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Article: Population et pathologies dépistées au Centre de dépistage départemental de la Seine-Saint-Denis.

Sulli, Laura / Mangin, Floréale / Lassau, François / Nicoulet, Isabelle / Marmier, Mathilde

Sante publique (Vandoeuvre-les-Nancy, France)

2019 Volume 30, Issue 5, Page(s) 697–702

Abstract: Context: Since 2016, the Seine-Saint-Denis County (France), have been provided with the state's label CeGIDD as a screening center, which is structured around a new main site in Bobigny and four sub-centers.: Methods: Data collection for public ... ...

Title translation	People and Diseases Screnned in 2016 by the Sexual Infection Screening Centre, Seine-Saint-Denis country (France).
Abstract	Context: Since 2016, the Seine-Saint-Denis County (France), have been provided with the state's label CeGIDD as a screening center, which is structured around a new main site in Bobigny and four sub-centers. Methods: Data collection for public health and activity studies was implanted at the main site in 2016. This study presents a description of the patients and diseases screened during the first year of activity. Results: There were 59.6% male, the median age was 26 years old and almost 30% were born abroad. The large majority of the active file was formed by a priority public (70.6%) including LGBT (8.3%) (lesbians, gays, bisexuals and transgenders), drugs users (6.3%), prostitute (2.4%) and former prisoners (2.3%). Conclusion: The CeGIDD is a new structure with a high potential. This study's results shows higher positive rates than national's or county's rates. After a first year the centre's activity should develop and target more and more people, including people who were not screened before, thanks to the data collection widespread in the sub-centers since 2017 and the development of outside actions, which will provide additional knowledge on the patients.
MeSH term(s)	Adult ; Ambulatory Care Facilities ; Drug Users/statistics & numerical data ; Female ; France ; Humans ; Male ; Mass Screening/statistics & numerical data ; Prisoners/statistics & numerical data ; Sex Workers/statistics & numerical data ; Sexual and Gender Minorities/statistics & numerical data ; Sexually Transmitted Diseases/diagnosis
Language	French
Publishing date	2019-02-15
Publishing country	France
Document type	Journal Article
ZDB-ID	1465524-x
ISSN	2104-3841 ; 0995-3914
ISSN (online)	2104-3841
ISSN	0995-3914
DOI	10.3917/spub.186.0697
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Zs.A 4994: Show issues

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Article ; Online: First case of chancroid in 14 years at the largest STI clinic in Paris, France.

Fouéré, Sébastien / Lassau, François / Rousseau, Clotilde / Bagot, Martine / Janier, Michel

International journal of STD & AIDS

2016 Volume 27, Issue 9, Page(s) 805–807

Abstract: We report the first case of chancroid seen at our clinic in 14 years. It was diagnosed by nuclear acid amplification test in a male patient returning from Madagascar. Although the disease is considered on the verge of disappearance even in tropical ... ...

Abstract	We report the first case of chancroid seen at our clinic in 14 years. It was diagnosed by nuclear acid amplification test in a male patient returning from Madagascar. Although the disease is considered on the verge of disappearance even in tropical countries, its real potential for reemergence - due to new strains of Haemophilus ducreyi, underreporting and a lack of widespread use of molecular testing - could be underestimated.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Chancroid/diagnosis ; Chancroid/drug therapy ; Chancroid/microbiology ; France ; Haemophilus ducreyi/genetics ; Haemophilus ducreyi/isolation & purification ; Humans ; Madagascar ; Male ; Middle Aged ; Polymerase Chain Reaction/methods ; Treatment Outcome ; Ulcer/diagnosis ; Ulcer/etiology
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2016-08
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1018089-8
ISSN	1758-1052 ; 0956-4624
ISSN (online)	1758-1052
ISSN	0956-4624
DOI	10.1177/0956462415598252
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Zs.A 2829: Show issues

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Article ; Online: Trends and determinants of condomless sex in gonorrhoea patients diagnosed in France through the sentinel surveillance network ResIST, 2005-2014.

Itodo, Oche Adam / Viriot, Delphine / Velter, Annie / Leon, Lucie / Dupin, Nicolas / Bercot, Beatrice / Goubard, Agathe / Lassau, François / Fouere, Sébastien / Martinet, Pervenche / Tosini, William / Florence, Sophie / Lot, Florence / Ndeikoundam Ngangro, Ndeindo

BMC public health

2020 Volume 20, Issue 1, Page(s) 1620

Abstract: Background: Gonorrhoea is increasing in France since its resurgence in the late 1990's. Understanding trends of condomless sex is a requirement to tailor prevention toward most exposed individuals. This study aims to analyse trends and determinants of ... ...

Abstract	Background: Gonorrhoea is increasing in France since its resurgence in the late 1990's. Understanding trends of condomless sex is a requirement to tailor prevention toward most exposed individuals. This study aims to analyse trends and determinants of condomless penetrative sex (PS) in MSM and heterosexuals diagnosed with gonorrhoea in France. Methods: A standardized self-administered questionnaire filled by 3453 patients was used to monitor condomless sex through the sentinel surveillance network ResIST between 2005 and 2014. Trends were used to describe consistent condom use for penetrative sex (PS). A logistic regression model analysed patients' characteristics associated with condomless PS. Results: Between 2005 and 2014, condomless PS increased regardless of sexual orientation. Condomless PS was particularly common among HIV positive men who have sex with men (MSM (65%)). People living in metropolitan regions outside Paris area (adjusted odds-ratio (AOR) [95% CI] =1.33[1.12-1.58]) were more likely to engage in condomless PS. Conversely, MSM (AOR [95% CI] =0.21 [0.16-0.29]), HIV seronegative patients (AOR [95% CI] =0.68 [0.51-0.89]), patients diagnosed in hospital (AOR [95% CI] = 0.66 [0.45-0.97]) and multi-partners (≥ 10 partners, AOR [95% CI] = 0.54 [0.40-0.74]) were more likely to use condoms. Conclusions: These findings highlight a decreasing use of condom in MSM and heterosexuals diagnosed with gonorrhoea. Prevention strategies should take in account drivers of condomless sex in a context of uncontrolled STI epidemics.
MeSH term(s)	Condoms ; Female ; France/epidemiology ; Gonorrhea/diagnosis ; Gonorrhea/epidemiology ; HIV Infections ; Homosexuality, Male ; Humans ; Male ; Paris/epidemiology ; Sentinel Surveillance ; Sexual Behavior ; Sexual Partners ; Sexual and Gender Minorities ; Unsafe Sex
Language	English
Publishing date	2020-10-28
Publishing country	England
Document type	Journal Article
ISSN	1471-2458
ISSN (online)	1471-2458
DOI	10.1186/s12889-020-09703-4
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Article ; Online: Actualités diagnostique et thérapeutique des infections à Neisseria gonorrhoeae.

Chanal, Johan / Lassau, François / Morand, Philippe / Janier, Michel / Dupin, Nicolas

Presse medicale (Paris, France : 1983)

2013 Volume 42, Issue 4 Pt 1, Page(s) 454–458

Abstract: Bacterial culture remains the gold standard for symptomatic infection. Nucleic Acid Amplification Tests (NAATs) have better sensitivity and specificity for rectal and pharyngeal specimens. A bacterial culture with antibiogram must be done for all NAAT ... ...

Title translation	What's new in the diagnosis and treatment of Neisseria gonorrhoeae.
Abstract	Bacterial culture remains the gold standard for symptomatic infection. Nucleic Acid Amplification Tests (NAATs) have better sensitivity and specificity for rectal and pharyngeal specimens. A bacterial culture with antibiogram must be done for all NAAT positive specimens in order to modify antibiotics prescription if needed. We must fear a diffusion of extensively drug-resistant Neisseria gonorrhoeae in the future. Nevertheless, ceftriaxone 500 mg intramuscular with 1 g of azithromycin against Chlamydia trachomatis remains the treatment of N. gonorrhoeae infections. Screening of partners of identified cases and other STDs is the main measure to add to the treatment of gonorrhea.
MeSH term(s)	Adult ; Azithromycin/therapeutic use ; Bacteriological Techniques ; Ceftriaxone/therapeutic use ; Chlamydia Infections/diagnosis ; Chlamydia Infections/drug therapy ; Chlamydia Infections/epidemiology ; Chlamydia Infections/transmission ; Chlamydia trachomatis ; Comorbidity ; Drug Resistance, Multiple, Bacterial ; Drug Therapy, Combination ; Female ; Gonorrhea/diagnosis ; Gonorrhea/drug therapy ; Gonorrhea/epidemiology ; Gonorrhea/transmission ; Humans ; Injections, Intramuscular ; Male ; Mass Screening ; Microbial Sensitivity Tests ; Nucleic Acid Amplification Techniques ; Predictive Value of Tests
Chemical Substances	Ceftriaxone (75J73V1629) ; Azithromycin (83905-01-5)
Language	French
Publishing date	2013-04
Publishing country	France
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	120943-7
ISSN	2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
ISSN (online)	2213-0276
ISSN	0032-7867 ; 0755-4982 ; 0301-1518
DOI	10.1016/j.lpm.2012.09.023
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Zs.A 794: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Ua VI Zs.87: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article: Infections à gonocoques.

Chaine, Bénédicte / Lassau, François / Janier, Michel

La Revue du praticien

2010 Volume 60, Issue 4, Page(s) 533–538

Abstract: Gonococcal infections as well as other sexually transmited diseases have been increasing for several years. Short incubation period and rich symptomatology of gonococcal urethritis in man, make it an epidemiological indicator of high-risk sexual behavior. ...

Title translation	Gonococcal infections.
Abstract	Gonococcal infections as well as other sexually transmited diseases have been increasing for several years. Short incubation period and rich symptomatology of gonococcal urethritis in man, make it an epidemiological indicator of high-risk sexual behavior. In women, cervicitis is often asymptomatic. Anorectitis is a classical form of gonococcal infection especially in men who have sex with men. Sepsis and conjunctivitis, while rare, are to be diagnosed as quickly as possible because of their severity. To limit the spread of gonococcal infections, prevention of sexually transmitted diseases must be strengthened, the screening of asymptomatic subjects can be improved by using the polymerase chain reaction technique and finally the latest therapeutic guidelines taking into account gonococcal antibiotic resistances must be applied.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Female ; Gonorrhea/diagnosis ; Gonorrhea/drug therapy ; Gonorrhea/physiopathology ; Humans ; Male
Chemical Substances	Anti-Bacterial Agents
Language	French
Publishing date	2010-04-20
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	205365-2
ISSN	2101-017X ; 0035-2640
ISSN (online)	2101-017X
ISSN	0035-2640
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Article ; Online: First HSV-1 non primary genital herpes in two patients.

Fouéré, Sébastien / Chaine, Bénédicte / Maylin, Sarah / Minier, Marine / Vallée, Pascale / Scieux, Catherine / Lassau, François / Legoff, Jérôme / Janier, Michel

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

2016 Volume 78, Page(s) 108–110

Abstract: First HSV-1 genital episodes in HSV-2 infected patients however, had never been demonstrated until the 2 cases we observed. This scarcity could reflect the lower impact of HSV-2 on western populations but questions the existence of cross-protection ... ...

Abstract	First HSV-1 genital episodes in HSV-2 infected patients however, had never been demonstrated until the 2 cases we observed. This scarcity could reflect the lower impact of HSV-2 on western populations but questions the existence of cross-protection between viral types.
MeSH term(s)	Coinfection/diagnosis ; Coinfection/pathology ; Coinfection/virology ; Herpes Genitalis/diagnosis ; Herpes Genitalis/pathology ; Herpes Genitalis/virology ; Herpesvirus 1, Human/isolation & purification ; Herpesvirus 2, Human/isolation & purification ; Humans ; Male ; Middle Aged
Language	English
Publishing date	2016-05
Publishing country	Netherlands
Document type	Case Reports ; Journal Article
ZDB-ID	1446080-4
ISSN	1873-5967 ; 1386-6532
ISSN (online)	1873-5967
ISSN	1386-6532
DOI	10.1016/j.jcv.2016.03.018
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Article ; Online: A survey of primary care physician practices in antibiotic prescribing for the treatment of uncomplicated male gonoccocal urethritis

Blanchon Thierry / Gallay Anne / Lasserre Andrea / Falchi Alessandra / Sednaoui Patrice / Lassau François / Massari Veronique / Turbelin Clément / Hanslik Thomas

BMC Family Practice, Vol 12, Iss 1, p

2011 Volume 35

Abstract: Abstract Background The development of resistance to antimicrobial therapy by Neisseria gonorrhoeae causes on-going problems for individual case management of gonorrhoea. Surveillance data about N. gonorrhoeae have indicated an increase in the incidence ... ...

Abstract	Abstract Background The development of resistance to antimicrobial therapy by Neisseria gonorrhoeae causes on-going problems for individual case management of gonorrhoea. Surveillance data about N. gonorrhoeae have indicated an increase in the incidence of gonorrhoea in France in 2006. As a consequence of the development of antibiotic resistance in N. gonorrhoeae , French guidelines excluded fluoroquinolones as a standard treatment for N. gonorrhoeae . Ceftriaxone became the recommended treatment, associated with azithromycin for Clamydia trachomatis infection. Our aim was to describe the practice patterns of general practitioners (GPs) in managing the antibiotic treatment of patients with symptoms suggestive of uncomplicated male urethritis. Methods We developed a clinical vignette describing a man with typical gonococcal urethritis symptoms to elicit questions about antibiotic treatment. We mailed the electronic questionnaire to a random sample of 1000 French GPs belonging to the Sentinelles Network. Results By the end of the survey period, 350 vignettes were received, yielding a response rate of 35%. Sixty-six GPs (20.2%) prescribed the recommended antibiotics for the simultaneous treatment of N . gonorrhoeae and C. trachomatis infections, while 132 GPs (40.4%) prescribed only non-recommended antibiotics, including ciprofloxacin in 69 cases (21.1%). General practitioners with less than 10 years in practice showed better compliance to guidelines than those with more years in practice (p < 0.05). Conclusions The results suggest a mismatch between the guidelines and the antibiotic treatment of male uncomplicated urethritis by French GPs, mostly among the subgroup of physicians who have been in practice longer. Educational approaches based on practice feedback need to be developed to improve these deficits in the quality of care.
Keywords	Medicine (General) ; R5-920
Subject code	310
Language	English
Publishing date	2011-05-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article ; Online: A survey of primary care physician practices in antibiotic prescribing for the treatment of uncomplicated male gonoccocal urethritis.

Falchi, Alessandra / Lasserre, Andrea / Gallay, Anne / Blanchon, Thierry / Sednaoui, Patrice / Lassau, François / Massari, Veronique / Turbelin, Clément / Hanslik, Thomas

BMC family practice

2011 Volume 12, Page(s) 35

Abstract: Background: The development of resistance to antimicrobial therapy by Neisseria gonorrhoeae causes on-going problems for individual case management of gonorrhoea. Surveillance data about N. gonorrhoeae have indicated an increase in the incidence of ... ...

Abstract	Background: The development of resistance to antimicrobial therapy by Neisseria gonorrhoeae causes on-going problems for individual case management of gonorrhoea. Surveillance data about N. gonorrhoeae have indicated an increase in the incidence of gonorrhoea in France in 2006. As a consequence of the development of antibiotic resistance in N. gonorrhoeae, French guidelines excluded fluoroquinolones as a standard treatment for N. gonorrhoeae. Ceftriaxone became the recommended treatment, associated with azithromycin for Clamydia trachomatis infection. Our aim was to describe the practice patterns of general practitioners (GPs) in managing the antibiotic treatment of patients with symptoms suggestive of uncomplicated male urethritis. Methods: We developed a clinical vignette describing a man with typical gonococcal urethritis symptoms to elicit questions about antibiotic treatment. We mailed the electronic questionnaire to a random sample of 1000 French GPs belonging to the Sentinelles Network. Results: By the end of the survey period, 350 vignettes were received, yielding a response rate of 35%. Sixty-six GPs (20.2%) prescribed the recommended antibiotics for the simultaneous treatment of N. gonorrhoeae and C. trachomatis infections, while 132 GPs (40.4%) prescribed only non-recommended antibiotics, including ciprofloxacin in 69 cases (21.1%). General practitioners with less than 10 years in practice showed better compliance to guidelines than those with more years in practice (p<0.05). Conclusions: The results suggest a mismatch between the guidelines and the antibiotic treatment of male uncomplicated urethritis by French GPs, mostly among the subgroup of physicians who have been in practice longer. Educational approaches based on practice feedback need to be developed to improve these deficits in the quality of care.
MeSH term(s)	Adult ; Anti-Bacterial Agents/therapeutic use ; Attitude of Health Personnel ; Drug Prescriptions/statistics & numerical data ; Drug Resistance, Multiple, Bacterial ; Female ; France ; Gonorrhea/drug therapy ; Health Care Surveys ; Health Knowledge, Attitudes, Practice ; Humans ; Male ; Middle Aged ; Physicians, Primary Care/statistics & numerical data ; Population Surveillance ; Practice Patterns, Physicians'/statistics & numerical data ; Urethritis/drug therapy ; Urethritis/microbiology
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2011-05-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1471-2296
ISSN (online)	1471-2296
DOI	10.1186/1471-2296-12-35
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Article ; Online: Molecular subtyping of Treponema pallidum in Paris, France.

Grange, Philippe Alain / Allix-Beguec, Caroline / Chanal, Johan / Benhaddou, Nadjet / Gerhardt, Philippe / Morini, Jean-Pierre / Deleuze, Jean / Lassau, François / Janier, Michel / Dupin, Nicolas

Sexually transmitted diseases

2013 Volume 40, Issue 8, Page(s) 641–644

Abstract: Two major Treponema pallidum subtypes, 14 d/g and 14 d/f, were identified in a population of 119 patients with syphilis in Paris, France, characterized by a high proportion of men who have sex with men. A new subtype named 11 q/j was characterized, and a ...

Abstract	Two major Treponema pallidum subtypes, 14 d/g and 14 d/f, were identified in a population of 119 patients with syphilis in Paris, France, characterized by a high proportion of men who have sex with men. A new subtype named 11 q/j was characterized, and a reinfection case was determined in 1 patient having consecuitve syphilis infection at 19-month interval.
MeSH term(s)	Adolescent ; Adult ; Coinfection ; DNA Polymerase I/genetics ; DNA, Bacterial/genetics ; France/epidemiology ; HIV Infections/epidemiology ; Homosexuality, Male ; Humans ; Male ; Middle Aged ; Molecular Epidemiology ; Molecular Typing ; Paris/epidemiology ; Polymerase Chain Reaction ; Sentinel Surveillance ; Specimen Handling ; Syphilis/epidemiology ; Syphilis/microbiology ; Treponema pallidum/genetics ; Treponema pallidum/isolation & purification
Chemical Substances	DNA, Bacterial ; DNA Polymerase I (EC 2.7.7.-)
Language	English
Publishing date	2013-08
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	435191-5
ISSN	1537-4521 ; 0148-5717
ISSN (online)	1537-4521
ISSN	0148-5717
DOI	10.1097/OLQ.0000000000000006
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Article ; Online: Treponema pallidum induces systemic TH17 and TH1 cytokine responses.

Bernardeschi, Celine / Grange, Philippe A / Janier, Michel / Gressier, Ludivine / Dion, Pierre L / Benhaddou, Nadjet / Bianchi, Anne / Lassau, François / Avril, Marie-Françoise / Batteux, Frédéric / Dupin, Nicolas

European journal of dermatology : EJD

2012 Volume 22, Issue 6, Page(s) 797–798

MeSH term(s)	Adult ; Analysis of Variance ; Cytokines/blood ; Female ; Humans ; Interferon-gamma/blood ; Male ; Syphilis/immunology ; Syphilis/microbiology ; Th1 Cells/metabolism ; Th17 Cells/metabolism ; Th2 Cells/metabolism ; Treponema pallidum ; Tumor Necrosis Factor-alpha/blood
Chemical Substances	Cytokines ; Tumor Necrosis Factor-alpha ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2012-11
Publishing country	France
Document type	Letter ; Research Support, Non-U.S. Gov't
ZDB-ID	1128666-0
ISSN	1952-4013 ; 1167-1122
ISSN (online)	1952-4013
ISSN	1167-1122
DOI	10.1684/ejd.2012.1841
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