LIVIVO - Search results -

Search results

Result 1 - 10 of total 68

Search options

Article ; Online: Endocan in Acute Leukemia: Current Knowledge and Future Perspectives.

Reikvam, Håkon / Hatfield, Kimberley Joanne / Wendelbo, Øystein / Lindås, Roald / Lassalle, Philippe / Bruserud, Øystein

Biomolecules

2022 Volume 12, Issue 4

Abstract: Endocan is a soluble dermatan sulfate proteoglycan expressed by endothelial cells and detected in serum/plasma. Its expression is increased in tumors/tumor vessels in several human malignancies, and high expression (high serum/plasma levels or tumor ... ...

Abstract	Endocan is a soluble dermatan sulfate proteoglycan expressed by endothelial cells and detected in serum/plasma. Its expression is increased in tumors/tumor vessels in several human malignancies, and high expression (high serum/plasma levels or tumor levels) has an adverse prognostic impact in several malignancies. The p14 endocan degradation product can also be detected in serum/plasma, but previous clinical studies as well as previously unpublished results presented in this review suggest that endocan and p14 endocan fragment levels reflect different biological characteristics, and the endocan levels seem to reflect the disease heterogeneity in acute leukemia better than the p14 fragment levels. Furthermore, decreased systemic endocan levels in previously immunocompetent sepsis patients are associated with later severe respiratory complications, but it is not known whether this is true also for immunocompromised acute leukemia patients. Finally, endocan is associated with increased early nonrelapse mortality in (acute leukemia) patients receiving allogeneic stem cell transplantation, and this adverse prognostic impact seems to be independent of the adverse impact of excessive fluid overload. Systemic endocan levels may also become important to predict cytokine release syndrome after immunotherapy/haploidentical transplantation, and in the long-term follow-up of acute leukemia survivors with regard to cardiovascular risk. Therapeutic targeting of endocan is now possible, and the possible role of endocan in acute leukemia should be further investigated to clarify whether the therapeutic strategy should also be considered.
MeSH term(s)	Acute Disease ; Endothelial Cells/metabolism ; Humans ; Leukemia, Myeloid, Acute ; Neoplasm Proteins/metabolism ; Proteoglycans/metabolism ; Sepsis
Chemical Substances	Neoplasm Proteins ; Proteoglycans
Language	English
Publishing date	2022-03-24
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom12040492
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: A high blood endocan profile during COVID-19 distinguishes moderate from severe acute respiratory distress syndrome.

Pascreau, Tiffany / Tcherakian, Colas / Zuber, Benjamin / Farfour, Eric / Vasse, Marc / Lassalle, Philippe

Critical care (London, England)

2021 Volume 25, Issue 1, Page(s) 166

MeSH term(s)	Aged ; Biomarkers/blood ; COVID-19/blood ; COVID-19/diagnosis ; Diagnosis, Differential ; Female ; Hospitalization/trends ; Humans ; Male ; Middle Aged ; Neoplasm Proteins/blood ; Proteoglycans/blood ; Respiratory Distress Syndrome/blood ; Respiratory Distress Syndrome/diagnosis ; Retrospective Studies ; Severity of Illness Index
Chemical Substances	Biomarkers ; ESM1 protein, human ; Neoplasm Proteins ; Proteoglycans
Language	English
Publishing date	2021-05-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2041406-7
ISSN	1466-609X ; 1364-8535
ISSN (online)	1466-609X
ISSN	1364-8535
DOI	10.1186/s13054-021-03589-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 5517: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Evaluation of Endocan as a Treatment for Acute Inflammatory Respiratory Failure.

Hureau, Maxence / Portier, Lucie / Prin, Méline / de Nadai, Patricia / Balsamelli, Joanne / Tsicopoulos, Anne / Mathieu, Daniel / Lassalle, Philippe / Grigoriu, Bogdan / Gaudet, Alexandre / De Freitas Caires, Nathalie

Cells

2023 Volume 12, Issue 2

Abstract: Background: Acute respiratory distress syndrome (ARDS) is a life-threatening condition resulting from acute pulmonary inflammation. However, no specific treatment for ARDS has yet been developed. Previous findings suggest that lung injuries related to ... ...

Abstract	Background: Acute respiratory distress syndrome (ARDS) is a life-threatening condition resulting from acute pulmonary inflammation. However, no specific treatment for ARDS has yet been developed. Previous findings suggest that lung injuries related to ARDS could be regulated by endocan (Esm-1). The aim of this study was to evaluate the potential efficiency of endocan in the treatment of ARDS. Methods: We first compared the features of acute pulmonary inflammation and the severity of hypoxemia in a tracheal LPS-induced acute lung injury (ALI) model performed in knockout ( Results: In our ALI model, we report higher alveolar leukocytes ( Conclusions: Endocan appears to be an effective treatment in an ARDS-like model in C57Bl/6 mice.
MeSH term(s)	Animals ; Mice ; Lipopolysaccharides/adverse effects ; Respiratory Distress Syndrome/pathology ; Acute Lung Injury/pathology ; Pneumonia ; Respiratory Insufficiency
Chemical Substances	Lipopolysaccharides
Language	English
Publishing date	2023-01-07
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12020257
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Impact of early postoperative blood glucose variability on serum endocan level in cardiac surgery patients: a sub study of the ENDOLUNG observational study.

Chazal, Etienne / Morin, Lucas / Chocron, Sidney / Lassalle, Philippe / Pili-Floury, Sebastien / Salomon du Mont, Lucie / Ferreira, David / Samain, Emmanuel / Perrotti, Andrea / Besch, Guillaume

Cardiovascular diabetology

2023 Volume 22, Issue 1, Page(s) 221

Abstract: Background: Early postoperative glycemic variability is associated with worse outcome after cardiac surgery, but the underlying mechanisms remain unknown. This study aimed to describe the relationship between postoperative glycemic variability and ... ...

Abstract	Background: Early postoperative glycemic variability is associated with worse outcome after cardiac surgery, but the underlying mechanisms remain unknown. This study aimed to describe the relationship between postoperative glycemic variability and endothelial function, as assessed by serum endocan level in cardiac surgery patients. Methods: We performed a post hoc analysis of patients included in the single-center observational ENDOLUNG study. Adult patients who underwent planned isolated coronary artery bypass graft surgery were eligible. Postoperative glycemic variability was assessed by calculating the coefficient of variability (CV) of blood glucose measured within 24 (CV Results: Data from 177 patients were analyzed. Median CV Conclusions: Early postoperative glycemic variability within 48 h after planned cardiac surgery does not appear to be correlated with postoperative serum endocan level. Clinical trial registration number: NCT02542423.
MeSH term(s)	Adult ; Humans ; Blood Glucose ; Cardiac Surgical Procedures ; Coronary Artery Bypass/adverse effects
Chemical Substances	Blood Glucose
Language	English
Publishing date	2023-08-24
Publishing country	England
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2093769-6
ISSN	1475-2840 ; 1475-2840
ISSN (online)	1475-2840
ISSN	1475-2840
DOI	10.1186/s12933-023-01959-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Highlight on mouse endocan.

De Freitas Caires, Nathalie / Lassalle, Philippe

Circulation research

2015 Volume 116, Issue 8, Page(s) e69–70

MeSH term(s)	Animals ; Cell Membrane/physiology ; Cell Membrane Permeability/physiology ; Endothelial Cells/physiology ; Male ; Proteoglycans/physiology ; Vascular Endothelial Growth Factor A/physiology
Chemical Substances	Proteoglycans ; Vascular Endothelial Growth Factor A
Language	English
Publishing date	2015-04-10
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	80100-8
ISSN	1524-4571 ; 0009-7330 ; 0931-6876
ISSN (online)	1524-4571
ISSN	0009-7330 ; 0931-6876
DOI	10.1161/CIRCRESAHA.115.306353
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui IV Zs.70: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Ui IV Zs.60: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Cleaved endocan acts as a biologic competitor of endocan in the control of ICAM-1-dependent leukocyte diapedesis.

Gaudet, Alexandre / Portier, Lucie / Mathieu, Daniel / Hureau, Maxence / Tsicopoulos, Anne / Lassalle, Philippe / De Freitas Caires, Nathalie

Journal of leukocyte biology

2020 Volume 107, Issue 5, Page(s) 833–841

Abstract: Dysregulated leukocyte diapedesis is a major contributor to acute severe inflammatory states like sepsis and acute respiratory distress syndrome, which are common conditions in critically ill subjects. Endocan is a circulating proteoglycan that binds to ... ...

Abstract	Dysregulated leukocyte diapedesis is a major contributor to acute severe inflammatory states like sepsis and acute respiratory distress syndrome, which are common conditions in critically ill subjects. Endocan is a circulating proteoglycan that binds to the leukocyte integrin LFA-1 and blocks its interaction with its endothelial ligand ICAM-1, subsequently leading to the inhibition of leukocyte recruitment. Recent data have highlighted the hypothetic role of p14, endocan's major catabolite found in the bloodstream of septic patients, as a potential antagonist of endocan, thus participating in the regulation of acute inflammation. We hereby characterize the role of p14 as a biologic competitor of endocan, through assessment of its molecular interactions with LFA-1, endocan, and ICAM-1, as well as its effects on human leukocyte trafficking. Using immunodetection assay, we report that p14 can bind to LFA-1, thus inhibiting the interaction between LFA-1 and endocan, which in turn leads to the restoration of the ICAM-1/LFA-1 interaction. In primary human T cells trafficking assays, we underline the absence of effect of p14 on ICAM-1-dependent adhesion and migration, as well as on transendothelial migration. However, in those models, p14 reverses the antimigratory effect of endocan. To conclude, our study supports the hypothesis of an antagonistic role of p14 versus endocan in its effect on the LFA-1/ICAM-1-dependent human leukocyte recruitment.
MeSH term(s)	Cell Adhesion/physiology ; Chemotaxis, Leukocyte/physiology ; Humans ; Intercellular Adhesion Molecule-1/metabolism ; Lymphocyte Function-Associated Antigen-1/metabolism ; Neoplasm Proteins/metabolism ; Proteoglycans/metabolism ; T-Lymphocytes/metabolism ; Transendothelial and Transepithelial Migration/physiology
Chemical Substances	ESM1 protein, human ; ICAM1 protein, human ; Lymphocyte Function-Associated Antigen-1 ; Neoplasm Proteins ; Proteoglycans ; Intercellular Adhesion Molecule-1 (126547-89-5)
Language	English
Publishing date	2020-04-09
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605722-6
ISSN	1938-3673 ; 0741-5400
ISSN (online)	1938-3673
ISSN	0741-5400
DOI	10.1002/JLB.3AB0320-612RR
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 603: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Endocan, sepsis, pneumonia, and acute respiratory distress syndrome.

De Freitas Caires, Nathalie / Gaudet, Alexandre / Portier, Lucie / Tsicopoulos, Anne / Mathieu, Daniel / Lassalle, Philippe

Critical care (London, England)

2018 Volume 22, Issue 1, Page(s) 280

Abstract: Acute respiratory distress syndrome (ARDS) and hospital-acquired pneumonia (HAP) are major problems of public health in intensive care units (ICUs), occurring in 15% of critically ill patients. Among the factors explaining ARDS development, sepsis is ... ...

Abstract	Acute respiratory distress syndrome (ARDS) and hospital-acquired pneumonia (HAP) are major problems of public health in intensive care units (ICUs), occurring in 15% of critically ill patients. Among the factors explaining ARDS development, sepsis is known as a frequent cause. Sepsis, ARDS, and HAP increase morbidity, mortality, length of stay in the ICU, and the overall costs of healthcare. The major challenge remains to identify accurately among critically ill patients those at risk of poor outcomes who could benefit from novel therapies. Endocan is released by the pulmonary endothelium in response to local or systemic injury. It inhibits mainly leukocyte diapedesis rather than leukocyte rolling or adhesion to the endothelial cells both in vitro and in vivo. Endocan was evaluated in 25 clinical reports, including 2454 critically ill patients and 452 healthy controls. The diagnostic value of endocan for sepsis or sepsis severity was equal to procalcitonin but its prognostic value was better. A predictive value for postoperative pneumonia was evidenced in two studies, and a predictive value for ARDS in four studies from three independent centers. This review presents an overview of the structure, expression, and functions of endocan. We also hereby summarize the potential applications of endocan in the prediction and prognosis of ARDS and HAP, as well as in the prognosis of sepsis.
MeSH term(s)	Critical Illness ; Female ; Healthcare-Associated Pneumonia/physiopathology ; Humans ; Intensive Care Units/organization & administration ; Male ; Middle Aged ; Neoplasm Proteins/biosynthesis ; Neoplasm Proteins/pharmacokinetics ; Proteoglycans/biosynthesis ; Proteoglycans/pharmacokinetics ; Respiratory Distress Syndrome, Adult/physiopathology ; Risk Factors ; Sepsis/physiopathology
Chemical Substances	ESM1 protein, human ; Neoplasm Proteins ; Proteoglycans
Language	English
Publishing date	2018-10-26
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2051256-9
ISSN	1466-609X ; 1364-8535
ISSN (online)	1466-609X
ISSN	1364-8535
DOI	10.1186/s13054-018-2222-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: The complex kinetics of blood endocan during the time course of sepsis and acute respiratory distress syndrome.

Gaudet, Alexandre / Parmentier, Erika / Dubucquoi, Sylvain / Poissy, Julien / Duburcq, Thibault / Portier, Lucie / Lassalle, Philippe / De Freitas Caires, Nathalie / Mathieu, Daniel

Critical care (London, England)

2019 Volume 23, Issue 1, Page(s) 86

MeSH term(s)	Biomarkers/analysis ; Biomarkers/blood ; Humans ; Kinetics ; Neoplasm Proteins/analysis ; Neoplasm Proteins/blood ; Proteoglycans/analysis ; Proteoglycans/blood ; Respiratory Distress Syndrome, Adult/blood ; Respiratory Distress Syndrome, Adult/physiopathology ; Sepsis/blood ; Sepsis/physiopathology ; Time Factors
Chemical Substances	Biomarkers ; ESM1 protein, human ; Neoplasm Proteins ; Proteoglycans
Language	English
Publishing date	2019-03-12
Publishing country	England
Document type	Letter
ZDB-ID	2051256-9
ISSN	1466-609X ; 1364-8535
ISSN (online)	1466-609X
ISSN	1364-8535
DOI	10.1186/s13054-019-2383-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Endocan regulates acute lung inflammation through control of leukocyte diapedesis.

Gaudet, Alexandre / Portier, Lucie / Prin, Méline / Copin, Marie-Christine / Tsicopoulos, Anne / Mathieu, Daniel / Lassalle, Philippe / De Freitas Caires, Nathalie

Journal of applied physiology (Bethesda, Md. : 1985)

2019 Volume 127, Issue 3, Page(s) 668–678

Abstract: Acute respiratory distress syndrome is a severe form of respiratory failure, occurring in up to 20% of patients admitted to the intensive care unit with sepsis. Dysregulated leukocyte diapedesis is a major contributor to acute respiratory distress ... ...

Abstract	Acute respiratory distress syndrome is a severe form of respiratory failure, occurring in up to 20% of patients admitted to the intensive care unit with sepsis. Dysregulated leukocyte diapedesis is a major contributor to acute respiratory distress syndrome. Endocan is a circulating proteoglycan that binds to the leukocyte integrin leukocyte functional antigen-1 and blocks its interaction with its endothelial ligand, ICAM-1. The objective of this study was to evaluate the role of endocan in the control of acute lung inflammation. In vitro, endocan inhibited human leukocyte transendothelial migration as well as ICAM-1-dependent migration but had a very mild effect on ICAM-1-dependent adhesion. Endocan also acted as an inhibitor of transendothelial migration of mouse leukocytes. The effect of systemic administration of recombinant human endocan was assessed in a model of acute lung inflammation in BALB/c mice. Treatment with endocan 1 h after intratracheal LPS challenge reduced the alveolar inflammatory response, diminished histological features of acute lung injury, and improved respiratory function. These results highlight the anti-inflammatory role of human endocan and its protective effect against acute lung injury.
MeSH term(s)	Acute Lung Injury/drug therapy ; Animals ; Capillary Permeability/drug effects ; Cell Adhesion/drug effects ; Cell Movement/drug effects ; Drug Evaluation, Preclinical ; HEK293 Cells ; Humans ; Intercellular Adhesion Molecule-1/metabolism ; Leukocytes/drug effects ; Lipopolysaccharides ; Male ; Mice, Inbred BALB C ; Neoplasm Proteins/isolation & purification ; Neoplasm Proteins/pharmacology ; Neoplasm Proteins/therapeutic use ; Proteoglycans/isolation & purification ; Proteoglycans/pharmacology ; Proteoglycans/therapeutic use ; Respiratory Rate/drug effects ; Transendothelial and Transepithelial Migration/drug effects
Chemical Substances	ESM1 protein, human ; Lipopolysaccharides ; Neoplasm Proteins ; Proteoglycans ; Intercellular Adhesion Molecule-1 (126547-89-5)
Language	English
Publishing date	2019-07-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	219139-8
ISSN	1522-1601 ; 0021-8987 ; 0161-7567 ; 8750-7587
ISSN (online)	1522-1601
ISSN	0021-8987 ; 0161-7567 ; 8750-7587
DOI	10.1152/japplphysiol.00337.2019
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.249: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Endocan is a reliable biomarker during continuous renal replacement therapy.

Hureau, Maxence / Gaudet, Alexandre / De Freitas Caires, Nathalie / Parmentier, Erika / Poissy, Julien / Duburcq, Thibault / Lassalle, Philippe / Mathieu, Daniel

Critical care (London, England)

2019 Volume 23, Issue 1, Page(s) 296

MeSH term(s)	Biomarkers ; Humans ; Pneumonia ; Renal Replacement Therapy ; Respiratory Distress Syndrome, Adult ; Sepsis
Chemical Substances	Biomarkers
Language	English
Publishing date	2019-09-03
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2051256-9
ISSN	1466-609X ; 1364-8535
ISSN (online)	1466-609X
ISSN	1364-8535
DOI	10.1186/s13054-019-2585-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito