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  1. Article ; Online: The rRNA m

    Ignatova, Valentina V / Stolz, Paul / Kaiser, Steffen / Gustafsson, Tobias H / Lastres, Palma Rico / Sanz-Moreno, Adrián / Cho, Yi-Li / Amarie, Oana V / Aguilar-Pimentel, Antonio / Klein-Rodewald, Tanja / Calzada-Wack, Julia / Becker, Lore / Marschall, Susan / Kraiger, Markus / Garrett, Lillian / Seisenberger, Claudia / Hölter, Sabine M / Borland, Kayla / Van De Logt, Erik /
    Jansen, Pascal W T C / Baltissen, Marijke P / Valenta, Magdalena / Vermeulen, Michiel / Wurst, Wolfgang / Gailus-Durner, Valerie / Fuchs, Helmut / Hrabe de Angelis, Martin / Rando, Oliver J / Kellner, Stefanie M / Bultmann, Sebastian / Schneider, Robert

    Genes & development

    2020  Volume 34, Issue 9-10, Page(s) 715–729

    Abstract: Covalent chemical modifications of cellular RNAs directly impact all biological processes. However, our mechanistic understanding of the enzymes catalyzing these modifications, their substrates and biological functions, remains vague. Amongst RNA ... ...

    Abstract Covalent chemical modifications of cellular RNAs directly impact all biological processes. However, our mechanistic understanding of the enzymes catalyzing these modifications, their substrates and biological functions, remains vague. Amongst RNA modifications N
    MeSH term(s) Adenosine/analogs & derivatives ; Adenosine/metabolism ; Animals ; Cell Differentiation/genetics ; Gene Expression Regulation, Developmental/genetics ; Mice ; Mouse Embryonic Stem Cells/cytology ; Mouse Embryonic Stem Cells/enzymology ; Mutation ; Pluripotent Stem Cells/cytology ; Pluripotent Stem Cells/metabolism ; Protein Biosynthesis/genetics ; RNA, Ribosomal, 18S/metabolism
    Chemical Substances RNA, Ribosomal, 18S ; N-methyladenosine (CLE6G00625) ; Adenosine (K72T3FS567)
    Language English
    Publishing date 2020-03-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 806684-x
    ISSN 1549-5477 ; 0890-9369
    ISSN (online) 1549-5477
    ISSN 0890-9369
    DOI 10.1101/gad.333369.119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2292: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MG 54: Show issues

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  2. Article ; Online: METTL6 is a tRNA m

    Ignatova, Valentina V / Kaiser, Steffen / Ho, Jessica Sook Yuin / Bing, Xinyang / Stolz, Paul / Tan, Ying Xim / Lee, Chee Leng / Gay, Florence Pik Hoon / Lastres, Palma Rico / Gerlini, Raffaele / Rathkolb, Birgit / Aguilar-Pimentel, Antonio / Sanz-Moreno, Adrián / Klein-Rodewald, Tanja / Calzada-Wack, Julia / Ibragimov, Emil / Valenta, Magdalena / Lukauskas, Saulius / Pavesi, Andrea /
    Marschall, Susan / Leuchtenberger, Stefanie / Fuchs, Helmut / Gailus-Durner, Valerie / de Angelis, Martin Hrabe / Bultmann, Sebastian / Rando, Oliver J / Guccione, Ernesto / Kellner, Stefanie M / Schneider, Robert

    Science advances

    2020  Volume 6, Issue 35, Page(s) eaaz4551

    Abstract: Recently, covalent modifications of RNA, such as methylation, have emerged as key regulators of all aspects of RNA biology and have been implicated in numerous diseases, for instance, cancer. Here, we undertook a combination of in vitro and in vivo ... ...

    Abstract Recently, covalent modifications of RNA, such as methylation, have emerged as key regulators of all aspects of RNA biology and have been implicated in numerous diseases, for instance, cancer. Here, we undertook a combination of in vitro and in vivo screens to test 78 potential methyltransferases for their roles in hepatocellular carcinoma (HCC) cell proliferation. We identified methyltransferase-like protein 6 (METTL6) as a crucial regulator of tumor cell growth. We show that METTL6 is a bona fide transfer RNA (tRNA) methyltransferase, catalyzing the formation of 3-methylcytidine at C32 of specific serine tRNA isoacceptors. Deletion of
    MeSH term(s) Animals ; Carcinoma, Hepatocellular/genetics ; Cell Proliferation ; Liver Neoplasms/genetics ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Mice ; RNA ; RNA, Transfer/genetics ; RNA, Transfer/metabolism ; tRNA Methyltransferases
    Chemical Substances RNA (63231-63-0) ; RNA, Transfer (9014-25-9) ; METTL6 protein, human (EC 2.1.1.-) ; Methyltransferases (EC 2.1.1.-) ; tRNA Methyltransferases (EC 2.1.1.-)
    Language English
    Publishing date 2020-08-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.aaz4551
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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