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  1. Article: Dementia in the elderly: the "silent epidemic" no more.

    Larson, E B

    Transactions of the American Clinical and Climatological Association

    2001  Volume 112, Page(s) 136–46; discussion 146–8

    MeSH term(s) Age Factors ; Aged ; Aged, 80 and over ; Alzheimer Disease/epidemiology ; Alzheimer Disease/prevention & control ; Dementia/epidemiology ; Dementia/prevention & control ; Disease Outbreaks ; Humans ; Risk Factors ; United States/epidemiology
    Language English
    Publishing date 2001
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603823-2
    ISSN 0065-7778
    ISSN 0065-7778
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: General internal medicine at the crossroads of prosperity and despair: caring for patients with chronic diseases in an aging society.

    Larson, E B

    Annals of internal medicine

    2001  Volume 134, Issue 10, Page(s) 997–1000

    Abstract: During the past quarter century, general internal medicine has emerged as a vital discipline. In the realm of patient care, it is the integrating discipline par excellence. Ironically, as general internists face the challenge of integrating advances of ... ...

    Abstract During the past quarter century, general internal medicine has emerged as a vital discipline. In the realm of patient care, it is the integrating discipline par excellence. Ironically, as general internists face the challenge of integrating advances of dizzying speed and complexity, and as their clinical practice becomes increasingly effective, it has become much more difficult for them to earn a living. General internists find themselves at the crossroads of prosperity and despair. Although general medicine research leads the research agenda in many departments of medicine, it is particularly vulnerable. The necessary multidisciplinary "programmatic" infrastructure is expensive, and results often take many years to obtain, particularly in the study of chronic disease. The educational environment in many institutions is particularly difficult for general medicine, both because the current emphasis on technical skills obscures patients' and learners' real needs and because complex patients on general medicine services are now so ill and their turnover so rapid. General internal medicine and geriatrics are synergistic, especially in today's marketplace. A focus on geriatric medicine could help general medicine continue to flourish. General internists are ideally suited to the integrated care of elderly patients with multiple problems, research opportunities are enormous in the geriatric population, and the teaching of geriatrics requires a high level of generalist skills. Problems that plague current generalist practice have unique significance to older patients. Organizations that represent general internists would do well to join forces with many other advocacy groups, especially those representing the interests of elderly patients and geriatric medicine.
    MeSH term(s) Chronic Disease/therapy ; Geriatrics/economics ; Geriatrics/trends ; Humans ; Internal Medicine/economics ; Internal Medicine/education ; Internal Medicine/trends ; Patient Care/economics ; Patient Care/trends ; Research ; United States
    Language English
    Publishing date 2001-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/0003-4819-134-10-200105150-00013
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  3. Article: An 80-year-old man with memory loss.

    Larson, E B

    JAMA

    2000  Volume 283, Issue 8, Page(s) 1046–1053

    MeSH term(s) Aged ; Aged, 80 and over ; Alzheimer Disease/diagnosis ; Alzheimer Disease/epidemiology ; Alzheimer Disease/therapy ; Cost of Illness ; Humans ; Male ; Memory Disorders/diagnosis ; Memory Disorders/etiology ; Risk Factors
    Language English
    Publishing date 2000-02-23
    Publishing country United States
    Document type Case Reports ; Clinical Conference ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0098-7484 ; 0254-9077 ; 0002-9955
    ISSN (online) 1538-3598
    ISSN 0098-7484 ; 0254-9077 ; 0002-9955
    DOI 10.1001/jama.283.8.1046
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  4. Article: Relapsing Fever revisited.

    Fihn, S D / Larson, E B

    The Western journal of medicine

    2008  Volume 134, Issue 3, Page(s) 263–264

    Language English
    Publishing date 2008-08-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 189235-6
    ISSN 1476-2978 ; 0093-0415 ; 0008-1264
    ISSN (online) 1476-2978
    ISSN 0093-0415 ; 0008-1264
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  5. Article: Must dementia remain a silent epidemic?

    Larson, E B

    Hospital practice (1995)

    1999  Volume 34, Issue 11, Page(s) 137–140

    MeSH term(s) Aged ; Aged, 80 and over ; Dementia/diagnosis ; Diagnostic Errors/prevention & control ; Emergency Service, Hospital ; Female ; Geriatric Assessment ; Humans ; Truth Disclosure
    Language English
    Publishing date 1999-10-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2570453-9
    ISSN 2377-1003 ; 2154-8331 ; 8750-2836
    ISSN (online) 2377-1003
    ISSN 2154-8331 ; 8750-2836
    DOI 10.1080/21548331.1999.11443935
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  6. Article: Evidence-based medicine: is translating evidence into practice a solution to the cost-quality challenges facing medicine?

    Larson, E B

    The Joint Commission journal on quality improvement

    1999  Volume 25, Issue 9, Page(s) 480–485

    Abstract: Background: Evidence-based medicine (EBM) and practice guidelines have been embraced by increasing numbers of scholars, administrators, and medical journalists as an intellectually attractive solution to the dilemma of improving health care quality ... ...

    Abstract Background: Evidence-based medicine (EBM) and practice guidelines have been embraced by increasing numbers of scholars, administrators, and medical journalists as an intellectually attractive solution to the dilemma of improving health care quality while reducing costs. However, certain factors have thus far limited the role that EBM might play in resolving cost-quality trade-offs.
    Factors for success of ebm recommendations and guidelines: Beyond the quality of the guideline and the evidence base itself, critical factors for success include local clinician involvement, a unified or closed medical staff, protocols that minimize use of clinical judgment and that call for involvement of so-called physician extenders (such as nurse practitioners and physician assistants), and financial incentive. TROUBLESOME ISSUES RELATED TO COST-QUALITY TRADE-OFFS: Rationing presents many dilemmas, but for physicians one critical problem is determining what is the physician's responsibility. Is the physician to be the patient's advocate, or should the physician be the advocate of all patients (the patients' advocate)? How do we get physicians out of potentially conflicted roles? EBM guidelines are needed to help minimize the number of instances physicians are asked to ration care at the bedside. If the public can decide to share and limit resources--presumably based on shared priorities--physicians would have a basis to act as advocates for all patients.
    Conclusions: Although EBM alone is not a simple solution to the problems of increasing costs and public expectations, it can be an important source of input and information in relating the value of service and medical technology to public priorities.
    MeSH term(s) Clinical Medicine/economics ; Clinical Medicine/standards ; Cost-Benefit Analysis ; Decision Making, Organizational ; Evidence-Based Medicine/economics ; Evidence-Based Medicine/standards ; Health Care Rationing/organization & administration ; Humans ; Marketing of Health Services/organization & administration ; Patient Advocacy ; Physician's Role ; Practice Guidelines as Topic/standards ; Practice Patterns, Physicians'/economics ; Practice Patterns, Physicians'/standards ; Quality of Health Care ; United States
    Language English
    Publishing date 1999-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1189890-2
    ISSN 1938-131X ; 1549-425X ; 1070-3241 ; 1553-7250 ; 1549-3741
    ISSN (online) 1938-131X ; 1549-425X
    ISSN 1070-3241 ; 1553-7250 ; 1549-3741
    DOI 10.1016/s1070-3241(16)30462-x
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  7. Article: New drug treatments for Alzheimer disease.

    Larson, E B

    Archives of internal medicine

    1998  Volume 158, Issue 9, Page(s) 941–942

    MeSH term(s) Alzheimer Disease/drug therapy ; Cholinesterase Inhibitors/therapeutic use ; Donepezil ; Humans ; Indans/therapeutic use ; Multicenter Studies as Topic ; Piperidines/therapeutic use ; Randomized Controlled Trials as Topic ; Treatment Outcome
    Chemical Substances Cholinesterase Inhibitors ; Indans ; Piperidines ; Donepezil (8SSC91326P)
    Language English
    Publishing date 1998-05-11
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 211575-x
    ISSN 1538-3679 ; 0003-9926 ; 0888-2479 ; 0730-188X
    ISSN (online) 1538-3679
    ISSN 0003-9926 ; 0888-2479 ; 0730-188X
    DOI 10.1001/archinte.158.9.941
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  8. Article: Recognition of dementia: discovering the silent epidemic.

    Larson, E B

    Journal of the American Geriatrics Society

    1998  Volume 46, Issue 12, Page(s) 1576–1577

    MeSH term(s) Aged ; Aged, 80 and over ; Cross-Sectional Studies ; Dementia/diagnosis ; Dementia/epidemiology ; Disease Outbreaks ; Female ; Geriatric Assessment ; Humans ; Incidence ; Male ; Patient Care Team ; United States/epidemiology
    Language English
    Publishing date 1998-12
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/j.1532-5415.1998.tb01546.x
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  9. Article: Management of Alzheimer's disease in a primary care setting.

    Larson, E B

    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

    1998  Volume 6, Issue 2 Suppl 1, Page(s) S34–40

    Abstract: This article covers a broad topic from the pragmatic point of view of a primary care physician. The perspective is that of a primary care physician who teaches resident physicians and students in a medical school and for almost 20 years has conducted ... ...

    Abstract This article covers a broad topic from the pragmatic point of view of a primary care physician. The perspective is that of a primary care physician who teaches resident physicians and students in a medical school and for almost 20 years has conducted clinical research in patient care settings, including a large Health Maintenance Organization in Seattle, Washington. This article addresses four general areas that are important for the management of dementia in primary care settings: recognition and diagnosis, treatment in the community (treatment before a person becomes permanently or semipermanently institutionalized), treatment as the disease progresses, and minimization of excess disability.
    MeSH term(s) Aged ; Aged, 80 and over ; Alzheimer Disease/therapy ; Chronic Disease ; Community Health Services/supply & distribution ; Disease Progression ; Humans ; Primary Health Care
    Language English
    Publishing date 1998
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1278145-9
    ISSN 1545-7214 ; 1064-7481
    ISSN (online) 1545-7214
    ISSN 1064-7481
    DOI 10.1097/00019442-199821001-00005
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  10. Article: How can clinicians incorporate research advances into practice?

    Larson, E B

    Journal of general internal medicine

    1997  Volume 12 Suppl 2, Page(s) S20–4

    MeSH term(s) Clinical Competence ; Decision Making ; Education, Medical, Continuing/methods ; Evidence-Based Medicine/methods ; Humans ; Internal Medicine/standards ; Internal Medicine/trends ; Practice Guidelines as Topic ; Practice Patterns, Physicians'/trends ; Research ; United States
    Language English
    Publishing date 1997-04
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1046/j.1525-1497.12.s2.3.x
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