; 0959-9851
    ISSN (online) 1619-1560
    ISSN 0959-9851
    DOI 10.1007/s10286-021-00811-8
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  10. Article ; Online: Holiday heart syndrome: do not drink during this holiday! and other updates on recent autonomic research.

    Miglis, Mitchell G / Larsen, Nicholas / Muppidi, Srikanth

    Clinical autonomic research : official journal of the Clinical Autonomic Research Society

    2021  Volume 31, Issue 4, Page(s) 473–475

    MeSH term(s) Autonomic Nervous System ; Ganglia, Autonomic ; Holidays ; Humans
    Language English
    Publishing date 2021-07-09
    Publishing country Germany
    Document type Editorial
    ZDB-ID 1080007-4
    ISSN 1619-1560 ; 0959-9851
    ISSN (online) 1619-1560
    ISSN 0959-9851
    DOI 10.1007/s10286-021-00818-1
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