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  1. Article ; Online: The Landscape of Pediatric Radiation Oncology in Nigeria.

    Joseph, Adedayo / Akinsete, Adeseye M / Lasebikan, Nwamaka N / Adeneye, Samuel / Awofeso, Opeyemi M / Oladipo, Aishat T / Ajose, Azeezat O / Ojo, Oluwatimileyin / Merrell, Kenneth / Ngwa, Wilfred / Puthoff, David S / Onitilo, Adedayo A

    JCO global oncology

    2024  Volume 10, Page(s) e2300219

    Abstract: Radiation therapy (RT) is an essential part of the multidisciplinary treatment of pediatric cancer. Over the past five decades, significant advances have been made in the delivery of RT, with better dose delivery to disease targets while minimizing ... ...

    Abstract Radiation therapy (RT) is an essential part of the multidisciplinary treatment of pediatric cancer. Over the past five decades, significant advances have been made in the delivery of RT, with better dose delivery to disease targets while minimizing exposure to nearby organs at risk. These advances have led to improved treatment outcomes, increased survival, and reduced treatment-related toxicities. Advanced treatment techniques, however, require significant investment in infrastructural and personnel resources. This review documents what is currently available regarding expertise and infrastructure for pediatric radiation oncology practice in Nigeria. It was performed to serve as a foundation for the creation and design of tailored solutions (initiatives and policies) to increase pediatric radiation availability, accessibility, and equity in Nigeria and ultimately improve pediatric cancer treatment outcomes in the region.
    MeSH term(s) Humans ; Child ; Radiation Oncology ; Nigeria ; Neoplasms/radiotherapy ; Medical Oncology ; Treatment Outcome
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Review ; Journal Article
    ISSN 2687-8941
    ISSN (online) 2687-8941
    DOI 10.1200/GO.23.00219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comparative effectiveness of implementation strategies for Accelerating Cervical Cancer Elimination through the integration of Screen-and-treat Services (ACCESS study): protocol for a cluster randomized hybrid type III trial in Nigeria.

    Olakunde, Babayemi O / Itanyi, Ijeoma U / Olawepo, John O / Liu, Lin / Bembir, Chinenye / Idemili-Aronu, Ngozi / Lasebikan, Nwamaka N / Onyeka, Tonia C / Dim, Cyril C / Chigbu, Chibuike O / Ezeanolue, Echezona E / Aarons, Gregory A

    Implementation science : IS

    2024  Volume 19, Issue 1, Page(s) 25

    Abstract: Background: Despite the increased risk of cervical cancer (CC) among women living with HIV (WLHIV), CC screening and treatment (CCST) rates remain low in Africa. The integration of CCST services into established HIV programs in Africa can improve CC ... ...

    Abstract Background: Despite the increased risk of cervical cancer (CC) among women living with HIV (WLHIV), CC screening and treatment (CCST) rates remain low in Africa. The integration of CCST services into established HIV programs in Africa can improve CC prevention and control. However, the paucity of evidence on effective implementation strategies (IS) has limited the success of integration in many countries. In this study, we seek to identify effective IS to enhance the integration of CCST services into existing HIV programs in Nigeria.
    Methods: Our proposed study has formative and experimental activities across the four phases of the Exploration, Preparation, Implementation, and Sustainment (EPIS) framework. Through an implementation mapping conducted with stakeholders in the exploration phase, we identified a core package of IS (Core) and an enhanced package of IS (Core+) mostly selected from the Expert Recommendations for Implementing Change. In the preparation phase, we refined and tailored the Core and Core+ IS with the implementation resource teams for local appropriateness. In the implementation phase, we will conduct a cluster-randomized hybrid type III trial to assess the comparative effectiveness of Core versus Core+. HIV comprehensive treatment sites (k = 12) will be matched by region and randomized to Core or Core+ in the ratio of 1:1 stratified by region. In the sustainment phase, we will assess the sustainment of CCST at each site. The study outcomes will be assessed using RE-AIM: reach (screening rate), adoption (uptake of IS by study sites), IS fidelity (degree to which the IS occurred according to protocol), clinical intervention fidelity (delivery of CC screening, onsite treatment, and referral according to protocol), clinical effectiveness (posttreatment screen negative), and sustainment (continued integrated CCST service delivery). Additionally, we will descriptively explore potential mechanisms, including organizational readiness, implementation climate, CCST self-efficacy, and implementation intentions.
    Discussion: The assessment of IS to increase CCST rates is consistent with the global plan of eliminating CC as a public health threat by 2030. Our study will identify a set of evidence-based IS for low-income settings to integrate evidence-based CCST interventions into routine HIV care in order to improve the health and life expectancy of WLHIV.
    Trial registration: Prospectively registered on November 7, 2023, at ClinicalTrials.gov no. NCT06128304. https://classic.
    Clinicaltrials: gov/ct2/show/study/NCT06128304.
    MeSH term(s) Humans ; Female ; Nigeria ; Uterine Cervical Neoplasms/diagnosis ; Uterine Cervical Neoplasms/prevention & control ; Self Efficacy ; HIV Infections/diagnosis ; HIV Infections/prevention & control ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2225822-X
    ISSN 1748-5908 ; 1748-5908
    ISSN (online) 1748-5908
    ISSN 1748-5908
    DOI 10.1186/s13012-024-01349-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Breast Cancer Research to Support Evidence-Based Medicine in Nigeria: A Review of the Literature.

    Fatiregun, Omolara A / Oluokun, Temiloluwa / Lasebikan, Nwamaka N / Nwachukwu, Emmanuella / Ibraheem, Abiola A / Olopade, Olufunmilayo

    JCO global oncology

    2021  Volume 7, Page(s) 384–390

    Abstract: Purpose: Breast cancer is the most common malignancy in women worldwide. In Nigeria, it accounts for 22.7% of all new cancer cases among women. Evidence-based medicine (EBM) entails using the results from healthcare research to enhance the clinical ... ...

    Abstract Purpose: Breast cancer is the most common malignancy in women worldwide. In Nigeria, it accounts for 22.7% of all new cancer cases among women. Evidence-based medicine (EBM) entails using the results from healthcare research to enhance the clinical decision-making process and develop evidence-based treatment guidelines. Level 1 and 2 studies, such as randomized controlled trials, meta-analyses, and systematic reviews of randomized controlled trials, yield more robust types of evidence. This study reviewed the levels of evidence of breast cancer publications in Nigeria.
    Methods: We conducted an electronic literature search of all studies published on breast cancer in Nigeria from January 1961 to August 2019. We reviewed all the articles found under the search term "Breast Cancer in Nigeria" on medical databases.
    Results: Our search identified 2,242 publications. One thousand two hundred fifty duplicates were removed, and 520 were excluded. A total of 472 articles were considered eligible for this review. Most of these articles were case series or reports (30.7%), qualitative studies (15.7%), followed by cross-sectional studies (13.3%), laboratory studies (12.9%), case-control studies (6.1%), case reports (7%), and cohort (5.7%).
    Conclusion: Breast cancer research in Nigeria is yet to produce much evidence of the types considered to best support EBM. The scarcity of data hampers the implementation of EBM in Nigeria. Currently, most treatment guidelines are adapted from those developed in other countries, despite genetic differences among populations and different environmental influencing factors.
    MeSH term(s) Breast Neoplasms/epidemiology ; Breast Neoplasms/therapy ; Cross-Sectional Studies ; Evidence-Based Medicine ; Female ; Health Services Research ; Humans ; Nigeria
    Language English
    Publishing date 2021-03-10
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2687-8941
    ISSN (online) 2687-8941
    DOI 10.1200/GO.20.00541
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Examining Cancer Patients' Perceptions of the Impact of COVID-19 on Teleoncology: Findings From 15 Nigerian Outpatient Cancer Clinics.

    Joseph, Adedayo / Shour, Abdul R / Lasebikan, Nwamaka N / Jimoh, Mutiu A / Adegboyega, Bolanle C / Nwachukwu, Emmanuella / Awofeso, Opeyemi / Ajose, Azeezat / Ibraheem, Abiola / Fatiregun, Omolara Aminat / Ali-Gombe, Musa / Aliyu, Usman M / Kotkat, Abdallah Elsaid / Biyi-Olutunde, Olusegun Abayomi / Oboh, Evaristus Oseiwe / Zubairu, Ismail H / Haider, Mohammad Rifat / Olatosi, Bankole / Puthoff, David /
    Onitilo, Adedayo A

    JCO global oncology

    2023  Volume 9, Page(s) e2200221

    Abstract: Purpose: To examine cancer patients' perspectives on the impact of COVID-19 on teleoncology in Nigeria.: Methods: Data from a multicenter survey conducted at 15 outpatient clinics to 1,097 patients with cancer from April and July 2020 were analyzed. ... ...

    Abstract Purpose: To examine cancer patients' perspectives on the impact of COVID-19 on teleoncology in Nigeria.
    Methods: Data from a multicenter survey conducted at 15 outpatient clinics to 1,097 patients with cancer from April and July 2020 were analyzed. The study outcome was telemedicine, defined as patients who reported their routine follow-up visits were converted to virtual visits because of COVID-19 (coded yes/no). Covariates included patient age, ethnicity, marital status, income, cancer treatment, service disruption, and cancer diagnosis/type. Stata/SE.v.17 (StataCorp, College Station, TX) was used to perform chi-square and logistic regression analyses.
    Results: The majority of the 1,097 patients with cancer were female (65.7%) and age 55 years and older (35.0%). Because of COVID-19, 12.6% of patients' routine follow-ups were converted to virtual visits. More patients who canceled/postponed surgery (17.7%
    Conclusion: COVID-19 caused many patients with cancer in Nigeria to convert visits to a virtual format. These conversions were more common in patients whose surgery, radiotherapy, chemotherapy, and injection chemotherapy treatments were canceled or postponed. Our findings suggest how COVID-19 affects cancer treatment services and the importance of collecting teleoncological care data in Nigeria.
    MeSH term(s) Humans ; Female ; Male ; Middle Aged ; Outpatients ; COVID-19 ; Neoplasms/therapy ; Ambulatory Care Facilities ; Ethnicity
    Language English
    Publishing date 2023-03-13
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ISSN 2687-8941
    ISSN (online) 2687-8941
    DOI 10.1200/GO.22.00221
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Patient's Perspective on the Impact of COVID-19 on Cancer Treatment in Nigeria.

    Joseph, Adedayo / Olatosi, Bankole / Haider, Mohammad Rifat / Adegboyega, Bolanle C / Lasebikan, Nwamaka N / Aliyu, Usman M / Ali-Gombe, Musa / Jimoh, Mutiu A / Biyi-Olutunde, Olusegun Abayomi / Awofeso, Opeyemi / Fatiregun, Omolara Aminat / Oboh, Evaristus Oseiwe / Nwachukwu, Emmanuella / Zubairu, Ismail H / Otene, Samuel A / Iyare, Oluwatoyin I / Andero, Temitope / Musbau, Alabi Babatunde / Ajose, Azeezat /
    Onitilo, Adedayo A

    JCO global oncology

    2022  Volume 8, Page(s) e2100244

    Abstract: Purpose: Because of the global COVID-19 pandemic, health care organizations introduced guidelines for modifications to health and cancer medical care delivery to mitigate transmission and ensure quality health outcomes. To examine the extent and impact ... ...

    Abstract Purpose: Because of the global COVID-19 pandemic, health care organizations introduced guidelines for modifications to health and cancer medical care delivery to mitigate transmission and ensure quality health outcomes. To examine the extent and impact of these modifications on oncology service disruptions in Nigeria, we surveyed oncology patients across selected public and private cancer treatment centers.
    Materials and methods: Participating in the study were 15 tertiary cancer treatment centers across 12 Nigerian states. We recruited adult patients with cancer (18+ years) on active treatment to complete a self-administered survey on cancer care during COVID-19. We conducted descriptive and multivariate data analysis using Stata 16.1.
    Results: Respondents were (n = 1,072), female (65.7%), ages 18-49 years (50.3%), and married (80.7%). The top two cancers were breast and prostate. Overall, 17.3% of respondents reported disruptions to cancer care, and more than half (51.0%) reported difficulties accessing care. Changes in chemotherapy regimens or route of administration were reported in 8.4% of respondents. Odds for any disruption were highest for older patients, western states, patients with prostate cancer, and patients with two or more flu symptoms. Odds for radiotherapy cancellation were highest for older patients, those with prostate cancer, and those with medium service perception.
    Conclusion: This study investigated COVID-19-influenced cancer treatment disruptions in Nigeria. Patients with cancer experienced significant disruptions to cancer care. Vulnerable patients are most likely to be negatively affected. Policies and strategies aimed at minimizing service disruptions while maintaining cancer patients' safety should be a priority for all health care institutions in the COVID-19 era.
    MeSH term(s) Adolescent ; Adult ; COVID-19 ; Female ; Humans ; Male ; Medical Oncology ; Middle Aged ; Neoplasms/epidemiology ; Neoplasms/therapy ; Nigeria/epidemiology ; Pandemics ; SARS-CoV-2 ; Young Adult
    Language English
    Publishing date 2022-02-13
    Publishing country United States
    Document type Journal Article
    ISSN 2687-8941
    ISSN (online) 2687-8941
    DOI 10.1200/GO.21.00244
    Database MEDical Literature Analysis and Retrieval System OnLINE

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