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  1. Article: Implementazione del modello ICD-ICF in medicina riabilitativa: presentazione di un caso clinico in riabilitazione respiratoria.

    Lastoria, Cinzia / Bido, Serena / Ceriana, Piero / Vitacca, Michele

    Giornale italiano di medicina del lavoro ed ergonomia

    2019  Volume 41, Issue 2, Page(s) 150–155

    Abstract: Summary: We present the clinical case of a 74 years old patient undergoing tracheotomy for persistent hypercapnic respiratory failure after lower right lobectomy surgery, performed as a result of pulmonary cancer recurrence. The patient was transferred ... ...

    Title translation Implementation of the ICD-ICF model in rehabilitation medicine: report of a clinical case in respiratory rehabilitation.
    Abstract Summary: We present the clinical case of a 74 years old patient undergoing tracheotomy for persistent hypercapnic respiratory failure after lower right lobectomy surgery, performed as a result of pulmonary cancer recurrence. The patient was transferred to the Department of Respiratory Sub Intensive Care for respiratory weaning, decannulation and cycle of motor and respiratory physiotherapy. The joint evaluation of physicians, nurses and physiotherapists has allowed the identification of ICD-9 and ICF codes of the severe disability shown by the patient in the first days of hospital stay (respiratory failure due to pneumonia that need invasive mechanical ventilation by tracheotomy, prolonged immobility, muscular deconditioning and inability to perform even the simplest activities of daily life; it required also artificial nutrition by naso gastric tube). ICF codes as respiratory functions (respiratory system functions, additional respiratory functions, sensations associated with cardiovascular and respiratory functions, moving with aids, walking, vestibular functions, muscle strength, tolerance to physical exercise, personal care, performing the routine daily sleep functions, energy and drive functions), were particularly compromised at admission. Medical intervention (antibiotic therapy based on microbiological isolations, optimization of inhalatory therapy, management of intestinal complications and cardiological which required cardiological treatment remodulation in order to obtain better heart rate control and better blood pressure control allowed a clear improvement of general and respiratory clinical conditions. The simultaneous physiotherapists'intervention (weaning not only from invasive mechanical ventilation but also from tracheotomic cannula and oxygen therapy, stationary and cycloergometer with arms and exercise training) and nurses'intervention (medication of pressure injuries, surveillance of the sleep-wake rhythm, management of the daily routine) allowed a gradual improvement of both motor and respiratory ability with a consequent indipendence in activities of daily living. Important were also psychological counseling and intervention of speech therapists (removal of naso gastric tube, once excluded dysphagia also by videofluoroscopy). During a long lasting clinical improvement, coincident with patient's discharge to home, has been assessed disability through ICF codes, largely improved under medical, nursing and physiotherapist profile.
    MeSH term(s) Aged ; Humans ; Hypercapnia/etiology ; Hypercapnia/rehabilitation ; International Classification of Diseases ; International Classification of Functioning, Disability and Health ; Lung Neoplasms/surgery ; Male ; Physical Therapy Modalities ; Pneumonectomy/methods ; Respiration, Artificial/methods ; Respiratory Insufficiency/etiology ; Respiratory Insufficiency/rehabilitation ; Tracheotomy
    Language Italian
    Publishing date 2019-06-26
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 603103-1
    ISSN 1592-7830 ; 0391-9889
    ISSN 1592-7830 ; 0391-9889
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Prevalence of exercise-induced oxygen desaturation after recovery from SARS-CoV-2 pneumonia and use of lung ultrasound to predict need for pulmonary rehabilitation.

    Carlucci, A / Paneroni, M / Carotenuto, M / Bertella, E / Cirio, S / Gandolfo, A / Simonelli, C / Vigna, M / Lastoria, C / Malovini, A / Fusar Poli, B / Vitacca, M

    Pulmonology

    2021  Volume 29 Suppl 4, Page(s) S4–S8

    Abstract: Background: Persistence of breathlessness after recovery from SARS-CoV-2 pneumonia is frequent. Recovery from acute respiratory failure (ARF) is usually determined by normalized arterial blood gases (ABGs), but the prevalence of persistent exercise- ... ...

    Abstract Background: Persistence of breathlessness after recovery from SARS-CoV-2 pneumonia is frequent. Recovery from acute respiratory failure (ARF) is usually determined by normalized arterial blood gases (ABGs), but the prevalence of persistent exercise-induced desaturation (EID) and dyspnea is still unknown.
    Methods: We investigated the prevalence of EID in 70 patients with normal arterial oxygen at rest after recovery from ARF due to COVID-19 pneumonia. Patients underwent a 6-min walking test (6MWT) before discharge from hospital. We recorded dyspnea score and heart rate during 6MWT. We also investigated the possible role of lung ultrasound (LU) in predicting EID. Patients underwent a LU scan and scores for each explored area were summed to give a total LU score.
    Results: In 30 patients (43%), oxygen desaturation was >4% during 6MWT. These patients had significantly higher dyspnea and heart rate compared to non-desaturators. LU score >8.5 was significantly able to discriminate patients with EID.
    Conclusion: In SARS-CoV-2 pneumonia, ABGs at discharge cannot predict the persistence of EID, which is frequent. LU may be useful to identify patients at risk who could benefit from a rehabilitation program.
    MeSH term(s) Humans ; SARS-CoV-2 ; Pulmonary Disease, Chronic Obstructive ; Prevalence ; Exercise Test ; COVID-19/epidemiology ; Lung/diagnostic imaging ; Oxygen ; Dyspnea/diagnosis ; Dyspnea/etiology
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2021-06-04
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 3009651-0
    ISSN 2531-0437 ; 2531-0429
    ISSN (online) 2531-0437
    ISSN 2531-0429
    DOI 10.1016/j.pulmoe.2021.05.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Prevalence and Predictors of Obstructive Sleep Apnea in Patients with Chronic Obstructive Pulmonary Disease Undergoing Inpatient Pulmonary Rehabilitation.

    Schreiber, Annia / Cemmi, Francesca / Ambrosino, Nicolino / Ceriana, Piero / Lastoria, Cinzia / Carlucci, Annalisa

    COPD

    2018  Volume 15, Issue 3, Page(s) 265–270

    Abstract: The aim of our study was to evaluate the prevalence and predictors of obstructive sleep apnea (OSA) in patients with chronic obstructive pulmonary disease (COPD) undergoing inpatient pulmonary rehabilitation programs (PRPs). A retrospective data review ... ...

    Abstract The aim of our study was to evaluate the prevalence and predictors of obstructive sleep apnea (OSA) in patients with chronic obstructive pulmonary disease (COPD) undergoing inpatient pulmonary rehabilitation programs (PRPs). A retrospective data review of consecutive stable patients with a known diagnosis of COPD, admitted for PRP between January 2007 and December 2013. Full overnight polysomnography (PSG) and Epworth Sleepiness Scale (ESS) were assessed in all patients. Out of 422 evaluated patients, 190 (45%) showed an Apnea Hypopnea Index (AHI) ≥ 15 events/hour and underwent OSA treatment. Patients with OSA were significantly younger and had a less severe airway obstruction as compared to patients without OSA. There were no significant differences in cardiac comorbidities nor in arterial blood gases. As expected, patients with OSA showed significantly more severe diurnal symptoms, as assessed by the ESS and higher body mass index (BMI). However, only 69 out of 190 patients with OSA (36.3%) showed an ESS >10, whereas 25% of them had BMI ≤25 and 41% of them had a BMI <30. In all, 68% of patients with OSA were discharged with continuous positive airway pressure (CPAP), 15% with Bilevel ventilation, and 17% without any ventilatory treatment. In conclusion, in the population studied, the combination of OSA and COPD was frequent. BMI and ESS values commonly considered cutoff values for the prediction of OSA in the general population may not be accurate in a subgroup of patients with COPD.
    MeSH term(s) Aged ; Aged, 80 and over ; Body Mass Index ; Cohort Studies ; Comorbidity ; Continuous Positive Airway Pressure ; Female ; Hospitalization ; Humans ; Logistic Models ; Male ; Middle Aged ; Obesity/epidemiology ; Polysomnography ; Prevalence ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Pulmonary Disease, Chronic Obstructive/rehabilitation ; Retrospective Studies ; Risk Factors ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/epidemiology ; Sleep Apnea, Obstructive/therapy ; Sleepiness
    Language English
    Publishing date 2018-09-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2171107-0
    ISSN 1541-2563 ; 1541-2555
    ISSN (online) 1541-2563
    ISSN 1541-2555
    DOI 10.1080/15412555.2018.1500533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Role of rehabilitation in the elderly after an acute event: insights from a real-life prospective study in the subacute care setting.

    Galizia, Gianluigi / Balestrieri, Giulio / De Maria, Beatrice / Lastoria, Cinzia / Monelli, Mauro / Salvaderi, Stefano / Romanelli, Giuseppe / Dalla Vecchia, Laura A

    European journal of physical and rehabilitation medicine

    2018  Volume 54, Issue 6, Page(s) 934–938

    Abstract: Background: Any acute event, either primary or secondary to a chronic disease, is generally followed by some degree of physical impairment. Subacute care (SAC) represents one of the inpatient intermediate care settings aimed at completing recovery and ... ...

    Abstract Background: Any acute event, either primary or secondary to a chronic disease, is generally followed by some degree of physical impairment. Subacute care (SAC) represents one of the inpatient intermediate care settings aimed at completing recovery and restoring functional capacity. Debate exists on the role of the rehabilitation treatment in the SAC setting.
    Aim: The aim of this study was to compare the outcomes of patients managed in two different SAC Units where A) patients undergo an individualized rehabilitation program on top of optimal medical therapy (OMT) B) patients receive OMT only.
    Design: Real-life prospective study.
    Setting: SAC units.
    Population: Seventy-five chronic heart failure (CHF) and chronic obstructive pulmonary disease (COPD) patients transferred after an acute hospitalization.
    Methods: Upon SAC admission, the following scales were obtained: cumulative illness rating scale comorbidity and severity (CIRSC and CIRSS), mini mental state examination (MMSE), Performance-Oriented Mobility Assessment (POMA), Barthel Index (BI), the 10-meter walking test (10MWT). Pre-admission BI was also collected based on history. Upon SAC discharge, BI, POMA, and 10MWT were repeated.
    Results: Patients (44 in Group A, 31 in Group B) were similar with regard to age, gender, MMSE, clinical complexity, pre-admission BI, admission 10MWT, POMA, and bedrest conditions. Admission BI was lower in Group A. In both groups BI was lower when compared to the respective pre-admission score. Upon discharge, Group A patients were characterized by a higher BI and POMA compared to Group B. Indeed, BI and POMA improved at discharge only in Group A patients. Only this latter group reached the pre-morbid BI. Upon discharge the number of bedrest patients decreased only in Group A. The percentage of patients discharged home was also much higher in Group A, while a greater number of Group B patients were transferred to a rehabilitation ward or were enrolled in an integrated home care assistance program.
    Conclusions: In a real-life prospective experience, a better outcome is demonstrated in elderly CHF and COPD patients undergoing a rehabilitative approach during their in-hospital SAC stay.
    Clinical rehabilitation impact: An individualized rehabilitation program should integrate medical treatment of CHF and BPCO patients in the SAC setting. This approach demonstrates a better cost-effectiveness management of these patients.
    MeSH term(s) Activities of Daily Living ; Age Factors ; Aged ; Aged, 80 and over ; Female ; Heart Failure/complications ; Heart Failure/rehabilitation ; Humans ; Male ; Outcome Assessment (Health Care) ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/rehabilitation ; Subacute Care
    Language English
    Publishing date 2018-06-11
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2426908-6
    ISSN 1973-9095 ; 1973-9087
    ISSN (online) 1973-9095
    ISSN 1973-9087
    DOI 10.23736/S1973-9087.18.05221-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Use of inhaled devices during a hospital exacerbation of COPD: a summary of an interdisciplinary audit held at ICS Maugeri Pavia, Italy (March-June 2019).

    Vitacca, Michele / Lastoria, Cinzia / Delmastro, Monica / Fiorenza, Domenico / De Cata, Pasquale / Fusar Poli, Barbara / Gilè, Sonia / Prometti, Paola / Paneroni, Mara / Bianchi, Cristina / Mandora, Elena / Porri, Roberta / Fracchia, Claudio

    Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace

    2020  Volume 90, Issue 1

    Abstract: To date treatment protocols in Respiratory and or Internal departments across Italy for treatment of chronic obstructive pulmonary disease (COPD) patients at hospital admission with relapse due to exacerbation do not find adequate support in current ... ...

    Abstract To date treatment protocols in Respiratory and or Internal departments across Italy for treatment of chronic obstructive pulmonary disease (COPD) patients at hospital admission with relapse due to exacerbation do not find adequate support in current guidelines. Here we describe the results of a recent clinical audit, including a systematic review of practices reported in literature and an open discussion comparing these to current real-life procedures. The process was dived into two 8-hour-audits 3 months apart in order to allow work on the field in between meeting and involved 13 participants (3 nurses, 1 physiotherapist, 2 internists and 7 pulmonologists). This document reports the opinions of the experts and their consensus, leading to a bundle of multidisciplinary statements on the use of inhaled drugs for hospitalized COPD patients. Recommendations and topics addressed include: i) monitoring and diagnosis during the first 24 h after admission; ii) treatment algorithm and options (i.e., short and long acting bronchodilators); iii) bronchodilator dosages when switching device or using spacer; iv) flow measurement systems for shifting to LABA+LAMA within 48 h; v) when nebulizers are recommended; vi) use of SMI to deliver LABA+LAMA when patient needs SABA <3 times/day independently from flow limitation; vii) use of DPI and pre-dosed MDI to deliver LABA+LAMA or TRIPLE when patient needs SABA <3 times/day, with inspiratory flow > 30 litres/min; viii) contraindication to use DPI; ix) continuation of LABA-LAMA when patient is already on therapy; x) possible LABA-LAMA dosage increase; xi) use of SABA and/or SAMA in addition to LABA+LABA; xii) use of SABA+SAMA restricted to real need; xiii) reconciliation of drugs in presence of comorbidities; xiv) check of knowledge and skills on inhalation therapy; xv) discharge bundle; xvi) use of MDI and SMI in tracheostomized patients in spontaneous and ventilated breathing.
    MeSH term(s) Administration, Inhalation ; Adrenergic beta-Agonists/administration & dosage ; Adrenergic beta-Agonists/therapeutic use ; Aged, 80 and over ; Bronchodilator Agents/administration & dosage ; Bronchodilator Agents/therapeutic use ; Clinical Audit/methods ; Disease Progression ; Drug Therapy, Combination ; Hospitalization/statistics & numerical data ; Humans ; Italy/epidemiology ; Muscarinic Antagonists/administration & dosage ; Muscarinic Antagonists/therapeutic use ; Nebulizers and Vaporizers/statistics & numerical data ; Patient Care Team/statistics & numerical data ; Pulmonary Disease, Chronic Obstructive/drug therapy
    Chemical Substances Adrenergic beta-Agonists ; Bronchodilator Agents ; Muscarinic Antagonists
    Language English
    Publishing date 2020-02-12
    Publishing country Italy
    Document type Journal Article ; Systematic Review
    ZDB-ID 1160940-0
    ISSN 1122-0643 ; 1120-0391
    ISSN 1122-0643 ; 1120-0391
    DOI 10.4081/monaldi.2020.1176
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Feasibility and clinical impact of out-of-ICU noninvasive respiratory support in patients with Covid-19 related pneumonia.

    Franco, C / Facciolongo, N / Tonelli, R / Dongilli, R / Vianello, A / Pisani, L / Scala, R / Malerba, M / Carlucci, A / Negri, Ea / Spoladore, G / Arcaro, G / Tillio, Pa / Lastoria, C / Schifino, G / Tabbi', L / Guidelli, L / Guaraldi, G / Ranieri, M /
    Clini, E / Nava, S.

    2020  

    Abstract: Introduction: The Coronavirus 2(SARS-CoV-2) outbreak spread rapidly in Italy and the lack of intensive care unit(ICU) beds soon became evident, forcing the application of noninvasive respiratory support(NRS) outside the ICU, raising concerns over staff ... ...

    Abstract Introduction: The Coronavirus 2(SARS-CoV-2) outbreak spread rapidly in Italy and the lack of intensive care unit(ICU) beds soon became evident, forcing the application of noninvasive respiratory support(NRS) outside the ICU, raising concerns over staff contamination. We aimed to analyze the safety of the hospital staff, the feasibility, and outcomes of NRS applied to patients outside the ICU. Methods: In this observational study, data from 670 consecutive patients with confirmed COVID-19 referred to the Pulmonology Units in nine hospitals between March 1st and May 10th,2020 were analyzed. Data were collected including medication, mode and usage of the NRS (i.e. high-flow nasal cannula (HFNC), continuous positive airway pressure (CPAP), noninvasive ventilation(NIV)), length of stay in hospital, endotracheal intubation(ETI) and deaths. Results: Forty-two health-care workers (11.4%) tested positive for infection, but only three of them required hospitalization. Data are reported for all patients (69.3% male), whose mean age was 68 (SD 13) years. The PaO2/FiO2 ratio at baseline was 152+79, and the majority of patients (49.3%) were treated with CPAP. The overall unadjusted 30-day mortality rate was 26.9% with 16%, 30%, and 30%, while the total ETI rate was 27% with 29%, 25% and 28%, for HFNC, CPAP, and NIV, respectively, and the relative probability to die was not related to the NRS used after adjustment for confounders. ETI and length of stay were not different among the groups. Mortality rate increased with age and comorbidity class progression. Conclusions: The application of NRS outside the ICU is feasible and associated with favourable outcomes. Nonetheless, it was associated with a risk of staff contamination.
    Keywords noninvasive ventilatory support ; acute respiratory failure ; SARS ; covid19
    Language English
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Feasibility and clinical impact of out-of-ICU noninvasive respiratory support in patients with COVID-19-related pneumonia.

    Franco, Cosimo / Facciolongo, Nicola / Tonelli, Roberto / Dongilli, Roberto / Vianello, Andrea / Pisani, Lara / Scala, Raffaele / Malerba, Mario / Carlucci, Annalisa / Negri, Emanuele Alberto / Spoladore, Greta / Arcaro, Giovanna / Tillio, Paolo Amedeo / Lastoria, Cinzia / Schifino, Gioachino / Tabbì, Luca / Guidelli, Luca / Guaraldi, Giovanni / Ranieri, V Marco /
    Clini, Enrico / Nava, Stefano

    The European respiratory journal

    2020  Volume 56, Issue 5

    Abstract: Introduction: The severe acute respiratory syndrome-coronavirus 2 outbreak spread rapidly in Italy and the lack of intensive care unit (ICU) beds soon became evident, forcing the application of noninvasive respiratory support (NRS) outside the ICU, ... ...

    Abstract Introduction: The severe acute respiratory syndrome-coronavirus 2 outbreak spread rapidly in Italy and the lack of intensive care unit (ICU) beds soon became evident, forcing the application of noninvasive respiratory support (NRS) outside the ICU, raising concerns over staff contamination. We aimed to analyse the safety of the hospital staff and the feasibility and outcomes of NRS applied to patients outside the ICU.
    Methods: In this observational study, data from 670 consecutive patients with confirmed coronavirus disease 2019 referred to pulmonology units in nine hospitals between March 1 and May 10, 2020 were analysed. Data collected included medication, mode and usage of NRS (
    Results: 42 (11.1%) healthcare workers tested positive for infection, but only three of them required hospitalisation. Data are reported for all patients (69.3% male), whose mean±sd age was 68±13 years. The arterial oxygen tension/inspiratory oxygen fraction ratio at baseline was 152±79, and the majority (49.3%) of patients were treated with CPAP. The overall unadjusted 30-day mortality rate was 26.9%, with 16%, 30% and 30% for HFNC, CPAP and NIV, respectively, while the total ETI rate was 27%, with 29%, 25% and 28%, respectively; the relative probability of death was not related to the NRS used after adjustment for confounders. ETI and length of stay were not different among the groups. Mortality rate increased with age and comorbidity class progression.
    Conclusions: The application of NRS outside the ICU is feasible and associated with favourable outcomes. Nonetheless, it was associated with a risk of staff contamination.
    MeSH term(s) Aged ; Aged, 80 and over ; Betacoronavirus ; COVID-19 ; Cohort Studies ; Coronavirus Infections/complications ; Coronavirus Infections/mortality ; Coronavirus Infections/therapy ; Critical Care ; Feasibility Studies ; Female ; Hospital Mortality ; Humans ; Length of Stay ; Male ; Middle Aged ; Noninvasive Ventilation ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/mortality ; Pneumonia, Viral/therapy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-11-05
    Publishing country England
    Document type Journal Article ; Observational Study
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02130-2020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: 37: Incidence of Upper and Lower Airway Viral Infections in a Cohort of Lung Transplant Recipients (LTRs)

    Bini, F. / Lastoria, C. / Cascina, A. / Lilleri, D. / Oggionni, T. / Meloni, F.

    J Heart Lung Transplant

    Keywords covid19
    Publisher PMC
    Document type Article ; Online
    DOI 10.1016/j.healun.2007.11.041
    Database COVID19

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  9. Article: Feasibility and clinical impact of out-of-ICU noninvasive respiratory support in patients with COVID-19-related pneumonia

    Franco, Cosimo / Facciolongo, Nicola / Tonelli, Roberto / Dongilli, Roberto / Vianello, Andrea / Pisani, Lara / Scala, Raffaele / Malerba, Mario / Carlucci, Annalisa / Negri, Emanuele Alberto / Spoladore, Greta / Arcaro, Giovanna / Tillio, Paolo Amedeo / Lastoria, Cinzia / Schifino, Gioachino / Tabbì, Luca / Guidelli, Luca / Guaraldi, Giovanni / Ranieri, V Marco /
    Clini, Enrico / Nava, Stefano

    Eur. respir. j

    Abstract: INTRODUCTION: The severe acute respiratory syndrome-coronavirus 2 outbreak spread rapidly in Italy and the lack of intensive care unit (ICU) beds soon became evident, forcing the application of noninvasive respiratory support (NRS) outside the ICU, ... ...

    Abstract INTRODUCTION: The severe acute respiratory syndrome-coronavirus 2 outbreak spread rapidly in Italy and the lack of intensive care unit (ICU) beds soon became evident, forcing the application of noninvasive respiratory support (NRS) outside the ICU, raising concerns over staff contamination. We aimed to analyse the safety of the hospital staff and the feasibility and outcomes of NRS applied to patients outside the ICU. METHODS: In this observational study, data from 670 consecutive patients with confirmed coronavirus disease 2019 referred to pulmonology units in nine hospitals between March 1 and May 10, 2020 were analysed. Data collected included medication, mode and usage of NRS (i.e. high-flow nasal cannula (HFNC), continuous positive airway pressure (CPAP), noninvasive ventilation (NIV)), length of stay in hospital, endotracheal intubation (ETI) and deaths. RESULTS: 42 (11.1%) healthcare workers tested positive for infection, but only three of them required hospitalisation. Data are reported for all patients (69.3% male), whose mean±sd age was 68±13†years. The arterial oxygen tension/inspiratory oxygen fraction ratio at baseline was 152±79, and the majority (49.3%) of patients were treated with CPAP. The overall unadjusted 30-day mortality rate was 26.9%, with 16%, 30% and 30% for HFNC, CPAP and NIV, respectively, while the total ETI rate was 27%, with 29%, 25% and 28%, respectively; the relative probability of death was not related to the NRS used after adjustment for confounders. ETI and length of stay were not different among the groups. Mortality rate increased with age and comorbidity class progression. CONCLUSIONS: The application of NRS outside the ICU is feasible and associated with favourable outcomes. Nonetheless, it was associated with a risk of staff contamination.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #694007
    Database COVID19

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  10. Article ; Online: Feasibility and clinical impact of out-of-ICU noninvasive respiratory support in patients with COVID-19-related pneumonia

    Franco, Cosimo / Facciolongo, Nicola / Tonelli, Roberto / Dongilli, Roberto / Vianello, Andrea / Pisani, Lara / Scala, Raffaele / Malerba, Mario / Carlucci, Annalisa / Negri, Emanuele Alberto / Spoladore, Greta / Arcaro, Giovanna / Tillio, Paolo Amedeo / Lastoria, Cinzia / Schifino, Gioachino / Tabbì, Luca / Guidelli, Luca / Guaraldi, Giovanni / Ranieri, V Marco /
    Clini, Enrico / Nava, Stefano

    2020  

    Abstract: INTRODUCTION: The severe acute respiratory syndrome-coronavirus 2 outbreak spread rapidly in Italy and the lack of intensive care unit (ICU) beds soon became evident, forcing the application of noninvasive respiratory support (NRS) outside the ICU, ... ...

    Abstract INTRODUCTION: The severe acute respiratory syndrome-coronavirus 2 outbreak spread rapidly in Italy and the lack of intensive care unit (ICU) beds soon became evident, forcing the application of noninvasive respiratory support (NRS) outside the ICU, raising concerns over staff contamination. We aimed to analyse the safety of the hospital staff and the feasibility and outcomes of NRS applied to patients outside the ICU.METHODS: In this observational study, data from 670 consecutive patients with confirmed coronavirus disease 2019 referred to pulmonology units in nine hospitals between March 1 and May 10, 2020 were analysed. Data collected included medication, mode and usage of NRS (i.e. high-flow nasal cannula (HFNC), continuous positive airway pressure (CPAP), noninvasive ventilation (NIV)), length of stay in hospital, endotracheal intubation (ETI) and deaths.RESULTS: 42 (11.1%) healthcare workers tested positive for infection, but only three of them required hospitalisation. Data are reported for all patients (69.3% male), whose mean±sd age was 68±13 years. The arterial oxygen tension/inspiratory oxygen fraction ratio at baseline was 152±79, and the majority (49.3%) of patients were treated with CPAP. The overall unadjusted 30-day mortality rate was 26.9%, with 16%, 30% and 30% for HFNC, CPAP and NIV, respectively, while the total ETI rate was 27%, with 29%, 25% and 28%, respectively; the relative probability of death was not related to the NRS used after adjustment for confounders. ETI and length of stay were not different among the groups. Mortality rate increased with age and comorbidity class progression.CONCLUSIONS: The application of NRS outside the ICU is feasible and associated with favourable outcomes. Nonetheless, it was associated with a risk of staff contamination.
    Keywords covid19
    Subject code 610
    Language English
    Publishing country it
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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