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  1. Article ; Online: Aging and Adiposity-Focus on Biological Females at Midlife and Beyond.

    Rehman, Amna / Lathief, Sanam / Charoenngam, Nipith / Pal, Lubna

    International journal of molecular sciences

    2024  Volume 25, Issue 5

    Abstract: Menopause is a physiological phase of life of aging women, and more than 1 billion women worldwide will be in menopause by 2025. The processes of global senescence parallel stages of reproductive aging and occur alongside aging-related changes in the ... ...

    Abstract Menopause is a physiological phase of life of aging women, and more than 1 billion women worldwide will be in menopause by 2025. The processes of global senescence parallel stages of reproductive aging and occur alongside aging-related changes in the body. Alterations in the endocrine pathways accompany and often predate the physiologic changes of aging, and interactions of these processes are increasingly being recognized as contributory to the progression of senescence. Our goal for this review is to examine, in aging women, the complex interplay between the endocrinology of menopause transition and post-menopause, and the metabolic transition, the hallmark being an increasing tendency towards central adiposity that begins in tandem with reproductive aging and is often exacerbated post menopause. For the purpose of this review, our choice of the terms 'female' and 'woman' refer to genetic females.
    MeSH term(s) Female ; Humans ; Adiposity ; Aging/metabolism ; Menopause/physiology ; Postmenopause ; Reproduction ; Obesity
    Language English
    Publishing date 2024-03-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25052972
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Approach to diabetes management in patients with CVD.

    Lathief, Sanam / Inzucchi, Silvio E

    Trends in cardiovascular medicine

    2016  Volume 26, Issue 2, Page(s) 165–179

    Abstract: Epidemiologic analyses have established a clear association between diabetes and macrovascular disease. Vascular dysfunction caused by metabolic abnormalities in patients with diabetes is associated with accelerated atherosclerosis and increased risk of ... ...

    Abstract Epidemiologic analyses have established a clear association between diabetes and macrovascular disease. Vascular dysfunction caused by metabolic abnormalities in patients with diabetes is associated with accelerated atherosclerosis and increased risk of myocardial infarction (MI), stroke, and peripheral arterial disease. Patients with diabetes are at two to four fold higher CV risk as compared to non-diabetic individuals, and CVD remains the leading cause of mortality in patients with this condition. One strategy to reduce CVD burden in patients with diabetes has been to focus on controlling the major metabolic abnormality in this condition, namely hyperglycemia. However, this has not been unequivocally demonstrated to reduced CV events, in contrast to controlling other CVD risk factors linked to hyperglycemia, such as blood pressure, dyslipidemia, and platelet dysfunction. However, In contradistinction, accrued data from a number of large, randomized clinical trials in both type 1 (T1DM) and type 2 diabetes (T2DM) over the past 3 decades have proven that more intensive glycemic control retards the onset and progression of microvascular disease. In this review, we will summarize the key glucose-lowering CV outcomes trials in diabetes, provide an overview of the different drugs and their impact on the CV system, and describe our approach to management of the frequently encountered patient with T2DM and coronary artery disease (CAD) and/or heart failure (HF).
    MeSH term(s) Coronary Artery Disease/complications ; Coronary Artery Disease/therapy ; Diabetes Complications/therapy ; Disease Management ; Humans ; Hyperglycemia/drug therapy ; Hypoglycemic Agents/classification ; Hypoglycemic Agents/pharmacology ; Outcome Assessment (Health Care) ; Randomized Controlled Trials as Topic
    Chemical Substances Hypoglycemic Agents
    Language English
    Publishing date 2016-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1097434-9
    ISSN 1873-2615 ; 1050-1738
    ISSN (online) 1873-2615
    ISSN 1050-1738
    DOI 10.1016/j.tcm.2015.05.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Predictors of depression in women with polycystic ovary syndrome.

    Naqvi, Syed Haider / Moore, Ava / Bevilacqua, Kris / Lathief, Sanam / Williams, Joanne / Naqvi, Nighat / Pal, Lubna

    Archives of women's mental health

    2015  Volume 18, Issue 1, Page(s) 95–101

    Abstract: The aim of this study is to assess the prevalence and predictors of depressive symptoms in women with polycystic ovary syndrome (PCOS). In a cross-sectional study of 114 women seeking consultation for symptoms of PCOS (menstrual irregularity, hirsutism, ... ...

    Abstract The aim of this study is to assess the prevalence and predictors of depressive symptoms in women with polycystic ovary syndrome (PCOS). In a cross-sectional study of 114 women seeking consultation for symptoms of PCOS (menstrual irregularity, hirsutism, and/or acne), personal and family history of depression (HD and FHD respectively) were enquired. Vitamin D status (n = 104) and manifest depressive symptoms assessed by personal health questionnaire (PHQ) (MD) were evaluated in a subset (85). Relationships between HD and MD with PCOS symptoms, FHD, and vitamin D status were assessed using adjusted analyses. Thirty-five percent acknowledged a HD; MD (PHQ > 4) was apparent in 43 %. HD was associated with hirsutism (OR 2.4, 95 % CI 1.01-5.9), disturbed sleep (OR 3.0, 95 % CI 1.3-6.9), and with FHD (OR 4.8, 95 % CI 1.7-13.5). Disturbed sleep (OR 2.4, 95 % CI 1.01-5.7) and FHD (OR 3.8, 95 % CI 1.3-11.2) were independent predictors of HD adjusting for race and BMI. An inverse correlation was noted between serum 25 OH vitamin D (25OHD) levels and PHQ score, but only in those with vitamin D deficiency (25OHD ≤ 30 ng/ml, n = 57, r =-0.32, p = 0.015). 25OHD < 20 ng/ml (OR 3.5, 95 % CI 1.1-11.8) and HD (OR 12.8, 95 % CI 3.6-45.2) predicted scoring in the highest PHQ tertile after adjusting for hirsutism, BMI, and race. In women with PCOS, disturbed nocturnal sleep and FDH predicted personal HD, whereas HD and vitamin D deficiency related to the severity of MD symptoms.
    MeSH term(s) 25-Hydroxyvitamin D 2/blood ; Adolescent ; Adult ; Body Mass Index ; Cross-Sectional Studies ; Depression/diagnosis ; Depression/epidemiology ; Depression/psychology ; Female ; Hirsutism/epidemiology ; Humans ; Logistic Models ; Multivariate Analysis ; Polycystic Ovary Syndrome/blood ; Polycystic Ovary Syndrome/epidemiology ; Polycystic Ovary Syndrome/psychology ; Prevalence ; Severity of Illness Index ; Surveys and Questionnaires ; Vitamin D/blood ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/epidemiology ; Vitamin D Deficiency/metabolism
    Chemical Substances Vitamin D (1406-16-2) ; 25-Hydroxyvitamin D 2 (21343-40-8)
    Language English
    Publishing date 2015-02
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 1480651-4
    ISSN 1435-1102 ; 1434-1816
    ISSN (online) 1435-1102
    ISSN 1434-1816
    DOI 10.1007/s00737-014-0458-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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