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  1. Article ; Online: Novel multifunctional robotically assisted bipolar instrument for simultaneous radiofrequency sealing and transection: preclinical and single-center experience.

    Ibanez Jimenez, Cristina / Lath, Adrit / Ringold, Forrest

    BMC surgery

    2022  Volume 22, Issue 1, Page(s) 37

    Abstract: Background: A novel robotic-assisted bipolar radiofrequency (RF) multifunctional vessel seal-and-transection instrument (SynchroSeal, Intuitive Surgical, Inc., Sunnyvale, CA) has been developed. The objective of the current paper is to describe the ... ...

    Abstract Background: A novel robotic-assisted bipolar radiofrequency (RF) multifunctional vessel seal-and-transection instrument (SynchroSeal, Intuitive Surgical, Inc., Sunnyvale, CA) has been developed. The objective of the current paper is to describe the design of SynchroSeal based on bench studies, assess the safety of SynchroSeal in ex vivo and in vivo porcine studies, and provide early clinical context.
    Methods: SynchroSeal grasping, energy activation time, and jaw temperature were evaluated with those of the Harmonic Ace+7. Data were analyzed with descriptive statistics, with Mann-Whitney for comparisons and statistical significance p < 0.05. Ex vivo and in vivo animal safety assessments of tissue after SynchroSeal use were evaluated for burst pressure, thermal spread, and acute sealing. Last, a single-center analysis of the technical metrics of SynchroSeal and Vessel Sealer Extend (robotically assisted seal-and-transection instrument) in bariatric cases is provided.
    Results: Bench studies of SynchroSeal and Harmonic Ace+7 evidenced SynchroSeal's greater slip resistance force (8.4 ± 1.0 vs. 3.1 ± 0.4 N; p = 0.0002), lower grip pressure (3.0 ± 0.2 vs. 4.2 ± 0.5 kg/cm
    Conclusions: SynchroSeal's multifunctional design provides enhanced sealing and transection capabilities with an acceptable safety profile.
    MeSH term(s) Animals ; Electrocoagulation ; Ligation ; Robotic Surgical Procedures ; Swine
    Language English
    Publishing date 2022-02-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050442-1
    ISSN 1471-2482 ; 1471-2482
    ISSN (online) 1471-2482
    ISSN 1471-2482
    DOI 10.1186/s12893-022-01483-5
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  2. Article ; Online: Anti-cancer peptides: their current trends in the development of peptide-based therapy and anti-tumor drugs

    Lath, Amit / Santal, Anita Rani / Kaur, Nameet / Kumari, Poonam / Singh, Nater Pal

    Biotechnology and Genetic Engineering Reviews. 2023 Jan. 02, v. 39, no. 1 p.45-84

    2023  

    Abstract: Human cancer remains a cause of high mortality throughout the world. The conventional methods and therapies currently employed for treatment are followed by moderate-to-severe side effects. They have not generated curative results due to the ... ...

    Abstract Human cancer remains a cause of high mortality throughout the world. The conventional methods and therapies currently employed for treatment are followed by moderate-to-severe side effects. They have not generated curative results due to the ineffectiveness of treatments. Besides, the associated high costs, technical requirements, and cytotoxicity further characterize their limitations. Due to relatively higher presidencies, bioactive peptides with anti-cancer attributes have recently become treatment choices within the therapeutic arsenal. The peptides act as potential anti-cancer agents explicitly targeting tumor cells while being less toxic to normal cells. The anti-cancer peptides are isolated from various natural sources, exhibit high selectivity and high penetration efficiency, and could be quickly restructured. The therapeutic benefits of compatible anti-cancer peptides have contributed to the significant expansion of cancer treatment; albeit, the mechanisms by which bioactive peptides inhibit the proliferation of tumor cells remain unclear. This review will provide a framework for assessing anti-cancer peptides’ structural and functional aspects. It shall provide appropriate information on their mode of action to support and strengthen efforts to improve cancer prevention. The article will mention the therapeutic health benefits of anti-cancer peptides. Their importance in clinical studies is elaborated for reducing cancer incidences and developing sustainable treatment models.
    Keywords biotechnology ; cancer therapy ; cytotoxicity ; humans ; mechanism of action ; mortality ; neoplasms ; peptides ; Anti-cancer peptides ; therapeutic benefits ; anti-tumor ; bioactive peptides
    Language English
    Dates of publication 2023-0102
    Size p. 45-84.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 2500039-1
    ISSN 2046-5556 ; 0264-8725
    ISSN (online) 2046-5556
    ISSN 0264-8725
    DOI 10.1080/02648725.2022.2082157
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  3. Article ; Online: Anti-cancer peptides: their current trends in the development of peptide-based therapy and anti-tumor drugs.

    Lath, Amit / Santal, Anita Rani / Kaur, Nameet / Kumari, Poonam / Singh, Nater Pal

    Biotechnology & genetic engineering reviews

    2022  Volume 39, Issue 1, Page(s) 45–84

    Abstract: Human cancer remains a cause of high mortality throughout the world. The conventional methods and therapies currently employed for treatment are followed by moderate-to-severe side effects. They have not generated curative results due to the ... ...

    Abstract Human cancer remains a cause of high mortality throughout the world. The conventional methods and therapies currently employed for treatment are followed by moderate-to-severe side effects. They have not generated curative results due to the ineffectiveness of treatments. Besides, the associated high costs, technical requirements, and cytotoxicity further characterize their limitations. Due to relatively higher presidencies, bioactive peptides with anti-cancer attributes have recently become treatment choices within the therapeutic arsenal. The peptides act as potential anti-cancer agents explicitly targeting tumor cells while being less toxic to normal cells. The anti-cancer peptides are isolated from various natural sources, exhibit high selectivity and high penetration efficiency, and could be quickly restructured. The therapeutic benefits of compatible anti-cancer peptides have contributed to the significant expansion of cancer treatment; albeit, the mechanisms by which bioactive peptides inhibit the proliferation of tumor cells remain unclear. This review will provide a framework for assessing anti-cancer peptides' structural and functional aspects. It shall provide appropriate information on their mode of action to support and strengthen efforts to improve cancer prevention. The article will mention the therapeutic health benefits of anti-cancer peptides. Their importance in clinical studies is elaborated for reducing cancer incidences and developing sustainable treatment models.
    MeSH term(s) Humans ; Neoplasms/drug therapy ; Antineoplastic Agents ; Peptides/therapeutic use
    Chemical Substances Antineoplastic Agents ; Peptides
    Language English
    Publishing date 2022-06-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 49457-4
    ISSN 2046-5556 ; 0264-8725
    ISSN (online) 2046-5556
    ISSN 0264-8725
    DOI 10.1080/02648725.2022.2082157
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  4. Article ; Online: Ehlers-Danlos syndrome--vascular type (ecchymotic variant): cutaneous and dermatopathologic features.

    Sharma, Nand L / Mahajan, Vikram K / Gupta, Neelam / Ranjan, Nitin / Lath, Anju

    Journal of cutaneous pathology

    2009  Volume 36, Issue 4, Page(s) 486–492

    Abstract: Ehlers-Danlos syndrome - vascular type, the only lethal form, is rarely reported in dermatology literature. It is characterized by translucent, atrophic skin, easy bruising, arterial, intestinal and/or uterine fragility manifesting as varicose veins, ... ...

    Abstract Ehlers-Danlos syndrome - vascular type, the only lethal form, is rarely reported in dermatology literature. It is characterized by translucent, atrophic skin, easy bruising, arterial, intestinal and/or uterine fragility manifesting as varicose veins, aneurysms and vascular/visceral/uterine rupture. As its dermatopathologic features are not well elucidated, diagnosis is often made after a catastrophic complication or at autopsy. This 36 year-old non-consanguineous male had brown-black plaques with atrophy and frequent ulceration over legs and dorsal feet and tortuous varicose veins around ankles for the past 15 years. Perivenous skin was translucent and hypopigmented. He had multiple and ecchymotic keloids and small atrophic, pityriasis versicolor-like lesions over trunk. He did not have hypermobile/hyperextensible skin and joints and showed no systemic or investigative abnormality. Histopathologic features of atrophic lesion included blood extravasation in atrophic epidermis/dermis, focal clustering and dilatation of blood vessels, malformed vessel walls, abundant hemosiderin in the dermis and homogenously stained/whorled patterned collagen especially around blood vessels. Pathology of keloidal lesion showed new collagen and vascular fragility. These histopathologic features appear of diagnostic value especially in patients who have compatible clinical findings but cannot afford confirmation by biochemical testing for abnormal synthesis of type III procollagen or identification of mutations in the COL3A1 gene.
    MeSH term(s) Adult ; Ecchymosis/etiology ; Ecchymosis/pathology ; Ehlers-Danlos Syndrome/complications ; Ehlers-Danlos Syndrome/pathology ; Humans ; Male ; Skin/pathology
    Language English
    Publishing date 2009-04
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 187078-6
    ISSN 1600-0560 ; 0303-6987
    ISSN (online) 1600-0560
    ISSN 0303-6987
    DOI 10.1111/j.1600-0560.2008.01065.x
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  5. Article ; Online: Hirsutism: clinico-investigative profile of 50 Indian patients.

    Sharma, Nand Lal / Mahajan, Vikram K / Jindal, Rashmi / Gupta, Mudita / Lath, Anju

    Indian journal of dermatology

    2009  Volume 53, Issue 3, Page(s) 111–114

    Abstract: Background: Despite worldwide prevalence of hirsutism studies on hirsutism in Indian patients are not many.: Aims: This retrospective study was carried out to assess the clinico-investigative profile of patients presenting with hirsutism.: ... ...

    Abstract Background: Despite worldwide prevalence of hirsutism studies on hirsutism in Indian patients are not many.
    Aims: This retrospective study was carried out to assess the clinico-investigative profile of patients presenting with hirsutism.
    Materials and methods: Medical records of 82 hirsutism patients diagnosed consecutively during July 2005 to October 2007 were analyzed.
    Results: The complete data of 50 patients aged between 13 and 47 years were available. Fifty percent patients were aged 20 to 30 years. The average F-G score was 10.3 +/- 2.46. Associated signs of hyperandrogenism were acne (64%), oligomenorrhea or menstrual irregularities (36%), androgenetic alopecia (16%), acanthosis nigricans (6%) and seborrhea (4%). Polycystic ovaries were detected in 30% patients and 22% patients had elevated serum free testosterone levels. Family history of hirsutism was present in 18% patients.
    Conclusion: Hirsutism in Indian patients is not uncommon. Adolescent patients appear to be more concerned about hirsutism as compared to those in the older age group who were more often worried of late onset acne. All patients, however, were more concerned for facial hair than those on other body areas signifying that facial hair need to be given higher than current value in F-G score.
    Language English
    Publishing date 2009-10-20
    Publishing country India
    Document type Journal Article
    ZDB-ID 416069-1
    ISSN 1998-3611 ; 0019-5154
    ISSN (online) 1998-3611
    ISSN 0019-5154
    DOI 10.4103/0019-5154.42387
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  6. Article: Detection of Marek's disease virus antigen in chickens by a novel immunoassay

    Scholten, R / Hilgers, L.A.Th / Jeurissen, S.H.M / Weststrate, M.W

    Journal of virological methods. Feb 1990. v. 27 (2)

    1990  

    Keywords chickens ; Marek disease ; antigens ; immunoassays ; monoclonal antibodies ; enzyme-linked immunosorbent assay
    Language English
    Dates of publication 1990-02
    Size p. 221-226., ill.
    Document type Article
    ZDB-ID 8013-5
    ISSN 1879-0984 ; 0166-0934
    ISSN (online) 1879-0984
    ISSN 0166-0934
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    Zs.A 1565: Show issues Location:
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  7. Article ; Online: Sulfolipo-cyclodextrin in squalane-in-water as a novel and safe vaccine adjuvant

    Hilgers, L.A.Th. / Lejeune, G. / Nicolas, I. / Fochesato, M. / Boon, B.

    Vaccine

    1999  Volume 17, Issue 3

    Abstract: Previously, we described synergistic adjuvanticity of combinations of synthetic sulfolipo(SL)-derivatives of polysaccharide (SL-polysaccharides) and squalane-in-water emulsions (squalane/W). In this paper, effects of type of polysaccharide and nature of ... ...

    Abstract Previously, we described synergistic adjuvanticity of combinations of synthetic sulfolipo(SL)-derivatives of polysaccharide (SL-polysaccharides) and squalane-in-water emulsions (squalane/W). In this paper, effects of type of polysaccharide and nature of oil on adjuvanticity, reactogenicity and stability are described. SL-derivatives of the following polysaccharides were synthesised: synthetic polysucroses with weight-average molecular weight (MW) of 400,000 (Ficoll400), 70,000 (Ficoll70) and 39,000 Da (Ficoll39), polyfructose of 5,000 Da (inulin), linear polyglucose of 1,200 Da (maltodextrin) and cyclic polyglucose of 1,135 Da (beta-cyclodextrin). The number of sulphate groups per monosaccharide of the different SL- polysaccharides varied between 0.15 and 0.23 and the number of lipid groups per monosaccharide between 1.15 and 1.29. Adjuvant formulations were prepared by incorporating these SL-polysaccharides into oil-in-water emulsions of either squalane, hexadecane, soya oil or mineral oil. Adjuvanticity of the formulations obtained for humoral responses to inactivated pseudorabies virus (PRV) and inactivated influenza virus strains A/Swine (A/Swine) and MRC-11 (MRC-11) in pigs and MRC-11 and ovalbumin (OVA) in mice depended on the type of oil (squalane = mineral oil > hexadecane = soya oil) but not on the type of polysaccharide backbone of the SL-derivative. Reactogenicity assessed by local swelling in mice decreased with decreasing MW (SL-Ficoll400 = Ficoll70 = Ficoll39 > SL-inulin = SL-mattodextrin > SL-cyclodextrin) when combined with squalane and decreased with the type of oil in the following order: squalane > mineral oil > hexadecane > soya oil when combined with SL- Ficoll400. Stability of the SL-polysaccharide/squalane/W emulsions at elevated temperature increased with decreasing MW of the SL-polysaccharide (SL-Ficoll400 < SL-Ficoll70 = SL-Ficoll39 < SL-inulin = SL-maltodextrin = SL- cyclodextrin). SL-cyclodextrin/squalane/W remained stable for > 2.5 years at 4°C, > 18 ...
    Keywords Adjuvant ; Cyclodextrin ; Emulsion ; Glycolipid ; Non-mineral oil
    Subject code 540
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
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  8. Article ; Online: Quantitative analysis of a synthetic adjuvant by an immunoassay

    Hilgers, L.A.Th. / Fochesato, M. / Nicolas, I. / Lejeune, G. / Boon, B.

    Journal of Immunological Methods

    1998  Volume 218

    Keywords Adjuvant ; Blocking-ELISA ; Ficoll ; Polysaccharide ; Vaccine
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 120142-6
    ISSN 1872-7905 ; 0022-1759
    ISSN (online) 1872-7905
    ISSN 0022-1759
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  9. Article ; Online: Alkyl-esters of polyacrylic acid as vaccine adjuvants

    Hilgers, L.A.Th. / Nicolas, I. / Lejeune, G. / Dewil, E. / Strebelle, M. / Boon, B.

    Vaccine

    1998  Volume 16

    Keywords Adjuvants ; Newcastle disease virus ; Polyaerylate esters ; Polymers
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
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  10. Article ; Online: Effect of various adjuvants on secondary immune response in chickens

    Hilgers, L.A.Th. / Nicolas, I. / Lejeune, G. / Dewil, E. / Boon, B.

    Veterinary Immunology and Immunopathology

    1998  Volume 66

    Keywords Adjuvants ; Chickens ; Emulsions ; Newcastle disease virus ; Polymers ; Secondary immune response
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 754160-0
    ISSN 1873-2534 ; 0165-2427
    ISSN (online) 1873-2534
    ISSN 0165-2427
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