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  1. Article ; Online: Association Between SGLT2 Inhibitor Use and Change in Hemoglobin Among Adults with Diabetes: A Nationwide Cohort Study.

    Lassen, Mats C Højbjerg / Colacci, Michael / Pareek, Manan / Lee, Stephanie G / Gislason, Gunnar / Fralick, Michael / Biering-Sørensen, Tor

    Journal of general internal medicine

    2024  

    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Letter
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-024-08640-x
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    Zs.A 2205: Show issues Location:
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  2. Article ; Online: Left atrial strain is reduced following trastuzumab in breast cancer patients.

    Lassen, Mats C Højbjerg / Arya, Farzin / Biering-Sørensen, Tor / Reeh, Jacob L T / Melisko, Michelle E / Sarwary, Shabir / Baik, Alan H / Aras, Mandar A / Qasim, Atif

    Echocardiography (Mount Kisco, N.Y.)

    2024  Volume 41, Issue 1, Page(s) e15751

    Abstract: Background: The effect of trastuzumab therapy on left atrial (LA) function remains largely unknown. Our aim was to assess the changes in LA strain parameters longitudinally in patients treated with trastuzumab.: Methods: We retrospectively studied ... ...

    Abstract Background: The effect of trastuzumab therapy on left atrial (LA) function remains largely unknown. Our aim was to assess the changes in LA strain parameters longitudinally in patients treated with trastuzumab.
    Methods: We retrospectively studied 170 patients with stage I-IV HER2+ breast cancer. All patients had baseline echocardiograms and repeat echocardiograms at 3 months and after 1 year. We measured LA strain at all three time points. Changes in LA strain and strain rate (sr) parameters were evaluated using repeated-measures mixed-effects models. The cohort was stratified according to development of cancer therapeutics-related cardiac dysfunction (CTRCD) during follow-up.
    Results: The mean age was 52.7 ± 13.8 years, 25.3% had hypertension and 16.0% had metastatic disease. Multiple LA strain parameters (predicted delta value, [95%CI]) showed statistically significant declines in patients who developed CTRCD from baseline to the 3-month follow-up after multivariable adjustment; LA reservoir strain (LAε
    Conclusion: Trastuzumab treatment was associated with declines in LA strain parameters in patients with breast cancer. The largest declines were observed in patients who developed CTRCD during treatment.
    MeSH term(s) Humans ; Adult ; Middle Aged ; Aged ; Female ; Trastuzumab/adverse effects ; Breast Neoplasms/drug therapy ; Retrospective Studies ; Heart Diseases/complications ; Heart Atria/diagnostic imaging ; Ventricular Function, Left
    Chemical Substances Trastuzumab (P188ANX8CK)
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 843645-9
    ISSN 1540-8175 ; 0742-2822
    ISSN (online) 1540-8175
    ISSN 0742-2822
    DOI 10.1111/echo.15751
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    Zs.A 2170: Show issues Location:
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    Zs.MO 359: Show issues

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  3. Article ; Online: The Effect of Sacubitril/Valsartan on Left Ventricular Myocardial Deformation in Heart Failure with Preserved Ejection Fraction (PARAMOUNT trial).

    Biering-Sørensen, Tor / Lassen, Mats C Højbjerg / Shah, Amil / Claggett, Brian / Zile, Michael / Pieske, Burkert / Pieske-Kraigher, Elisabeth / Voors, Adriaan / Shi, Victor / Lefkowitz, Martin / Packer, Milton / McMurray, John J V / Solomon, Scott D

    Journal of cardiac failure

    2023  Volume 29, Issue 6, Page(s) 968–973

    Abstract: Background: Global longitudinal strain (GLS) and global circumferential strain (GCS) have been shown to be impaired in heart failure with preserved ejection fraction. We sought to assess whether treating patients with heart failure with preserved ... ...

    Abstract Background: Global longitudinal strain (GLS) and global circumferential strain (GCS) have been shown to be impaired in heart failure with preserved ejection fraction. We sought to assess whether treating patients with heart failure with preserved ejection fraction with sacubitril/valsartan would significantly improve GLS and GCS compared with valsartan alone.
    Methods and results: PARAMOUNT (Prospective Comparison of ARNI With ARB on Management of Heart Failure With Preserved Ejection Fraction Trial) was a phase II, randomized, parallel-group, double-blind multicenter trial in 301 patients with New York Heart Association functional class II-III heart failure, a left ventricular ejection fraction of 45%, and an N-terminal pro-B-type natriuretic peptide of ≥400 pg/mL. Participants were randomly assigned (1:1) to sacubitril/valsartan titrated to 200 mg twice daily or valsartan titrated to 160 mg twice daily for 36 weeks. We assessed changes in the GLS and the GCS from baseline to 36 weeks, adjusting for baseline value, in patients with sufficient imaging quality for 2-dimensitonal speckle tracking analysis at both timepoints (n = 60 sacubitril/valsartan, n = 75 valsartan only). GCS was significantly improved at 36 weeks in the sacubitril/valsartan group when compared with the valsartan group (Δ4.42%, 95% confidence interval [CI] 0.67-8.17, P = .021), with no significant difference observed in GLS (Δ0.25%, 95% CI, -1.19 to 1.70, P = .73). Patients with a history of hospitalization for heart failure had a differentially greater improvement in GCS when treated with sacubitril/valsartan.
    Conclusions: In patients with heart failure with preserved ejection fraction, sacubitril/valsartan improved GCS but not GLS when compared with valsartan during a 36-week period. This trial is registered at ClinicalTrials.gov, NCT00887588.
    MeSH term(s) Humans ; Heart Failure/diagnostic imaging ; Heart Failure/drug therapy ; Heart Failure/chemically induced ; Stroke Volume ; Angiotensin Receptor Antagonists ; Tetrazoles/adverse effects ; Ventricular Function, Left ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Valsartan ; Aminobutyrates ; Biphenyl Compounds ; Drug Combinations
    Chemical Substances sacubitril (17ERJ0MKGI) ; Angiotensin Receptor Antagonists ; Tetrazoles ; Angiotensin-Converting Enzyme Inhibitors ; Valsartan (80M03YXJ7I) ; Aminobutyrates ; Biphenyl Compounds ; Drug Combinations
    Language English
    Publishing date 2023-04-07
    Publishing country United States
    Document type Randomized Controlled Trial ; Multicenter Study ; Clinical Trial, Phase II ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1281194-4
    ISSN 1532-8414 ; 1071-9164
    ISSN (online) 1532-8414
    ISSN 1071-9164
    DOI 10.1016/j.cardfail.2023.03.019
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    Zs.A 4340: Show issues Location:
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  4. Article ; Online: Effects of high-dose versus standard-dose quadrivalent influenza vaccine among patients with diabetes: A post-hoc analysis of the DANFLU-1 trial.

    Lassen, Mats C Højbjerg / Johansen, Niklas Dyrby / Modin, Daniel / Nealon, Joshua / Samson, Sandrine / Dufournet, Marine / Loiacono, Matthew M / Larsen, Carsten Schade / Jensen, Anne Marie Reimer / Landler, Nino Emanuel / Claggett, Brian L / Solomon, Scott D / Landray, Martin J / Gislason, Gunnar H / Køber, Lars / Jensen, Jens Ulrik Stæhr / Sivapalan, Pradeesh / Vestergaard, Lasse Skafte / Krause, Tyra Grove /
    Biering-Sørensen, Tor

    Diabetes, obesity & metabolism

    2024  Volume 26, Issue 5, Page(s) 1821–1829

    Abstract: Aim: High-dose quadrivalent influenza vaccine (QIV-HD) has been shown to be more effective than standard-dose (QIV-SD) in reducing influenza infection, but whether diabetes status affects relative vaccine effectiveness (rVE) is unknown. We aimed to ... ...

    Abstract Aim: High-dose quadrivalent influenza vaccine (QIV-HD) has been shown to be more effective than standard-dose (QIV-SD) in reducing influenza infection, but whether diabetes status affects relative vaccine effectiveness (rVE) is unknown. We aimed to assess rVE on change in glycated haemoglobin [HbA1c (∆HbA1c)], incident diabetes, total all-cause hospitalizations (first + recurrent), and a composite of all-cause mortality and hospitalization for pneumonia or influenza.
    Methods: DANFLU-1 was a pragmatic, open-label trial randomizing adults (65-79 years) 1:1 to QIV-HD or QIV-SD during the 2021/22 influenza season. Cox proportional hazards regression was used to estimate rVE against incident diabetes and the composite endpoint, negative binomial regression to estimate rVE against all-cause hospitalizations, and ANCOVA when assessing rVE against ∆HbA1c.
    Results: Of the 12 477 participants, 1162 (9.3%) had diabetes at baseline. QIV-HD, compared with QIV-SD, was associated with a reduction in the rate of all-cause hospitalizations irrespective of diabetes [overall: 647 vs. 742 events, incidence rate ratio (IRR): 0.87, 95% CI (0.76-0.99); diabetes: 93 vs. 118 events, IRR: 0.80, 95% CI (0.55-1.15); without diabetes: 554 vs. 624 events, IRR: 0.88, 95% CI (0.76-1.01), p
    Conclusions: In this post-hoc analysis, QIV-HD versus QIV-SD was associated with an increased rVE against the composite of all-cause death and hospitalization for pneumonia/influenza, and the all-cause hospitalization rate irrespective of diabetes status.
    MeSH term(s) Aged ; Humans ; Diabetes Mellitus ; Hospitalization ; Influenza Vaccines/therapeutic use ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Pneumonia/prevention & control ; Pragmatic Clinical Trials as Topic
    Chemical Substances Influenza Vaccines
    Language English
    Publishing date 2024-04-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 1454944-x
    ISSN 1463-1326 ; 1462-8902
    ISSN (online) 1463-1326
    ISSN 1462-8902
    DOI 10.1111/dom.15498
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    Zs.A 5442: Show issues Location:
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  5. Article ; Online: Electronically Delivered Nudges to Increase Influenza Vaccination Uptake in Older Adults With Diabetes: A Secondary Analysis of the NUDGE-FLU Trial.

    Lassen, Mats C Højbjerg / Johansen, Niklas Dyrby / Vaduganathan, Muthiah / Bhatt, Ankeet S / Lee, Simin Gharib / Modin, Daniel / Claggett, Brian L / Dueger, Erica L / Samson, Sandrine I / Loiacono, Matthew M / Fralick, Michael / Køber, Lars / Solomon, Scott D / Sivapalan, Pradeesh / Jensen, Jens Ulrik Stæhr / Martel, Cyril Jean-Marie / Krause, Tyra Grove / Biering-Sørensen, Tor

    JAMA network open

    2023  Volume 6, Issue 12, Page(s) e2347630

    Abstract: Importance: Influenza vaccination is associated with a reduced risk of mortality in patients with diabetes, but vaccination rates remain suboptimal.: Objective: To assess the effect of electronic nudges on influenza vaccination uptake according to ... ...

    Abstract Importance: Influenza vaccination is associated with a reduced risk of mortality in patients with diabetes, but vaccination rates remain suboptimal.
    Objective: To assess the effect of electronic nudges on influenza vaccination uptake according to diabetes status.
    Design, setting, and participants: The NUDGE-FLU (Nationwide Utilization of Danish Government Electronic Letter System for Increasing Influenza Vaccine Uptake) trial was a nationwide clinical trial of Danish citizens 65 years or older that randomized participants at the household level to usual care or 9 different electronic nudge letters during the 2022 to 2023 influenza season. End of follow-up was January 1, 2023. This secondary analysis of the NUDGE-FLU trial was performed from May to July 2023.
    Intervention: Nine different electronic nudge letters designed to boost influenza vaccination were sent in September to October 2022. Effect modification by diabetes status was assessed in a pooled analysis of all intervention arms vs usual care and for individual letters.
    Main outcomes and measures: The primary end point was receipt of a seasonal influenza vaccine.
    Results: The trial included 964 870 participants (51.5% female; mean [SD] age, 73.8 [6.3] years); 123 974 had diabetes. During follow-up, 83.5% with diabetes vs 80.2% without diabetes received a vaccine (P < .001). In the pooled analysis, nudges improved vaccination uptake in participants without diabetes (80.4% vs 80.0%; difference, 0.37 percentage points; 99.55% CI, 0.08 to 0.66), whereas there was no evidence of effect in those with diabetes (83.4% vs 83.6%; difference, -0.19 percentage points; 99.55% CI, -0.89 to 0.51) (P = .02 for interaction). In the main results of NUDGE-FLU, 2 of the 9 behaviorally designed letters (cardiovascular benefits letter and a repeated letter) significantly increased uptake of influenza vaccination vs usual care; these benefits similarly appeared attenuated in participants with diabetes (cardiovascular gain letter: 83.7% vs 83.6%; difference, 0.04 percentage points; 99.55% CI, -1.52 to 1.60; repeated letter: 83.5% vs 83.6%; difference, -0.15 percentage points; 99.55% CI, -1.71 to 1.41) vs those without diabetes (cardiovascular gain letter: 81.1% vs 80.0%; difference, 1.06 percentage points; 99.55% CI, 0.42 to 1.70; repeated letter: 80.9% vs 80.0%; difference, 0.87 percentage points; 99.55% CI, 0.22 to 1.52) (P = .07 for interaction).
    Conclusions and relevance: In this exploratory subgroup analysis, electronic nudges improved influenza vaccination uptake in persons without diabetes, whereas there was no evidence of an effect in persons with diabetes. Trials are needed to investigate the effect of digital nudges specifically tailored to individuals with diabetes.
    Trial registration: ClinicalTrials.gov Identifier: NCT05542004.
    MeSH term(s) Humans ; Female ; Aged ; Male ; Influenza Vaccines/therapeutic use ; Influenza, Human/prevention & control ; Vaccination ; Diabetes Mellitus ; Government
    Chemical Substances Influenza Vaccines
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.47630
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  6. Article ; Online: Risk of Incident Thromboembolic and Ischemic Events After COVID-19 Vaccination Compared With SARS-CoV-2 Infection.

    Lassen, Mats C Højbjerg / Modin, Daniel / Skaarup, Kristoffer Grundtvig / Johansen, Niklas Dyrby / Claggett, Brian / Solomon, Scott D / Fralick, Michael / Jensen, Jens Ulrik Stæhr / Sivapalan, Pradeesh / Vaduganathan, Muthiah / Pareek, Manan / Schou, Morten / Krause, Tyra Grove / Hviid, Anders / Køber, Lars / Torp-Pedersen, Christian / Gislason, Gunnar / Biering-Sørensen, Tor

    Circulation

    2023  Volume 147, Issue 10, Page(s) 843–845

    MeSH term(s) Humans ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; SARS-CoV-2 ; Vaccination/adverse effects
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-03-06
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.122.063296
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